CN110772533A - Multi-ion liquid for treating onychomycosis and preparation method and application thereof - Google Patents
Multi-ion liquid for treating onychomycosis and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a polyion liquid for treating onychomycosis, which comprises the following components: the compound containing manganese ions, the compound containing selenium ions, the compound containing calcium ions, the compound containing magnesium ions, the compound containing ferrous ions and deionized water. The invention also provides a preparation method of the polyion liquid for treating onychomycosis, and the method has the advantages of simple production process and low cost. The invention has good functions of dispelling itch, removing beriberi and treating onychomycosis. The raw materials are natural in source, safe, mild and non-irritant, and do not contain antiseptic, disinfectant, bactericide, hormone and other harmful additives.
Description
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a polyion liquid for treating onychomycosis as well as a preparation method and application thereof.
Background
Onychomycosis, commonly known as onychomycosis, refers to a disease caused by fungi such as dermatophytes invading the nail plate or under the nail. Onychomycosis is an infection of the nail caused by dermatophytes, yeasts and non-dermatophytes. Fungal nail is common in two types: the first fungal onychomycosis, superficial onychomycosis. The lesion is limited to one side of the nail or is a tip; the second type is the onychomycosis, which is classified into distal lateral type, proximal onychomycosis type, and superficial white type. Lesions of this type begin on both sides of the nail, or distal, and develop infection below the nail plate. The patient's nails become thick, dull or black, white or brittle. Easy to break, deform and damage.
Beriberi is a common name of tinea pedis, is a superficial mycosis of skin caused by dermatophyte, and usually is good for feet; the infected fungi are the root cause of the beriberi, and the beriberi is also easily induced by the damp and sweaty feet. The beriberi is different according to different clinical types and different symptoms: 1. pachynsis type beriberi: dryness, laceration and pain; 2. scale type: papules, desquamation with pruritus; 3. and (3) soaking: the pruritus is more serious; 4. erosion type: erosion, damage and susceptibility to infection.
Foot tinea caused by humid environment in many places in China has high incidence, the foot itching, beriberi and onychomycosis conditions are very common, the incidence rate is high, and the diseases are easy to relapse after treatment. The market has urgent need for targeted products and the demand is very large.
The western medicine has single effect on treating beriberi and onychomycosis, has side effect, is easy to resist medicine and relapse, and cannot be frequently used.
Chinese patent CN105943445A discloses a health preserving liquid with fresh aloe juice as main component and its preparation method, the effect is to cure beriberi and onychomycosis. However, in the patent examples, a combination of phenoxyethanol 0.6% + benzalkonium chloride 0.04% and salicylic acid 0.5% + chlorphenesin 0.3% + chlorhexidine gluconate 0.08% of these antiseptic bactericides was used, in amounts sufficient to perform the antiseptic and bactericidal action. Obviously, the fresh aloe juice is not separately effective and needs to be combined with antiseptic and bactericidal agents to have the functions of sterilization and bacteriostasis.
Chinese patent CN103340922A discloses a health preserving liquid and a preparation method thereof, the health preserving liquid consists of microelements of Fe, B, Mn, Zn, Cu, Mo, magnesium, potassium, alkaloid, emulsifier and water, and the health preserving liquid is used for treating or preventing foot diseases such as tinea pedis, foot odor and the like. The components are complex, and the main components with the sterilization effect are alkaloid and borax which need to be dissolved by the aid of an emulsifier. The emulsifier is alkyl alcohol polyoxyethylene ether, preferably dodecyl alcohol polyoxyethylene ether, is a synthetic organic emulsifier from petroleum sources, is added in an amount of 6-8 g/L, and is harmful to human bodies.
The ionic fruit and vegetable detergent disclosed in Chinese patent CN103540452A is composed of ions such as sodium, potassium, silicon, calcium, magnesium and the like and water, can clean stains and pesticide residues on fruits and vegetables, and has an average bacteriostasis rate of 95.76% on Escherichia coli for 20 minutes in a 1% diluent, but does not show the bacteriostasis effect on fungi.
Disclosure of Invention
The invention aims to solve the technical problems of developing a health-care product aiming at foot care and health care, itch dispelling, beriberi removing and onychomycosis treatment, and particularly relates to a multi-ion liquid for treating onychomycosis. In practice, compared with Chinese herbal medicines, the multi-ion liquid for treating onychomycosis is convenient to prepare and store, high in cost performance, obvious in effect and free of side effects of western medicines.
In order to achieve the purpose, the invention adopts the technical scheme that: a polyion liquid for treating onychomycosis comprises the following components: the compound containing manganese ions, the compound containing selenium ions, the compound containing calcium ions, the compound containing magnesium ions, the compound containing ferrous ions and deionized water. Namely, the polyion liquid for treating onychomycosis is prepared from the following raw materials: the compound containing manganese ions, the compound containing selenium ions, the compound containing calcium ions, the compound containing magnesium ions, the compound containing ferrous ions and deionized water.
On the basis of the technical scheme, the invention can further have the following specific selection or optimized selection.
Specifically, the compound containing manganese ions is one or more of manganese sulfate, manganese gluconate and manganese aspartate; the compound containing selenium ions is selenium disulfide, and the compound containing calcium ions is one or more of calcium oxide, calcium carbonate or calcium hydroxide; the compound containing magnesium ions is one or more of magnesium oxide, basic magnesium carbonate or magnesium hydroxide; the compound containing ferrous ions is one or more of ferric sulfate, ferric chloride or ferrous acetate.
More specifically, the polyion liquid for treating onychomycosis contains ions with the following concentrations:
manganese ion: 0.06-0.10 mM;
selenium ion: 0.01-0.05 mM;
ferrous ion: 0.05-0.09 mM;
calcium ion: 1.5-4.8 mM;
magnesium ion: 0.5-1.0 mM.
Preferably, the polyion liquid for treating onychomycosis contains ions with the following concentrations:
manganese ion: 0.08 mM;
selenium ion: 0.03mM
Ferrous ion: 0.07mM
Calcium ion: 3.0mM
Magnesium ion: 0.7 mM.
In addition, the invention also provides a method for preparing the polyion liquid for treating onychomycosis, which comprises the following steps:
1) respectively weighing a compound containing manganese ions and a compound containing selenium ions according to the concentration of each ion, sequentially adding the compounds into deionized water weighed in advance, and stirring for the first time;
2) weighing a ferrous ion compound according to the concentration of ferrous ions, adding the ferrous ion compound into the ionic liquid obtained in the step 1), and stirring for the second time;
3) respectively weighing a calcium ion-containing compound and a magnesium ion-containing compound according to the concentrations of calcium ions and magnesium ions, sequentially adding the calcium ion-containing compound and the magnesium ion-containing compound into the ionic liquid obtained in the step 2), stirring for the third time, standing for 24 hours, and taking supernate to obtain the multi-ionic liquid for treating onychomycosis.
Specifically, the first stirring is heating to 70-80 ℃ and stirring for 1-2 hours. The second stirring is carried out at the temperature of 50-60 ℃ for 0.5-1 hour. The third stirring is at a temperature of 40-50 ℃ for 0.5-1 hour, and then the stirring is continued until the solution is cooled to room temperature.
In addition, the invention also provides application of the polyion liquid for treating onychomycosis in treating and preventing onychomycosis or dermatophytosis.
In the preparation process of the raw materials, a process such as pulverization and grinding may be performed in advance for the purpose of dissolution. Although compounds containing different ions may react with each other during the dissolution process and even precipitate, the ion content is the content of reactive residual ions in the supernatant, and the content of these ions is rather low, which differs from the conventional definition of solubility under the influence of interactions.
Compared with the prior art, the multi-ion liquid for treating onychomycosis provided by the invention has the following advantages:
1. the multi-ion liquid for treating onychomycosis has low ion content concentration, low cost, mild property, safety, no toxicity, health and no harmful chemical components.
2. The ions of manganese, selenium, iron, calcium, magnesium and the like are not simply dispersed in water, but have synergistic effect. The elements are in an ionic state in aqueous solution, have strong permeability, can quickly clean skin, remove cutin and dead skin, can also obstruct the metabolism of bacteria, and have the effects of relieving itching, removing beriberi and treating onychomycosis.
3. After the multi-ion liquid is used for treatment, ions still adhere to the surface and the horny layer of the skin, and the activity can be recovered when the skin meets moist water vapor, so that the bacteriostatic and bactericidal effects are achieved, and therefore, the tinea unguium is treated by the multi-ion liquid for treating the onychomycosis, and the recurrence is not easy after the cure.
4. Selenium is a necessary nutrient element for human body, and has anticancer, antioxidant and immunity enhancing effects. It is noted that the multi-ion liquid for treating onychomycosis contains selenium ions only in the content of 0.01-0.05mM, which is far lower than the content requirement of preservative, and is not a preservative and bactericide in the general sense.
5. The polyionic liquid for treating onychomycosis contains manganese ions only in an amount of 0.06-0.10 mM. Manganese is a trace element required by human body, is beneficial to health and longevity, and has multiple functions of diminishing inflammation. Lack of manganese can cause osteoporosis.
6. Iron, calcium and magnesium are also trace elements required by human body, and participate in important physiological processes of human body, improve sterilization and improve immune function.
Detailed Description
For better understanding of the present invention, the following examples are given for further illustration of the present invention, but the present invention is not limited to the following examples.
Example 1: a polyionic liquid for treating onychomycosis contains ions with the following concentrations: manganese ion: 0.08 mM; selenium ion: 0.03 mM; ferrous ion: 0.07 mM; calcium ion: 3.0 mM;
magnesium ion: 0.7 mM.
The preparation method comprises the following steps: adding manganese sulfate and selenium disulfide into water weighed in advance, heating to 75 ℃, stirring for 2 hours, cooling to 55 ℃, adding ferrous chloride, and stirring for 1 hour; the temperature is continuously reduced to 45 ℃, calcium carbonate and magnesium oxide are added, and the mixture is stirred for 1 hour. And continuously cooling to room temperature, standing for 24 hours, taking supernatant, and detecting that all technical indexes are qualified to obtain the polyion liquid for treating onychomycosis.
Example 2: a polyionic liquid for treating onychomycosis contains ions with the following concentrations: manganese ion: 0.06 mM; selenium ion: 0.05 mM; ferrous ion: 0.06 mM; calcium ion: 4.6 mM; magnesium ion: 0.5 mM.
The preparation method comprises the following steps: adding manganese gluconate and selenium disulfide into water weighed in advance, heating to 70 ℃, stirring for 1 hour, cooling to 60 ℃, adding ferrous acetate, continuously cooling to 40 ℃, adding calcium carbonate and basic magnesium carbonate, and stirring for 1 hour. And continuously cooling to room temperature, standing for 24 hours, taking supernatant, and detecting that all technical indexes are qualified to obtain the polyion liquid for treating onychomycosis.
Example 3: a polyionic liquid for treating onychomycosis contains ions with the following concentrations: manganese ion: 0.10 mM; selenium ion: 0.01 mM; ferrous ion: 0.09 mM; calcium ion: 2.7 mM; magnesium ion 1.0 mM.
The preparation method comprises the following steps: adding the aspartic acid manganese salt and the selenium disulfide into water with weighed weight in advance, heating to 80 ℃, stirring for 1 hour, cooling to 55 ℃, adding the ferrous sulfate, continuously cooling to 45 ℃, adding the calcium hydroxide and the magnesium hydroxide, and stirring for 1 hour. And continuously cooling to room temperature, standing for 24 hours, taking supernatant, and detecting that all technical indexes are qualified to obtain the polyion liquid for treating onychomycosis.
Example 4: a polyionic liquid for treating onychomycosis contains ions with the following concentrations: manganese ion: 0.09 mM; selenium ion: 0.02 mM; ferrous ion: 0.08 mM; calcium ion: 1.5 mM; magnesium ion: 0.6 mM.
The preparation method comprises the following steps: adding manganese sulfate and selenium disulfide into water weighed in advance, heating to 70 ℃, stirring for 1 hour, cooling to 50 ℃, adding ferrous sulfate, continuously cooling to 40 ℃, adding calcium oxide and magnesium oxide, and stirring for 1 hour. And continuously cooling to room temperature, standing for 24 hours, taking supernatant, and detecting that all technical indexes are qualified to obtain the polyion liquid for treating onychomycosis.
Comparative example 5: a control liquid was prepared according to the preparation method of example 1 and the same content of raw materials, with only the addition of the manganese ion-containing compound, the ferrous ion-containing compound, the calcium ion-containing compound and the magnesium ion-containing compound, and without the addition of the selenium ion compound.
The fungal inhibition effect of the polyionic liquids prepared in examples 1-4 and the control liquid prepared in example 5 was tested, wherein Candida albicans and Trichophyton trichophyton were used as representative strains of fungi, and the test results are as follows:
TABLE 1 comparison of the fungicidal inhibiting effects
And (4) conclusion: candida albicans is one of representative fungi, trichophyton is one of dermatophytes, and is the most main pathogenic fungi of foot odor, dermatophytosis and onychomycosis, and experiments show that: the polyion liquid in the embodiments 1 to 4 has bacteriostatic action on fungi, and particularly, the polyion liquid in the embodiment 1 has the best bacteriostatic action on the fungi; in comparative example 5, no selenium ion was added, and the bacteriostatic action was significantly reduced. The addition of the selenium ions greatly improves the bacteriostatic action of the multi-ion liquid, and the selenium ions play a better synergistic and reinforcing role in an ion system. Moreover, the selenium element is scientifically proved to have the functions of protecting, repairing blood vessels, regulating immunity and enhancing resistance. Therefore, the selenium element is added to play a certain health care role and simultaneously have a better antibacterial treatment effect, which is a technical effect unexpected by the technical personnel in the field.
The detection basis is as follows: GB 15979 + 2002 standard of disposable sanitary article
Test microorganisms: candida albicans
Detection conditions are as follows: the culture temperature of the fungus is 28 +/-1 ℃; the culture period is 48-72 hours.
The polyion liquid for treating onychomycosis obtained in the above examples 1 to 4 is subjected to a plurality of complete skin irritation tests, and the specific test method is as follows:
1. the detection basis is as follows: disinfection technical Specification, Ministry of public health of the people's republic of China (2002)
2. The test substance: polyionic liquid for treating onychomycosis
3. The operation procedure is as follows:
(1) the two sides of the spine of the animal are unhaired 24 hours before the test, and the unhairing ranges are about 3cm by 3cm respectively;
(2) the next day, a 2.5cm by 2.5cm test area was drawn on the left intact, dehaired skin, and the test article was smeared on the test area skin, with the right unhaired skin as a blank control;
(3) cleaning with warm water 4h after smearing, removing residual test substance, smearing once per day for 14 days, observing the result 24h after each smearing, scoring the skin irritation response of the tested part according to Table 2-11 of Disinfection technical Specification, shearing hair if necessary, and calculating the average integral of each animal every day. And the stimulus intensity of the test substance was graded according to tables 2 to 12.
(4) The animals were also observed for general signs.
TABLE 2 Multi-Ionic liquid irritation test results for the treatment of onychomycosis
The experimental results show that the multi-ion liquid for treating onychomycosis provided by the invention is mild in components and has no irritation to skin, so that the multi-ion liquid has no irritation to patients with onychomycosis or beriberi with damaged skin, can be used safely, and has wider application.
Effects of the implementation
A, 40 patients with beriberi are selected, the patients are respectively sprayed on the affected part three times in the morning, at noon and at night every day by using the polyion liquid for treating the onychomycosis obtained in the examples 1-4, the spraying time is kept for 10 minutes, the treatment effect is continuously observed for 15 days, and the treatment effect is observed on the 2 nd day, the 5 th day, the 10 th day and the 15 th day.
TABLE 3 therapeutic effect on tinea unguium by using polyionic liquid
B, selecting 40 patients suffering from onychomycosis, spraying the polyion liquid for treating onychomycosis obtained in examples 1-4 to the affected part three times in the morning, at noon and at night every day, keeping spraying for 10 minutes, continuously spraying for 30 days, and observing the treatment effects on the 5 th day, the 10 th day, the 20 th day and the 30 th day.
TABLE 4 therapeutic effect on onychomycosis with polyionic liquids for onychomycosis
Typical cases are:
for a woman 23 years old, there are blisters between the sole and toes and itching, before treatment, the scales are dissolved in potassium hydroxide solution and directly examined under the microscope or cultured to detect dermatophytes, which proves that the dermatophytes exist in the scales scraped from the damaged part. The polyion liquid for treating onychomycosis in example 1 is sprayed on affected parts three times a day in the morning, at noon and at night, the spraying time is kept for 10 minutes, after the polyion liquid is continuously used for 5 days, symptoms basically disappear, pruritus is eliminated, and the tinea unguium is healed after the polyion liquid is continuously used for two weeks, and the foot skin is smooth and soft. After treatment, the scales are taken and dissolved in a potassium hydroxide solution, and then direct microscopic examination or culture is carried out, so that no dermatophyte is detected, and the fact that no dermatophyte exists in the scales scraped from the damaged part is proved.
For a woman of 47 years old, scales are peeled off from the soles and toes, and the woman has no pruritus, thick cuticle and slight chapping. Before treatment, the scales are dissolved in a potassium hydroxide solution and directly subjected to microscopic examination or culture to detect dermatophytes, and the existence of the dermatophytes in the scales scraped from the damaged part is proved. The polyion liquid for treating onychomycosis in example 2 is sprayed on affected parts three times a day in the morning, at noon and at night, the spraying time is kept for 10 minutes, after continuous use for 6 days, symptoms basically disappear, the cutin of feet is obviously softened, and after continuous use for 13 days, the feet are healed, and the skin of the feet is smooth and soft. After treatment, the scales are taken and dissolved in a potassium hydroxide solution, and then direct microscopic examination or culture is carried out, so that no dermatophyte is detected, and the fact that no dermatophyte exists in the scales scraped from the damaged part is proved.
For a male, age 27, there are blisters between the sole and toes, and the thumb has a onychomycosis. Before treatment, the scales are dissolved in a potassium hydroxide solution and directly subjected to microscopic examination or culture to detect dermatophytes, and the existence of the dermatophytes in the scales scraped from the damaged part is proved. The polyion liquid for treating onychomycosis in example 3 is sprayed on the affected part three times a day in the morning, at noon and at night, the spraying time is kept for 10 minutes, after the polyion liquid is continuously used for 8 days, the symptoms basically disappear, the onychomycosis is obviously softened, the onychomycosis is healed after the polyion liquid is continuously used for 25 days, and the foot skin is smooth and soft. After treatment, the scales are taken and dissolved in a potassium hydroxide solution, and then direct microscopic examination or culture is carried out, so that no dermatophyte is detected, and the fact that no dermatophyte exists in the scales scraped from the damaged part is proved.
A male, 39 years old, has severe beriberi and foot odor, and has onychomycosis on the thumb and little finger. Before treatment, the scales are dissolved in a potassium hydroxide solution and directly subjected to microscopic examination or culture to detect dermatophytes, and the existence of the dermatophytes in the scales scraped from the damaged part is proved. The polyion liquid for treating onychomycosis in example 4 is sprayed on affected parts three times a day in the morning, at noon and at night, the spraying time is kept for 10 minutes, after 20 days of continuous use, the symptoms basically disappear, the onychomycosis is obviously softened, and after 30 days of continuous use, the feet skin is smooth and soft. After treatment, the scales are taken and dissolved in a potassium hydroxide solution, and then direct microscopic examination or culture is carried out, so that no dermatophyte is detected, and the fact that no dermatophyte exists in the scales scraped from the damaged part is proved.
Although the present invention has been described with reference to various embodiments, it should be understood that the invention is not limited thereto, and that various insubstantial modifications and adaptations of the invention may be made by those skilled in the art without departing from the spirit and scope of the invention.
Claims (9)
1. The polyion liquid for treating onychomycosis is characterized by comprising the following components: the compound containing manganese ions, the compound containing selenium ions, the compound containing calcium ions, the compound containing magnesium ions, the compound containing ferrous ions and deionized water.
2. The polyionic liquid for treating onychomycosis according to claim 1, wherein: the compound containing manganese ions is one or more of manganese sulfate, manganese gluconate or manganese aspartate; the compound containing selenium ions is selenium disulfide, and the compound containing calcium ions is one or more of calcium oxide, calcium carbonate or calcium hydroxide; the compound containing magnesium ions is one or more of magnesium oxide, basic magnesium carbonate or magnesium hydroxide; the compound containing ferrous ions is one or more of ferrous sulfate, ferrous chloride or ferrous acetate.
3. The polyionic liquid for treating onychomycosis according to claim 1 or 2, wherein: ions were contained at the following concentrations:
manganese ion: 0.06-0.10 mM;
selenium ion: 0.01-0.05 mM;
ferrous ion: 0.05-0.09 mM;
calcium ion: 1.5-4.8 mM;
magnesium ion: 0.5-1.0 mM.
4. The polyionic liquid for treating onychomycosis according to claim 3, wherein: mainly contains ions with the following concentrations:
manganese ion: 0.08 mM;
selenium ion: 0.03mM
Ferrous ion: 0.07mM
Calcium ion: 3.0mM
Magnesium ion: 0.7 mM.
5. A method of preparing a polyionic liquid for treating onychomycosis according to any one of claims 1 to 4, comprising the steps of:
1) respectively weighing a compound containing manganese ions and a compound containing selenium ions according to the concentration of each ion, sequentially adding the compounds into deionized water weighed in advance, and stirring for the first time;
2) weighing a ferrous ion compound according to the concentration of ferrous ions, adding the ferrous ion compound into the ionic liquid obtained in the step 1), and stirring for the second time;
3) respectively weighing a calcium ion-containing compound and a magnesium ion-containing compound according to the concentrations of calcium ions and magnesium ions, sequentially adding the calcium ion-containing compound and the magnesium ion-containing compound into the ionic liquid obtained in the step 2), stirring for the third time, standing for 24 hours, and taking supernate to obtain the multi-ionic liquid for treating onychomycosis.
6. The preparation method of the polyion liquid for treating onychomycosis according to claim 5, comprising the following steps: the first stirring is heating to 70-80 deg.C, and stirring for 1-2 hr.
7. The preparation method of the polyion liquid for treating onychomycosis according to claim 5, comprising the following steps: the second stirring is carried out at the temperature of 50-60 ℃ for 0.5-1 hour.
8. The preparation method of the polyion liquid for treating onychomycosis according to claim 5, comprising the following steps: the third stirring is at a temperature of 40-50 ℃ for 0.5-1 hour, and then the stirring is continued until the solution is cooled to room temperature.
9. Use of a polyionic liquid for treating onychomycosis according to any one of claims 1 to 4 for the treatment and prevention of onychomycosis or beriberi.
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| CN114452257A (en) * | 2022-04-14 | 2022-05-10 | 新基元(北京)医药科技有限公司 | Selenium disulfide foaming agent for skin care and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114452257A (en) * | 2022-04-14 | 2022-05-10 | 新基元(北京)医药科技有限公司 | Selenium disulfide foaming agent for skin care and preparation method thereof |
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