CN110772622A - 用于风湿类风湿的中药药浴剂 - Google Patents
用于风湿类风湿的中药药浴剂 Download PDFInfo
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- CN110772622A CN110772622A CN201911217354.0A CN201911217354A CN110772622A CN 110772622 A CN110772622 A CN 110772622A CN 201911217354 A CN201911217354 A CN 201911217354A CN 110772622 A CN110772622 A CN 110772622A
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Abstract
提供了治疗风湿类风湿的中药组合物，包括以下重量份的原料：三七20‑40份、川芎20‑40份、桂枝20‑40份、乳香10‑20份、没药10‑20份、血蝎5‑10份、当归20‑30份、三白草根10‑20份、黄芪20‑30份、木香5‑15份、薏仁30‑50份、苍术10‑20份、泽泻10‑20份、忍冬藤10‑20份、海风藤10‑20份、连翘5‑15份、知母10‑20份、生地5‑10份、丹皮25‑35份、稀茧草10‑20份、姜黄5‑10份、藏红花10‑20份、蜈蚣5‑10份、地龙5‑10份、僵蚕10‑20份，该组合物为药浴剂。
Description
一技术领域
本发明涉及中药领域和风湿病治疗领域，具体地说，本发明涉及一种用于风湿类风湿的中药组合物，其为药浴剂。
二背景技术
风湿性关节炎是一种常见的结缔组织炎症，，受累关节以大关节为主，多始于侵袭下肢关节者膝和踝关节最为常见，其次为肩、肘和腕。风湿性关节炎病变呈多发性和游走性，关节局部炎症明显，表现有红、肿、热、痛、压痛及活动受限，持续时间不长，但发作频繁且痛苦程度高。类风湿是一种病因尚未明了的慢性全身性炎症性疾病，一般认为为自身免疫病，以慢性关节炎和关节外病变为主要临床表现，多发于手、腕、足等小关节，反复发作。症状有关节红肿热痛和功能障碍、僵硬畸形、骨和骨骼肌的萎缩，处理不当经常导致残基。
处置风湿性关节炎和类风湿病时西医常用激素类以及非甾体抗炎药，此类药物副作用大，且疗效不稳定。中医一般认为治疗风湿痹毒思路为祛风、胜湿、温经散寒，经常使用雷公藤等毒性中药成分以毒攻毒，不能充分发挥中药毒副作用低的优点和声誉。
因此，从新成分和给药途径上寻找开发更安全且有效的抗风湿关节炎中药组合物很有必要。
三发明内容
针对上述问题，申请人在家传风湿骨痛病验方的基础上，开发了一种中药药浴剂，其使用安全，不与其他治疗风湿类风湿的口服药物冲突，作为轻症风湿类风湿的治疗药物和中重度风湿类风湿的辅助治疗药物均有良好的实践效果。
一方面，本发明提供了一种治疗风湿类风湿的中药组合物，包括以下重量份的原料：三七20-40份、川芎20-40份、桂枝20-40份、乳香10-20份、没药10-20份、血蝎5-10份、当归20-30份、三白草根10-20份、黄芪20-30份、木香5-15份、薏仁30-50份、苍术10-20份、泽泻10-20份、忍冬藤10-20份、海风藤10-20份、连翘5-15份、知母10-20份、生地5-10份、丹皮25-35份、稀茧草10-20份、姜黄5-10份、藏红花10-20份、蜈蚣5-10份、地龙5-10份、僵蚕10-20份。
进一步地，本发明提供的治疗风湿类风湿的中药组合物，由以下重量份的原料药制成：三七30份、川芎30份、桂枝30份、乳香15份、没药15份、血蝎5份、当归20份、三白草根10份、黄芪20份、木香10份、薏仁40份、苍术15份、泽泻15份、忍冬藤15份、海风藤15份、连翘10份、知母10份、生地10份、丹皮25份、稀茧草15份、姜黄5份、藏红花10份、蜈蚣5份、地龙5份、僵蚕15份。
进一步地，本发明的中药组合物为外用剂。
进一步地，本发明的中药组合物为药浴剂。
进一步地，本发明的中药组合物使用时加入药材总重量10倍的水，煮开1小时后凉至适合的温度药浴使用。
进一步地，本发明而的中药组合物配制成的药浴液可以在加热后反复使用。
以下药材：三七30份、川芎30份、桂枝30份、乳香15份、没药15份、血蝎5份、当归20份、三白草根10份、黄芪20份、木香10份、薏仁40份、苍术15份、泽泻15份、忍冬藤15份、海风藤15份、连翘10份、知母10份、生地10份、丹皮25份、稀茧草15份、姜黄5份、藏红花10份、蜈蚣5份、地龙5份、僵蚕15份在制备治疗风湿类风湿的药浴组合物中的应用。
本发明的中药组合物适用于各种原因和症状的风湿和类风湿关节炎，包括但不限于感染、免疫、遗传、中毒等导致的关节炎。
本发明而的中药组合物配制成的药浴液可与各种按摩手法、按摩器械、现有治疗风湿类风湿的中西医药物配合使用。
本发明中的药材可以根据质量标准选择各种产地的产品。
四具体实施方式
实施例1 本申请药浴液的配制
称取三七30份、川芎30份、桂枝30份、乳香15份、没药15份、血蝎5份、当归20份、三白草根10份、黄芪20份、木香10份、薏仁40份、苍术15份、泽泻15份、忍冬藤15份、海风藤15份、连翘10份、知母10份、生地10份、丹皮25份、稀茧草15份、姜黄5份、藏红花10份、蜈蚣5份、地龙5份、僵蚕15份；
加入药材总重量10倍的水，煮开1小时，凉至适合的温度即可药浴使用，每次30分钟左右；
药浴液加热后可以反复使用10次。
实施例2 本申请药浴液对风湿的实际疗效
在申请人诊所内参照《实用内科学》和《中医病证诊断疗效标准》选用年龄30-50岁的轻度风湿性、类风湿性关节炎患者30名，使用实施例1的药浴液每日药浴30分钟，除按摩、热疗等物理治疗外，不使用其他中西药制剂，连续治疗2周。
参照《中医病症诊断疗效标准》评价疗效。①临床治愈：肢体关节疼痛消失，其他伴随症状恢复正常；②好转：肢体关节疼痛明显减轻，其他伴随症状也明显好转；③无效：肢体关节疼痛及伴随症状无明显改善。
30名患者中治愈2例，显效20例，有效6例，无效仅2例，而且这是在仅使用药浴这一外用方式的情况下获得的疗效，结合其他内服治疗药物可以预期更好的疗效。
实施例3 大鼠炎症模型实验
为了进一步明确药物的效果，委托浙江中医药大学动物实验中心进行药浴治疗大鼠炎症模型实验
取SD大鼠，用戊巴比妥钠溶液腹腔注射后，尾根部皮下注射胶原200μg(乳剂，约0.1mL)；初次免疫后第7日于大鼠臀背部两侧各皮下注射100μg(乳剂，约0.05mL)。
取20只模型大鼠，其中10只每日给予药浴治疗20分钟(40度)，另10只每日以40度温水模拟治疗20分钟。连续一周后使用评分法评价大鼠关节炎程度和右下肢踝关节肿胀度。
结果表明，药浴治疗组的平均评分(2.8)和踝关节肿胀度(0.92)明显低于温水模拟治疗组的平均评分4.1和踝关节肿胀度(1.23)。
Claims (7)
1.一种治疗风湿类风湿的中药组合物，包括以下重量份的原料：三七20-40份、川芎20-40份、桂枝20-40份、乳香10-20份、没药10-20份、血蝎5-10份、当归20-30份、三白草根10-20份、黄芪20-30份、木香5-15份、薏仁30-50份、苍术10-20份、泽泻10-20份、忍冬藤10-20份、海风藤10-20份、连翘5-15份、知母10-20份、生地5-10份、丹皮25-35份、稀茧草10-20份、姜黄5-10份、藏红花10-20份、蜈蚣5-10份、地龙5-10份、僵蚕10-20份。
2.根据权利要求1的中药组合物，由以下重量份的原料药制成：三七30份、川芎30份、桂枝30份、乳香15份、没药15份、血蝎5份、当归20份、三白草根10份、黄芪20份、木香10份、薏仁40份、苍术15份、泽泻15份、忍冬藤15份、海风藤15份、连翘10份、知母10份、生地10份、丹皮25份、稀茧草15份、姜黄5份、藏红花10份、蜈蚣5份、地龙5份、僵蚕15份。
3.根据权利要求1或2的中药组合物，其为外用剂。
4.根据权利要求3的中药组合物，其为药浴剂。
5.根据权利要求1-4任一项的中药组合物，其使用时加入药材总重量10倍的水，煮开1小时后凉至适合的温度药浴使用。
6.根据权利要求5的中药组合物，其配制成的药浴液可以在加热后反复使用。
7.以下药材：三七30份、川芎30份、桂枝30份、乳香15份、没药15份、血蝎5份、当归20份、三白草根10份、黄芪20份、木香10份、薏仁40份、苍术15份、泽泻15份、忍冬藤15份、海风藤15份、连翘10份、知母10份、生地10份、丹皮25份、稀茧草15份、姜黄5份、藏红花10份、蜈蚣5份、地龙5份、僵蚕15份在制备治疗风湿类风湿的药浴组合物中的应用。
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