CN110742062A - Refreshing type shoe and sock disinfection aerosol and preparation method thereof - Google Patents

Refreshing type shoe and sock disinfection aerosol and preparation method thereof Download PDF

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Publication number
CN110742062A
CN110742062A CN201911129076.3A CN201911129076A CN110742062A CN 110742062 A CN110742062 A CN 110742062A CN 201911129076 A CN201911129076 A CN 201911129076A CN 110742062 A CN110742062 A CN 110742062A
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CN
China
Prior art keywords
aerosol
disinfection
refreshing
propellant
dimethylphenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911129076.3A
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Chinese (zh)
Inventor
王小兵
叶美玲
沈显灿
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ZHEJIANG LUDAO TECHNOLOGY Co Ltd
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ZHEJIANG LUDAO TECHNOLOGY Co Ltd
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Priority to CN201911129076.3A priority Critical patent/CN110742062A/en
Publication of CN110742062A publication Critical patent/CN110742062A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06—Aerosols
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a refreshing type shoe and sock disinfection aerosol and a preparation method thereof, wherein the aerosol comprises the following components in percentage by weight: 25-32% of ethanol, 58-66% of propellant, 4-10% of emulsifier and 0.3-0.6% of p-chloro-m-dimethylphenol. The refreshing shoe and sock disinfection aerosol is obtained by reasonable compatibility of limited components, can realize basic performance, sterilization and disinfection and other functions, is filled by adopting a 360-degree aerosol release technology, is directly sprayed on the surface of an article in an aerosol spray mode, effectively kills bacteria in shoes and socks, forms a protective layer and avoids bacteria generated in other ways, is convenient to operate, uniform in spraying and convenient to carry, and is particularly suitable for sterilization and disinfection of the inner surfaces of the shoes and socks which are in daily contact with feet and the skin surface of a human body, and the uniform comment of patients is obtained.

Description

Refreshing type shoe and sock disinfection aerosol and preparation method thereof
Technical Field
The invention relates to the technical field of daily necessity manufacturing, in particular to a refreshing type shoe and sock disinfection aerosol and a preparation method thereof.
Background
Along with the improvement of the existing living standard, the requirements on sanitation and the like are higher and higher, and shoes are required to be taken out of a plurality of places, so that embarrassment and trouble caused by beriberi (caused by fungi), foot odor and the like are often encountered. However, the drugs for treating beriberi, foot odor and the like in the market at present are all liquid formulations such as emulsion, cream and the like, and when the drugs are used, a patient needs to coat the drugs on feet or in shoes, otherwise the drugs are inconvenient to use, and the places coated with the drugs are sticky, so that the shoes are inconvenient to wear. Therefore, it is important to develop a portable and convenient medicament.
Disclosure of Invention
In view of the above problems in the prior art, the present invention aims to provide a refreshing type footwear disinfection aerosol and a preparation method thereof. Based on the functions of performance, sterilization, disinfection and the like, the unique aerosol packaging technology is adopted, and the produced refreshing shoe and sock disinfection aerosol can effectively eliminate odor and bacteria on the surfaces of shoes and socks, so that the purposes of refreshing, disinfection and cleaning are achieved, and the vacancy in the market is filled.
The refreshing type shoe and sock disinfection aerosol is characterized by comprising the following components in percentage by weight: 25-32% of ethanol, 58-66% of propellant, 4-10% of emulsifier and 0.3-0.6% of p-chloro-m-dimethylphenol.
The refreshing type shoe and sock disinfection aerosol is characterized by comprising the following components in percentage by weight: 28-32% of ethanol, 60-66% of propellant, 5-8% of emulsifier and 0.4-0.6% of p-chloro-m-dimethylphenol.
The refreshing type footwear disinfection aerosol is characterized in that the propellant is carbon dioxide.
The refreshing type footwear disinfection aerosol is characterized in that the emulsifier is PPG-12-butanol polyether-16.
The refreshing type shoe and sock disinfection aerosol is characterized by comprising the following components in percentage by weight: 30% of ethanol, 63.5% of carbon dioxide, 166% of PPG-12-butanol polyether and 0.5% of p-chloro-m-dimethylphenol.
The preparation method of the refreshing type shoe and sock disinfection aerosol is characterized by comprising the following steps:
1) mixing ethanol, an emulsifier and p-chloro-m-dimethylphenol in turn according to a feeding ratio, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and filling propellant simultaneously to ensure that the material body and the propellant are mixed uniformly in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
By adopting the technology, the aerosol prepared by the invention has the following beneficial effects:
1) the refreshing type shoe and sock disinfection aerosol is obtained by reasonable compatibility of limited components, can have basic performance, sterilization and disinfection functions and the like, is filled by adopting a 360-degree aerosol release technology, is directly sprayed on the surface of an article in an aerosol spray mode, effectively kills bacteria in shoes and socks, forms a protective layer and avoids bacteria generated in other ways, is convenient to operate and carry, is uniform in spraying, and is particularly suitable for sterilization and disinfection of the inner surfaces of the shoes and socks which are in contact with feet and the skin surface of a human body, and the consistent comment of a patient is obtained;
2) the invention adopts the parachlorometaxylenol as a disinfection component, improves the disinfection and deodorization effects, adopts PPG-12-butanol polyether-16 as emulsifying Liu to enable all raw materials to be ready to be dissolved together, adopts ethanol as a solvent, can volatilize quickly after being sprayed, improves the comfort of a user, adopts carbon dioxide as a propellant, improves the aerosol effect, is nonflammable, cannot break an ozone layer, and has the characteristics of safety and environmental protection;
3) the preparation method of the aerosol is simple, is suitable for large-scale production, and is favorable for industrial popularization.
Detailed Description
The invention is further described with reference to the following examples, but the scope of the invention is not limited thereto:
example 1 a refreshing type footwear disinfection aerosol, which is prepared by the following preparation method according to the weight percentage of the components:
1) mixing 30% of ethanol, 30% of PPG-12-butanol polyether-166% and 0.5% of p-chloro-m-dimethylphenol in sequence, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and simultaneously filling 63.5% of carbon dioxide to ensure that the material body and the propellant are uniformly mixed in the aerosol tank body in a static state;
3) after filling, leak detection is carried out on the aerosol tank body, air is dried, plastic parts are assembled, and packaging is completed to obtain the refreshing shoe and sock disinfection aerosol.
Example 2 a refreshing type footwear disinfection aerosol, which is prepared by the following preparation method according to the weight percentage of the components:
1) mixing 25% of ethanol, 25% of PPG-12-butanol polyether-1610% and 0.4% of p-chloro-m-dimethylphenol in sequence, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and simultaneously filling 64.6% of carbon dioxide to ensure that the material body and the propellant are uniformly mixed in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
Example 3 a refreshing type footwear disinfection aerosol, which is prepared by the following preparation method according to the weight percentage of the components:
1) sequentially mixing and uniformly stirring 32% of ethanol, 164% of PPG-12-butanol polyether and 0.6% of p-chloro-m-dimethylphenol to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and simultaneously filling 63.4% of carbon dioxide to ensure that the material body and the propellant are uniformly mixed in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
Example 4 a refreshing type footwear disinfection aerosol, which is prepared by the following preparation method according to the weight percentage of the components:
1) mixing 31.5% of ethanol, 10-1610% of PPG-butanol polyether and 0.5% of p-chloro-m-dimethylphenol in sequence, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and simultaneously filling 58% of carbon dioxide to ensure that the material body and the propellant are uniformly mixed in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
Example 5 a refreshing type footwear disinfection aerosol, which is prepared by the following preparation method according to the weight percentage of the components:
1) sequentially mixing 28% of ethanol, 168% of PPG-12-butanol polyether and 0.3% of p-chloro-m-dimethylphenol, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and simultaneously filling 63.7% of carbon dioxide to ensure that the material body and the propellant are uniformly mixed in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
The product refreshing type footwear disinfection aerosol obtained in the embodiments 1-5 of the invention has smooth spraying and uniform fog particles; the internal pressure is 0.5-1.0MPa, and the ejection rate is more than or equal to 98 percent; the pH value is 6.0-8.0; the killing log values of the antibacterial agent for escherichia coli and staphylococcus aureus are all more than or equal to 5.0, and the killing log values of the antibacterial agent for candida albicans are all more than or equal to 4.0.
The product of the invention is used for 100 beriberi patients, and tests show that the product obtained by each embodiment of the invention can realize the purpose of the invention, effectively solve the problems of beriberi, foot odor and the like which need to be solved, and after 2-4 weeks of use, the symptoms can be completely eliminated, and the beriberi and the foot odor cannot relapse after 4-8 weeks.
The above general description of the invention and the description of the specific embodiments thereof referred to in this application should not be construed as limiting the technical solutions of the invention. Those skilled in the art can add, reduce or combine the technical features disclosed in the general description and/or the embodiments to form other technical solutions within the protection scope of the present application without departing from the present disclosure.

Claims (6)

1. The refreshing type shoe and sock disinfection aerosol is characterized by comprising the following components in percentage by weight: 25-32% of ethanol, 58-66% of propellant, 4-10% of emulsifier and 0.3-0.6% of p-chloro-m-dimethylphenol.
2. The aerosol disinfectant for refreshing footwear according to claim 1, comprising the following components by weight percent: 28-32% of ethanol, 60-66% of propellant, 5-8% of emulsifier and 0.4-0.6% of p-chloro-m-dimethylphenol.
3. The aerosol refreshing footwear disinfection according to claim 1 or 2, wherein the propellant is carbon dioxide.
4. The aerosol for disinfecting footwear with refreshing feeling according to claim 1 or 2, wherein the emulsifier is PPG-12-Butanethol-16.
5. The aerosol disinfectant for refreshing footwear according to claim 1, comprising the following components by weight percent: 30% of ethanol, 63.5% of carbon dioxide, 166% of PPG-12-butanol polyether and 0.5% of p-chloro-m-dimethylphenol.
6. A method for preparing a refreshing type sterilizing aerosol for footwear according to claim 1 or 2, comprising the steps of:
1) mixing ethanol, an emulsifier and p-chloro-m-dimethylphenol in turn according to a feeding ratio, and uniformly stirring to obtain a material body for later use;
2) filling the material body obtained in the step 1) into an aerosol tank body, assembling an aerosol valve for sealing, and filling propellant simultaneously to ensure that the material body and the propellant are mixed uniformly in the aerosol tank body in a static state;
3) after filling, the aerosol tank body is subjected to leak detection, air is dried, plastic parts are assembled, and packaging is completed.
CN201911129076.3A 2019-11-18 2019-11-18 Refreshing type shoe and sock disinfection aerosol and preparation method thereof Pending CN110742062A (en)

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Application Number Priority Date Filing Date Title
CN201911129076.3A CN110742062A (en) 2019-11-18 2019-11-18 Refreshing type shoe and sock disinfection aerosol and preparation method thereof

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Application Number Priority Date Filing Date Title
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1247762A (en) * 1998-09-17 2000-03-22 大连铖烨日用化工厂 Footwear cleaning and aromatizing agent and its preparation
JP2004107667A (en) * 2002-09-18 2004-04-08 Vinod K Narula Sterilization detergent for hand
CN104740666A (en) * 2013-12-25 2015-07-01 程忠于 Footgear rapid sterilization deodorant
CN106172515A (en) * 2016-06-28 2016-12-07 郑州雷曼药业有限公司 A kind of disinfectant solution and preparation method thereof
CN106359468A (en) * 2015-07-22 2017-02-01 徐伟 Shoe-foot deodorizing cleaning aerosol
CN106719771A (en) * 2016-12-28 2017-05-31 于文 Footgear antibacterial deodorizing agent and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1247762A (en) * 1998-09-17 2000-03-22 大连铖烨日用化工厂 Footwear cleaning and aromatizing agent and its preparation
JP2004107667A (en) * 2002-09-18 2004-04-08 Vinod K Narula Sterilization detergent for hand
CN104740666A (en) * 2013-12-25 2015-07-01 程忠于 Footgear rapid sterilization deodorant
CN106359468A (en) * 2015-07-22 2017-02-01 徐伟 Shoe-foot deodorizing cleaning aerosol
CN106172515A (en) * 2016-06-28 2016-12-07 郑州雷曼药业有限公司 A kind of disinfectant solution and preparation method thereof
CN106719771A (en) * 2016-12-28 2017-05-31 于文 Footgear antibacterial deodorizing agent and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张磊等: "复合对氯间二甲苯酚消毒剂消毒效果研究", 《预防医学情报杂志》 *
潘华伟: "气相色谱法测定消毒气雾剂中对氯间二甲苯酚含量", 《气雾剂通讯》 *

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