CN110787132A - Veterinary disinfectant citric acid and malic acid powder and preparation method thereof - Google Patents
Veterinary disinfectant citric acid and malic acid powder and preparation method thereof Download PDFInfo
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- CN110787132A CN110787132A CN201911302846.XA CN201911302846A CN110787132A CN 110787132 A CN110787132 A CN 110787132A CN 201911302846 A CN201911302846 A CN 201911302846A CN 110787132 A CN110787132 A CN 110787132A
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- Prior art keywords
- disinfectant
- citric acid
- malic acid
- raw materials
- acid powder
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention belongs to the technical field of veterinary drug preparations, and discloses a disinfectant citric acid malic acid powder for animals and a preparation method thereof. The composite material consists of the following raw materials in percentage by weight: 36-44% of citric acid, 9-11% of DL-malic acid, 4-6% of sodium dodecyl sulfate, 15-25% of mannitol, 0.3-0.5% of sodium hexametaphosphate and the balance of anhydrous glucose. The preparation method comprises the following steps of: the temperature is room temperature, and the relative humidity is below 30%; the method comprises the following steps: (1) respectively crushing and sieving all the raw materials; (2) premixing sodium hexametaphosphate and anhydrous glucose for several times by adopting an equivalent progressive dilution method, adding all the rest raw materials, and then carrying out total mixing; in the whole mixing process of the step, drying and mixing are carried out simultaneously; (3) subpackaging and sealing the mixed semi-finished product obtained in the step (2) to obtain the veterinary disinfectant citric acid malic acid powder. The prepared product has low moisture content, difficult deliquescence and good fluidity, completely meets the detection requirement of the product quality standard, and has no national pharmaceutical risk.
Description
Technical Field
The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a disinfectant citric acid malic acid powder for animals and a preparation method thereof.
Background
In the intensive livestock and poultry breeding process, the livestock and poultry breeding environment is very easy to cause pathogenic microorganism pollution, and in the livestock and poultry house, air, breeding equipment, drinking water, feed, excrement and the like carry a large amount of pathogenic microorganisms, so that the outbreak of infectious diseases is very easy to cause epidemic situations, and huge economic loss is caused to the livestock and poultry breeding. Therefore, the livestock and poultry breeding environment is extremely important for disinfection and purification, and prevention of epidemic occurrence and spread.
The citric acid and the DL-malic acid can reduce the pH value of pathogenic microorganisms, thereby inhibiting the growth of the pathogenic microorganisms. In addition, the organic acid can also influence the enzyme reaction and the substance transportation process of pathogenic microorganisms, so that the pathogenic microorganisms are dead due to energy exhaustion. The citric acid malic acid powder is a solid disinfectant, and has the advantages of good physical and chemical property stability, low production, manufacture and transportation cost, convenient market circulation and the like compared with the common liquid disinfectant.
Because citric acid and DL-malic acid both have hygroscopicity, the products circulating in the market are easy to agglomerate and discolor, and the quality is unstable, and at present, no mature product exists in the veterinary drug preparation.
Disclosure of Invention
The invention aims to provide a stable veterinary disinfectant citric acid malic acid powder capable of being stored for a long time and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a disinfectant citric acid malic acid powder for animals is composed of the following raw materials by weight percent:
36-44% of citric acid, 9-11% of DL-malic acid, 4-6% of sodium dodecyl sulfate, 15-25% of mannitol, 0.3-0.5% of sodium hexametaphosphate and the balance of anhydrous glucose.
Preferably, the material consists of the following raw materials in percentage by weight: 40% of citric acid, 10% of DL-malic acid, 5% of sodium dodecyl sulfate, 20% of mannitol, 0.4% of sodium hexametaphosphate and 24.6% of anhydrous glucose.
The preparation method comprises the following steps of: the temperature is room temperature, and the relative humidity is below 30%; the method comprises the following steps:
(1) respectively crushing and sieving all the raw materials;
(2) premixing sodium hexametaphosphate and anhydrous glucose for several times by adopting an equivalent progressive dilution method, adding all the rest raw materials, and then carrying out total mixing; in the whole mixing process of the step, drying and mixing are carried out simultaneously;
(3) subpackaging and sealing the mixed semi-finished product obtained in the step (2) to obtain the veterinary disinfectant citric acid malic acid powder.
Preferably, in the step (1), the mixture is crushed and sieved by a sieve of 80-100 meshes.
Preferably, in the step (2), premixing is carried out for 3-4 times, and each time is 20-30 min; the total mixing time is 20-30 min.
Preferably, in step (2), the whole mixing process (including pre-mixing and total mixing) is mixed while drying by using a drying mixer, so as to control the moisture in the raw materials.
The disinfectant citric acid malic acid powder for livestock needs to be dissolved and diluted by water in the clinical use process, and the product can be used for disinfecting drinking water of livestock, so that auxiliary materials which have good water solubility and stable physical and chemical properties and can be used for oral administration need to be selected. The sodium dodecyl sulfate, the mannitol, the sodium hexametaphosphate and the anhydrous glucose selected by the invention have the characteristics of good water solubility, stable physicochemical properties and oral administration, and can ensure the long-term stability of the product and meet the clinical use requirements. The sodium dodecyl sulfate can keep stability to acid conditions and hard water, is used as a stabilizer, is beneficial to the stability of the product, has good permeability and decontamination capability, and can ensure the clinical use effect of the product. Mannitol also has the characteristic of being not influenced by acidic conditions, and can be compatible with moisture sensitive drugs due to the characteristic of hygroscopicity, so that the stability of the product is facilitated; it also has the effect of improving palatability. Because of the limitation of environmental factors, underground water or tap water containing metal ions such as calcium, magnesium and the like is mostly selected in clinical use, and sodium hexametaphosphate is used as a metal ion chelating agent, has the function of softening water and also has a certain dispersion function in the dissolving process. Anhydrous glucose was used as the bulking agent.
Has the advantages that: in order to improve the stability of the product, the invention carries out systematic research on auxiliary materials, the auxiliary materials with good stability and high safety are finally screened, meanwhile, the moisture of the raw materials and the humidity of the production environment are effectively controlled in production, and the prepared product has low moisture, is difficult to deliquesce and has good fluidity, thereby obtaining a stable and excellent product; the preparation product completely meets the detection requirements of product quality standards and has no national pharmaceutical risk.
Detailed Description
The present invention will be further described with reference to the following specific examples. It should be understood that the following examples are illustrative only and are not intended to limit the scope of the present invention.
Comparative examples 1 to 2 and examples 1 to 8
A veterinary disinfectant, citric acid malic acid powder, has the raw material composition shown in Table 1.
The preparation method comprises the following steps of temperature and humidity control of a production workshop: the temperature is 26 ℃ and the relative humidity is 27%, and the preparation steps are as follows:
(1) weighing the prescription amounts of citric acid, DL-malic acid, sodium dodecyl sulfate, mannitol, sodium hexametaphosphate and anhydrous glucose according to the table 1, respectively crushing all the raw materials by using a water-cooled crusher and sieving the crushed raw materials by a sieve of 80 meshes;
(2) adding sodium hexametaphosphate and equal amount of anhydrous glucose into a drying mixer to mix for 20 min to obtain a mixture I; adding anhydrous glucose equal to the mixture I, and continuously mixing for 20 min to obtain a mixture II; adding anhydrous glucose equal to the mixture II, and continuously mixing for 20 min to obtain a mixture III; finally, adding all the rest raw materials into a drying mixer, and totally mixing for 20 min to obtain a semi-finished product;
(3) and subpackaging the mixed semi-finished products by adopting an aluminum-plastic composite bag, and sealing.
Stability test
In order to verify the feasibility of the invention, the eight batches of citric malic acid powder products in the comparative examples 1-2 and examples 1-6 were subjected to accelerated stability investigation and long-term stability investigation. The specific method for accelerating stability investigation comprises the following steps: respectively placing different batches of products in a medicine acceleration and stabilization box, setting the temperature at 40 ℃ and the relative humidity at 75%, sampling in 0 th, 1 st, 2 th, 3 th and 6 th months, and detecting according to product standards; the specific method for long-term stability investigation is as follows: respectively placing different batches of products in a medicine acceleration stabilization box, setting the temperature to be 25 ℃ and the relative humidity to be 60%, sampling in 0 th, 3 th, 6 th, 9 th and 12 th months, and detecting according to product quality standards; the test results are shown in Table 2 and its continuation, and Table 3 and its continuation.
The product stability investigation test result shows that: the products obtained in the comparative examples 1-2 can not pass accelerated stability and long-term stability investigation, the properties, acidity, citric acid content and DL-malic acid content of the products are obviously changed, and the products do not meet the requirements of product quality standards and the requirements of products on the market; the products obtained in the examples 1-6 are verified by accelerated stability and long-term stability investigation, and the properties, solubility, drying weight loss, acidity, citric acid content and DL-malic acid content related to the product quality standard have no obvious change, and meet the requirements of the product quality standard. Meanwhile, the stability test results of the embodiments 1 to 6 also show that the product quality obtained by the production amplification test of the preparation method has no obvious difference and meets the product quality standard requirements. Therefore, the disinfectant citric acid malic acid powder for animals produced by the invention has stable and reliable product quality and can meet the market demand.
Claims (6)
1. A disinfectant citric acid malic acid powder for animals is characterized by comprising the following raw materials in percentage by weight: 36-44% of citric acid, 9-11% of DL-malic acid, 4-6% of sodium dodecyl sulfate, 15-25% of mannitol, 0.3-0.5% of sodium hexametaphosphate and the balance of anhydrous glucose.
2. The disinfectant citric acid malic acid powder for animals according to claim 1, which comprises the following raw materials by weight percent: 40% of citric acid, 10% of DL-malic acid, 5% of sodium dodecyl sulfate, 20% of mannitol, 0.4% of sodium hexametaphosphate and 24.6% of anhydrous glucose.
3. A process for the preparation of the disinfectant citric acid malic acid powder for animals according to claim 1 or 2, wherein the temperature and humidity control conditions in the production plant are: the temperature is room temperature, and the relative humidity is below 30%; the preparation steps are as follows:
(1) respectively crushing and sieving all the raw materials;
(2) premixing sodium hexametaphosphate and anhydrous glucose for several times by adopting an equivalent progressive dilution method, adding all the rest raw materials, and then carrying out total mixing; in the whole mixing process of the step, drying and mixing are carried out simultaneously;
(3) subpackaging and sealing the mixed semi-finished product obtained in the step (2) to obtain the veterinary disinfectant citric acid malic acid powder.
4. The method for preparing the disinfectant citric acid malic acid powder for animals according to claim 3, wherein the disinfectant comprises: in the step (1), crushing and sieving with a sieve of 80-100 meshes.
5. The method for preparing the disinfectant citric acid malic acid powder for animals according to claim 3, wherein the disinfectant comprises: in the step (2), premixing for 3-4 times, wherein each time is 20-30 min; the total mixing time is 20-30 min.
6. The method for preparing the disinfectant citric acid malic acid powder for animals according to claim 3, wherein the disinfectant comprises: in the step (2), a drying mixer is adopted in the whole mixing process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911302846.XA CN110787132A (en) | 2019-12-17 | 2019-12-17 | Veterinary disinfectant citric acid and malic acid powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911302846.XA CN110787132A (en) | 2019-12-17 | 2019-12-17 | Veterinary disinfectant citric acid and malic acid powder and preparation method thereof |
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| CN110787132A true CN110787132A (en) | 2020-02-14 |
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| CN201911302846.XA Pending CN110787132A (en) | 2019-12-17 | 2019-12-17 | Veterinary disinfectant citric acid and malic acid powder and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0505763A1 (en) * | 1991-03-27 | 1992-09-30 | Fresenius AG | Aqueous disinfectant, its use for inactivation of Hepatitus-B virus, bacterial spores and Legionella pneumophila, and method of disinfection |
| CN1545883A (en) * | 2003-12-15 | 2004-11-17 | 韶山大北农动物药业有限公司 | Water soluble composite potassium monopersulfate powder disinfectant |
| KR20070084900A (en) * | 2006-02-22 | 2007-08-27 | (주)동원파마 | A disinfectant equipped with deodorizing function |
| CN101108257A (en) * | 2007-05-18 | 2008-01-23 | 张勤福 | Method of preparing liquid antibiotic deodorizer and application thereof |
| CN101347126A (en) * | 2007-07-20 | 2009-01-21 | 东部高科技株式会社 | Sterilizing and virus-eradicating composition with improved sterilizing capability |
| CN107232199A (en) * | 2017-06-05 | 2017-10-10 | 江西省养蜂研究所 | A kind of honeybee is dry to use disinfectant |
| CN110419539A (en) * | 2019-08-02 | 2019-11-08 | 广州斯宾农牧科技有限公司 | A kind of Potassium Monopersulfate compound cleaning and sterilizing agent and preparation method thereof |
-
2019
- 2019-12-17 CN CN201911302846.XA patent/CN110787132A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0505763A1 (en) * | 1991-03-27 | 1992-09-30 | Fresenius AG | Aqueous disinfectant, its use for inactivation of Hepatitus-B virus, bacterial spores and Legionella pneumophila, and method of disinfection |
| CN1545883A (en) * | 2003-12-15 | 2004-11-17 | 韶山大北农动物药业有限公司 | Water soluble composite potassium monopersulfate powder disinfectant |
| KR20070084900A (en) * | 2006-02-22 | 2007-08-27 | (주)동원파마 | A disinfectant equipped with deodorizing function |
| CN101108257A (en) * | 2007-05-18 | 2008-01-23 | 张勤福 | Method of preparing liquid antibiotic deodorizer and application thereof |
| CN101347126A (en) * | 2007-07-20 | 2009-01-21 | 东部高科技株式会社 | Sterilizing and virus-eradicating composition with improved sterilizing capability |
| CN107232199A (en) * | 2017-06-05 | 2017-10-10 | 江西省养蜂研究所 | A kind of honeybee is dry to use disinfectant |
| CN110419539A (en) * | 2019-08-02 | 2019-11-08 | 广州斯宾农牧科技有限公司 | A kind of Potassium Monopersulfate compound cleaning and sterilizing agent and preparation method thereof |
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Application publication date: 20200214 |