CN110769861A - 治疗缺血性组织的方法 - Google Patents

治疗缺血性组织的方法 Download PDF

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Publication number
CN110769861A
CN110769861A CN201880040949.0A CN201880040949A CN110769861A CN 110769861 A CN110769861 A CN 110769861A CN 201880040949 A CN201880040949 A CN 201880040949A CN 110769861 A CN110769861 A CN 110769861A
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aav
ser
individual
selectin
cys
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O·韦拉斯克斯
Z-J·刘
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University of Miami
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University of Miami
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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CN201880040949.0A 2017-05-02 2018-05-02 治疗缺血性组织的方法 Pending CN110769861A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762500470P 2017-05-02 2017-05-02
US62/500,470 2017-05-02
PCT/US2018/030615 WO2018204475A1 (en) 2017-05-02 2018-05-02 Method for treating ischemic tissue

Publications (1)

Publication Number Publication Date
CN110769861A true CN110769861A (zh) 2020-02-07

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CN201880040949.0A Pending CN110769861A (zh) 2017-05-02 2018-05-02 治疗缺血性组织的方法

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US (1) US20200062820A1 (https=)
EP (1) EP3618852A4 (https=)
JP (1) JP7450244B2 (https=)
KR (1) KR20200013674A (https=)
CN (1) CN110769861A (https=)
AU (1) AU2018261420A1 (https=)
CA (1) CA3097135A1 (https=)
IL (1) IL270388B2 (https=)
WO (1) WO2018204475A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102545491B1 (ko) * 2020-08-13 2023-06-21 동국대학교 산학협력단 신규한 뇌혈관질환 동물모델 제조방법 및 이에 의해 제조된 뇌혈관질환 동물모델을 이용하여 뇌혈관질환 발병 감수성 개체 차이가 작은 동물을 생산하기 위한 방법
CA3221884A1 (en) * 2021-06-11 2022-12-15 Norman Lafrance Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
EP4694905A1 (en) * 2023-04-13 2026-02-18 University of Miami Method for promoting myogenesis and skeletal muscle recovery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120058086A1 (en) * 2009-04-21 2012-03-08 Velazquez Omaida C Compositions, kits, and methods for promoting ischemic and diabetic wound healing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2494845A1 (en) * 2002-08-16 2004-02-26 Cardium Therapeutics, Inc. Gene therapy for critical limb ischemia with wild type or mutant enos
CA2779118A1 (en) * 2009-10-30 2011-05-05 University Of Miami Hypoxia regulated conditionally silenced aav expressing angiogenic inducers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120058086A1 (en) * 2009-04-21 2012-03-08 Velazquez Omaida C Compositions, kits, and methods for promoting ischemic and diabetic wound healing

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAVIS B. HORKAN等: "PC224. Increasing E-Selectin by Recombinant Adenoassociated Virus Improves Angiogenesis in a Murine Model of Hind Limb Ischemia", 《JOURNAL OF VASCULAR SURGERY》 *
KEWAL K. JAIN编著: "《Drug Delivery Systems. Methods in Molecular Biology》", 31 December 2008, HUMANA PRESS *
L. WANG等: "Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors", 《JOURNAL OF THROMBOSIS AND HAEMOSTASIS》 *
NISHANTH GABRIEL等: "Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo", 《HUMAN GENE THERAPY METHODS》 *
TAEYOUNG KOO等: "Delivery of AAV2/9-Microdystrophin Genes Incorporating Helix 1 of the Coiled-Coil Motif in the C-Terminal Domain of Dystrophin Improves Muscle Pathology and Restores the Level of a1-Syntrophin and a-Dystrobrevin in Skeletal Muscles of mdx Mice", 《HUMAN GENE THERAPY》 *

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Publication number Publication date
JP2020518644A (ja) 2020-06-25
IL270388B1 (en) 2023-11-01
IL270388A (https=) 2019-12-31
AU2018261420A1 (en) 2019-12-12
US20200062820A1 (en) 2020-02-27
KR20200013674A (ko) 2020-02-07
JP7450244B2 (ja) 2024-03-15
IL270388B2 (en) 2024-03-01
EP3618852A4 (en) 2021-01-06
CA3097135A1 (en) 2018-11-08
WO2018204475A1 (en) 2018-11-08
EP3618852A1 (en) 2020-03-11

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Application publication date: 20200207