CN110801305B - Heart failure animal model induction device - Google Patents
Heart failure animal model induction device Download PDFInfo
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- CN110801305B CN110801305B CN201911112617.1A CN201911112617A CN110801305B CN 110801305 B CN110801305 B CN 110801305B CN 201911112617 A CN201911112617 A CN 201911112617A CN 110801305 B CN110801305 B CN 110801305B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a heart failure animal model induction device which comprises a base, wherein a storage groove is formed in the side wall of the base, a rotating plate is arranged in the storage groove, two strip-shaped grooves are formed in two opposite side walls of the rotating plate, an inlet and an outlet which are communicated with the storage groove are formed in the two opposite side walls of the base respectively, an installation groove is formed in the inner wall of the storage groove, and an injection part for injecting medicine is installed in the installation groove. According to the invention, under the action of the driving device and the pushing device, the rotating plate can be pushed to rotate along the horizontal direction, at the moment, the injection part can inject the model animals, after the injection is finished, the rotating plate is pushed to rotate along the vertical direction again, the model animals in the strip-shaped groove can be pushed out, and thus, a large number of model animals can be injected in a circulating manner, so that the injection is convenient and rapid, meanwhile, the model animals enter the device through the inlet and then are conveyed out through the outlet, the confusion is avoided, and the error of experimental data is avoided.
Description
Technical Field
The invention relates to the technical field of relevant equipment for heart failure experiments, in particular to a heart failure animal model induction device.
Background
Heart failure is a common critical disease in clinic, and related experiments need to be carried out by establishing an animal model in order to find an effective treatment method.
In the existing experimental technical means, most of the experimental technical means are that relevant medicines are injected into model animals, and various experimental data of the injected animals are collected. However, during injection, experimenters need to hold an animal to inject the needle tube, the injection process is very difficult due to factors such as mobility of the animal and panic, meanwhile, more animals need to be tested for pursuing more accurate experimental data, confusion is easy to occur, data confusion is caused, and finally, more serious results are caused.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides the heart failure animal model induction device which injects a large number of model animals in a circulating manner, so that the injection is convenient and quick, and meanwhile, the model animals enter the device through an inlet and are then conveyed out through an outlet, so that the chaos is avoided, and the error of experimental data is avoided; the output of a stepping motor simultaneously drives the driving device, the pushing device and the infusion device to operate, so that the electric power energy can be saved, and meanwhile, the coordinated linkage is generated among all the components, and the motion interference is avoided; through the continuous infusion to injection part of infusion set, drive rotor plate cycle simultaneously rotates for this device can the circulation function repeatedly, only need regularly to stock solution intracavity add the liquid medicine can, make this device easy and simple to handle.
In order to achieve the purpose, the invention adopts the following technical scheme:
the heart failure animal model induction device comprises a base, wherein the side wall of the base is provided with a storage groove, the article placing groove is internally provided with a rotating plate, two opposite side walls of the rotating plate are respectively provided with two strip-shaped grooves, the two opposite side walls of the base are respectively provided with an inlet and an outlet which are communicated with the article placing groove, the inner wall of the article placing groove is provided with an installation groove, an injection part for injecting medicine is arranged in the mounting groove, a liquid injection cavity is arranged on the side wall of the base, the liquid injection cavity is communicated with the inner part of the medicine inlet of the injection component, an infusion device for inputting medicine liquid to the injection component is arranged in the liquid injection cavity, the article placing groove is internally provided with a driving rotating plate driving device rotating along a horizontal axis, the article placing groove is internally provided with a first pushing device pushing the rotating plate to rotate along a vertical axis, the side wall of the base is provided with a square groove, and the square groove is internally provided with a second pushing device pushing the second rotating shaft to rotate.
Preferably, drive arrangement is including rotating the first pivot of connection on putting the inner wall of thing groove, first rectangular channel has been seted up to the lateral wall of first pivot, install on the lateral wall of rotor plate with the first rectangular channel complex first rectangle piece, the lateral wall fixedly connected with step motor of base, just step motor's output shaft and the coaxial fixed connection of first pivot.
Preferably, second thrust unit rotates the second pivot of connection at the interior bottom of putting the thing groove, the second rectangular channel has been seted up to the upper end of second pivot, install on the lateral wall of rotor plate with second rectangular channel complex second rectangular block, the lower extreme of base rotates and is connected with the first belt pulley with the coaxial fixed connection of second pivot, the lower extreme of base rotates and is connected with the second belt pulley, just first belt pulley passes through belt transmission with the second belt pulley and is connected, square groove has been seted up to the lateral wall of base, square inslot is installed and is promoted second belt pulley pivoted pushing mechanism.
Preferably, the pushing mechanism comprises an internal gear rotatably connected to the bottom in the square groove, the top in the square groove is rotatably connected with a telescopic cylinder, the telescopic end of the telescopic cylinder is fixedly connected with a first gear matched with the internal gear, a first mechanism groove is formed in the side wall of the base, a first bevel gear which is fixedly connected with a first rotating shaft in a coaxial mode is rotatably connected in the first mechanism groove, the bottom in the first mechanism groove is rotatably connected with a second bevel gear meshed with the first bevel gear, and the lower end of the second bevel gear is fixedly connected with the telescopic cylinder through a connecting rod.
Preferably, infusion set includes that sealed sliding connection is at the piston of annotating the liquid intracavity, the stock solution chamber has been seted up to the lateral wall of base, the stock solution chamber passes through the passageway and annotates the liquid chamber intercommunication, just install first check valve in the passageway, install the second check valve on the piston, second mechanism groove has been seted up to the lateral wall of base, the moving mechanism that the drive piston reciprocated is installed to the second mechanism inslot.
Preferably, moving mechanism is including rotating the runner of connection on second mechanism inslot wall, it is connected with the dwang to rotate on the lateral wall of runner, the upper end of dwang is rotated and is connected with the straight-bar, the straight-bar extend to annotate the liquid intracavity and with the lower extreme fixed connection of piston.
Preferably, the inner wall of the first mechanism groove is rotatably connected with a second gear, the second gear is coaxially and fixedly connected with an output shaft of the stepping motor, the inner wall of the first mechanism groove is rotatably connected with a third gear meshed with the second gear, and the third gear is coaxially and fixedly connected with the rotating wheel.
Preferably, the first one-way valve only allows the liquid medicine to flow from the liquid storage chamber to the liquid injection chamber, and the second one-way valve only allows the liquid medicine to flow from the upper end of the piston to the lower end of the piston.
Preferably, the upper end of the base is provided with a liquid filling port communicated with the interior of the liquid storage cavity, and a switch valve is installed in the liquid filling port.
The invention has the following beneficial effects:
1. through setting up the rotatable platen that can level, vertical rotation in putting the thing groove, can input the experimental animal into the bar inslot from the import, at this moment under drive arrangement and thrust unit's effect, can promote the rotatable platen to rotate along the horizontal direction, injection part can inject the model animal at this moment, promote the rotatable platen to rotate along the vertical direction again after finishing injecting, can push away the model animal in the bar inslot, so can circulate and inject a large amount of model animals, not only make the injection convenient, swift, the model animal gets into this device by the import and transports away from the export again at the same time, can not cause the confusion, avoid the experimental data to appear the mistake;
2. the output of a stepping motor simultaneously drives the driving device, the pushing device and the infusion device to operate, so that the electric power energy can be saved, and meanwhile, the coordinated linkage is generated among all the components, and the motion interference is avoided;
3. through the continuous infusion to injection part of infusion set, drive rotor plate cycle simultaneously rotates for this device can the circulation function repeatedly, only need regularly to stock solution intracavity add the liquid medicine can, make this device easy and simple to handle.
Drawings
FIG. 1 is a schematic structural diagram of an induction device of an animal model of heart failure according to the present invention;
FIG. 2 is a schematic diagram of a back side structure of an induction device of an animal model of heart failure according to the present invention;
FIG. 3 is an enlarged schematic view of the structure at the position A of the induction device of the animal model of heart failure according to the present invention;
FIG. 4 is an enlarged view of the structure at B of the induction device of animal model of heart failure in accordance with the present invention;
FIG. 5 is an enlarged view of the structure at position C of the induction device of animal model of heart failure according to the present invention;
fig. 6 is an enlarged schematic view of the structure at position D of the induction device of the animal model of heart failure provided by the invention.
In the figure: the device comprises a base 1, a storage groove 2, a rotating plate 3, a strip-shaped groove 4, an inlet 5, an outlet 6, a first mechanism groove 7, a first bevel gear 8, a first rotating shaft 9, a first rectangular groove 10, a first rectangular block 11, a second bevel gear 12, a second gear 13, a second rectangular groove 14, a second rectangular block 15, a second rotating shaft 16, a first belt pulley 17, a second belt pulley 18, a stepping motor 19, a third gear 20, a square groove 21, a telescopic cylinder 22, a first gear 23, a gear 24, a liquid storage cavity 25, a liquid filling opening 26, a liquid injection cavity 27, a channel 28, a piston 29, a straight rod 30, a rotating rod 31, a rotating wheel 32, a mounting groove 33 and a second mechanism groove 34.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Referring to fig. 1-6, heart failure animal model induction device, including base 1, the lateral wall of base 1 has been seted up and has been put thing groove 2, is equipped with rotor plate 3 in putting thing groove 2, and two bar grooves 4 have all been seted up to two relative lateral walls of rotor plate 3, and import 5 and export 6 that put thing groove 2 intercommunication are seted up respectively to two relative lateral walls of base 1, have seted up mounting groove 33 on putting the inner wall of thing groove 2, install the injection part that is used for injecting the medicine in mounting groove 33.
The injection member is a conventional injection device for injecting a drug solution into an animal, and its control method is a conventional technique.
Annotate the liquid chamber 27 has been seted up to the lateral wall of base 1, annotate the inside intercommunication of liquid chamber 27 and injection unit's income liquid medicine mouth, annotate the infusion set of liquid intracavity 27 interior directional injection unit input liquid medicine of installation, install drive rotor plate 3 along horizontal axis pivoted drive arrangement in putting thing groove 2, it installs promotion rotor plate 3 along vertical axis pivoted thrust unit to put thing inslot 2, square groove 21 has been seted up to the lateral wall of base 1, install in the square groove 21 and promote 16 pivoted thrust unit in the second pivot.
Drive arrangement is including rotating first pivot 9 of connection on putting the inner wall of thing groove 2, and first rectangular channel 10 has been seted up to the lateral wall of first pivot 9, installs on the lateral wall of rotor plate 3 with the first rectangular block 11 of first rectangular channel 10 complex, the lateral wall fixedly connected with step motor 19 of base 1, and step motor 19's output shaft and the coaxial fixed connection of first pivot 9.
It should be noted that the stepping motor 19 is an existing power output device, and the interior of the stepping motor 19 is controlled by a pulse signal so that the output shaft of the stepping motor 19 can be intermittently rotated.
The thrust unit rotates to be connected at the second pivot 16 of putting the interior bottom of thing groove 2, second rectangular channel 14 has been seted up to the upper end of second pivot 16, install on the lateral wall of rotor plate 3 with second rectangular channel 14 complex second rectangular block 15, the lower extreme of base 1 rotates and is connected with the first belt pulley 17 with the coaxial fixed connection of second pivot 16, the lower extreme of base 1 rotates and is connected with second belt pulley 18, and first belt pulley 17 passes through belt transmission with second belt pulley 18 and is connected, square groove 21 has been seted up to the lateral wall of base 1, install in the square groove 21 and promote second belt pulley 18 pivoted pushing mechanism.
It should be noted that, the first rectangular block 11 and the first rectangular groove 10, and the second rectangular block 15 and the second rectangular groove 14 are both connected in a sliding manner, so that the first rectangular block 11 and the first rectangular groove 10, and the second rectangular block 15 and the second rectangular groove 14 can both be separated, and meanwhile, when the first rotating shaft 9 or the second rotating shaft 16 rotates, the rotating plate 3 is driven to rotate along the horizontal direction or the vertical direction. And an electric control module for controlling the first rectangular block 11 and the second rectangular block 15 to be separated from the first rectangular groove 10 and the second rectangular groove 14 is arranged on the rotating plate 3.
Pushing mechanism is including rotating the internal gear 24 of connection bottom in square groove 21, the interior top of square groove 21 is rotated and is connected with telescopic cylinder 22, and telescopic cylinder 22's the coaxial fixedly connected with of flexible end and the first gear 23 of internal gear 24 complex, first mechanism groove 7 has been seted up to the lateral wall of base 1, first mechanism groove 7 internal rotation is connected with the first bevel gear 8 with the coaxial fixed connection of first pivot 9, the interior bottom of first mechanism groove 7 is rotated and is connected with the second bevel gear 12 with the meshing of first bevel gear 8, and the lower extreme of second bevel gear 12 passes through connecting rod and telescopic cylinder 22 fixed connection.
Infusion set includes piston 29 of sealed sliding connection in annotating liquid chamber 27, stock solution chamber 25 has been seted up to the lateral wall of base 1, filling opening 26 with the inside intercommunication of stock solution chamber 25 is seted up to the upper end of base 1, and install switch valve in the filling opening 26, stock solution chamber 25 communicates with annotating liquid chamber 27 through passageway 28, and install first check valve in the passageway 28, install the second check valve on the piston 29, second mechanism groove 34 has been seted up to the lateral wall of base 1, install the moving mechanism that drive piston 29 reciprocated in the second mechanism groove 34, first check valve only allows the liquid medicine to flow into liquid chamber 27 from stock solution chamber 25 flow direction, the second check valve only allows the liquid medicine to flow into the lower extreme of piston 29 from the upper end of piston 29.
The moving mechanism comprises a rotating wheel 32 which is rotatably connected to the inner wall of the second mechanism groove 34, a rotating rod 31 is rotatably connected to the side wall of the rotating wheel 32, a straight rod 30 is rotatably connected to the upper end of the rotating rod 31, and the straight rod 30 extends into the liquid injection cavity 27 and is fixedly connected with the lower end of the piston 29.
The inner wall of the first mechanism groove 7 is rotatably connected with a second gear 13, the second gear 13 is coaxially and fixedly connected with an output shaft of the stepping motor 19, the inner wall of the first mechanism groove 7 is rotatably connected with a third gear 20 meshed with the second gear 13, and the third gear 20 is coaxially and fixedly connected with a rotating wheel 32.
When the device is used, a model animal can be input into the strip-shaped groove 4 of the rotating plate 3 from the inlet 5, at the moment, the stepping motor 19 sends out a pulse signal to enable the output shaft of the stepping motor to rotate for a certain angle, at the moment, the first rotating shaft 9 can be driven to rotate for a corresponding angle, thereby driving the first rectangular block 11 disposed in the first rectangular groove 10 to rotate, thereby rotating the rotating plate 3 along the horizontal axis, so that the strip-shaped groove 4 provided with the model animal is opposite to the injection part, and the output shaft of the stepping motor 19 can drive the second gear 13 to rotate, thereby driving the third gear 20 engaged with the second gear 13 to rotate, and then driving the rotating wheel 32 coaxially arranged with the third gear 20 to rotate, under the linkage of the rotating rod 31 and the straight rod 30, the piston 29 can be pushed to move upwards for a certain distance, the liquid medicine at the upper end of the piston 29 can be squeezed into the lower end thereof and injected into the model animal body by the injection part.
After the injection is finished, the interior of the stepping motor 19 sends out a pulse signal again to enable the output shaft to rotate for a certain angle, because the first rectangular block 11 is separated from the first rectangular groove 10 at the moment, the rotating plate 3 cannot rotate along the horizontal axis, and meanwhile, the first bevel gear 8 and the second bevel gear 12 can be driven to rotate, the telescopic cylinder 22 pushes the first gear 23 to move downwards, so that the first gear 23 enters the internal gear 24 and is meshed with the internal gear 24, the second belt pulley 18 and the first belt pulley 17 are driven to rotate, the second rotating shaft 16 and the second rectangular block 15 can be driven to rotate, the rotating plate 3 rotates along the vertical axis, at the moment, the strip-shaped groove 4 is opposite to the outlet 6, and the injected model animal can be conveyed out through the outlet 6.
Meanwhile, the rotation of the output shaft of the stepping motor 19 can make the rotating wheel 32 and then the piston 29 move downwards again under the linkage of all the parts, and the liquid medicine in the liquid storage cavity 25 can be pumped into the liquid injection cavity 27 for supplement, so that the device can be repeatedly recycled.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. Heart failure animal model induction device, including base (1), its characterized in that, the lateral wall of base (1) has been seted up and has been put thing groove (2), it is equipped with rotor plate (3) in putting thing groove (2), two relative lateral walls of rotor plate (3) have all been seted up two bar grooves (4), import (5) and export (6) that put thing groove (2) intercommunication have been seted up respectively to two relative lateral walls of base (1), seted up mounting groove (33) on putting the inner wall of thing groove (2), install the injection part that is used for injecting the medicine in mounting groove (33), annotate liquid chamber (27) have been seted up to the lateral wall of base (1), annotate liquid chamber (27) and the inside intercommunication of the income liquid medicine mouth of injection part, it installs the infusion set of inputing the liquid medicine to the injection part in liquid chamber (27), it installs drive rotor plate (3) along horizontal axis pivoted drive arrangement to put thing groove (2), install in putting thing groove (2) and promote rotor plate (3) along vertical axis pivoted first thrust unit, square groove (21) have been seted up to the lateral wall of base (1), install in square groove (21) and promote second pivot (16) pivoted second thrust unit.
2. The heart failure animal model induction device according to claim 1, wherein the driving device comprises a first rotating shaft (9) rotatably connected to an inner wall of the storage groove (2), a first rectangular groove (10) is formed in a side wall of the first rotating shaft (9), a first rectangular block (11) matched with the first rectangular groove (10) is installed on a side wall of the rotating plate (3), a stepping motor (19) is fixedly connected to a side wall of the base (1), and an output shaft of the stepping motor (19) is coaxially and fixedly connected with the first rotating shaft (9).
3. The heart failure animal model induction device according to claim 1, wherein the second pushing device is rotatably connected to a second rotating shaft (16) at the inner bottom of the storage groove (2), a second rectangular groove (14) is formed in the upper end of the second rotating shaft (16), a second rectangular block (15) matched with the second rectangular groove (14) is installed on the side wall of the rotating plate (3), a first belt pulley (17) coaxially and fixedly connected with the second rotating shaft (16) is rotatably connected to the lower end of the base (1), a second belt pulley (18) is rotatably connected to the lower end of the base (1), the first belt pulley (17) is connected with the second belt pulley (18) through belt transmission, and a pushing mechanism for pushing the second belt pulley (18) to rotate is installed in the square groove (21).
4. The animal model heart failure induction device according to claim 3, the pushing mechanism comprises an inner gear (24) which is rotationally connected with the inner bottom of the square groove (21), the inner top of the square groove (21) is rotationally connected with a telescopic cylinder (22), and the telescopic end of the telescopic cylinder (22) is coaxially and fixedly connected with a first gear (23) matched with an internal gear (24), a first mechanism groove (7) is formed in the side wall of the base (1), a first bevel gear (8) which is coaxially and fixedly connected with a first rotating shaft (9) is rotationally connected in the first mechanism groove (7), the inner bottom of the first mechanism groove (7) is rotationally connected with a second bevel gear (12) meshed with the first bevel gear (8), and the lower end of the second bevel gear (12) is fixedly connected with a telescopic cylinder (22) through a connecting rod.
5. The heart failure animal model induction device according to claim 1, wherein the infusion device comprises a piston (29) connected in a liquid injection cavity (27) in a sealing and sliding manner, a liquid injection cavity (25) is formed in the side wall of the base (1), the liquid injection cavity (25) is communicated with the liquid injection cavity (27) through a channel (28), a first one-way valve is installed in the channel (28), a second one-way valve is installed on the piston (29), a second mechanism groove (34) is formed in the side wall of the base (1), and a moving mechanism for driving the piston (29) to move up and down is installed in the second mechanism groove (34).
6. The heart failure animal model induction device according to claim 5, wherein the moving mechanism comprises a rotating wheel (32) rotatably connected to the inner wall of the second mechanism groove (34), a rotating rod (31) is rotatably connected to the side wall of the rotating wheel (32), a straight rod (30) is rotatably connected to the upper end of the rotating rod (31), and the straight rod (30) extends into the liquid injection cavity (27) and is fixedly connected with the lower end of the piston (29).
7. The apparatus for inducing an animal model with heart failure as claimed in claim 4, wherein the inner wall of the first mechanism groove (7) is rotatably connected with a second gear (13), the second gear (13) is coaxially and fixedly connected with the output shaft of the stepping motor (19), the inner wall of the first mechanism groove (7) is rotatably connected with a third gear (20) engaged with the second gear (13), and the third gear (20) is coaxially and fixedly connected with the rotating wheel (32).
8. The apparatus for inducing an animal model of heart failure as claimed in claim 5, wherein the first one-way valve allows only the liquid medicine to flow from the liquid storage chamber (25) to the liquid injection chamber (27), and the second one-way valve allows only the liquid medicine to flow from the upper end of the piston (29) to the lower end of the piston (29).
9. The apparatus for inducing an animal model with heart failure as claimed in claim 5, wherein the base (1) is provided at an upper end thereof with a filling opening (26) communicating with the interior of the reservoir (25), and the filling opening (26) is provided therein with a switch valve.
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| CN201911112617.1A CN110801305B (en) | 2019-11-14 | 2019-11-14 | Heart failure animal model induction device |
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| CN201911112617.1A CN110801305B (en) | 2019-11-14 | 2019-11-14 | Heart failure animal model induction device |
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| CN110801305B true CN110801305B (en) | 2021-06-22 |
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| CN110801305A (en) | 2020-02-18 |
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