CN110664976A - Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials: 11-16 parts of dried ginger, 13-19 parts of astragalus membranaceus, 8-14 parts of Chinese yam, 7-12 parts of endothelium corneum gigeriae galli, 4-7 parts of curcuma zedoary, 7-14 parts of smoked plum, 5-9 parts of white paeony root, 4-8 parts of curcuma aromatica and 4-7 parts of liquorice. The traditional Chinese medicine composition for treating chronic atrophic gastritis has the advantages of good curative effect, safety, no toxic or side effect and low treatment cost on treating chronic atrophic gastritis, particularly has the most obvious effect on the early stage of chronic atrophic gastritis, and also has a good delay effect on the middle and late stages of chronic atrophic gastritis.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method and application thereof.
Background
Chronic atrophic gastritis is a chronic digestive system disease characterized by atrophy, decreased number of gastric mucosal epithelium and glands, thinning of gastric mucosa, thickening of mucosal basal layer, or accompanying pyloric glandular metaplasia and intestinal glandular metaplasia, or atypical hyperplasia. It is usually manifested as vague pain, fullness and distention in the upper abdomen, belching, inappetence, emaciation, anemia, etc., and has no specificity. There is currently a lack of effective therapeutic agents.
Although the curative effect of the chemical drug treatment is rapid, the treatment mainly aims at relieving symptoms, treats the symptoms and the root causes, and is often accompanied with a series of side effects. Modern medicine is mostly symptomatic treatment to chronic atrophic gastritis, and does not have ideal treatment method, and traditional chinese medicine mostly adopts individualized decoction whole syndrome differentiation to administer prescription medicine, nevertheless because need take medicine time long, the taste is poor, it wastes time and energy to decoct medicine, and the patient is difficult to persist, therefore influences the sustainability of curative effect.
Disclosure of Invention
In order to solve the technical problems, the invention provides the traditional Chinese medicine composition for treating chronic atrophic gastritis and the preparation method thereof.
One of the purposes of the invention is to provide a traditional Chinese medicine composition for treating chronic atrophic gastritis, which comprises the following traditional Chinese medicine raw materials:
11-16 parts of dried ginger, 13-19 parts of astragalus membranaceus, 8-14 parts of Chinese yam, 7-12 parts of endothelium corneum gigeriae galli, 4-7 parts of curcuma zedoary, 7-14 parts of smoked plum, 5-9 parts of white paeony root, 4-8 parts of curcuma aromatica and 4-7 parts of liquorice.
Further, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials:
12-15 parts of dried ginger, 14-18 parts of astragalus membranaceus, 9-13 parts of Chinese yam, 8-11 parts of endothelium corneum gigeriae galli, 5-6 parts of curcuma zedoary, 8-12 parts of dark plum, 6-8 parts of white paeony root, 5-7 parts of curcuma aromatica and 5-6 parts of curcuma zedoary.
Further, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials:
14 parts of dried ginger, 15 parts of astragalus, 11 parts of Chinese yam, 10 parts of chicken's gizzard-membrane, 6 parts of curcuma zedoary, 10 parts of dark plum, 7 parts of white paeony root, 6 parts of curcuma aromatica and 6 parts of curcuma zedoary.
According to another object of the present invention, there is provided a method for preparing the above-mentioned Chinese medicinal composition for treating chronic atrophic gastritis, which comprises the steps of:
s1, extracting the dried ginger, the astragalus root, the Chinese yam, the chicken' S gizzard-membrane, the zedoary, the dark plum fruit, the white paeony root and the turmeric root-tuber in parts by weight with water to obtain an extracting solution;
s2, concentrating the extracting solution prepared in the previous step into primary extract;
s3, adding ethanol into the primary extract until the alcohol content volume percentage concentration is 55-65%, uniformly stirring, standing, filtering, and concentrating the filtrate into a secondary extract with active ingredients;
s4, processing the secondary extract into granules.
Furthermore, in S1, the number of times of water extraction is 3-4, each time, water which is 12-15 times of the total weight of the medicinal materials is added, and the extraction time is 3.5-4.5 hours.
Further, in S2, the extract is concentrated into a primary extract with a relative density of 1.15-1.25 at 85 ℃.
Further, in S3, the standing time is not less than 12 hours.
Further, in S3, the secondary extract is a secondary extract with a relative density of 1.15-1.25 at 65 ℃.
Further, in S4, when the secondary extract is made into granules, sucrose is added as an auxiliary material, and the addition amount of sucrose is less than 25%.
According to a further object of the present invention, there is provided a use of the above-mentioned Chinese medicinal composition for treating chronic atrophic gastritis.
The properties and the like of the above-mentioned raw materials of the present invention are described below:
dried ginger: pungent flavor and warm property. It enters spleen, stomach, kidney, heart and lung meridians. Warming the middle energizer to dispel cold, restoring yang to activate collaterals, warming the lung to resolve retained fluid. Can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, cough and asthma due to cold fluid retention.
Astragalus root: sweet in flavor and slightly warm in nature. Tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, rectocele, spontaneous perspiration, edema, chronic nephritis, albuminuria, and unhealed wound.
Chinese yam: sweet and neutral. To invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, and frequent micturition. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, deficiency heat, and diabetes. The bran-parched rhizoma Dioscoreae has effects of invigorating spleen and invigorating stomach. It can be used for treating spleen deficiency, anorexia, diarrhea, and loose stool.
Endothelium corneum gigeriae galli: sweet and neutral. Strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus. Can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, gallbladder distention, and hypochondriac pain.
Zedoary turmeric: pungent and bitter with warm nature. Can be used for treating blood, qi and heart pain, food stagnation, abdominal distention and pain, blood stagnation amenorrhea, abdominal mass, tumor, and traumatic injury.
Dark plum: sour and astringent taste, mild in nature. Can be used for treating lung deficiency, chronic cough, chronic diarrhea, dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain.
White peony root: bitter and sour in taste, slightly cold in nature. Can be used for treating blood deficiency, sallow complexion, spontaneous perspiration, night sweat, hypochondriac pain, and abdominal pain.
Turmeric root-tuber: pungent, bitter and cold. Promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice. Can be used for treating pricking pain in chest and hypochondrium, thoracic obstruction, cardialgia, jaundice, and dark urine.
Licorice root: sweet in flavor and neutral in nature. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
The invention has the beneficial effects that:
the traditional Chinese medicine composition for treating chronic atrophic gastritis has the advantages of good curative effect, safety, no toxic or side effect and low treatment cost on treating chronic atrophic gastritis, particularly has the most obvious effect on the early stage of chronic atrophic gastritis, and also has a good delay effect on the middle and late stages of chronic atrophic gastritis.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to specific embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The preparation of the traditional Chinese medicine composition granules for treating chronic atrophic gastritis comprises the following steps:
the raw materials comprise: 11 parts of dried ginger, 13 parts of astragalus, 8 parts of Chinese yam, 7 parts of chicken's gizzard-membrane, 4 parts of curcuma zedoary, 7 parts of dark plum, 5 parts of white paeony root, 4 parts of curcuma aromatica and 4 parts of liquorice;
the preparation method comprises the following steps: taking 11 parts of dried ginger, 13 parts of astragalus, 8 parts of Chinese yam, 7 parts of endothelium corneum gigeriae galli, 4 parts of curcuma zedoary, 7 parts of dark plum, 5 parts of white paeony root, 4 parts of curcuma aromatica and 4 parts of liquorice, adding water which is 12 times of the total weight of the medicinal materials, extracting for 3.5 hours, and extracting for 3 times to obtain an extracting solution; mixing the extracting solutions extracted for 3 times, and concentrating to obtain a primary extract with the relative density of 1.15-1.25 at 85 ℃; adding ethanol into the primary extract until the volume percentage concentration of the ethanol content is 55%, uniformly stirring, standing for 12 hours, filtering, and concentrating the filtrate to a secondary extract with the relative density of 1.15-1.25 at 65 ℃; adding sucrose into the secondary extract, and processing into granule with sucrose addition of 15%.
Example 2
The preparation of the traditional Chinese medicine composition granules for treating chronic atrophic gastritis comprises the following steps:
the raw materials comprise: 14 parts of dried ginger, 15 parts of astragalus, 11 parts of Chinese yam, 10 parts of chicken's gizzard-membrane, 6 parts of curcuma zedoary, 8 parts of dark plum fruit, 7 parts of white paeony root, 6 parts of curcuma aromatica and 6 parts of liquorice;
the preparation method comprises the following steps: 14 parts of dried ginger, 15 parts of astragalus, 11 parts of Chinese yam, 10 parts of chicken's gizzard-membrane, 6 parts of curcuma zedoary, 8 parts of dark plum, 7 parts of white paeony root, 6 parts of curcuma aromatica and 6 parts of liquorice, adding water which is 15 times of the total weight of the medicinal materials, extracting for 4.5 hours, and extracting for 4 times to obtain an extracting solution; mixing the extracting solutions extracted for 4 times, and concentrating to obtain a primary extract with the relative density of 1.15-1.25 at 85 ℃; adding ethanol into the primary extract until the ethanol content volume percentage concentration is 65%, uniformly stirring, standing for 18 hours, filtering, and concentrating the filtrate to a secondary extract with the relative density of 1.15-1.25 at 65 ℃; adding sucrose into the secondary extract, and processing into granule with sucrose addition of 25%.
Example 3
The preparation of the traditional Chinese medicine composition granules for treating chronic atrophic gastritis comprises the following steps:
the raw materials comprise: 16 parts of dried ginger, 19 parts of astragalus, 4 parts of Chinese yam, 12 parts of chicken's gizzard-membrane, 7 parts of curcuma zedoary, 14 parts of dark plum, 9 parts of white paeony root, 8 parts of curcuma aromatica and 7 parts of liquorice;
the preparation method comprises the following steps: 16 parts of dried ginger, 19 parts of astragalus, 4 parts of Chinese yam, 12 parts of chicken's gizzard-membrane, 7 parts of curcuma zedoary, 14 parts of dark plum, 9 parts of white paeony root, 8 parts of curcuma aromatica and 7 parts of liquorice, adding water which is 13 times of the total weight of the medicinal materials, extracting for 4 hours, and extracting for 4 times to obtain an extracting solution; mixing the extracting solutions extracted for 4 times, and concentrating to obtain a primary extract with the relative density of 1.15-1.25 at 85 ℃; adding ethanol into the primary extract until the volume percentage concentration of the ethanol content is 60%, uniformly stirring, standing for 24 hours, filtering, and concentrating the filtrate to a secondary extract with the relative density of 1.15-1.25 at 65 ℃; adding sucrose into the secondary extract, and processing into granule with sucrose addition of 18%.
Example 4
The administration method of the traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps: the medicine is taken 30 minutes before meals for three times a day, 15g each time, and is taken with light saline, cold and hot foods are not suitable to be eaten in the medicine taking process, pregnant women are prohibited to take the medicine, and patients with digestive tract ulcer diseases need to take the medicine with caution.
The traditional Chinese medicine composition for treating chronic atrophic gastritis has obvious curative effect through clinical treatment, and the chronic atrophic gastritis does not relapse after being taken according to the course of treatment. The following are clinical tests carried out by adopting the traditional Chinese medicine for treating urolithiasis, and the treatment results of the cases are as follows:
the preparations prepared according to examples 1-3 of the present invention were clinically tested for chronic atrophic gastritis. Clinical observation shows that the total effective rate of 50 cases of chronic atrophic gastritis is 92.5 percent, wherein the significant efficiency is 50.5 percent and the effective rate is 42 percent by taking the traditional Chinese medicine for 3 times/day and 15g each time through fiber gastroscopy and gastric mucosa examination. After the clinical visit, the subjective symptoms do not relapse, and the atrophy degree is also reduced.
Specific cases
1. Plum, male, age 35, has chronic atrophic gastritis. The traditional Chinese medicine can be cured after being taken for two months, chronic inflammation of gastric mucosa is obviously improved after being rechecked by a gastroscope, and gland atrophy and intestinal metaplasia are recovered to be normal or disappear after being verified by pathological histological examination.
2. Wu Yi in Wu, female, 25 years old, suffers from chronic atrophic gastritis. After the traditional Chinese medicine is taken for two months, the traditional Chinese medicine is recovered to be normal, the improvement of chronic inflammation of gastric mucosa is rechecked by a gastroscope, and gland atrophy and intestinal metaplasia are verified to be recovered to be normal or reduced by two grades by pathological histological examination.
3. Zhao, a man aged 26 years, with chronic atrophic gastritis. After the traditional Chinese medicine is taken for three months, clinical symptoms disappear. The chronic inflammation of the gastric mucosa is obviously improved after the gastroscope review, and the gland atrophy and the intestinal metaplasia are recovered to be normal or disappear after the histopathological examination.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A traditional Chinese medicine composition for treating chronic atrophic gastritis is characterized by comprising the following traditional Chinese medicine raw materials: 11-16 parts of dried ginger, 13-19 parts of astragalus membranaceus, 8-14 parts of Chinese yam, 7-12 parts of endothelium corneum gigeriae galli, 4-7 parts of curcuma zedoary, 7-14 parts of smoked plum, 5-9 parts of white paeony root, 4-8 parts of curcuma aromatica and 4-7 parts of liquorice.
2. The traditional Chinese medicine composition for treating chronic atrophic gastritis of claim 1, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials: 12-15 parts of dried ginger, 14-18 parts of astragalus membranaceus, 9-13 parts of Chinese yam, 8-11 parts of endothelium corneum gigeriae galli, 5-6 parts of curcuma zedoary, 8-12 parts of dark plum, 6-8 parts of white paeony root, 5-7 parts of curcuma aromatica and 5-6 parts of liquorice.
3. The traditional Chinese medicine composition for treating chronic atrophic gastritis of claim 1, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials: 14 parts of dried ginger, 15 parts of astragalus, 11 parts of Chinese yam, 10 parts of chicken's gizzard-membrane, 6 parts of curcuma zedoary, 10 parts of dark plum fruit, 7 parts of white paeony root, 6 parts of curcuma aromatica and 6 parts of liquorice.
4. The preparation method of the traditional Chinese medicine composition for treating chronic atrophic gastritis according to any one of claims 1 to 3, which comprises the following steps:
s1, extracting the dried ginger, the astragalus root, the Chinese yam, the chicken' S gizzard-membrane, the zedoary, the dark plum fruit, the white paeony root, the turmeric root-tuber and the liquorice root in parts by weight with water to obtain an extracting solution;
s2, concentrating the extracting solution prepared in the previous step into primary extract;
s3, adding ethanol into the primary extract until the alcohol content volume percentage concentration is 55-65%, uniformly stirring, standing, filtering, and concentrating the filtrate into a secondary extract with active ingredients;
s4, processing the secondary extract into a granular formulation or a capsule formulation.
5. The preparation method of the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 4, wherein the number of water extraction in S1 is 3-4, and each time, the amount of water added is 12-15 times of the total weight of the herbs, and the extraction time is 3.5-4.5 hours.
6. The method for preparing a Chinese medicinal composition for treating chronic atrophic gastritis as defined in claim 4, wherein in S2, the extract is concentrated into a primary extract with a relative density of 1.15-1.25 at 85 ℃.
7. The method for preparing a Chinese medicinal composition for treating chronic atrophic gastritis of claim 4, wherein the standing time in S3 is not less than 12 hours.
8. The method for preparing a Chinese medicinal composition for treating chronic atrophic gastritis of claim 4, wherein in S3, the relative density of the secondary extract is 1.15-1.25 at 65 ℃.
9. The method for preparing a Chinese medicinal composition for treating chronic atrophic gastritis as defined in claim 4, wherein in S4, sucrose is added as an adjuvant when the secondary extract is made into granule, and the addition amount of sucrose is below 25%.
10. The use of the Chinese medicinal composition for treating chronic atrophic gastritis as defined in any one of claims 1 to 3, wherein the Chinese medicinal composition is used for treating chronic atrophic gastritis.
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| 欣然书斋: "胃肠调平散", 《HTTP://WWW.360DOC.COM/CONTENT/19/0629/22/8541396_845664115.SHTML》 * |
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