CN110721266A - Medicine for coronary heart disease, preparation method and application thereof - Google Patents

Medicine for coronary heart disease, preparation method and application thereof Download PDF

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CN110721266A
CN110721266A CN201911224821.2A CN201911224821A CN110721266A CN 110721266 A CN110721266 A CN 110721266A CN 201911224821 A CN201911224821 A CN 201911224821A CN 110721266 A CN110721266 A CN 110721266A
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heart disease
coronary heart
medicine
radix
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何正禄
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何正禄
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/884Alismataceae (Water-plantain family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention provides a medicine for coronary heart disease, a preparation method and application thereof, and relates to the technical field of Chinese herbal medicines. The medicine for treating coronary heart disease comprises the following raw materials in parts by mass: 10-25 parts of radix ophiopogonis, 15-35 parts of prepared rehmannia root, 15-35 parts of radix rehmanniae, 20-35 parts of poria with hostwood, 15-25 parts of rhizoma alismatis, 15-30 parts of glossy privet fruit, 25-35 parts of salvia miltiorrhiza, 15-25 parts of jujube kernel, 20-30 parts of eclipta alba, 15-25 parts of angelica sinensis, 25-50 parts of keel, 15-25 parts of platycladi seed, 25-50 parts of oyster, 45-55 parts of astragalus membranaceus, 45-55 parts of deerhorn glue and 45-55 parts of red ginseng. The medicine for coronary heart disease solves the technical problems that the traditional medicine has slow effect, is easy to relapse and is difficult to simultaneously relieve various symptoms caused by coronary heart disease. The preparation method of the medicine for coronary heart disease can effectively release the cell contents of each component of the raw materials and better maintain the activity of the medicine components.

Description

Medicine for coronary heart disease, preparation method and application thereof
Technical Field
The invention relates to the technical field of Chinese herbal medicines, in particular to a medicine for treating coronary heart disease, a preparation method and application thereof.
Background
Coronary heart disease belongs to cardiovascular system diseases, and the variety, cause and clinical manifestations of coronary heart disease are various, and the clinical manifestations of coronary heart disease are various due to different causes and individual differences, for example: myocardial ischemia, night sweat, asthma, vascular occlusion obstruction, heart qi deficiency, cold limbs, short breath, asthma and lying down, limb edema, chest distress, angina, palpitation, arrhythmia and the like, and other diseases of the patients with red tongue, throat dryness, vexation, insomnia, constipation, hot chest, dysphoria, palpitation, asthma, insomnia, dreaminess, dry mouth, night sweat, myasthenia of limbs and the like are difficult to relieve.
The treatment method and the medicines for the coronary heart disease are more, wherein western medicines have the phenomenon of non-lasting effect in treatment, and for some severe coronary heart diseases, a stent or a cardiac pacemaker is usually required to be placed in the treatment, so that the operation treatment cost is higher, and adverse effects are brought to the body; wherein, the traditional Chinese medicine treatment usually takes effect slowly, and common symptoms of coronary heart disease are as follows: the symptoms of myocardial ischemia, night sweat, asthma syndrome, cold limbs, edema of four limbs, chest distress, angina, palpitation, arrhythmia, red tongue, dry throat, vexation, insomnia, constipation, fever in chest, dysphoria, palpitation, asthma, insomnia, dreaminess, dry mouth, night sweat, myasthenia of limbs and the like are difficult to relieve comprehensively, only part of symptoms can be relieved, and the curative effect is not lasting and easy to relapse. Therefore, the development of a medicament which can relieve various symptoms caused by the coronary heart disease, has quick response and lasting effect and is not easy to relapse after treatment has important application value.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
One of the purposes of the invention is to provide a medicine for coronary heart disease, which comprises the following raw materials in parts by mass: 10-25 parts of radix ophiopogonis, 15-35 parts of prepared rehmannia root, 15-35 parts of radix rehmanniae, 20-35 parts of poria with hostwood, 15-25 parts of rhizoma alismatis, 15-30 parts of glossy privet fruit, 25-35 parts of salvia miltiorrhiza, 15-25 parts of jujube kernel, 20-30 parts of eclipta alba, 15-25 parts of angelica sinensis, 25-50 parts of keel, 15-25 parts of platycladi seed, 25-50 parts of oyster, 45-55 parts of astragalus membranaceus, 45-55 parts of deerhorn glue and 45-55 parts of red ginseng. The medicine for treating coronary heart disease relieves the technical problems that the traditional Chinese medicine has slow effect on treating coronary heart disease, is difficult to widely adapt to various symptoms generated by coronary heart disease, has non-lasting treatment effect and is easy to relapse.
The second purpose of the invention is to provide the preparation method of the medicine for coronary heart disease, which can effectively release the cell contents of the components of the raw materials and effectively maintain the activity of the Chinese herbal medicine extract.
The invention also aims to provide the application of the medicine for coronary heart disease or the medicine for coronary heart disease prepared by the preparation method in preparing the medicine for coronary heart disease.
In order to achieve the above purpose, the invention adopts the following technical scheme, a medicine for coronary heart disease comprises the following raw materials in parts by mass: 10-25 parts of radix ophiopogonis, 15-35 parts of prepared rehmannia root, 15-35 parts of radix rehmanniae, 20-35 parts of poria with hostwood, 15-25 parts of rhizoma alismatis, 15-30 parts of glossy privet fruit, 25-35 parts of salvia miltiorrhiza, 15-25 parts of jujube kernel, 20-30 parts of eclipta alba, 15-25 parts of angelica sinensis, 25-50 parts of keel, 15-25 parts of platycladi seed, 25-50 parts of oyster, 45-55 parts of astragalus membranaceus, 45-55 parts of deerhorn glue and 45-55 parts of red ginseng.
Preferably, on the basis of the scheme of the invention, the medicine for coronary heart disease comprises the following raw materials in parts by mass: 10-20 parts of radix ophiopogonis, 15-30 parts of prepared rhizome of rehmannia, 18-35 parts of radix rehmanniae, 25-32 parts of poria with hostwood, 15-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 28-32 parts of salvia miltiorrhiza, 18-22 parts of jujube kernel, 20-30 parts of eclipta alba, 18-22 parts of angelica, 28-50 parts of keel, 15-22 parts of platycladi seed, 28-50 parts of oyster, 48-55 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng.
Preferably, on the basis of the scheme of the invention, the raw materials comprise the following components in parts by mass: 15-20 parts of radix ophiopogonis, 20-30 parts of prepared rehmannia root, 20-35 parts of radix rehmanniae, 20-32 parts of poria with hostwood, 18-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 29-31 parts of salvia miltiorrhiza, 18-21 parts of jujube kernel, 20-22 parts of eclipta alba, 18-20 parts of angelica, 28-50 parts of keel, 18-22 parts of platycladi seed, 28-50 parts of oyster, 48-52 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng.
Preferably, on the basis of the scheme of the invention, the raw materials comprise the following components in parts by mass: 20 parts of dwarf lilyturf tuber, 30 parts of prepared rehmannia root, 30 parts of poria with hostwood, 20 parts of oriental waterplantain rhizome, 20 parts of glossy privet fruit, 30 parts of red-rooted salvia root, 20 parts of jujube kernel, 20 parts of eclipta alba, 20 parts of Chinese angelica, 50 parts of dragon bone, 20 parts of platycladi seed, 50 parts of oyster shell, 50 parts of astragalus root, 50 parts of deerhorn gelatin and 50 parts of red ginseng.
Preferably, on the basis of the scheme of the invention, the raw materials further comprise, in parts by mass: 20-40 parts of pseudo-ginseng;
preferably, the raw materials further comprise, in parts by mass: 25-35 parts of pseudo-ginseng;
preferably, on the basis of the scheme of the invention, the raw materials further comprise, in parts by mass: 30 parts of pseudo-ginseng.
In a second aspect, a preparation method of the above medicine for coronary heart disease is provided, which comprises the following steps:
respectively refining radix Ophiopogonis, radix rehmanniae Preparata, radix rehmanniae, Poria, Alismatis rhizoma, fructus Ligustri Lucidi, Saviae Miltiorrhizae radix, semen Ziziphi Spinosae, Ecliptae herba, radix Angelicae sinensis, Os Draconis, semen Platycladi, Concha Ostreae, radix astragali, colla Cornus Cervi and Ginseng radix Rubri and optional Notoginseng radix, mixing, soaking in water, and boiling to obtain the medicine for treating coronary heart disease.
Preferably, on the basis of the scheme of the invention, the method comprises the following steps: after boiling, cooling at room temperature to obtain the medicine for treating coronary heart disease;
preferably, the number of boiling times is 1-5, preferably 3.
Preferably, on the basis of the scheme of the invention, the method comprises the following steps:
respectively refining the dwarf lilyturf tuber, the prepared rehmannia root, the poria with hostwood, the oriental waterplantain rhizome, the glossy privet fruit, the red sage root, the jujube kernel, the eclipta alba, the Chinese angelica, the dragon bone, the platycladi seed, the oyster shell, the astragalus root, the deerhorn glue and the red ginseng and optional pseudo-ginseng according to the formula ratio, mixing, adding water with the mass being 5-10 times of the total mass of the mixture for soaking, boiling, cooling at room temperature, and repeatedly boiling for 2-3 times to obtain the medicine for treating the coronary heart disease.
In a third aspect, the use of the above mentioned medicament for coronary heart disease or the medicament for coronary heart disease prepared by the above mentioned method for preparation of a medicament for treating coronary heart disease is provided.
Compared with the prior art, the invention has the following beneficial effects:
(1) the invention provides a medicine for coronary heart disease, which comprises radix ophiopogonis, prepared rhizome of rehmannia, dried rehmannia root, poria with hostwood, rhizoma alismatis, glossy privet fruit, salvia miltiorrhiza, jujube kernel, eclipta alba, angelica, dragon bone, platycladi seed, oyster shell, astragalus, deerhorn glue and red ginseng. The components are reasonably combined according to the formula amount, comprehensively condition and nourish heart, liver, spleen, lung and kidney, can comprehensively condition viscera operation, dredge blood vessels, fundamentally improve and improve the physiological function of the body, quickly relieve symptoms, have lasting effect and low recurrence rate, are all from natural animals and plants, and have low toxic and side effects.
(2) The invention provides a preparation method of a medicine for coronary heart disease, which respectively refines raw materials according to a proportion, then mixes and boils the raw materials, can fully extract the content in the raw materials, and has simple process and short time. In addition, the medicine for coronary heart disease or the medicine for coronary heart disease prepared by the preparation method can be applied to the preparation of medicines for treating coronary heart disease.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer.
According to the first aspect of the invention, the medicine for treating coronary heart disease comprises the following raw materials in parts by mass: 10-25 parts of radix ophiopogonis, 15-35 parts of prepared rehmannia root, 15-35 parts of radix rehmanniae, 20-35 parts of poria with hostwood, 15-25 parts of rhizoma alismatis, 15-30 parts of glossy privet fruit, 25-35 parts of salvia miltiorrhiza, 15-25 parts of jujube kernel, 20-30 parts of eclipta alba, 15-25 parts of angelica sinensis, 25-50 parts of keel, 15-25 parts of platycladi seed, 25-50 parts of oyster, 45-55 parts of astragalus membranaceus, 45-55 parts of deerhorn glue and 45-55 parts of red ginseng.
Coronary heart disease is a disease of the circulatory system, which is composed of the heart, blood vessels, and neurohumoral tissues that regulate blood circulation, also known as cardiovascular disease, including diseases of all the above tissues and organs. Therefore, in the treatment of coronary heart disease, it is necessary to comprehensively regulate the various factors of body channels and collaterals, nutrition, nerve and body fluid regulation, etc., and comprehensively regulate the body functions, so as to better alleviate the symptoms of coronary heart disease.
Radix Ophiopogonis is a herbal plant of Liliaceae, and has effects of promoting fluid production, quenching thirst, moistening lung, and relieving cough. Sweet, slightly bitter and slightly cold. The ophiopogon root contains a large amount of saponin, steroid saponin, alkaloid, sitosterol, glucose, amino acid, vitamin and the like, and is used as a medicine for resisting myocardial ischemia and arrhythmia, has the effects of moistening lung and clearing heart fire, purging heat and promoting fluid production, reducing phlegm and preventing vomiting, treating cough and promoting urination, and also has the effects of resisting fatigue, eliminating free radicals and improving cellular immunity. Typical but non-limiting parts of ophiopogon root are, for example: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts or 25 parts and the like.
The prepared rehmannia root is root tuber of rehmannia root of Scrophulariaceae, is sweet in nature and slightly warm, has the effects of enriching blood and nourishing yin, promoting the production of body fluid to quench thirst, has good relieving effect on palpitation, has the effect of inhibiting thrombosis, has the effects of promoting blood circulation and lowering blood pressure, has the antioxidant effect, effectively relieves the decline of the functions of body cells and improves the physiological function. Typical but non-limiting parts of prepared rehmannia glutinosa by weight are as follows: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, or the like.
The rehmannia root is also called radix rehmanniae, and the main chemical components of the rehmannia root are iridoid and glycosides thereof, organic acids, amino acids, phenols, saccharides and the like, wherein the iridoid glycosides can regulate endocrine and improve the immune function of the organism and also have the function of reducing blood sugar. Sweet, bitter and cold in nature. It has the functions of clearing away heat, cooling blood, nourishing Yin and promoting the production of body fluid. Typical but non-limiting parts of rehmannia glutinosa are, by mass: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, or the like.
The Poria is part of sclerotium of Poria cocos (Schw.) wolf of Polyporaceae with pine root sandwiched therein, and the medicinal part is white part of dry sclerotium with pine root sandwiched therebetween. Sweet in nature and taste, bland and mild. Has effects in eliminating dampness, invigorating spleen, calming heart, and relieving edema, palpitation, and vertigo. Typical but non-limiting parts of poria with hostwood, by mass, are for example: 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts or 35 parts and the like.
Rhizoma alismatis is a herb which can generate aquatic water or marsh gas for many years, and can regulate the kidney function and well relieve edema by using rhizoma alismatis as a medicine. Typical but non-limiting parts of alisma orientale are, for example, in parts by mass: 20 parts, 21 parts, 22 parts, 23 parts, 24 parts or 25 parts and the like.
The glossy privet fruit is a plant glossy privet fruit of the Oleaceae, has mild fruit nature, sweet and bitter taste, and enters liver and kidney meridians, and the records of Shen nong Ben Cao Jing record that the glossy privet fruit mainly tonifies the middle energizer, calms the five internal organs, nourishes the spirit and eliminates various diseases. The glossy privet fruit is used as a medicine and has the effects of tonifying liver and kidney, clearing heat and improving eyesight, and simultaneously relieving symptoms such as dizziness, tinnitus, dim eyesight, soreness and pain of waist and knees, internal heat and the like. Typical but non-limiting parts of fructus ligustri lucidi are, for example: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts and the like.
The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae, and has bitter taste and slight cold property, and can enter heart and liver channels. The salvia miltiorrhiza is used as a prescription, and has the effects of activating blood and dissolving stasis, stimulating the menstrual flow and relieving pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Typical but non-limiting parts of salvia miltiorrhiza, by weight, are for example: 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, or the like.
The jujube kernel is also called wild jujube stone, and has sour, sweet and mild taste. It is recorded in Shen nong Ben Cao Jing that it has the actions of tonifying middle-jiao and liver, strengthening tendons and bones, and tonifying yin qi, all of which are the actions of Zizyphi Spinosae semen. The jujube kernel is used as the prescription, and has the effects of nourishing the liver, calming the heart, soothing the nerves and arresting sweating. Typical but non-limiting parts by weight of the jujube kernel are as follows: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts or 25 parts and the like.
The eclipta alba is the whole plant of eclipta prostrata of Compositae, is sweet and cool. Enter liver and kidney meridians. The eclipta alba is used as a medicine, can obviously enhance the immune function of the organism, has the effects of nourishing the liver and tonifying the kidney, and cooling blood and stopping bleeding, and has the effect of relieving symptoms such as heartache, angina pectoris and the like. Typical but non-limiting parts of eclipta alba are, by mass: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts and the like.
The root of Chinese angelica can be used as a medicine, is sweet, pungent and warm, and enters liver, heart and spleen channels, and the Chinese angelica is used as a formula, and has the effects of tonifying qi and blood, relieving pain, moistening dryness, lubricating intestines, resisting aging, preventing aging and improving the immunity of the organism. Typical but non-limiting parts of eclipta alba are, by mass: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts and the like.
Keel is a mineral, and contains calcium carbonate, calcium phosphate, and small amount of iron, magnesium, aluminum, potassium, sodium, chloride, sulfate radical, etc. Astringent and sweet taste, mild in nature. It enters heart, liver, kidney and large intestine meridians. Long Gu is used to treat mental stress, pacify liver and subdue yang, induce astringency and astringe. Has obvious relieving effect on symptoms such as palpitation and insomnia, convulsive epilepsy, mania, dizziness, spontaneous perspiration, night sweat, spermatorrhea, enuresis, yin deficiency and yang hyperactivity. Typical but non-limiting parts of keel are, for example: 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, or the like.
Semen Platycladi is dry mature kernel of Platycladus orientalis of Cupressaceae, and has sweet taste and mild property. It enters heart, kidney and large intestine meridians. Has the effects of nourishing heart, tranquilizing mind, loosening bowel to relieve constipation, and arresting sweating. Can be used for treating yin and blood deficiency, vexation, insomnia, palpitation, constipation due to intestinal dryness, and night sweat due to yin deficiency. Typical but non-limiting parts of cedar seed, in parts by weight, are for example: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts or 25 parts and the like.
Oyster, commonly known as oyster seed, is first recorded in Shen nong Ben Cao Jing (Shen nong's herbal Jing) to record that oyster is salty and flat in taste, mainly causes typhoid fever, chills and fever, warms malaria and sprinkles, fright anger anger, removes spasm and slow rat fistula, leukorrhagia and white, is taken for a long time, strengthens bone joints, kills pathogenic qi and prolongs the life. Oyster is used as a prescription to play roles in protecting liver, enhancing immunity, reducing blood sugar, resisting body oxidative damage and preventing various cardiovascular diseases such as hypertension, arteriosclerosis, cerebral apoplexy and the like. The oyster contains a large amount of trace elements such as calcium, phosphorus, zinc, iron and the like, contains various vitamins and mineral elements, has higher contents of aminic acid, nicotinic acid and riboflavin, supplements the nutrition of the organism, and comprehensively improves the physiological function of the organism. Typical but non-limiting parts of oysters, by weight, are for example: 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, or the like.
Radix astragali is root of Astragalus membranaceus bge of Leguminosae, and has sweet taste and mild nature; it enters spleen and lung meridians. Astragalus root is used as the prescription to tonify qi, strengthen exterior, expel toxin, expel pus, promote urination and promote tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound. Typical but non-limiting parts of astragalus membranaceus are, for example: 45 parts, 46 parts, 47 parts, 48 parts, 49 parts or 50 parts and the like.
Antler glue, light smell, slightly sweet taste. To warm and nourish liver and kidney, replenish vital essence and nourish blood. Can be used for treating blood deficiency, dizziness, soreness of waist and knees, asthenia, and marasmus. Typical but non-limiting parts of antler glue, by weight, are for example: 45 parts, 46 parts, 47 parts, 48 parts, 49 parts or 50 parts and the like.
Ginseng radix Rubri belongs to Araliaceae and Umbelliferae, and is prepared by soaking Ginseng radix, cleaning, sorting, steaming, air drying, oven drying, etc. The red ginseng is used as a prescription to greatly tonify primordial qi, recover pulse and relieve depletion, benefit qi and control blood. Heart qi and blood deficiency may lead to heart function decline, manifested as slow and weak pulse, blood circulation due to qi circulation, blood blockage due to qi deficiency, arrhythmia, heart qi and blood deficiency, and severe deficiency, and the lack of the pulse channel may lead to atrial fibrillation or ventricular fibrillation. Meanwhile, the red ginseng has the efficacies of tonifying qi, controlling blood and tonifying yang. The red ginseng is used as a medicine, so that the symptoms of weakness, collapse, slight cold limbs and pulse, qi failing to control blood, metrorrhagia and metrostaxis caused by coronary heart disease can be relieved; heart failure, cardiogenic shock. Red ginseng is a good tonic product for people with deficiency of qi and blood and yang deficiency, and has remarkable curative effects on symptoms such as intolerance of cold, warmness of hands and feet, dizziness, lassitude, limb weakness, easy fatigue, shortness of breath, dyspnea and tachypnea, chronic cold in stomach, long-term diarrhea, insomnia, dreaminess, impotence, frequent micturition and the like. Typical but non-limiting parts of red ginseng, by mass, are for example: 45 parts, 46 parts, 47 parts, 48 parts, 49 parts or 50 parts and the like.
In conclusion, the components in the formula have the tonifying effect on the body, and the mutual compatibility can comprehensively condition the functions of the liver, the kidney, the lung, the spleen and the heart, fundamentally improve the physiological function, adjust the operation of the viscera, wherein, the dwarf lilyturf tuber, the prepared rhizome of rehmannia, the red sage root, the angelica, the platycladi seed, the deer-horn glue and the red ginseng all have better effect of improving the heart function, can quickly develop the heart function by mutual compatibility, the traditional Chinese medicine composition has good relieving and treating effects on myocardial ischemia, vascular occlusion obstruction, heart qi deficiency, cardiodynia, angina, palpitation, arrhythmia and the like, and the mutual compatibility of the rehmannia root, the poria with hostwood, the rhizoma alismatis, the glossy privet fruit, the oyster and the astragalus root can improve the immunity of organisms, nourish viscera and comprehensively improve the physiological function of bodies, and can effectively relieve night sweat, vascular occlusion obstruction, cold limbs, asthma, limb edema and chest distress. The Chinese medicine diagnosis is characterized by studying, smelling, inquiring and cutting, the running conditions of the heart, liver, kidney and lung channels of a patient are known through pulse taking, the physical condition of the patient is known, reasonable Chinese medicinal components are used for compatibility, the medicine for coronary heart disease is obtained, and the medicine is named as 'coronary heart disease pill'.
In a preferred embodiment, the medicament for treating coronary heart disease comprises the following raw materials in parts by mass: 10-20 parts of radix ophiopogonis, 15-30 parts of prepared rhizome of rehmannia, 18-35 parts of radix rehmanniae, 25-32 parts of poria with hostwood, 15-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 28-32 parts of salvia miltiorrhiza, 18-22 parts of jujube kernel, 20-30 parts of eclipta alba, 18-22 parts of angelica, 28-50 parts of keel, 15-22 parts of platycladi seed, 28-50 parts of oyster, 48-55 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng. Through actual experience and treatment effect, the proportion of each component in the formula is optimized, and the measurement is adjusted, so that the speed of relieving symptoms can be further improved.
In a preferred embodiment, the raw materials comprise, in parts by mass: 15-20 parts of radix ophiopogonis, 20-30 parts of prepared rehmannia root, 20-35 parts of radix rehmanniae, 20-32 parts of poria with hostwood, 18-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 29-31 parts of salvia miltiorrhiza, 18-21 parts of jujube kernel, 20-22 parts of eclipta alba, 18-20 parts of angelica, 28-50 parts of keel, 18-22 parts of platycladi seed, 28-50 parts of oyster, 48-52 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng. On the basis of relieving and treating various different symptoms, the prescription is further optimized, the measurement of each component is adjusted, the symptom relieving speed can be further improved, the recurrence rate is reduced, and the durability of the treatment effect is ensured.
In a preferred embodiment, the raw materials comprise, in parts by mass: 20 parts of dwarf lilyturf tuber, 30 parts of prepared rehmannia root, 30 parts of poria with hostwood, 20 parts of oriental waterplantain rhizome, 20 parts of glossy privet fruit, 30 parts of red-rooted salvia root, 20 parts of jujube kernel, 20 parts of eclipta alba, 20 parts of Chinese angelica, 50 parts of dragon bone, 20 parts of platycladi seed, 50 parts of oyster shell, 50 parts of astragalus root, 50 parts of deerhorn gelatin and 50 parts of red ginseng. The formula with the proportion can quickly relieve symptoms of myocardial ischemia, night sweat, asthma, vascular occlusion obstruction, heart-qi deficiency, cold limbs, short breath, asthma and incapability of lying on the back, limb edema, chest distress, angina, palpitation or arrhythmia and the like caused by coronary heart disease, and the symptoms are quickly relieved and are not easy to relapse.
In a preferred embodiment, the raw materials further comprise, in parts by mass: 20-40 parts of pseudo-ginseng;
notoginseng, radix is sweet, slightly bitter and warm. Enters liver and stomach meridians, has the effect of relieving pain, and further strengthens the relief of symptoms such as heartache, angina and the like caused by some severe coronary heart diseases. Typical but non-limiting mass parts of pseudo-ginseng are, for example: 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts and the like.
Preferably, the raw materials further comprise, in parts by mass: 25-35 parts of pseudo-ginseng; the part of pseudo-ginseng is further optimized, the pseudo-ginseng can be more reasonably compatible with other components in the formula, the treatment effect is not enhanced by too much dosage, and the better pain relieving effect cannot be achieved by too little dosage and insufficient dosage.
In a preferred embodiment, the raw materials further comprise, in parts by mass: 30 parts of pseudo-ginseng. The added pseudo-ginseng is further determined in parts, so that the pseudo-ginseng can be better compatible with other components in the formula, and the pseudo-ginseng is mild and conditioned, and a better pain relieving effect is achieved.
In a second aspect, a preparation method of the above medicine for coronary heart disease is provided, which comprises the following steps:
respectively refining radix Ophiopogonis, radix rehmanniae Preparata, radix rehmanniae, Poria, Alismatis rhizoma, fructus Ligustri Lucidi, Saviae Miltiorrhizae radix, semen Ziziphi Spinosae, Ecliptae herba, radix Angelicae sinensis, Os Draconis, semen Platycladi, Concha Ostreae, radix astragali, colla Cornus Cervi and Ginseng radix Rubri and optional Notoginseng radix, mixing, soaking in water, and boiling to obtain the medicine for treating coronary heart disease.
The thinning can increase the specific surface area of the medicine and the contact area of the medicine and the water, so that the cell content is easier to dissolve out, and the active ingredients can enter the water more fully under the boiling action.
In a preferred embodiment, the method comprises the following steps: after boiling, cooling at room temperature to obtain the medicine for treating coronary heart disease;
preferably, the number of boiling times is 1-5, preferably 3.
Boiling for 3 times can fully dissolve out active ingredients in the medicine, further increase the content of effective ingredients in the solution, and enhance the therapeutic effect obtained in application.
In a preferred embodiment, the method comprises the following steps:
respectively refining the dwarf lilyturf tuber, the prepared rehmannia root, the poria with hostwood, the oriental waterplantain rhizome, the glossy privet fruit, the red sage root, the jujube kernel, the eclipta alba, the Chinese angelica, the dragon bone, the platycladi seed, the oyster shell, the astragalus root, the deerhorn glue and the red ginseng and optional pseudo-ginseng according to the formula ratio, mixing, adding water with the mass being 5-10 times of the total mass of the mixture for soaking, boiling, cooling at room temperature, and repeatedly boiling for 2-3 times to obtain the medicine for treating the coronary heart disease.
After soaking, the dried cells absorb water to swell, and then are boiled, which is beneficial to quickly dissolving out the content in the raw material cells and improving the content of the active ingredients in the medicine.
In a third aspect, the use of the above mentioned medicament for coronary heart disease or the medicament for coronary heart disease prepared by the above mentioned method for preparation of a medicament for treating coronary heart disease is provided.
The medicine for coronary heart disease and the medicine for coronary heart disease prepared by the preparation method can be used as raw materials for preparing other medicines for treating coronary heart disease, have the same advantages as the Chinese herbal medicines, are widely suitable for various symptoms caused by coronary heart disease, and have the advantages of quick response, lasting treatment effect and difficult recurrence.
The invention is further illustrated by the following specific examples and comparative examples, but it should be understood that these examples are for purposes of illustration only and are not to be construed as limiting the invention in any way.
Example 1
Weighing: 20g of radix ophiopogonis, 30g of prepared rhizome of rehmannia, 30g of dried rehmannia root, 30g of poria with hostwood, 20g of rhizoma alismatis, 20g of glossy privet fruit, 30g of salvia miltiorrhiza, 20g of jujube kernel, 20g of eclipta alba, 20g of angelica, 50g of dragon bone, 20g of platycladi seed, 50g of oyster, 50g of astragalus membranaceus, 50g of deerhorn gelatin, 50g of red ginseng and 30g of pseudo-ginseng.
Grinding the mixture into powder by using a grinder respectively, and then mixing the powder of each component.
Adding water with the mass 10 times of the total mass of the raw materials into the mixture, soaking for 30min, boiling, and decocting to obtain the medicine for treating coronary heart disease, wherein the final volume is about 300 ml.
Example 2
15g of dwarf lilyturf tuber, 20g of prepared rehmannia root, 20g of rehmannia root, 30g of poria with hostwood, 20g of oriental waterplantain rhizome, 20g of glossy privet fruit, 30g of red-rooted salvia root, 20g of jujube kernel, 20g of eclipta alba, 20g of Chinese angelica, 50g of dragon bone, 20g of platycladi seed, 50g of oyster, 50g of astragalus root, 50g of deerhorn gelatin, 50g of red ginseng and 30g of pseudo-ginseng.
Grinding the mixture into powder by using a grinder respectively, and then mixing the powder of each component.
Adding water with the mass 10 times of the total mass of the raw materials into the mixture, soaking for 30min, boiling, and decocting to obtain the medicine for treating coronary heart disease, wherein the final volume is about 300 ml.
Example 3
Example 3 differs from example 1 only in that the components of the starting material do not include notoginseng.
Example 4
Example 4 differs from example 1 only in that 12g of ophiopogon root is present in the starting material.
Comparative example 1
Comparative example 1 differs from example 1 only in the absence of ophiopogon root in the raw material component of comparative example 1.
Comparative example 2
Comparative example 2 differs from example 1 only in the absence of prepared rhizome of rehmannia in the feed components of comparative example 2.
Comparative example 3
Comparative example 3 differs from example 1 only in that there is no place in the feed components in comparative example 3.
Comparative example 4
Comparative example 4 differs from example 1 only in that there is no poria with hostwood in the feed components in comparative example 4.
Comparative example 5
Comparative example 5 differs from example 1 only in the absence of alisma orientale in the feed composition of comparative example 5.
Comparative example 6
Comparative example 6 differs from example 1 only in the absence of fructus ligustri lucidi in the feed composition of comparative example 6.
Comparative example 7
Comparative example 7 differs from example 1 only in the absence of salvia miltiorrhiza in the feed components of comparative example 7.
Comparative example 8
Comparative example 8 differs from example 1 only in the absence of date kernels in the feed components of comparative example 8.
Comparative example 9
Comparative example 9 differs from example 1 only in the absence of eclipta alba in the feed components of comparative example 9.
Comparative example 10
Comparative example 10 differs from example 1 only in the absence of angelica in the feed composition of comparative example 10.
Comparative example 11
Comparative example 11 differs from example 1 only in the absence of a keel in the raw material components of comparative example 11.
Comparative example 12
Comparative example 12 differs from example 1 only in the absence of cedar seed in the raw ingredients of comparative example 12.
Comparative example 13
Comparative example 13 differs from example 1 only in that there are no oysters in the feed components in comparative example 13.
Comparative example 14
Comparative example 14 differs from example 1 only in the absence of astragalus in the feed composition of comparative example 14.
Comparative example 15
Comparative example 15 differs from example 1 only in the absence of antler glue in the feed components of comparative example 15.
Comparative example 16
Comparative example 16 differs from example 1 only in that there is no red ginseng in the raw material components in comparative example 15.
Test examples
200 coronary heart disease patients with symptoms of myocardial ischemia, night sweat and asthma are randomly selected, 10 patients are taken as a group, the medicines for the coronary heart disease are respectively taken by the embodiment and the comparative example, the treatment course is 15 days, the patients are respectively taken for 1 time every day, noon, morning and evening, 100ml is taken for each time, the symptom remission condition is counted, the relapse condition within 3 years after the treatment is counted, and the statistical results of the medicine treatment conditions of the application embodiment group and the comparative example of the coronary heart disease patients with the symptoms of myocardial ischemia, night sweat and asthma are shown in table 1.
TABLE 1 statistics of the drug treatment of patients with coronary heart disease with symptoms of myocardial ischemia, night sweat and asthma using the example group and the comparative example group
200 coronary heart disease patients with symptoms of angina pectoris, palpitation, arrhythmia and limb edema are randomly selected, one group is taken for 10 people, the medicines for coronary heart disease obtained by the embodiment and the comparative example are respectively taken for treatment, the treatment course is 15 days, the medicines are respectively taken for 1 time every day, noon, morning and evening, 100ml is taken for each time, the symptom relieving condition is counted, and the relapse condition within 3 years after treatment is counted. The statistics of the medication of the application example group and the comparative example group of patients with coronary heart disease with symptoms of angina pectoris, palpitation, arrhythmia and edema of limbs are shown in table 2.
TABLE 2 statistics of the medication of the patients with coronary heart disease with symptoms of angina pectoris, palpitation, arrhythmia and edema of limbs
200 coronary heart disease patients with symptoms of red tongue, dry throat, vexation and insomnia, dry stool, fever in chest, dysphoria and palpitation, insomnia and dreaminess, dry mouth and myasthenia of limbs are randomly selected, one group is taken by 10 patients, the medicines for the coronary heart disease are obtained by the embodiment and the comparative example scheme respectively, the treatment is carried out, the treatment course is 15 days, the patients are taken for 1 time every day, noon, morning and evening, 100ml is taken every time, the symptom relieving condition is counted, and the relapse condition within 3 years after the treatment is counted. The statistical results of the drug treatment conditions of the application example group and the comparative example group of the patients with coronary heart disease with the symptoms of red tongue, dry throat, vexation, insomnia, dry stool, heat in chest, dysphoria, palpitation, insomnia, dreaminess, dry mouth and myasthenia of limbs are shown in the table 3.
TABLE 3 statistics of the drug treatment conditions of the application example group and the comparative example group of patients with coronary heart disease with red tongue, dry throat, vexation, insomnia, dry stool, fever in chest, dysphoria, palpitation, insomnia, dreaminess, dry mouth and myasthenia of limbs
The patients in the groups of examples 1-4 had no recurrence within 3 years of follow-up.
As can be seen from the treatment results of the examples 1 to 4 in the table 1, the coronary heart disease symptoms of patients can be treated quickly by adjusting the components of the medicine within a certain range, and the medicine has good treatment effects on myocardial ischemia, night sweat and asthma symptoms and takes effect quickly; after 3 years of follow-up visit, patients do not have recurrence, and the visible drug effect is relatively durable and not easy to recur.
As can be seen from the treatment results of the examples 1 to 4 in the table 2, the coronary heart disease symptoms of patients can be treated quickly by adjusting the components of the medicament within a certain range, and the medicament has good treatment effects on angina pectoris, palpitation, arrhythmia and limb edema symptoms and takes effect quickly; after 3 years of follow-up visit, patients do not have recurrence, and the visible drug effect is relatively durable and not easy to recur. As can be seen from the comparison between example 1 and example 3 in Table 1, the pain can be better relieved by adding Panax notoginseng, and the drug effect is durable and not easy to recur.
As can be seen from the therapeutic effects of examples 1-4 in tables 1, 2 and 3, the compatibility and the dosage of the components in the formula are coordinated, so that various symptoms of coronary heart disease can be rapidly and comprehensively relieved, and the effect is lasting and difficult to relapse.
As can be seen from the therapeutic effects of comparative examples 1 to 16 in tables 1, 2 and 3, the absence of any component in the formulation does not result in a good therapeutic effect, and does not provide a complete relief from the symptoms of coronary heart disease, such as myocardial ischemia, night sweats, asthma, angina pectoris, palpitation, arrhythmia, edema of limbs, reddened tongue, dry throat, restlessness, insomnia, dry stool, fever in the chest, dysphoria, palpitation, insomnia, dreaminess, dry mouth, myasthenia of limbs, etc., with poor therapeutic effect or rapid onset of action. While particular embodiments of the present invention have been illustrated and described, it would be obvious that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (10)

1. The medicine for treating coronary heart disease is characterized by comprising the following raw materials in parts by mass: 10-25 parts of radix ophiopogonis, 15-35 parts of prepared rehmannia root, 15-35 parts of radix rehmanniae, 20-35 parts of poria with hostwood, 15-25 parts of rhizoma alismatis, 15-30 parts of glossy privet fruit, 25-35 parts of salvia miltiorrhiza, 15-25 parts of jujube kernel, 20-30 parts of eclipta alba, 15-25 parts of angelica sinensis, 25-50 parts of keel, 15-25 parts of platycladi seed, 25-50 parts of oyster, 45-55 parts of astragalus membranaceus, 45-55 parts of deerhorn glue and 45-55 parts of red ginseng.
2. The medicament for coronary heart disease according to claim 1, wherein the raw materials comprise, in parts by mass: 10-20 parts of radix ophiopogonis, 15-30 parts of prepared rhizome of rehmannia, 18-35 parts of radix rehmanniae, 25-32 parts of poria with hostwood, 15-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 28-32 parts of salvia miltiorrhiza, 18-22 parts of jujube kernel, 20-30 parts of eclipta alba, 18-22 parts of angelica, 28-50 parts of keel, 15-22 parts of platycladi seed, 28-50 parts of oyster, 48-55 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng.
3. The medicament for coronary heart disease according to claim 1, wherein the raw materials comprise, in parts by mass: 15-20 parts of radix ophiopogonis, 20-30 parts of prepared rehmannia root, 20-35 parts of radix rehmanniae, 20-32 parts of poria with hostwood, 18-22 parts of rhizoma alismatis, 18-30 parts of glossy privet fruit, 29-31 parts of salvia miltiorrhiza, 18-21 parts of jujube kernel, 20-22 parts of eclipta alba, 18-20 parts of angelica, 28-50 parts of keel, 18-22 parts of platycladi seed, 28-50 parts of oyster, 48-52 parts of astragalus membranaceus, 48-52 parts of deerhorn glue and 48-52 parts of red ginseng.
4. The medicament for coronary heart disease according to claim 3, wherein the raw materials comprise, in parts by mass: 20 parts of dwarf lilyturf tuber, 30 parts of prepared rehmannia root, 30 parts of poria with hostwood, 20 parts of oriental waterplantain rhizome, 20 parts of glossy privet fruit, 30 parts of red-rooted salvia root, 20 parts of jujube kernel, 20 parts of eclipta alba, 20 parts of Chinese angelica, 50 parts of dragon bone, 20 parts of platycladi seed, 50 parts of oyster shell, 50 parts of astragalus root, 50 parts of deerhorn gelatin and 50 parts of red ginseng.
5. The medicament for coronary heart disease according to any one of claims 1 to 4, wherein the raw materials further comprise, in parts by mass: 20-40 parts of pseudo-ginseng;
preferably, the raw materials further comprise, in parts by mass: 25-35 parts of pseudo-ginseng.
6. The medicine for coronary heart disease according to claim 5, characterized in that the raw materials further comprise, in parts by mass: 30 parts of pseudo-ginseng.
7. A process for the preparation of a medicament for coronary heart disease according to any one of claims 1 to 6, comprising the steps of:
respectively refining radix Ophiopogonis, radix rehmanniae Preparata, radix rehmanniae, Poria, Alismatis rhizoma, fructus Ligustri Lucidi, Saviae Miltiorrhizae radix, semen Ziziphi Spinosae, Ecliptae herba, radix Angelicae sinensis, Os Draconis, semen Platycladi, Concha Ostreae, radix astragali, colla Cornus Cervi and Ginseng radix Rubri and optional Notoginseng radix, mixing, soaking in water, and boiling to obtain the medicine for treating coronary heart disease.
8. The method for preparing a drug for coronary heart disease according to claim 7, comprising the steps of: after the boiling, cooling at room temperature to obtain the medicine for treating coronary heart disease;
preferably, the number of boiling times is 1-5, preferably 3.
9. The process for the preparation of a medicament for coronary heart disease according to any of claims 6 to 8, characterized by comprising the steps of:
respectively refining the dwarf lilyturf tuber, the prepared rehmannia root, the poria with hostwood, the oriental waterplantain rhizome, the glossy privet fruit, the red sage root, the jujube kernel, the eclipta alba, the Chinese angelica, the dragon bone, the platycladi seed, the oyster shell, the astragalus root, the deerhorn glue and the red ginseng and optional pseudo-ginseng according to the formula ratio, mixing, adding water with the mass being 5-10 times of the total mass of the mixture for soaking, boiling, cooling at room temperature, and repeatedly boiling for 2-3 times to obtain the medicine for treating the coronary heart disease.
10. Use of a medicament for coronary heart disease according to any one of claims 1 to 6 or a medicament for coronary heart disease prepared by a process for the preparation of a medicament for coronary heart disease according to any one of claims 7 to 9 in the preparation of a medicament for the treatment of coronary heart disease.
CN201911224821.2A 2019-12-04 2019-12-04 Medicine for coronary heart disease, preparation method and application thereof Withdrawn CN110721266A (en)

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Application publication date: 20200124