CN110710685A - Oral liquid for improving sleep quality and preparation method thereof - Google Patents
Oral liquid for improving sleep quality and preparation method thereof Download PDFInfo
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- CN110710685A CN110710685A CN201911052368.1A CN201911052368A CN110710685A CN 110710685 A CN110710685 A CN 110710685A CN 201911052368 A CN201911052368 A CN 201911052368A CN 110710685 A CN110710685 A CN 110710685A
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- 230000003860 sleep quality Effects 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 244000046738 asparagus lettuce Species 0.000 claims abstract description 19
- 235000006705 asparagus lettuce Nutrition 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 18
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 14
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 14
- 235000012907 honey Nutrition 0.000 claims abstract description 14
- 244000062793 Sorghum vulgare Species 0.000 claims abstract description 9
- 235000019713 millet Nutrition 0.000 claims abstract description 9
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 7
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- 229930003451 Vitamin B1 Natural products 0.000 claims description 6
- 229960003495 thiamine Drugs 0.000 claims description 6
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
- A23L21/25—Honey; Honey substitutes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of health-care food, in particular to an oral liquid for improving sleep quality and a preparation method thereof, wherein the oral liquid comprises the following raw materials, by weight, 15 ~ parts of apples, 8 ~ parts of barbary wolfberry fruits, 5 ~ parts of spina date seeds, 5 ~ parts of asparagus lettuce, 4 ~ parts of longans, 4 ~ parts of millets, 12 ~ parts of vitamin B, 2 ~ parts of honey and 9000 ~ 12000mL of purified water.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to an oral liquid for improving sleep quality and a preparation method thereof.
Background
Sleep is a process necessary for life, is an important link for restoring, integrating and consolidating body memory, and is an indispensable component for health. Sleep disorder refers to abnormal sleep quality and abnormal sleep quantity, or some clinical symptoms such as sleep reduction or hypersomnia, sleepwalking and the like during sleep. Difficulty in falling asleep, shallow sleep and easy wakening, difficulty in falling asleep after waking up and dreaminess, and are often accompanied by symptoms of listlessness, weakness of limbs, slow response, low working efficiency, headache, hypomnesis and the like in the daytime. Poor sleep and insomnia cause discomfort and inattention, seriously affect daily life and work, and increase the risk of diseases such as hypertension and depression for people with long-term insomnia.
The world health organization surveys that 27% of people worldwide have sleep problems and 45% of Chinese have varying degrees of sleep disturbance, and the international mental health organization sponsored global sleep and health program and 2001 initiated a global activity that identified day 21/3 of each year, the first day of spring as "world sleep day", and thus sleep had received worldwide attention.
At present, with the progress of society and the improvement of living standard of people, more and more people begin to pay attention to daily health care. Therefore, health care products with the main function of improving sleep quality have great market potential, most of the products on the market are health care products which are prepared from pure traditional Chinese medicines and have the function of improving sleep quality, and the situation is single.
Disclosure of Invention
Based on the problems, the invention aims to provide an oral liquid for improving sleep quality and a preparation method thereof.
An oral liquid for improving sleep quality comprises, by weight, 15 ~ 45 parts of apples, 8 ~ 30 parts of wolfberry fruits, 5 ~ 20 parts of spina date seeds, 5 ~ 18 parts of asparagus lettuce, 4 ~ 12 parts of longan, 4 ~ 12 parts of millet, 12 ~ 5 parts of vitamin B, 2 ~ 5 parts of honey and 9000 ~ 12000mL of purified water.
Preferably, the oral liquid comprises the following raw materials in parts by weight: 38 parts of apple, 8 parts of wolfberry fruit, 16 parts of spina date seed, 12 parts of asparagus lettuce, 11 parts of longan, 11 parts of millet, 12 parts of vitamin B, 2 parts of honey and 10000mL of purified water.
The preparation method of the oral liquid for improving sleep quality comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: washing fructus Mali Pumilae, fructus Lycii, semen Ziziphi Spinosae and arillus longan with water, decocting in interlayer pan for 1.5 hr, sieving with 200 mesh sieve, and placing the filtrate in preparation tank;
step two: cleaning asparagus lettuce, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the asparagus lettuce is hot, wherein the filtrate is reserved;
step three: washing semen Setariae, decocting with water for 2 times, sieving to obtain filtrate, and concentrating the filtrate to relative density of 2 to obtain concentrated solution;
step four: uniformly mixing the filtrate obtained in the three steps with vitamin B1 and honey in proportion, and metering the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting.
Further, the steps two to six are all carried out in a hundred thousand grade clean space.
Compared with the prior art, the invention has the following beneficial effects:
the oral liquid for improving sleep quality is prepared from the following main raw materials in parts by weight: the apple, the medlar, the spina date seed, the asparagus lettuce, the longan, the millet and the vitamin B1 play a role in comprehensively improving the sleep quality. In consideration of the taste, honey is added into the product to adjust the taste, so that the taste is better. The preparation method of the oral liquid for improving the sleep quality is simple and convenient to operate; cost and labor are saved; the process equipment is safe and sanitary.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An oral liquid for improving sleep quality comprises the following raw materials in parts by weight: 450g of apple, 300g of medlar, 50g of spina date seed, 50g of asparagus lettuce, 40g of longan, 40g of millet, 130g of vitamin B, 20g of honey and 9000mL of purified water.
The preparation method of the oral liquid for improving sleep quality comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: washing fructus Mali Pumilae, fructus Lycii, semen Ziziphi Spinosae and arillus longan with water, decocting in interlayer pan for 1.5 hr, sieving with 200 mesh sieve, and placing the filtrate in preparation tank;
step two: cleaning asparagus lettuce, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the asparagus lettuce is hot, wherein the filtrate is reserved;
step three: washing semen Setariae, decocting with water for 2 times, sieving to obtain filtrate, and concentrating the filtrate to relative density of 2 to obtain concentrated solution;
step four: uniformly mixing the filtrate obtained in the three steps with vitamin B1 and honey in proportion, and metering the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 2
An oral liquid for improving sleep quality comprises the following raw materials in parts by weight: 380g of apple, 80g of medlar, 160g of spina date seed, 120g of asparagus lettuce, 110g of longan, 110g of millet, 120g of vitamin B, 20g of honey and 10000mL of purified water.
The preparation method of the oral liquid for improving sleep quality comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: washing fructus Mali Pumilae, fructus Lycii, semen Ziziphi Spinosae and arillus longan with water, decocting in interlayer pan for 1.5 hr, sieving with 200 mesh sieve, and placing the filtrate in preparation tank;
step two: cleaning asparagus lettuce, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the asparagus lettuce is hot, wherein the filtrate is reserved;
step three: washing semen Setariae, decocting with water for 2 times, sieving to obtain filtrate, and concentrating the filtrate to relative density of 2 to obtain concentrated solution;
step four: uniformly mixing the filtrate obtained in the three steps with vitamin B1 and honey in proportion, and metering the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 3
An oral liquid for improving sleep quality comprises the following raw materials in parts by weight: 150g of apple, 130g of medlar, 200g of spina date seed, 180g of asparagus lettuce, 120g of longan, 120g of millet, 150g of vitamin B150 g, 50g of honey and 12000mL of purified water.
The preparation method of the oral liquid for improving sleep quality comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: washing fructus Mali Pumilae, fructus Lycii, semen Ziziphi Spinosae and arillus longan with water, decocting in interlayer pan for 1.5 hr, sieving with 200 mesh sieve, and placing the filtrate in preparation tank;
step two: cleaning asparagus lettuce, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the asparagus lettuce is hot, wherein the filtrate is reserved;
step three: washing semen Setariae, decocting with water for 2 times, sieving to obtain filtrate, and concentrating the filtrate to relative density of 2 to obtain concentrated solution;
step four: uniformly mixing the filtrate obtained in the three steps with vitamin B1 and honey in proportion, and metering the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 4
And (3) toxicological experiments:
1. the purpose of the test is as follows: the oral liquid for improving the sleep quality is toxic or not.
Experimental materials: (1) sample preparation: the recommended dosage of the oral liquid for improving the sleep quality is 20mL per day, the weight of an adult is calculated according to 60kg, the reduced dose is 0.333 mL/kg/day, and 5 times of concentrated solution is taken for carrying out an experiment.
2. Experimental animals: clean-grade Kunming mouse, SD rat and feed.
3. The experimental environmental conditions comprise the temperature of 22 ~ 24 ℃ and the humidity of 52 ~ 58%.
4. The experimental method comprises the following steps:
through mouse acute toxicity experiment (taking oral liquid 5 times concentrated solution for improving sleep quality to mouse, and giving mouse with stomach-filling volume of 0.2mL/10 g.bw), Ames experiment (five doses are set for the experiment, wherein the five doses are respectively 5000 mug/vessel, 1000 mug/vessel, 200 mug/vessel, 40 mug/vessel and 8 mug/vessel, and self-reversion, solvent contrast and positive mutagen contrast are set simultaneously), mouse marrow pleochromophily red nucleus experiment (taking cyclophosphamide with dose of 40mg/kg.bw as positive contrast and distilled water as negative contrast, 3 doses in experiment group are respectively 10.0mL/kg.bw, 5.0mL/kg.bw and 2.5mL/kg.bw, taking oral liquid 5 times concentrated solution with sleep quality to 50.0mL, 25mL and 12.5mL to 100mL, preparing test liquid with corresponding dose to mouse, and giving mouse stomach-filling with mouse with test liquid, and taking cyclophosphamide with dose of 40 mg/kg/sperm abnormality as contrast, distilled water is used as a negative control, 3 doses of a test group are respectively 10.0mL/kg.bw, 5.0mL/kg.bw and 2.5mL/kg.bw, 50.0mL, 25.0mL and 12.5mL of oral liquid 5-fold concentrated solution for improving sleep quality are taken, distilled water is added to 50mL to prepare test solution with corresponding dose to be filled into a mouse for intragastric administration, and toxicological test evaluation is carried out by a 30-day feeding test (17 mL, 33mL and 67mL of oral liquid 5-fold concentrated solution for improving sleep quality are taken, distilled water is added to a constant volume of 100mL, and an equal volume of distilled water is given to a control group for intragastric administration once a day for 30 days).
5. And (3) test results:
(1) acute oral toxicity test: the maximum tolerance dose to female and male Kunming mice is more than 20.0mL/kg.bw, and the drug belongs to a nontoxic grade.
(2) And (3) genetic toxicity test: the Ames test, mouse marrow pleochromocyte micronucleus test and mouse teratospermia test results are all negative.
(3) And feeding the rats for 30 days by using 1.7mL/kg.bw, 3.3mL/kg.bw and 6.7mL/kg.bw of oral liquid 5-fold concentrated solution for improving the sleep quality, wherein the rats are gavaged for 30 days, animals grow and develop well during the experiment period, and the weight, the weight gain, the food utilization rate, the blood conventional index, the organ weight and the organ/weight ratio of each dose group are compared with those of a control group, so that no significant difference exists.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The oral liquid for improving the sleep quality is characterized by comprising, by weight, 15 ~ 45 parts of apples, 8 ~ 30 parts of wolfberry fruits, 5 ~ 20 parts of spina date seeds, 5 ~ 18 parts of asparagus lettuce, 4 ~ 12 parts of longan, 4 ~ 12 parts of millet, 12 ~ 5 parts of vitamin B, 2 ~ 5 parts of honey and 9000 ~ 12000mL of purified water.
2. The oral liquid for improving sleep quality as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 38 parts of apple, 8 parts of wolfberry fruit, 16 parts of spina date seed, 12 parts of asparagus lettuce, 11 parts of longan, 11 parts of millet, 12 parts of vitamin B, 2 parts of honey and 10000mL of purified water.
3. The preparation method of the oral liquid for improving sleep quality as claimed in claim 1, which is characterized by comprising the following steps:
the method comprises the following steps: washing fructus Mali Pumilae, fructus Lycii, semen Ziziphi Spinosae and arillus longan with water, decocting in interlayer pan for 1.5 hr, sieving with 200 mesh sieve, and placing the filtrate in preparation tank;
step two: cleaning asparagus lettuce, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the asparagus lettuce is hot, wherein the filtrate is reserved;
step three: washing semen Setariae, decocting with water for 2 times, sieving to obtain filtrate, and concentrating the filtrate to relative density of 2 to obtain concentrated solution;
step four: uniformly mixing the filtrate obtained in the three steps with vitamin B1 and honey in proportion, and metering the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting.
4. The method for preparing oral liquid for improving sleep quality as claimed in claim 3, wherein the steps two to six are all performed in a clean space of hundred thousand grade.
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| CN201911052368.1A CN110710685A (en) | 2019-10-31 | 2019-10-31 | Oral liquid for improving sleep quality and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870304A (en) * | 2021-02-25 | 2021-06-01 | 安徽省芬格欣生物药业有限公司 | Oral liquid capable of effectively helping sleep and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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