CN110755493A - A Chinese medicinal composition for treating tumor, and its preparation method - Google Patents
A Chinese medicinal composition for treating tumor, and its preparation method Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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Abstract
The invention relates to a traditional Chinese medicine composition for treating tumors and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The raw materials for preparing the traditional Chinese medicine composition comprise internal organs of chamois, stems and leaves of citrus and castor beans; the mass ratio of the internal organs of the chamois, the stems and leaves of the citrus plants and the castor beans is (1250-5000): (50-500): (1-4). The traditional Chinese medicine composition can effectively treat various tumors, has better curative effect, short period and no pain for patients, has the advantages of good curative effect, safety, no toxicity, and the like in the aspect of preventing and treating the tumors compared with the traditional pharmacotherapy and radiotherapy and chemotherapy, and can achieve the aim of preventing and treating the tumors.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating tumors and a preparation method thereof.
Background
The cells have special growth modes of immune monitoring escape, promotion of self angiogenesis, anti-apoptosis and the like, seriously threaten the health of human beings, and at present, no method and medicament for radically treating tumors exist. The existing tumor drug therapy is divided into three drug therapies of cytotoxic drugs, molecular targeted drugs and immunotherapy drugs. The cytotoxic drugs can cause certain damage and influence on normal tissues and cells which proliferate quickly while killing tumor cells, and have certain toxic and side effects; the molecular targeted drug can generate drug resistance no matter in a single target or multiple targets, and the generation of the drug resistance is an obstacle which is difficult to overcome by the molecular targeted drug; the tumor immunotherapy has the characteristics of individual difference, tumor heterogeneity, tumor microenvironment difference and the like of patients, so that the overall effective rate of the tumor immunotherapy is lower, the number of people is small, the response rate is not high, and the phenomena of drug resistance, even disease state 'over progress' and the like of some patients also exist. Therefore, the development of novel antitumor drugs with remarkable effect, small damage and good prognosis is particularly necessary and urgent.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating tumors and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention is good in curative effect, short in period, safe and non-toxic.
The invention provides a traditional Chinese medicine composition for treating tumors, which is prepared from raw materials including chamois viscera, citrus stems and leaves and castor beans; the mass ratio of the internal organs of the chamois, the stems and leaves of the citrus plants and the castor beans is (1250-5000): (50-500): (1-4).
Preferably, the tumor comprises gastric cancer, rectal cancer, colorectal cancer, colon cancer, esophageal cancer, breast cancer or cervical cancer.
Preferably, the weight of each chamois organ is 250 to 1000 g.
Preferably, the internal organs of the chamois include one or more of the uterus and its appendages, heart, liver, kidney and intestines.
Preferably, the citrus plant comprises one or more of citrus, orange and grapefruit.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps:
1) drying and grinding the chamois viscera to obtain chamois viscera powder;
2) frying the castor seeds with soft fire, and grinding to obtain castor seed powder;
3) drying or baking the stems and leaves of the citrus plants in the sun, and grinding to obtain stem and leaf powder of the citrus plants;
4) mixing the chamois viscera powder obtained in the step 1), the castor seed powder obtained in the step 2) and the stems and leaves powder of citrus plants obtained in the step 3) to obtain a traditional Chinese medicine composition;
the steps 1), 2) and 3) are not limited in chronological order.
Preferably, the grain size of the chamois-grain viscera powder is 50-250 meshes.
Preferably, the grain size of the castor seed powder is 50-250 meshes.
Preferably, the particle size of the citrus stem and leaf powder is 50-250 meshes.
The invention provides a traditional Chinese medicine composition for treating tumors and a preparation method thereof. The traditional Chinese medicine composition can effectively treat various tumors, has better curative effect, short period and no pain for patients, has the advantages of good curative effect, safety, no toxicity, and the like in the aspect of preventing and treating the tumors compared with the traditional pharmacotherapy and radiotherapy and chemotherapy, and can achieve the aim of preventing and treating the tumors.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating tumors, which is prepared from raw materials including chamois viscera, citrus stems and leaves and castor beans; the mass ratio of the internal organs of the chamois, the stems and leaves of the citrus plants and the castor beans is (1250-5000): (50-500): (1-4).
In the present invention, the tumor includes gastric cancer, rectal cancer, colorectal cancer, colon cancer, esophageal cancer, breast cancer or cervical cancer.
The traditional Chinese medicine composition for treating tumors comprises internal organs of chamois, the mass ratio of which is 1250-5000, more preferably 1500-3000, and most preferably 2000. In the present invention, the internal organs of the chamois preferably include one or more of the uterus and its appendages, heart, liver, kidney and intestine. In the present invention, the mass of each chamois organ is preferably 250 to 1000 g. In the present invention, the source of the chamois viscera is conventionally commercially available. In the present invention, the internal organs of the chamois leather play a role in the pharmaceutical composition of the present invention in preventing metastasis of cancer cells, enhancing the immune competence of the human body, and improving the anti-tumor ability of the patient.
The traditional Chinese medicine composition for treating tumors comprises stems and leaves of citrus plants with a mass ratio of 50-500, more preferably 100-250, and most preferably 150. In the invention, the stems and leaves of the citrus plant play a role in treating tumors and can prevent cancer cell metastasis.
The traditional Chinese medicine composition for treating tumors further comprises castor beans with the mass ratio of 1-4, more preferably 1-2.5, and most preferably 1.5. In the present invention, about 10 grains per g of castor bean are preferable. In the present invention, the castor bean has a function of strongly inhibiting protein synthesis of various cancer cells for the treatment of tumors, thereby inactivating nucleic acids and leading to cancer cell death.
The source of the castor beans is not particularly limited in the present invention, and a conventional commercially available castor bean product well known to those skilled in the art may be used.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps:
1) drying chamois viscera, and grinding to obtain chamois viscera powder;
2) frying castor seeds with soft fire, and grinding to obtain castor seed powder;
3) sun drying or oven drying stems and leaves of Citrus plant, and grinding to obtain stems and leaves powder of Citrus plant;
4) mixing the chamois viscera powder obtained in the step 1), the castor seed powder obtained in the step 2) and the stems and leaves powder of citrus plants obtained in the step 3) to obtain a traditional Chinese medicine composition;
the steps 1), 2) and 3) are not limited in chronological order.
The chamois viscera powder is obtained by drying and grinding chamois viscera. The source of the viscera in the present invention is not particularly limited, and conventional commercially available chamois viscera known to those skilled in the art may be used. The drying method is not particularly limited, and the kang drying method is adopted. The invention is preferably dried until the water content of the viscera is less than 10 percent. The grinding method is not particularly limited in the invention, and the conventional traditional Chinese medicine grinding method well known to those skilled in the art can be adopted. In the present invention, the grain size of the chamois-grain viscera powder is preferably 100-200 meshes, and more preferably 150 meshes.
According to the invention, castor seeds are fried with small fire and ground to obtain castor seed powder. In the invention, the grain size of the castor seed powder is preferably 100-200 meshes, and more preferably 150 meshes. The grinding method is not particularly limited in the invention, and the conventional traditional Chinese medicine grinding method well known to those skilled in the art can be adopted.
The stems and leaves of citrus are dried or baked and ground to obtain the stem and leaf powder of citrus. In the invention, the particle size of the citrus stem and leaf powder is preferably 100-200 meshes, and more preferably 150 meshes. The invention has no special limitation on the drying or baking mode, and the traditional Chinese medicine drying or baking method which is well known by the technicians in the field is adopted. The invention is preferably dried in the sun or baked until the water content of the stems and leaves of the citrus is below 10 percent. The grinding method is not particularly limited in the invention, and the conventional traditional Chinese medicine grinding method well known to those skilled in the art can be adopted.
After obtaining the internal organ powder, castor seed powder and citrus stem and leaf powder of chamois, the invention mixes the internal organ powder, castor seed powder and citrus stem and leaf powder of chamois to obtain the traditional Chinese medicine composition.
The traditional Chinese medicine composition is preferably divided into 10-20 parts, is taken once every 2-7 days, and is taken with warm wine, and the treatment period is 2-4 months. The warm wine is preferably rice wine, and the temperature is preferably 35-50 ℃.
The present invention relates to a method for preparing a Chinese medicinal composition for treating tumor, and more particularly, to a method for preparing a Chinese medicinal composition for treating tumor.
Example 1
1 heart of chamois (300g), 40g of citrus stem and 4 castor bean (0.4 g). Oven drying chamois heart, sun drying citrus stem, parching semen Ricini with slow fire, grinding into powder, mixing, and dividing into 20 parts, and administering once every 2 days, 5 times, 5 days, 5 times, weekly, and 10 times. The medicine is taken with warm wine, and the treatment period is 3 months.
Monday men have stomach cancer, suddenly hematemesis occurs in 11 months in 1996 after lunch, and the stomach cancer is confirmed through a series of examinations, and surgical excision is performed by the Monday men according to the advice of doctors. But only half a year after the operation, the reexamination result shows that the disease relapse is repeated, and the male in the week receives the radiotherapy and chemotherapy treatment in the hospital, but the serious toxic and side effects, nausea, vomiting and no meal are caused after the treatment, the whole person is thin for a large circle, and the body is not strong. After patients take the medicine again, the body is obviously improved, the spirit and the color are much better, people are fat, and physical labor can be engaged in. After administration, the gastric mass completely disappeared by CT examination until it is still alive.
Comparative example
The Tangmen suffer from gastric cancer, suffer from hematemesis and stomachache in 6 months in 1997, are confirmed to be gastric cancer through a series of examinations, are subjected to surgical excision according to the advice of doctors, are treated by radiotherapy and chemotherapy in hospitals, but have severe toxic and side effects after treatment, nausea, vomiting, weakened resistance, weak body and death after 2 years.
Example 2
1 stomach of the chamois (1000g), 60g of citrus stem and 5 grains of castor bean (0.5 g). Oven drying chamois seed, sun drying citrus stem, parching semen Ricini with slow fire, grinding into powder, mixing, and dividing into 20 parts, and administering once every 2 days, 5 times, 5 days, 5 times, weekly, and 10 times. The medicine is taken with warm wine, and the treatment period is 3 months.
The aged women are diagnosed with rectal cancer in 2006 due to 'intermittent hematochezia with abdominal distension and stool thinning' as the main reason, the patient is subjected to radical resection of the rectal cancer, differentiated adenocarcinoma infiltration appears in liver tissues, the tumor is affected by liver capsule, the cut is clean, and the metastatic tumor is considered by combining the form and the medical history. The patients who receive the radiotherapy and chemotherapy treatment in hospitals have no improvement. After patients take the medicine again, the body is obviously improved, the spirit and the color are much better, and simple labor can be engaged. After the medicine is taken, the medicine is checked regularly, and no abnormality exists until now.
Comparative example
The Gui women also confirmed the rectal cancer and the metastasis in 2007, made radical resection of the rectal cancer, and treated with chemoradiotherapy, which caused the damage of the heart, the liver and the kidney, and died after 3 months.
Example 3
1 uterus and attachments of chamois (500g), 30g of citrus stem and 3 grains of castor bean (0.3 g). Oven drying uterus and attachments of chamois, sun drying stems of Mandarin orange, parching semen Ricini with slow fire, grinding into powder, mixing, and dividing into 20 parts, and administering once every 2 days, 5 times, 5 days, 5 times, weekly, and 10 times. The medicine is taken with warm wine, and the treatment period is 3 months.
Ruan women, beginning to feel uncomfortable in 12 months in 2009, have confirmed cervical cancer in tumor hospitals, obvious lumbosacral and bilateral sacral pain, emaciation and poor appetite. After patients take the medicine again, the pain of the lumbosacral part and the bilateral hip bones is obviously relieved, the general conditions of diet and the like are improved, the patients can go out by themselves, and the colporrhagia symptom disappears. The regular review shows that no exception exists up to now.
Comparative example
Cervical cancer of the ney ladies in 2007 is caused, and after a large number of treatments such as surgery, radiotherapy and chemotherapy, relapse occurs, immunity is reduced, and the cervical cancer cannot be treated and died finally.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. A Chinese medicinal composition for treating tumor is prepared from chamois viscera, stems and leaves of Citrus plant and semen Ricini; the mass ratio of the internal organs of the chamois, the stems and leaves of the citrus plants and the castor beans is (1250-5000): (50-500): (1-4).
2. The composition of claim 1, wherein the tumor comprises gastric cancer, rectal cancer, colorectal cancer, colon cancer, esophageal cancer, breast cancer or cervical cancer.
3. The traditional Chinese medicine composition according to claim 1, wherein the mass of each of the chamois viscera is 250-1000 g.
4. The composition of claim 1, wherein the internal organs of the chamois include one or more of the uterus and its appendages, heart, liver, kidney and intestine.
5. The composition of claim 1, wherein the citrus plant comprises one or more of citrus, orange, and grapefruit.
6. A method for preparing the Chinese medicinal composition of any one of claims 1 to 5, comprising the steps of:
1) drying and grinding the chamois viscera to obtain chamois viscera powder;
2) frying the castor seeds with soft fire, and grinding to obtain castor seed powder;
3) drying or baking the stems and leaves of the citrus plants in the sun, and grinding to obtain stem and leaf powder of the citrus plants;
4) mixing the chamois viscera powder obtained in the step 1), the castor seed powder obtained in the step 2) and the stems and leaves powder of citrus plants obtained in the step 3) to obtain a traditional Chinese medicine composition;
the steps 1), 2) and 3) are not limited in chronological order.
7. The method of manufacturing according to claim 5, wherein the grain size of the chamois viscera powder is 50-250 mesh.
8. The method according to claim 5, wherein the castor seed powder has a particle size of 50 to 250 mesh.
9. The method according to claim 5, wherein the citrus plant stem and leaf powder has a particle size of 50 to 250 mesh.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911233010.9A CN110755493A (en) | 2019-12-05 | 2019-12-05 | A Chinese medicinal composition for treating tumor, and its preparation method |
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| CN201911233010.9A CN110755493A (en) | 2019-12-05 | 2019-12-05 | A Chinese medicinal composition for treating tumor, and its preparation method |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127055A (en) * | 2013-02-04 | 2013-06-05 | 四川大学 | Application of tangeretin serving as sensitizer used for preparing chemotherapeutics used for curing solid tumor |
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- 2019-12-05 CN CN201911233010.9A patent/CN110755493A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127055A (en) * | 2013-02-04 | 2013-06-05 | 四川大学 | Application of tangeretin serving as sensitizer used for preparing chemotherapeutics used for curing solid tumor |
Non-Patent Citations (4)
| Title |
|---|
| 丁祥等: "蓖麻油微胶囊化及对鼠抗生育研究", 《四川动物》 * |
| 任百尊: "《中国食经》", 30 June 2001, 上海文化出版社 * |
| 关爱生命更长久: "胃癌晚期一直持续发烧是病情恶化了吗", 《西祠（HTTPS://WWW.XICI.NET/D247290179.HTM）》 * |
| 抗击癌症从了解开: "中医如何治疗宫颈癌晚期", 《搜狐（HTTPS://WWW.SOHU.COM/A/61003151_189966 ）》 * |
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