CN110664965A

CN110664965A - Composition for treating sleep disorder caused by depression or anxiety and preparation method thereof

Info

Publication number: CN110664965A
Application number: CN201911056806.1A
Authority: CN
Inventors: 牛琪惠; 牛明敏; 房新荷; 郑若楠; 牛江腾; 牛玲玲; 牛攀东
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-31
Filing date: 2019-10-31
Publication date: 2020-01-10

Abstract

The invention relates to the technical field of combined medicaments, in particular to a composition for treating sleep disorder caused by depression or anxiety and a preparation method thereof. A composition for treating sleep disorders caused by depression or anxiety comprising the following ingredients: vinegar processed bupleuri radix, vinegar processed rhizoma Cyperi, cortex Albizziae, caulis Polygoni Multiflori, cortex moutan, fructus Gardeniae preparata, Coptidis rhizoma cortex Cinnamomi, rhizoma Ligustici Chuanxiong, rhizoma anemarrhenae, radix Curcumae, cortex et radix Polygalae, Os Draconis, parched semen Ziziphi Spinosae, semen Platycladi and Zhubo beef heart. The method comprises the following steps: preparing a Zhupo beef heart; taking the medicinal components according to the proportion, crushing, and separating coarse powder and fine powder by a filter screen; mixing the coarse powder with water to obtain medicinal liquid, cooking semen Setariae in the medicinal liquid, wrapping the fine powder with semen Setariae to obtain pill. The invention can well relieve the sleep disorder caused by anxiety and depression, so that the patient can fundamentally relieve the problem and does not have side effect on the human body.

Description

Composition for treating sleep disorder caused by depression or anxiety and preparation method thereof

Technical Field

The invention relates to the technical field of combined medicaments, in particular to a composition for treating sleep disorder caused by depression or anxiety and a preparation method thereof.

Background

Depression is a emotional experience of loss of interest, depressed mood, and diminished mental activity. Anxiety refers to a stressful fear or fear of fear that is not compatible with the environment, with varying degrees of vegetative nerve disturbance. The common and common clinical manifestations of the two diseases are sleep disorder, depression is characterized by early awakening, anxiety is more common for difficulty in falling asleep, the sleep problem accompanied by depression and anxiety seriously affects the quality of life of patients, and insomnia is often the most common chief complaint of patients and is a symptom of particular concern to the patients. Therefore, clinicians also aim at improving the sleep symptoms of patients while treating the depressed anxiety emotions of the patients, but the current treatment measures for the depressed anxiety have no direct effect on insomnia, and can partially aggravate the insomnia symptoms, thereby bringing great troubles to the clinicians and the patients.

The current treatment for patients with depression anxiety is as follows:

1. and (3) drug treatment: is a main treatment mode, and currently, the treatment for patients with depression and anxiety mostly depends on western medicines, such as a 5-hydroxytryptamine reuptake inhibitor, a 5-hydroxytryptamine and norepinephrine reuptake inhibitor, a norepinephrine and specific 5-hydroxytryptamine antidepressant, a 5-hydroxytryptamine partial agonist and the like. Western medicines are various in types, the curative effect of resisting depression and anxiety is definite, but adverse drug reactions are not negligible, the sleep is not directly improved, the blood routine, liver and kidney functions, electrocardiogram, blood pressure, blood sugar, blood fat metabolism and the like need to be monitored regularly, part of the medicines can cause drug-induced anxiety, the insomnia symptom is aggravated, and the medication compliance of patients is reduced.

2. Benzodiazepine drugs: belongs to sedative hypnotic drugs, can effectively improve insomnia symptoms, but has addiction and dependence and limited clinical use.

3. Psychotherapy: (1) supportive psychotherapy (2) interpersonal psychotherapy (3) cognitive behavioral therapy (4) marital therapy (5) home therapy. The traditional Chinese medicine composition is suitable for patients with psychosocial stress factors, needs high patient comprehensiveness, develops in good doctor-patient relationship, is not suitable for all patients with depression and anxiety, mainly aims at the psychosocial stress factors, and has no direct effect on sleep.

4. Repeat transcranial magnetic stimulation treatment: has moderate antidepressant effect, is effective in improving depressive symptoms and suicide behavior in a short time, and has adverse reaction: epileptic seizures, headache, skin damage at the stimulation site, and mania induction, etc., and electromagnetic radiation may be generated by this treatment, which is not suitable for patients with cardiac pacemakers. The adverse effects of repeated transcranial magnetic stimulation treatment exacerbate the symptoms of insomnia.

5. Electric shock treatment: the administration of a suitable amount of current stimulation to the central nervous system, which causes transient loss of consciousness and generalized seizures in the patient, improves the mood of the patient, and the specific mechanisms are not known, and possible mechanisms include increasing permeability of the blood brain barrier, changing the functional state of acetylcholine and GABAergic neurons, increasing sensitivity of 5-hydroxytryptamine receptors, and increasing prolactin release and the concentration of endorphin and prostaglandin E2 in the plasma, etc. Adverse reactions: headache, nausea, vomiting, hypomnesis, postoperative delirium, contraindications: intracranial hypertension, severe cardiovascular disease, severe kidney disease, recent or unhealed osteoarticular disease, severe glaucoma and retinal detachment, severe peptic ulcer. It is not suitable for conventional treatment, but only for major and refractory depression and other mental diseases. The insomnia symptom can be aggravated by the adverse reaction of the electric shock treatment, and in addition, the treatment measures need to use anesthetic drugs, and the normal sleep rhythm of a patient can be interfered, so that the sleep quality at night is influenced.

6. Surgical treatment (deep brain stimulation): the pulse generator is implanted into the brain to stimulate relative nuclei in the brain by releasing weak electric pulses, thereby improving depression symptoms. There may be problems with side effects and complications: infection, hemorrhage, perioperative headache, epilepsy and the like, and the effective rate is lower and is 40 to 70 percent. Is still in the experimental treatment stage.

Therefore, the traditional therapeutic articles or therapeutic methods cannot fundamentally solve the sleep disorder caused by depression and anxiety, and a more reasonable technical scheme needs to be provided to solve the technical problems in the prior art.

Disclosure of Invention

The invention provides a composition for treating sleep disorder caused by depression or anxiety, which aims to relieve and treat the sleep disorder caused by depression and anxiety through a traditional Chinese medicine composition, wherein the treatment process is from inside to outside, and no side effect is generated.

In order to achieve the above effects, the technical scheme of the invention is as follows:

the composition for treating sleep disorder caused by depression or anxiety comprises the following components in parts by weight: 9-11 parts of vinegar radix bupleuri, 10-14 parts of vinegar rhizoma cyperi, 27-33 parts of cortex albiziae, 27-33 parts of tuber fleeceflower stem, 9-11 parts of tree peony bark, 5-7 parts of scorched gardenia, 5-7 parts of coptis chinensis, 5-7 parts of cinnamon, 9-11 parts of ligusticum wallichii, 9-11 parts of rhizoma anemarrhenae, 13-17 parts of radix curcumae, 9-11 parts of polygala tenuifolia, 27-33 parts of keel, 27-33 parts of fried jujube kernel, 27-33 parts of platycladi seed and 27-33 parts of Zhubo beef heart.

Wherein, the efficacies of part of the components are as follows:

vinegar radix bupleuri, harmonizes and relieves fever, soothes liver and relieves depression, and raises yang qi.

Vinegar-processed Xiang Fu is pungent, slightly bitter and sweet in flavor and neutral in nature. Has the functions of soothing liver, regulating qi, regulating menstruation and relieving pain. The main components of the composition comprise volatile oil, beta-pinene and camphene.

Albizzia julibrissin dura is sweet and mild in nature and taste. Has the functions of resolving depression, regulating blood, calming heart and eliminating carbuncle and swelling. It has the effects of treating uneasiness, melancholy, insomnia, pulmonary abscess, carbuncle, scrofula, and fracture and injury of tendons and bones.

Caulis Polygoni Multiflori has effects of nourishing heart, tranquilizing mind, dispelling pathogenic wind, and dredging collaterals. Can be used for treating insomnia, dreaminess, blood deficiency, body pain, skin numbness, rheumatalgia, and rubella pruritus.

Cortex moutan, bitter and pungent with slight cold, enters heart, liver and kidney meridians, and has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and relieving deficiency heat.

Charred Zhi Zi has light smell and slightly sour and bitter taste. Cool blood and stop bleeding. Can be used for treating hematemesis, epistaxis, hematuria, metrorrhagia, and metrostaxis.

Huang Lian can clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.

Cinnamon has the functions of warming the middle-jiao and tonifying the kidney, and dispelling cold and relieving pain, and is used for treating cold pain of waist and knees, deficiency-cold stomachache, chronic dyspepsia, abdominal pain, vomiting and diarrhea, and amenorrhea due to cold.

The ligusticum wallichii is used for activating blood and promoting qi, dispelling wind and relieving pain, and is pungent, warm, fragrant and dry in flavor and is out of the way; promoting blood circulation and removing blood stasis, and is suitable for various diseases caused by blood stasis; it has good effect in dispelling pathogenic wind and relieving pain, and can be used for treating headache, rheumatalgia, etc.

Rhizoma anemarrhenae, bitter and cold; entering lung, stomach and kidney meridians; clearing heat and purging fire, nourishing yin and moistening dryness; feverish sensation with polydipsia, cough due to lung heat, hectic fever due to yin-deficiency, internal heat, diabetes, constipation due to intestinal dryness.

Turmeric root-tuber, pungent, bitter and cold; entering liver, heart and lung meridians; promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice.

Polygala root, bitter, pungent and warm; the heart, kidney and lung meridians are entered; induce tranquilization, improve intelligence and relieve depression. It is indicated for palpitation, amnesia, nocturnal emission, insomnia, cough with excessive phlegm, abscess, deep-rooted carbuncle, sore and swelling.

Long Gu has the actions of tranquilizing mind, calming liver and suppressing yang hyperactivity, inducing astringency and astringing. It is commonly used for palpitation, insomnia, amnesia, fright epilepsy, mania, dizziness, night sweat, spermatorrhea, enuresis, metrorrhagia, leukorrhagia, chronic diarrhea, chronic dysentery, ulcer, and eczema.

The fried jujube kernel contains natural glycoside substances, a large amount of unsaturated fatty acids, abundant vitamin C and mineral substances such as amino acids, ferrum, phosphorus, zinc and the like. Has effects of tranquilizing, promoting sleep, relieving convulsion, and reducing anxiety, insomnia, dreaminess, depression, and other adverse symptoms.

Baizi ren has the functions of nourishing heart, tranquilizing, moistening intestine, relaxing bowels and arresting sweating. Can be used for treating yin and blood deficiency, vexation, insomnia, palpitation, constipation due to intestinal dryness, and night sweat due to yin deficiency.

Further, the composition disclosed in the above technical scheme is optimized, and specifically, the following preferable scheme can be adopted, and the composition comprises the following components in parts by weight: 10 parts of vinegar radix bupleuri, 12 parts of vinegar rhizoma cyperi, 30 parts of cortex albiziae, 30 parts of tuber fleeceflower stem, 10 parts of tree peony bark, 6 parts of scorched gardenia, 6 parts of coptis root, 6 parts of cinnamon, 10 parts of ligusticum wallichii, 10 parts of rhizoma anemarrhenae, 15 parts of radix curcumae, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of fried jujube kernel, 30 parts of platycladi seed and 30 parts of Zhubo beef heart.

Further, the amber beef heart disclosed in the technical scheme is explained in detail, and specifically, the amber beef heart comprises the following components in parts by weight: 9-11 parts of cinnabar, 81-99 parts of amber powder and a proper amount of fresh beef heart slices.

Still further, the amber beef heart disclosed in the technical scheme is explained in detail, and the amber beef heart comprises the following components in parts by weight: 10 parts of cinnabar, 90 parts of amber powder and a proper amount of fresh beef heart slices.

The invention also provides a preparation method of the composition, aiming at quickly preparing the composition, and realizing mass production and application.

a process for preparing the above composition comprising the steps of:

preparing a Zhupo beef heart;

taking vinegar radix bupleuri, vinegar rhizoma Cyperi, cortex Albizziae, caulis Polygoni Multiflori, cortex moutan, fructus Gardeniae preparata, Coptidis rhizoma cortex Cinnamomi, rhizoma Ligustici Chuanxiong, rhizoma anemarrhenae, radix Curcumae, cortex et radix Polygalae, Os Draconis, parched semen Ziziphi Spinosae and semen Platycladi according to a certain proportion, pulverizing the above components, and sieving to separate coarse powder and fine powder;

mixing the coarse powder with water to obtain medicinal liquid, cooking semen Setariae in the medicinal liquid, wrapping the fine powder with semen Setariae to obtain pill.

Further, optimize the technical scheme disclosed in the above-mentioned technical scheme, explain especially the process of preparing zhupo beef heart, it is specific, prepare zhupo beef heart includes:

taking cinnabar in proportion;

taking amber according to a certain proportion and grinding the amber into fine powder;

taking healthy fresh beef hearts and cutting into slices;

mixing Cinnabaris, Succinum fine powder and Cor bovis Seu Bubali slice, stirring, and sun drying.

Further, the above technical scheme discloses a step of separating coarse powder and fine powder, and specifically, a 100-mesh sieve is adopted to separate the crushed coarse powder and fine powder.

Further, the above technical scheme discloses a step of preparing a liquid medicine by using coarse powder, and the specific preparation method is that the coarse powder is mixed with water to prepare the liquid medicine, and the steps of water soaking, decoction, filtration and concentration are included.

Compared with the prior art, the invention has the beneficial effects that:

the invention can well relieve the sleep disorder caused by anxiety and depression, so that the patient can fundamentally relieve the problem and does not have side effect on the human body.

Detailed Description

The present invention is further illustrated below with reference to specific examples.

It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. Specific structural and functional details disclosed herein are merely illustrative of example embodiments of the invention. This invention may, however, be embodied in many alternate forms and should not be construed as limited to the embodiments set forth herein.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises," "comprising," "includes," and/or "including," when used herein, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, numbers, steps, operations, elements, components, and/or groups thereof.

In the following description, specific details are provided to facilitate a thorough understanding of example embodiments. However, it will be understood by those of ordinary skill in the art that the example embodiments may be practiced without these specific details. In other instances, well-known processes, structures and techniques may be shown without unnecessary detail in order to avoid obscuring example embodiments.

Example 1

The embodiment discloses a composition for treating sleep disorder caused by depression or anxiety, which comprises the following components in parts by weight: 9-11 parts of vinegar radix bupleuri, 10-14 parts of vinegar rhizoma cyperi, 27-33 parts of cortex albiziae, 27-33 parts of tuber fleeceflower stem, 9-11 parts of tree peony bark, 5-7 parts of scorched gardenia, 5-7 parts of coptis chinensis, 5-7 parts of cinnamon, 9-11 parts of ligusticum wallichii, 9-11 parts of rhizoma anemarrhenae, 13-17 parts of radix curcumae, 9-11 parts of polygala tenuifolia, 27-33 parts of keel, 27-33 parts of fried jujube kernel, 27-33 parts of platycladi seed and 27-33 parts of Zhubo beef heart.

Wherein, the efficacies of part of the components are as follows:

The amber beef heart disclosed in the technical scheme is explained in detail, and specifically, the amber beef heart comprises the following components in parts by weight: 9-11 parts of cinnabar, 81-99 parts of amber powder and a proper amount of fresh beef heart slices.

Example 2

The embodiment discloses a composition for treating sleep disorder caused by depression or anxiety, and different from the embodiment 1, the embodiment optimizes the composition components disclosed in the technical scheme, and specifically adopts a preferable scheme as follows, wherein the composition comprises the following components in parts by weight:

10 parts of vinegar radix bupleuri, 12 parts of vinegar rhizoma cyperi, 30 parts of cortex albiziae, 30 parts of tuber fleeceflower stem, 10 parts of tree peony bark, 6 parts of scorched gardenia, 6 parts of coptis root, 6 parts of cinnamon, 10 parts of ligusticum wallichii, 10 parts of rhizoma anemarrhenae, 15 parts of radix curcumae, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of fried jujube kernel, 30 parts of platycladi seed and 30 parts of Zhubo beef heart.

The amber beef heart disclosed in the technical scheme is explained in detail, and the amber beef heart comprises the following components in parts by weight: 10 parts of cinnabar, 90 parts of amber powder and a proper amount of fresh beef heart slices.

Example 3

This example discloses a process for preparing the composition disclosed in the above examples, comprising the steps of:

preparing a Zhupo beef heart;

To optimizing the technical scheme who discloses among the above-mentioned technical scheme, especially explain the process of preparation zhupo beef heart, it is specific, preparation zhupo beef heart includes:

taking cinnabar in proportion;

taking healthy fresh beef hearts and cutting into slices;

The technical scheme discloses a step of separating coarse powder and fine powder, and particularly, the coarse powder and the fine powder which are crushed are separated by adopting a 100-mesh sieve.

The above technical scheme discloses a step of preparing a liquid medicine by using coarse powder, and the specific preparation method is that the coarse powder is mixed with water to prepare the liquid medicine, and the steps of water soaking, decoction, filtration and concentration are included.

Specifically, this embodiment also exemplifies a more specific manufacturing process:

the upper ten doses, totaling 2450 g.

Pulverizing and sieving with 100 mesh sieve, collecting fine powder about 1500 g, adding 3000 ml of cold water into the rest coarse powder, soaking for 60 min, decocting for 60 min, filtering with 100 mesh gong, and collecting filtrate about 1000 ml;

adding about 3000 ml of cold water into the dregs of a decoction, decocting for 60 minutes, filtering by using a 100-mesh gong, taking about 2000 ml of filtrate, and discarding the dregs of a decoction. Mixing the two filtrates, taking about 300 g of millet, cooking, and cutting into pieces which can not be boiled to be full (blossom).

Taking the millet out for later use, and continuously decocting the liquid medicine to 1500 ml.

The medicinal powder, millet and the liquid medicine are sequentially put into a pill making machine, and the finished product is dried, polished and packaged (6 g in one bag).

The use method comprises the following steps: one bag is taken every time, warm water is delivered 30 minutes after meals twice a day in the morning and at night, and one month is a treatment course.

The effect of the composition is remarkable, and the composition is used for a part of cases:

case 1:

xueze, woman, age 39, visit before mainly complaining of "depressed mood, insomnia and anorexia" for 1 year ", diagnosis and treatment of" depression "in local hospital, taking sertraline 100mg/d half a year ago, taking Chinese patent medicine (detailed content is unknown) in combination, taking for 2 months with insistence, poor effect, local hospital changing therapeutic scheme of venlafaxine 150mg/d, taking Chinese patent medicine (detailed content is unknown), taking for 1 month, patient still is not good sleep, difficulty in going to sleep, dreaminess, early awakening, depressed mood with anxiety, and found that blood pressure is raised by 15mmhg, compared with the height before taking medicine. The patient has strong appeals to sleep, deep pain experience, low mood and anxiety, and the treatment scheme is reset according to the disease characteristics of the patient: the medicine composition has the advantages that the mirtazapine content is 30mg/d, the alprazolam content is 0.4-0.8mg/d, the patient can be subjected to a double-diagnosis after taking the medicine for half a month, the effect is good, the sleeping time can be maintained for about 6 hours, but the sleeping quality is poor, dreaminess exists, hangover reaction occurs on the next day, and when the alprazolam is gradually stopped, the insomnia symptom of the patient rebounds and the medicine withdrawal is difficult. By administering 30mg/d of mirtazapine and taking the composition disclosed in the embodiment together with the administration of the composition, the administration of the composition stops the administration of alprazolam, the sleep is improved obviously, the sleep time can be prolonged to 6-7 hours, no sleepiness and discomfort are caused the next day, and after the administration of the mirtazapine and the composition for more than 20 days, the mood and sleep symptoms of patients are obviously improved and the patients return to normal life.

Case 2:

zhangyi, male, 43 years old, take a diagnosis with 'insomnia with emotional anxiety for 3 months' as the chief complaint, the patient has insomnia, difficulty in falling asleep, frequent insomnia all over night, dysphoria, irritability, spleen qi generation, emotional anxiety, inattention, and incapability of staying at work before 3 months, the patient has been on duty for 1 month before taking the composition provided by the embodiment, the patient can take a double-diagnosis after 20 days, sleep for 4-5 hours every day, sleep quality is satisfied, next day emotion is stable, the patient can engage in housework with mood, after 40 days of taking the medicine, the sleep time of one day can be maintained for more than 6 hours, and the patient can return to the work position.

The present invention is not limited to the above-described alternative embodiments, and various other embodiments can be obtained by those skilled in the art from the above-described embodiments in any combination, and any other embodiments can be obtained in various forms while still being within the spirit of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.

Claims

1. The composition for treating sleep disorder caused by depression or anxiety is characterized by comprising the following components in parts by weight: 9-11 parts of vinegar radix bupleuri, 10-14 parts of vinegar rhizoma cyperi, 27-33 parts of cortex albiziae, 27-33 parts of tuber fleeceflower stem, 9-11 parts of tree peony bark, 5-7 parts of scorched gardenia, 5-7 parts of coptis chinensis, 5-7 parts of cinnamon, 9-11 parts of ligusticum wallichii, 9-11 parts of rhizoma anemarrhenae, 13-17 parts of radix curcumae, 9-11 parts of polygala tenuifolia, 27-33 parts of keel, 27-33 parts of fried jujube kernel, 27-33 parts of platycladi seed and 27-33 parts of Zhubo beef heart.

2. The composition for treating sleep disorders due to depression or anxiety according to claim 1, comprising the following ingredients in parts by weight: 10 parts of vinegar radix bupleuri, 12 parts of vinegar rhizoma cyperi, 30 parts of cortex albiziae, 30 parts of tuber fleeceflower stem, 10 parts of tree peony bark, 6 parts of scorched gardenia, 6 parts of coptis root, 6 parts of cinnamon, 10 parts of ligusticum wallichii, 10 parts of rhizoma anemarrhenae, 15 parts of radix curcumae, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of fried jujube kernel, 30 parts of platycladi seed and 30 parts of Zhubo beef heart.

3. The composition for treating sleep disorders due to depression or anxiety according to claim 1 or 2, wherein the Zhu Bo heart comprises the following ingredients in parts by weight: 9-11 parts of cinnabar, 81-99 parts of amber powder and a proper amount of fresh beef heart slices.

4. The composition for treating sleep disorders due to depression or anxiety according to claim 3, wherein the Zhu Bo heart comprises the following ingredients in parts by weight: 10 parts of cinnabar, 90 parts of amber powder and a proper amount of fresh beef heart slices.

5. A process for preparing the composition according to any one of claims 1 to 4, characterized in that it comprises the following steps:

preparing a Zhupo beef heart;

taking vinegar radix bupleuri, vinegar rhizoma Cyperi, cortex Albizziae, caulis Polygoni Multiflori, cortex moutan, fructus Gardeniae preparata, rhizoma Coptidis, cortex Cinnamomi, rhizoma Chuanxiong, rhizoma anemarrhenae, radix Curcumae, radix Polygalae, Os Draconis, semen Ziziphi Spinosae and semen Platycladi at a certain proportion, pulverizing the above components, and sieving to separate coarse powder and fine powder;

6. The method of preparing a composition of claim 5, wherein preparing a Zhuper heart comprises:

taking cinnabar in proportion;

taking healthy fresh beef hearts and cutting into slices;

7. The method of preparing a composition according to claim 5, wherein: and separating the crushed coarse powder and fine powder by using a 100-mesh sieve.

8. The method of preparing a composition according to claim 5, wherein: mixing the coarse powder with water to obtain medicinal liquid, and soaking in water, decocting, filtering, and concentrating.