CN110809716B - 基于hla的方法和组合物及其用途 - Google Patents
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- CN110809716B CN110809716B CN201880024774.4A CN201880024774A CN110809716B CN 110809716 B CN110809716 B CN 110809716B CN 201880024774 A CN201880024774 A CN 201880024774A CN 110809716 B CN110809716 B CN 110809716B
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
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- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G—PHYSICS
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- G16B35/10—Design of libraries
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- G—PHYSICS
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- G16B35/20—Screening of libraries
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- Bioinformatics & Cheminformatics (AREA)
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- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310647697.0A CN116693695A (zh) | 2017-02-12 | 2018-02-12 | 基于hla的方法和组合物及其用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457978P | 2017-02-12 | 2017-02-12 | |
| US62/457,978 | 2017-02-12 | ||
| US201762461162P | 2017-02-20 | 2017-02-20 | |
| US62/461,162 | 2017-02-20 | ||
| PCT/US2018/017849 WO2018148671A1 (en) | 2017-02-12 | 2018-02-12 | Hla-based methods and compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310647697.0A Division CN116693695A (zh) | 2017-02-12 | 2018-02-12 | 基于hla的方法和组合物及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110809716A CN110809716A (zh) | 2020-02-18 |
| CN110809716B true CN110809716B (zh) | 2023-07-07 |
Family
ID=61386919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880024774.4A Active CN110809716B (zh) | 2017-02-12 | 2018-02-12 | 基于hla的方法和组合物及其用途 |
| CN202310647697.0A Pending CN116693695A (zh) | 2017-02-12 | 2018-02-12 | 基于hla的方法和组合物及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310647697.0A Pending CN116693695A (zh) | 2017-02-12 | 2018-02-12 | 基于hla的方法和组合物及其用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11965892B2 (https=) |
| EP (2) | EP4287191A3 (https=) |
| JP (3) | JP7370861B2 (https=) |
| KR (2) | KR102565256B1 (https=) |
| CN (2) | CN110809716B (https=) |
| BR (1) | BR112019016657A2 (https=) |
| CA (1) | CA3053133A1 (https=) |
| DK (1) | DK3580561T3 (https=) |
| ES (1) | ES2965475T3 (https=) |
| FI (1) | FI3580561T3 (https=) |
| HU (1) | HUE065174T2 (https=) |
| SI (1) | SI3580561T1 (https=) |
| WO (1) | WO2018148671A1 (https=) |
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| CN105190656B (zh) | 2013-01-17 | 2018-01-16 | 佩索纳里斯公司 | 用于遗传分析的方法和系统 |
| US10125399B2 (en) | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| JP2019505512A (ja) | 2016-01-08 | 2019-02-28 | バッシボディ アクスイェ セルスカプ | 治療用抗癌ネオエピトープワクチン |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| WO2018148671A1 (en) | 2017-02-12 | 2018-08-16 | Neon Therapeutics, Inc. | Hla-based methods and compositions and uses thereof |
| WO2018187515A1 (en) | 2017-04-04 | 2018-10-11 | Avidea Technologies, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
| JP7763588B2 (ja) * | 2017-09-05 | 2025-11-04 | グリットストーン バイオ インコーポレイテッド | T細胞療法用の新生抗原の特定法 |
| CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
| BR112020025764A2 (pt) | 2018-06-19 | 2021-05-11 | Biontech Us Inc. | neoantígenos e usos dos mesmos |
| AU2019404547B2 (en) | 2018-12-21 | 2025-01-30 | Biontech Us Inc. | Method and systems for prediction of HLA class II-specific epitopes and characterization of CD4+ T cells |
| CN113645982A (zh) * | 2019-03-29 | 2021-11-12 | 普梭梅根公司 | 微生物群副产物及其应用 |
| EP4055610A4 (en) | 2019-11-05 | 2023-11-29 | Personalis, Inc. | ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES |
| EP4168569A4 (en) * | 2020-06-18 | 2024-08-07 | Personalis, Inc. | Machine-learning techniques for predicting surface-presenting peptides |
| WO2022013154A1 (en) * | 2020-07-14 | 2022-01-20 | Myneo Nv | Method, system and computer program product for determining presentation likelihoods of neoantigens |
| AU2021325082A1 (en) | 2020-08-13 | 2023-04-20 | Biontech Us Inc. | RAS neoantigens and uses thereof |
| CN116710115A (zh) | 2020-11-20 | 2023-09-05 | 思维疗法股份有限公司 | 用于优化的肽疫苗的组合物和方法 |
| US11058751B1 (en) | 2020-11-20 | 2021-07-13 | Think Therapeutics, Inc. | Compositions for optimized RAS peptide vaccines |
| US11421015B2 (en) | 2020-12-07 | 2022-08-23 | Think Therapeutics, Inc. | Method of compact peptide vaccines using residue optimization |
| WO2022121973A1 (zh) * | 2020-12-09 | 2022-06-16 | 江苏恒瑞医药股份有限公司 | 基于机器学习的肽免疫原性预测、鉴别系统及方法 |
| US11464842B1 (en) | 2021-04-28 | 2022-10-11 | Think Therapeutics, Inc. | Compositions and method for optimized peptide vaccines using residue optimization |
| EP4413580A4 (en) | 2021-10-05 | 2025-08-13 | Personalis Inc | PERSONALIZED TESTS FOR PERSONALIZED CANCER MONITORING |
| CN114582423B (zh) * | 2022-02-26 | 2024-10-22 | 河南省健康元生物医药研究院有限公司 | 一种基于组合型机器学习模型的蛋白质溶解性预测方法 |
| CN115171792B (zh) * | 2022-06-30 | 2025-08-26 | 湖南大学 | 一种毒力因子和抗生素抗性基因的混合预测方法 |
| AU2023321890A1 (en) * | 2022-08-12 | 2025-02-27 | Biontech Us Inc. | Methods and systems for prediction of hla epitopes |
| AR130389A1 (es) * | 2022-09-08 | 2024-12-04 | Hoffmann La Roche | Identificación de receptores de linfocitos t |
| CN116024183B (zh) * | 2023-02-15 | 2023-10-31 | 中国农业科学院兰州兽医研究所 | 一种用于荧光染色的重组蓝舌病毒及其构建方法 |
| WO2024187199A1 (en) * | 2023-03-09 | 2024-09-12 | Immunitybio, Inc. | Method and system for t-cell receptor (tcr) assay design |
| CN121127606A (zh) * | 2023-03-24 | 2025-12-12 | 基金会医学公司 | 用于鉴定hla变体的系统和方法 |
| WO2024233887A1 (en) * | 2023-05-10 | 2024-11-14 | Science Corporation | A hypoimmunogenic cell and methods of generation thereof |
| IL326066A (en) * | 2023-08-02 | 2026-03-01 | Broad Inst Inc | Compositions and methods for activating and maturing immune cells |
| WO2025202937A1 (en) | 2024-03-26 | 2025-10-02 | BioNTech SE | Cancer vaccines |
| EP4628502A1 (en) * | 2024-03-26 | 2025-10-08 | Acer Incorporated | Method for changing hla presentation of peptide in cell line, cell line with changed hla presentation of peptide and use thereof |
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| CA3053133A1 (en) | 2018-08-16 |
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| EP4287191A2 (en) | 2023-12-06 |
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| CN116693695A (zh) | 2023-09-05 |
| HUE065174T2 (hu) | 2024-05-28 |
| US20200105378A1 (en) | 2020-04-02 |
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| CN110809716A (zh) | 2020-02-18 |
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| US20200096521A1 (en) | 2020-03-26 |
| EP3580561B1 (en) | 2023-11-01 |
| ES2965475T3 (es) | 2024-04-15 |
| BR112019016657A2 (pt) | 2020-04-07 |
| KR20200015454A (ko) | 2020-02-12 |
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| JP2025184923A (ja) | 2025-12-18 |
| EP4287191A3 (en) | 2024-03-06 |
| RU2019128435A3 (https=) | 2021-06-10 |
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| RU2019128435A (ru) | 2021-03-12 |
| US11965892B2 (en) | 2024-04-23 |
| WO2018148671A1 (en) | 2018-08-16 |
| JP2020511121A (ja) | 2020-04-16 |
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