CN110755318A - Application of clove extract in preparation of cosmetics - Google Patents
Application of clove extract in preparation of cosmetics Download PDFInfo
- Publication number
- CN110755318A CN110755318A CN201910996858.0A CN201910996858A CN110755318A CN 110755318 A CN110755318 A CN 110755318A CN 201910996858 A CN201910996858 A CN 201910996858A CN 110755318 A CN110755318 A CN 110755318A
- Authority
- CN
- China
- Prior art keywords
- clove extract
- cosmetics
- clove
- extract
- water bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 115
- 244000223014 Syzygium aromaticum Species 0.000 title claims abstract description 113
- 235000016639 Syzygium aromaticum Nutrition 0.000 title claims abstract description 113
- 239000002537 cosmetic Substances 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000002245 particle Substances 0.000 claims abstract description 28
- 238000002156 mixing Methods 0.000 claims abstract description 21
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 9
- 238000002390 rotary evaporation Methods 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 24
- 239000000839 emulsion Substances 0.000 claims description 23
- 239000011248 coating agent Substances 0.000 claims description 19
- 238000000576 coating method Methods 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 13
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 11
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 11
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 229940031709 peg-30-dipolyhydroxystearate Drugs 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 1
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 abstract description 28
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 abstract description 14
- 239000005770 Eugenol Substances 0.000 abstract description 14
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 abstract description 14
- 229960002217 eugenol Drugs 0.000 abstract description 14
- 230000000813 microbial effect Effects 0.000 abstract description 7
- 230000000843 anti-fungal effect Effects 0.000 abstract description 6
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 6
- 230000005808 skin problem Effects 0.000 abstract description 6
- 238000011109 contamination Methods 0.000 abstract description 5
- 230000002542 deteriorative effect Effects 0.000 abstract description 4
- 230000003712 anti-aging effect Effects 0.000 abstract description 3
- 238000013268 sustained release Methods 0.000 description 27
- 239000012730 sustained-release form Substances 0.000 description 27
- 210000003491 skin Anatomy 0.000 description 24
- 241000628997 Flos Species 0.000 description 20
- 230000000694 effects Effects 0.000 description 14
- 230000001815 facial effect Effects 0.000 description 13
- 239000011859 microparticle Substances 0.000 description 11
- 235000019441 ethanol Nutrition 0.000 description 10
- 239000000419 plant extract Substances 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 238000009792 diffusion process Methods 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000233866 Fungi Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 239000000341 volatile oil Substances 0.000 description 5
- 244000005700 microbiome Species 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000000287 crude extract Substances 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 231100000274 skin absorption Toxicity 0.000 description 3
- 230000037384 skin absorption Effects 0.000 description 3
- SCCDQYPEOIRVGX-UHFFFAOYSA-N Acetyleugenol Chemical compound COC1=CC(CC=C)=CC=C1OC(C)=O SCCDQYPEOIRVGX-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 2
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000010681 turmeric oil Substances 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241001252601 Blumea Species 0.000 description 1
- 241000123650 Botrytis cinerea Species 0.000 description 1
- 240000009138 Curcuma zedoaria Species 0.000 description 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 240000002045 Guettarda speciosa Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241001052560 Thallis Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetic preparation, and discloses an application of a clove extract in preparing cosmetics, wherein the addition amount of the clove extract in the cosmetics is 1-5% (w/w), the clove extract is added in a form of slow-release particles, and the extraction method of the clove extract comprises the following steps: mixing the clove powder and a solvent, performing ultrasonic-assisted extraction under the water bath heating condition, then incubating for 20-30 hours at 130-160 rpm and 37 ℃, filtering, and removing the solvent by rotary evaporation to finally obtain the clove extract. According to the invention, the clove extract is added into the cosmetics, so that the cosmetics can be effectively prevented from deteriorating due to microbial contamination; the clove extract has antifungal effect, and the cosmetic added with eugenol can relieve skin problems and the like through the antifungal effect; in addition, the clove extract also has a certain antioxidation function, so that the cosmetics have the functions of antioxidation and anti-aging.
Description
Technical Field
The invention relates to the technical field of cosmetic preparation, in particular to application of a clove extract in preparation of cosmetics.
Background
In recent years, plant extract cosmetics having less side effects and less toxicity have been increasingly favored, and under such a trend, cosmetics containing plant extracts as active ingredients have a wide market prospect. The plant extract is a plant product mainly composed of biological small molecules and macromolecules and formed by separating and purifying one or more active ingredients in plant materials by means of physical, chemical and biological methods. The cosmetic prepared by using the plant extract as an active ingredient has many advantages compared with the traditional cosmetic: overcomes the defect that the traditional cosmetics depend on chemical synthetic products, and ensures that the safety performance of the product is higher; the natural components are easier to be absorbed by the skin, so that the effect of the product is more obvious; more outstanding functionality, etc. The Chinese herbal medicine extract cosmetic is a bright point in the development of cosmetics, combines the characteristics of skin care products and Chinese herbal medicines, solves different skin problems by utilizing the characteristics of the Chinese herbal medicines which are purely natural and have obvious curative effects, and effectively improves skin quality.
The research reports now that more natural plant extracts mainly comprise saponin, alkaloid, polysaccharide, tea polyphenol, flavonoid, volatile oil and the like, and the functional components and related action mechanisms of the natural plant extracts are gradually discovered and proved by people, so that the natural plant extracts have obvious curative effects on the aspects of sun screening, whitening, aging resistance, sterilization and the like. For example, the publication of "a Chinese medicinal volatile oil and its application in cosmetics" in Chinese patent literature has a publication number of CN105287265A, which is composed of the following raw materials in parts by weight: 1.0-2.8 parts of angelica oil, 0.9-2.5 parts of turmeric oil, 0.9-2.5 parts of zedoary turmeric oil and 0.8-2.2 parts of blumea oil. The traditional Chinese medicine volatile oil and the cosmetics thereof provided by the invention are safe, have no stimulation, are easy to be absorbed by skin, have obvious effects of preventing and/or treating calluses, and solve the problem that the stratum corneum of the skin difficultly absorbs effective components. Therefore, the full application of the effective components of the plant extract in the cosmetic industry is a hot topic of future research.
The clove is a perennial plant, grows around the world and is used for commercial use, flower buds of the clove are used as spice after being ripe and harvested, the clove is rich in various active ingredients (eugenol, β -caryophyllene and the like) and has the effects of resisting oxidation, inhibiting bacteria, expelling parasites, treating neuralgia and the like, wherein the eugenol is the most main antibacterial active ingredient of clove essential oil, the eugenol is rich in resources, low in production cost and good in inhibition effect on various microorganisms, so that the clove has wide application prospects in cosmetics, medicines and foods, and the application research of the clove extract in the cosmetics is not available in the prior art.
Disclosure of Invention
The invention provides the application of the clove extract in preparing the cosmetics in order to overcome the problems that the traditional cosmetics depend on chemical synthetic products, can cause certain influence on human health after long-term use, have short shelf life and are easy to deteriorate due to microbial pollution after being unsealed, the clove extract is a natural plant extract, natural components are easier to be absorbed by skin, and the safety performance is high; the crude extract of clove is added into cosmetics, so that the cosmetics can be effectively prevented from deteriorating due to microbial contamination; and can relieve skin problems caused by fungi, and also has certain functions of preventing oxidation and resisting aging.
In order to achieve the purpose, the invention adopts the following technical scheme:
an application of a clove extract in preparing cosmetics, wherein the addition amount of the clove extract in the cosmetics is 1-5% (w/w).
The clove extract is a natural plant extract, natural components are easier to be absorbed by skin, and the safety performance is high; the crude extract of clove is added into cosmetics because the clove extract has an antibacterial function, so that the cosmetics can be effectively prevented from deteriorating due to microbial contamination; the clove extract has antifungal effect, and the cosmetic added with eugenol can relieve skin problems and the like through the antifungal effect; in addition, the clove extract also has a certain antioxidation function, so that the cosmetics have the functions of antioxidation and anti-aging.
The flos Caryophylli extract mainly contains volatile oil containing eugenol, acetyl eugenol, caryophyllene, methyl salicylate, methyl n-amyl ketone, benzaldehyde, benzyl acetate, etc., wherein the main antibacterial component is eugenol. Eugenol has broad-spectrum antibacterial effect, and can inhibit the growth of Staphylococcus aureus, Escherichia coli, Botrytis cinerea, etc. Because the eugenol is a natural extract, the eugenol has high safety, and has the advantages of safety, no toxicity, greenness and environmental protection compared with a chemical preservative. The bacteriostatic mechanism of the eugenol is that cell permeability is changed by acting on a cell wall and a biological membrane system, so that cell metabolism is disordered or acts on an enzyme system or functional protein in a bacterial cell to inhibit the cell metabolism; meanwhile, eugenol may act on genetic materials such as nucleic acid and the like, so that DNA replication, transcription and expression are inhibited. In addition, eugenol contains aromatic rings and polar groups on the aromatic rings, and can be combined with active groups of certain enzymes to destroy normal metabolic functions, thereby influencing the growth of thalli.
Preferably, the extraction method of the clove extract comprises the following steps: mixing the clove powder and a solvent, performing ultrasonic-assisted extraction under the water bath heating condition, then incubating for 20-30 hours at 130-160 rpm and 37 ℃, filtering, and removing the solvent by rotary evaporation to finally obtain the clove extract.
Preferably, the solvent is ethanol, and the mixing ratio of the clove powder to the ethanol is 1: 5-1: 20 (w/v).
Preferably, the water bath temperature is 85-95 ℃, and the ultrasonic-assisted extraction time is 10-40 min.
The invention adopts the ultrasonic-assisted extraction technology to carry out alcohol extraction on the clove powder, can effectively extract antibacterial active substances in the clove, and can play roles of preventing microbial contamination and resisting fungi when being added into cosmetics, so that the cosmetics are not easy to deteriorate and can relieve skin problems caused by fungi.
Preferably, the clove extract is added to the cosmetic in the form of sustained-release microparticles, and the preparation method of the sustained-release microparticles comprises the following steps:
(1) adding deionized water into the clove extract, and uniformly stirring the mixture in a water bath at 70-75 ℃ to obtain an aqueous solution of the clove extract;
(2) mixing caprylic capric acid glyceride, cetostearyl alcohol and PEG-30-dipolyhydroxystearate, and uniformly stirring in a water bath at 70-75 ℃ to obtain a coating solution;
(3) adding the clove extract aqueous solution into the coating solution, and stirring for 15-30 min in water bath at 70-75 ℃ to obtain emulsion;
(4) adding Tween 80 into the obtained emulsion, and stirring for 1-3 h at 45-55 ℃ to obtain the slow-release particles.
Preferably, in the step (1), the mixing ratio of the clove extract to the deionized water is 1: 10-1: 20(w/v), and the stirring time is 30-60 min.
Preferably, in the step (2), the mass fraction of the PEG-30-dipolyhydroxystearate in the coating liquid is 5-15%, and the mass ratio of the caprylic-capric glyceride to the cetostearyl alcohol is (3-5): 1.
preferably, the volume ratio of the clove extract aqueous solution to the coating solution in the step (3) is 1: (1-2).
Preferably, the tween 80 added in the step (4) accounts for 5-15% of the mass of the emulsion.
Firstly, adding a clove extract aqueous solution into a coating solution consisting of lipid and an emulsifier through the steps (1) to (3) to prepare a water-in-oil emulsion, then adding an emulsifier Tween 80 into the water-in-oil emulsion through the step (4), stirring and reacting at a specific temperature to effectively encapsulate the clove extract in the oil to prepare the sustained-release particles. The sustained release microparticles can self-emulsify in an aqueous solution to form water-in-oil-in-water (W)1/O/W2) The multiple emulsion has the functions of protecting, slowly releasing and promoting skin absorption of the clove extract wrapped in the multiple emulsion.
Because the lipid used in the coating liquid is the mixed lipid of the liquid lipid of caprylic capric acid glyceride and the solid lipid of cetostearyl alcohol, the fluidity of the oil phase in a water-in-oil system can be reduced, so that the prepared sustained-release particles are solid at normal temperature, the fusion between water phases and the oil phase and the interaction phenomenon of the inner and outer water phases penetrating through an oil film are reduced, and the storage stability of the sustained-release particles is improved.
The slow release particles encapsulated with the clove extract are added into cosmetics, so that the cosmetics have a strong slow release effect and can have the efficacy of the clove extract for a long time in one day; the slow-release particles can improve the retention amount of the clove extract in the skin and the amount of the clove extract penetrating through the skin, promote the absorption of the clove extract on the surface of the skin and enable cosmetics to better exert the effect.
Therefore, the invention has the following beneficial effects:
(1) the clove powder is subjected to alcohol extraction by adopting an ultrasonic-assisted extraction technology, so that antibacterial active substances in the clove can be effectively extracted;
(2) the crude extract of clove is added into cosmetics, so that the cosmetics can be effectively prevented from deteriorating due to microbial contamination; the clove extract has antifungal effect, and the cosmetic added with eugenol can relieve skin problems and the like through the antifungal effect; in addition, the clove extract also has a certain antioxidation function, so that the cosmetics have the functions of antioxidation and anti-aging;
(3) the slow release particles encapsulated with the clove extract are added into cosmetics, so that the cosmetics have a strong slow release effect and can have the efficacy of the clove extract for a long time in one day; the slow-release particles can improve the retention amount of the clove extract in the skin and the amount of the clove extract penetrating through the skin, promote the absorption of the clove extract on the surface of the skin and enable cosmetics to better exert the effect.
Drawings
FIG. 1 is a photograph showing the inhibition zone of clove extract against E.coli in example 1;
FIG. 2 is a photograph showing the inhibition zone of clove extract against Staphylococcus aureus in example 1.
In the figure: negative control 0, and zone of inhibition of 2 clove extract.
Detailed Description
The invention is further described with reference to the following detailed description and accompanying drawings.
The starting materials used in the present invention are commercially available without specific reference.
Example 1:
an application of flos Caryophylli extract in preparing facial cleanser is prepared by mixing flos Caryophylli extract with facial cleanser in an amount of 2% (w/w) thoroughly. The extraction method of the clove extract comprises the following steps: mixing flos Caryophylli powder and ethanol at a ratio of 1:10(w/v), performing ultrasonic-assisted extraction at 90 deg.C in water bath for 30min, incubating at 150rpm and 37 deg.C for 24 hr, filtering, and removing solvent by rotary evaporation to obtain flos Caryophylli extract.
Example 2:
the application of clove extract in preparing the facial cleanser is to fully mix the clove extract with the facial cleanser in a sustained-release microparticle form, wherein the addition amount of the clove extract in the facial cleanser is 2% (w/w).
The extraction method of the clove extract comprises the following steps: mixing flos Caryophylli powder and ethanol at a ratio of 1:10(w/v), performing ultrasonic-assisted extraction at 90 deg.C in water bath for 30min, incubating at 150rpm and 37 deg.C for 24 hr, filtering, and removing solvent by rotary evaporation to obtain flos Caryophylli extract.
The preparation method of the sustained-release particles comprises the following steps:
(1) adding deionized water into flos Caryophylli extract at a mixing ratio of 1:15(w/v), and stirring at 72 deg.C for 40min to obtain water solution of flos Caryophylli extract;
(2) mixing caprylic capric acid glyceride, cetostearyl alcohol and PEG-30-dipolyhydroxystearate, and stirring in a water bath at 72 ℃ for 40min to obtain a coating liquid, wherein the mass fraction of the PEG-30-dipolyhydroxystearate in the coating liquid is 10%, and the mass ratio of the caprylic capric acid glyceride to the cetostearyl alcohol is 4: 1;
(3) adding the clove extract water solution into the coating solution according to the volume ratio of 1:1, and stirring for 20min in a water bath at 72 ℃ to obtain emulsion;
(4) adding Tween 80 accounting for 10% of the emulsion mass into the obtained emulsion, and stirring at 50 deg.C for 2h to obtain sustained-release microparticles.
Example 3:
the application of clove extract in preparing the facial cleanser is to fully mix the clove extract with the facial cleanser in a sustained-release microparticle form, wherein the addition amount of the clove extract in the facial cleanser is 1% (w/w).
The extraction method of the clove extract comprises the following steps: mixing flos Caryophylli powder and ethanol at a ratio of 1:5(w/v), ultrasonic-assisted extracting at 85 deg.C in water bath for 10min, incubating at 130rpm and 37 deg.C for 20 hr, filtering, and removing solvent by rotary evaporation to obtain flos Caryophylli extract.
The preparation method of the sustained-release particles comprises the following steps:
(1) adding deionized water into flos Caryophylli extract at a mixing ratio of 1:10(w/v), and stirring at 70 deg.C for 30min to obtain water solution of flos Caryophylli extract;
(2) mixing caprylic capric acid glyceride, cetostearyl alcohol and PEG-30-dipolyhydroxystearate, and stirring in a water bath at 70 ℃ for 30min to obtain a coating liquid, wherein the mass fraction of the PEG-30-dipolyhydroxystearate in the coating liquid is 5%, and the mass ratio of the caprylic capric acid glyceride to the cetostearyl alcohol is 3: 1;
(3) adding the clove extract water solution into the coating solution according to the volume ratio of 1:1.5, and stirring for 15min in water bath at 70 ℃ to obtain emulsion;
(4) adding Tween 80 accounting for 5% of the emulsion, and stirring at 45 deg.C for 1 hr to obtain sustained release microparticle.
Example 4:
an application of flos Caryophylli extract in preparing cosmetic is prepared by mixing flos Caryophylli extract with facial cleanser in form of sustained release microparticle, wherein the addition amount of flos Caryophylli extract in the facial cleanser is 5% (w/w).
The extraction method of the clove extract comprises the following steps: mixing flos Caryophylli powder and ethanol at a ratio of 1:20(w/v), ultrasonic-assisted extracting at 95 deg.C in water bath for 40min, incubating at 160rpm and 37 deg.C for 30 hr, filtering, and removing solvent by rotary evaporation to obtain flos Caryophylli extract.
The preparation method of the sustained-release particles comprises the following steps:
(1) adding deionized water into flos Caryophylli extract at a mixing ratio of 1:20(w/v), and stirring at 75 deg.C for 60min to obtain water solution of flos Caryophylli extract;
(2) mixing caprylic capric acid glyceride, cetostearyl alcohol and PEG-30-dipolyhydroxystearate, and stirring in a water bath at 75 ℃ for 60min to obtain a coating liquid, wherein the mass fraction of the PEG-30-dipolyhydroxystearate in the coating liquid is 15%, and the mass ratio of the caprylic capric acid glyceride to the cetostearyl alcohol is 5: 1;
(3) adding the clove extract water solution into the coating solution according to the volume ratio of 1:2, and stirring for 30min in a water bath at the temperature of 75 ℃ to obtain emulsion;
(4) adding Tween 80 accounting for 15% of the emulsion by mass into the obtained emulsion, and stirring at 55 ℃ for 3h to obtain the sustained-release particles.
Firstly, testing the bacteriostatic performance of a clove extract:
the clove extract dilutions extracted in the above examples were added to the culture medium containing the standard strains of escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and candida albicans, respectively, by agar punch method, and fully diffused into the culture medium, and the diameters of the inhibition zones were measured after culturing in a biochemical incubator at 37 ℃ for 24h, with the results shown in table 1.
Table 1: the diameter (mm) of the inhibition zone.
| Numbering | Escherichia coli | Staphylococcus aureus | Pseudomonas aeruginosa | Candida albicans |
| Example 1 | 18.2 | 17.7 | 17.5 | 26.6 |
| Example 2 | 18.2 | 17.7 | 17.5 | 26.6 |
| Example 3 | 16.8 | 17.2 | 17.3 | 26.0 |
| Example 4 | 17.4 | 16.7 | 17.0 | 25.2 |
As can be seen from Table 1, the clove extract extracted by the invention has good bacteriostatic performance on bacteria and fungi.
Secondly, testing the antibacterial performance of the facial cleanser added with the clove extract:
the facial cleanser added with clove extract in the above examples was mixed with mixed bacterial and mixed fungal suspensions, and the bacteria were selected from escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, respectively, according to the microbial challenge test method of USP in the united states; the fungi are Candida albicans and Aspergillus niger. Samples were taken for analysis on days 0, 7, 14, 21 and 28 after inoculation by plate counting method. The colony number is less than 10CFU/g measured on the 7 th day, which shows that the facial cleanser added with the clove extract has the effect of inhibiting and killing microorganisms, and the product is not easily polluted by the microorganisms during production, storage and use through a microorganism challenge test.
And thirdly, testing the slow release performance of the slow release particles:
the sustained-release microparticles prepared in the above examples were examined for in vitro release by the following method:
(1) 2.5g of sustained-release particles are dissolved in 5g of deionized water to form multiple emulsion;
(2) taking 0.4mL multiple emulsion, diluting with ethanol to a constant volume of 10mL, ultrasonically demulsifying for 20min, filtering with 0.45 μ filter membrane, taking 0.4mL filtrate, and measuring absorbance A at 282nm wavelengthGeneral assembly；
(3) Adding 4mL of multiple emulsion into a dialysis bag with the molecular weight cutoff of 10kDa, placing the dialysis bag into 100mL of physiological saline, and stirring the physiological saline in a water bath kettle at 37 ℃ at the rotating speed of 200 rpm;
(4) taking 2mL of liquid from the beaker in the step (3) at regular intervals, and adding 2mL of fresh physiological saline to keep the volume of the liquid in the beaker constant;
(5) measuring the absorbance A of the liquid taken out in the step (4) at a wavelength of 282nmt。
The release amount of the sustained-release fine particles is (A)t/AGeneral assembly)×100％。
The result shows that the clove extract is directly dissolved in water in the embodiment 1, the release rate of the clove extract reaches 80.5% after 5 hours, and the release is basically complete; while the release rates of the clove extracts in the sustained-release particles of the embodiments 2 to 4 tend to be balanced after 15 hours, the maximum release rate of the sustained-release particles of the embodiments 2 reaches 79.4%, the maximum release rate of the sustained-release particles of the embodiments 3 reaches 81.2%, and the maximum release rate of the sustained-release particles of the embodiments 4 reaches 79.2%. The slow release particles prepared in the invention are proved to have good slow release effect on the clove extract, and are beneficial to the lasting exertion of the efficacy of cosmetics on human skin.
And fourthly, testing the skin absorption performance of the sustained-release particles:
the research on the skin absorption performance is carried out by a vertical Franz diffusion cell, and the effective diffusion area of the diffusion cell is 2.8cm2The volume of the receiving pool is 6.5mL, the water bath temperature of the interlayer of the diffusion pool is 32 ℃ which is close to the skin surface temperature, and the receiving pool is selected to be used with a human bodyThe skin of pigs with similar skin permeability was used as the test skin. The receiving reservoir was filled with physiological saline, and then the pig skin was fixed between the supply reservoir and the receiving reservoir with the stratum corneum of the skin facing the supply reservoir.
(1) Dissolving 3g of sustained-release particles in deionized water to form multiple emulsion, and metering to 25 mL;
(2) taking 0.4mL multiple emulsion, diluting with ethanol to a constant volume of 10mL, ultrasonically demulsifying for 20min, filtering with 0.45 μ filter membrane, taking 0.4mL filtrate, and measuring absorbance A at 282nm wavelengthGeneral assembly；
(3) 0.4mL of multiple emulsion is dripped on the skin surface in a supply pool, a diffusion pool is placed in a water bath, and a receiving pool is stirred at the rotating speed of 200 rpm;
(4) after 24 hours, taking out the diffusion cell, washing away the sustained-release particles remained on the surface of the skin by using normal saline, then cutting the pigskin into pieces, fixing the volume to a 25mL volumetric flask by using absolute ethyl alcohol, performing ultrasonic emulsion breaking for 60min, taking out 0.4mL, and measuring the absorbance A of the pigskin at the wavelength of 282nm1；
(5) 0.4mL of the thus-obtained sample was taken out of the receiving solution, and the absorbance A at a wavelength of 282nm was measured2。
Calculating the concentration of the clove extract corresponding to each absorbance according to the standard curve, thereby calculating the mass m of the clove extract corresponding to each absorbanceGeneral assembly、m1、m2。
The retention rate of the clove extract is (m)1/mGeneral assembly)×100％
Transmittance of (m)2/mGeneral assembly)×100％。
The results showed that after 24h, the retention rate of the clove extract in the sustained release microparticles in examples 2 to 4 in the skin was about 2.2 times the retention rate of the aqueous solution of the clove extract in example 1, and the permeation rate of the clove extract in the aqueous solution of the clove extract in example 1 was 3.9 times the permeation rate of the clove extract in the sustained release microparticles in examples 2 to 4. The slow release particles are proved to be capable of promoting the clove extract to be absorbed on the surface of the skin, and the slow release particles can better exert the effect on the skin when being added into cosmetics.
Claims (9)
1. The application of the clove extract in preparing the cosmetics is characterized in that the addition amount of the clove extract in the cosmetics is 1-5% (w/w).
2. The use of the clove extract in the preparation of cosmetics according to claim 1, wherein the extraction method of the clove extract comprises the following steps: mixing the clove powder and a solvent, performing ultrasonic-assisted extraction under the water bath heating condition, then incubating for 20-30 hours at 130-160 rpm and 37 ℃, filtering, and removing the solvent by rotary evaporation to finally obtain the clove extract.
3. The use of the clove extract in preparing cosmetics according to claim 2, wherein the solvent is ethanol, and the mixing ratio of clove powder to ethanol is 1: 5-1: 20 (w/v).
4. The application of the clove extract in preparing the cosmetics as claimed in claim 2 or 3, wherein the water bath temperature is 85-95 ℃, and the ultrasonic-assisted extraction time is 10-40 min.
5. The use of clove extract as claimed in claim 1 for the preparation of cosmetics, wherein said clove extract is added to cosmetics in the form of slow release particles, said slow release particles being prepared by a process comprising the steps of:
(1) adding deionized water into the clove extract, and uniformly stirring the mixture in a water bath at 70-75 ℃ to obtain an aqueous solution of the clove extract;
(2) mixing caprylic capric acid glyceride, cetostearyl alcohol and PEG-30-dipolyhydroxystearate, and uniformly stirring in a water bath at 70-75 ℃ to obtain a coating solution;
(3) adding the clove extract aqueous solution into the coating solution, and stirring for 15-30 min in water bath at 70-75 ℃ to obtain emulsion;
(4) adding Tween 80 into the obtained emulsion, and stirring for 1-3 h at 45-55 ℃ to obtain the slow-release particles.
6. The application of the clove extract in preparing the cosmetics is characterized in that the mixing ratio of the clove extract and deionized water in the step (1) is 1: 10-1: 20(w/v), and the stirring time is 30-60 min.
7. The use of clove extract in the preparation of cosmetics according to claim 5, wherein in the step (2), the mass fraction of PEG-30-dipolyhydroxystearate in the coating liquid is 5-15%, and the mass ratio of caprylic capric glyceride to cetostearyl alcohol is (3-5): 1.
8. the use of clove extract in the preparation of cosmetics according to claim 5, wherein the volume ratio of the clove extract aqueous solution to the coating solution in the step (3) is 1: (1-2).
9. The application of the clove extract in preparing the cosmetics as claimed in claim 5, wherein the Tween 80 added in the step (4) accounts for 5-15% of the weight of the emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910996858.0A CN110755318A (en) | 2019-10-19 | 2019-10-19 | Application of clove extract in preparation of cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910996858.0A CN110755318A (en) | 2019-10-19 | 2019-10-19 | Application of clove extract in preparation of cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110755318A true CN110755318A (en) | 2020-02-07 |
Family
ID=69331205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910996858.0A Pending CN110755318A (en) | 2019-10-19 | 2019-10-19 | Application of clove extract in preparation of cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110755318A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419765A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Bletilla striata extract and application thereof in preparation of cosmetics |
| CN111419745A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Roxburgh rose extract and application thereof in preparation of cosmetics |
| CN113679092A (en) * | 2021-09-08 | 2021-11-23 | 湖北中烟工业有限责任公司 | Preparation method of cigarette spice capable of reducing harmful substances in smoke |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697672A (en) * | 2012-06-05 | 2012-10-03 | 东南大学 | Multiple emulsion of arbutin and preparation method thereof |
| CN103040718A (en) * | 2012-12-20 | 2013-04-17 | 广州栋方日化有限公司 | Anti-corrosion composition, preparation method thereof and cosmetic |
| CN103584254A (en) * | 2013-11-19 | 2014-02-19 | 广东嘉豪食品股份有限公司 | Preparation method for aseptic containing compound clove/cinnamon extracts and aseptic application of aseptic in sauce products |
| CN109674702A (en) * | 2019-01-25 | 2019-04-26 | 华东理工大学 | Cloves Compositional type natural antiseptic agent and preparation method and the application in cosmetics |
-
2019
- 2019-10-19 CN CN201910996858.0A patent/CN110755318A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697672A (en) * | 2012-06-05 | 2012-10-03 | 东南大学 | Multiple emulsion of arbutin and preparation method thereof |
| CN103040718A (en) * | 2012-12-20 | 2013-04-17 | 广州栋方日化有限公司 | Anti-corrosion composition, preparation method thereof and cosmetic |
| CN103584254A (en) * | 2013-11-19 | 2014-02-19 | 广东嘉豪食品股份有限公司 | Preparation method for aseptic containing compound clove/cinnamon extracts and aseptic application of aseptic in sauce products |
| CN109674702A (en) * | 2019-01-25 | 2019-04-26 | 华东理工大学 | Cloves Compositional type natural antiseptic agent and preparation method and the application in cosmetics |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419765A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Bletilla striata extract and application thereof in preparation of cosmetics |
| CN111419745A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Roxburgh rose extract and application thereof in preparation of cosmetics |
| CN113679092A (en) * | 2021-09-08 | 2021-11-23 | 湖北中烟工业有限责任公司 | Preparation method of cigarette spice capable of reducing harmful substances in smoke |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110755318A (en) | Application of clove extract in preparation of cosmetics | |
| CN103432047B (en) | Natural preservative composition and application thereof in cosmetics | |
| JP6626902B2 (en) | Antimicrobial herbal composition, method for producing and using the same | |
| CN101453898A (en) | Parthenolide free bioactive ingredients from feverfew (tanacetum parthenium) and processes for their production | |
| CN108294060B (en) | Plant source bacteriostatic agent and preparation method thereof | |
| CN108904376B (en) | Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof | |
| CN105722974A (en) | Method for inducing pluripotent stem cells and pluripotent stem cells prepared by said method | |
| CN111228169A (en) | Magnolia officinalis plant anticorrosion and antibacterial composition and preparation process and application thereof | |
| CN106619380A (en) | Anti-acne essence | |
| CN103913564A (en) | Method for testing bacteriostatic activity of spire wampee extractive | |
| CN109044859B (en) | Oolong acne removing lotion and preparation method thereof | |
| CN105963151A (en) | No-preservative composite used for cosmetics corrosion prevention | |
| CN112516031B (en) | Plant extraction multi-effect composition and preparation method thereof | |
| CN116492385B (en) | Compound essential oil for repairing skin and pharmaceutical composition containing compound essential oil | |
| CN105362140B (en) | A kind of non-cosmetics preservative composition and its application with preservative efficacy | |
| CN104606097B (en) | A kind of composition with potent preservative efficacy and the application in cosmetics | |
| CN113413341B (en) | Plant source compound bacteriostatic agent | |
| CN109674702A (en) | Cloves Compositional type natural antiseptic agent and preparation method and the application in cosmetics | |
| CN107137316B (en) | Dendrobium lip balm and preparation method thereof | |
| CN106983691A (en) | A kind of anti-oxidant pore refining sleep mask of the polyphenol containing lotus and preparation method thereof | |
| CN108635287A (en) | A kind of Dendrobidium huoshanness moisturizing emulsion and preparation method thereof | |
| JP7432218B2 (en) | Uses of primrose extracts | |
| CN104127351B (en) | A kind of cosmetic composition and preparation method thereof | |
| CN103655987A (en) | Special antibacterial agent for raising river crab | |
| KR20130044475A (en) | Anti-microbial effect from boehmeria nivea extract and its applicant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200207 |