CN110652472A - Method for improving aging appearance of human body by using skin physiotherapy formula of deep sea concentrate - Google Patents
Method for improving aging appearance of human body by using skin physiotherapy formula of deep sea concentrate Download PDFInfo
- Publication number
- CN110652472A CN110652472A CN201811563016.8A CN201811563016A CN110652472A CN 110652472 A CN110652472 A CN 110652472A CN 201811563016 A CN201811563016 A CN 201811563016A CN 110652472 A CN110652472 A CN 110652472A
- Authority
- CN
- China
- Prior art keywords
- concentrate
- agent
- fiber membrane
- use according
- power supply
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012141 concentrate Substances 0.000 title claims abstract description 63
- 238000000554 physical therapy Methods 0.000 title claims abstract description 57
- 238000000034 method Methods 0.000 title claims abstract description 42
- 230000032683 aging Effects 0.000 title description 6
- 239000012528 membrane Substances 0.000 claims abstract description 53
- 239000000835 fiber Substances 0.000 claims description 43
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 27
- 238000009472 formulation Methods 0.000 claims description 19
- 102000008186 Collagen Human genes 0.000 claims description 14
- 108010035532 Collagen Proteins 0.000 claims description 14
- 229920001436 collagen Polymers 0.000 claims description 14
- 230000005611 electricity Effects 0.000 claims description 10
- 239000011575 calcium Substances 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 7
- 239000011707 mineral Substances 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000011777 magnesium Substances 0.000 claims description 6
- 229910052749 magnesium Inorganic materials 0.000 claims description 6
- 239000011591 potassium Substances 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 230000035755 proliferation Effects 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 230000002500 effect on skin Effects 0.000 claims description 3
- 230000003020 moisturizing effect Effects 0.000 claims description 3
- 230000000638 stimulation Effects 0.000 claims description 3
- 230000002087 whitening effect Effects 0.000 claims description 3
- 230000005484 gravity Effects 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 230000037303 wrinkles Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 49
- 239000013535 sea water Substances 0.000 description 28
- 230000000694 effects Effects 0.000 description 19
- 239000000047 product Substances 0.000 description 14
- 230000008859 change Effects 0.000 description 13
- 238000010586 diagram Methods 0.000 description 12
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 11
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 11
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 description 11
- 102100030416 Stromelysin-1 Human genes 0.000 description 11
- 206010040954 Skin wrinkling Diseases 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 6
- 201000003004 ptosis Diseases 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 210000004709 eyebrow Anatomy 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000006872 improvement Effects 0.000 description 4
- JIRXORZYIXSWOB-UHFFFAOYSA-N n-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide Chemical compound COC1=CC=C(S(=O)(=O)N(CC(C)C)CC(=O)NO)C=C1 JIRXORZYIXSWOB-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 235000002673 Dioscorea communis Nutrition 0.000 description 3
- 241000544230 Dioscorea communis Species 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 3
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 3
- 208000035753 Periorbital contusion Diseases 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 239000005416 organic matter Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 229910052790 beryllium Inorganic materials 0.000 description 2
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 2
- -1 but not limited to Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 239000011733 molybdenum Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010002482 Angiosclerosis Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 229910000861 Mg alloy Inorganic materials 0.000 description 1
- VEQPNABPJHWNSG-UHFFFAOYSA-N Nickel(2+) Chemical compound [Ni+2] VEQPNABPJHWNSG-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- LCKIEQZJEYYRIY-UHFFFAOYSA-N Titanium ion Chemical compound [Ti+4] LCKIEQZJEYYRIY-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- XHCLAFWTIXFWPH-UHFFFAOYSA-N [O-2].[O-2].[O-2].[O-2].[O-2].[V+5].[V+5] Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[V+5].[V+5] XHCLAFWTIXFWPH-UHFFFAOYSA-N 0.000 description 1
- MMDJDBSEMBIJBB-UHFFFAOYSA-N [O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[NH6+3] Chemical compound [O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[NH6+3] MMDJDBSEMBIJBB-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 150000005323 carbonate salts Chemical class 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010909 chemical acidification Methods 0.000 description 1
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910001935 vanadium oxide Inorganic materials 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a method for improving the appearance of skin by using a skin physiotherapy formula of a deep sea concentrate; the method comprises providing a first preparation, a second preparation and a fibrous membrane, applying on the surface of the affected part, and applying with a physiotherapy instrument. The current applied by the physiotherapy instrument is 0.1-0.8 mA/cm2。
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to a method for improving the appearance of skin by using a deep sea concentrate skin physiotherapy formula; the method comprises providing deep sea concentrate, skin physiotherapy formula and fiber membrane, and applying on the affected part surface, and is especially suitable for application with physiotherapy equipment.
[ background of the invention ]
Ocean deep water (DSW) is low temperature, clean and pollution-free seawater taken below sea level by 200 meters, and its characteristics include (1) cleanliness: the deep seawater is different from the surface seawater, the deep seawater is not affected by artificial pollution, and bacteria can be gradually reduced along with the depth due to decomposition effects of chemical acidification, precipitation, migration diffusion and the like in the process of precipitation of the surface seawater. The deep sea has no organic matter precipitate and no nitrate nitrogen supply, and this makes it difficult for bacteria to propagate. Therefore, the content of various harmful bacteria or germs causing pathological changes in the deep seawater is very rare, and is only one thousandth to one ten thousandth of the surface water. Furthermore, the resistance of the organic matter remaining in the deep seawater to the action of the microbial decomposition residue organic matter is stable, and this is why the deep seawater is microbiologically or physicochemically stable, inorganic and clean. (2) Low temperature: because the sunlight cannot irradiate the deep seawater, the water temperature is lower than that of the surface seawater, and the temperature does not change relatively obviously, so that the low-temperature stable state is maintained throughout the year. (3) Rich inorganic nutrient salt: because deep seawater is not sufficiently lighted, and organisms cannot perform photosynthesis, essential nutrient salts, such as nitrogen, phosphorus, silicon, nitric acid and the like, required by the vegetative plankton cannot be consumed, and a large amount of nutrient salts are accumulated in the deep seawater. (4) Aging stability: the influence of high pressure and absolute atmospheric pressure makes the deep seawater stable in composition for a long time. (5) Mineral-rich property: minerals in the sea mainly come from rock stratum and are flushed to the sea through rainwater to form water-soluble minerals which are uniformly distributed in the sea water.
In recent years, deep seawater has been widely used in food processing industry, agriculture, and medicine. Research literature indicates that the deep seawater can reduce blood fat, lipid oxidation, angiosclerosis and hypertension, and can also reduce vascular wall hyperplasia; although it has been found that patients who drink or soak deep seawater can improve the symptoms of skin inflammation and allergy in the research of atopic dermatitis, it has not been applied in the cosmetic industry on a large scale. In addition, drinking deep ocean water has also been found to improve cataracts. It has been reported in the literature that deep ocean water can stimulate the regeneration of collagen, whiten skin, and inhibit or treat inflammation.
Various cosmetics or care products on the market are macromolecular and deep sea concentrates have high surface tension, so that the cosmetics or care products are not easy to be absorbed by skin. Furthermore, the deep seawater concentrate or deep seawater mixed with skin care product and cosmetic can deteriorate after a certain period of time. Therefore, the skin care product and the cosmetics are not suitable to be placed for too long after being mixed with the deep seawater concentrate or the deep seawater, and the invention provides a method for applying the deep seawater concentrate skin physical therapy formula on the affected part, which can solve the problems, and ensure that the skin care product and the deep seawater concentrate quickly penetrate through a sebum membrane to reach a dermis layer, so that the appearance and the appearance of a patient are improved.
[ summary of the invention ]
In view of the above, the present invention provides a method for improving the appearance of aging by using a skin treatment formulation of a marine deep concentrate. The skin physiotherapy formula of the deep ocean concentrate is characterized by immediately micronizing the skin physiotherapy formula, immediately reducing the high surface tension of the deep ocean concentrate, solving the problem that the skin is not easy to absorb and the material characteristics of the deep ocean concentrate, serving as a penetration Driving Force (Driving Force) of the micronized skin physiotherapy formula, and being matched with a physiotherapy instrument for use, so that the skin physiotherapy formula can quickly penetrate through a sebum membrane to reach a dermis layer, and the effects of slowing down the loss of collagen and resisting aging are achieved.
The invention provides a method of using a deep ocean concentrate skin treatment formulation comprising the steps of (a) providing a first agent, wherein the first agent is a deep ocean concentrate; (b) providing a second dose, wherein the second dose is a dermatological treatment formulation; (c) providing a fiber membrane, and soaking the fiber membrane in the second agent and then in the first agent to form a soaked fiber membrane; (d) immediately applying the infiltrated fiber membrane on the surface of the affected part; (e) applying a physiotherapy instrument on the infiltrated fiber membrane, wherein the current applied by the physiotherapy instrument per square centimeter is 0.1 mA-0.8 mA, and the application time per square centimeter is 15-30 seconds; wherein the first and second agents are caused to rapidly penetrate the sebaceous membrane to the dermal layer and to stimulate collagen proliferation by the step (e).
Preferably, wherein the effective concentration of the first agent in the infiltrated fiber membrane is at least greater than or equal to 1.25 (v/v)%.
Preferably, in step (d), the infiltrated fiber membrane is applied to the affected area within 10 minutes.
Preferably, in step (e), the physiotherapy instrument is applied to the infiltrated fiber membrane within 10 minutes.
Preferably, wherein the affected part is a face, an arm, an abdomen, or a leg.
Preferably, the current applied by the physiotherapy instrument is 0.1 mA-0.8 mA/cm according to the size and the position of the fiber membrane used by the affected part2The application time is 15-30 seconds/cm of the affected part film2。
Preferably, the magnesium concentration of the first agent is 6500-110000 mg/l, the sodium concentration is 3800-30000 mg/l, the potassium concentration is 400-18000 mg/l, and the calcium concentration is 100-500 mg/l. The hardness is 80000-420000 mg/l, and the salinity is 380-430 per mill. The first agent contains 1000-1500 mg of calcium, 1400-2100 mg of magnesium, 2000-4000 mg of sodium, 1400-2100 mg of potassium and sulfate radical of less than 6.5 wt% per 100g of the first agent, and the specific gravity of the first agent is 1.17-1.32g/cm3A solution of marine minerals of (a). Preferably, the first agent is taken from a water source below 200m of the ocean; preferably, the first agent is taken from a water source below 500m of the ocean. Preferably, the first agent is liquid or powder.
Preferably, the second agent is an anti-aging, anti-lifting, tightening, whitening, moisturizing, medical or cosmetic introducing product, or a collagen proliferation promoting product. Preferably, the second agent is gel-like.
Preferably, the physiotherapy instrument comprises a power supply device and a sensor, wherein the power supply device comprises an outer surface and an inner device; the external surface of the power supply device comprises an operation panel, a power supply device and a control device, wherein the operation panel is arranged on the side surface of the physiotherapy instrument so as to provide a control instruction and regulate and control direct current output by the power supply device, and the direct current is combined by positive electricity and negative electricity with different intensities and different time proportions; a sensor connection hole for externally connecting the sensor, the sensor connection hole having a stable current detection circuit electrically connected to the control circuit and the sensor connection hole for amplifying a voltage of the stimulus current; the power input end is arranged on the other side surface of the physiotherapy instrument and used for providing power for the power supply device, and the power input end is provided with a plurality of safety circuits which are electrically connected with the control circuit and the power input end and used for controlling different voltages of the power supply; wherein, the control circuit is arranged in the power supply device, the control circuit is electrically connected with the operation panel to obtain the control instruction, the power supply is obtained by the power supply input end, and the direct current is output through the sensor connecting hole; and a switching valve circuit which controls the positive and negative electricity of the direct current by the selection of the control instruction; the sensor is externally connected with the sensor connecting hole of the power supply device through a wire, and is provided with a discharging end with a specific area interface, so that the direct current outputs the stimulation current through the sensor.
Preferably, the current applied by the physiotherapy instrument is 2 mA-25 mA, preferably, the current is changed according to the size of the fiber membrane, the current is applied to each square centimeter at 0.1-0.8 mA, and the application time is 15-30 seconds/cm of the fiber membrane of the affected part2。
Preferably, the second agent is used in an amount of 0.4 grams per square centimeter, depending on the size of the fibrous membrane.
To achieve the foregoing and other objects, one or more specific embodiments of the present invention are described below. Other features and advantages of the invention are described in detail in the examples.
[ description of the drawings ]
Fig. 1 is a schematic diagram of the aging appearance change of the human face.
Fig. 2A is a schematic diagram of an eye before use of the method of the present invention.
Figure 2B is a schematic view of the eye after use of the method of the invention for the eye,
fig. 2C is a schematic eye diagram of the day after the use of the method for using the eye part of the invention, and fig. 2A-2C show the change of the black eye circle and the crow's feet of the eye part before and after the use of the method for using the invention.
Fig. 2D is a schematic diagram of the eye before use of the method of the present invention.
Fig. 2E is a schematic diagram of an eye after the use of the method of the present invention for the eye.
Fig. 2F is a schematic eye diagram of the method of use of the present invention one day after use of the eye, and fig. 2D-2F show the change of the method of use of the present invention for the anterior and posterior eye.
Fig. 3A is a schematic view of the face before use of the method of the present invention.
FIG. 3B is a schematic view of the face on the fourth day after use of the method of the present invention for facial treatment.
Fig. 3C is a schematic view of the face at the fifth day after the use of the method of the present invention for the face, and fig. 3A to 3C show the change of the statute and puppet grain of the face before and after the use of the method of the present invention for the face.
FIG. 3D is a schematic diagram of a face before the method of use of the present invention is applied to the face.
FIG. 3E is a schematic diagram of a face after the use of the method of the present invention on the face, FIGS. 3D-3E show the change of the facial grain and puppet grain before and after the use of the method of the present invention on the face
FIG. 4A is a schematic diagram of a face before the method of use of the present invention is applied to the face.
Fig. 4B is a schematic view of the face after the method of use of the present invention is applied to the face, and fig. 4A-4B show the change in neck laxity (i.e., double chin) before and after the method of use of the present invention is applied to the face.
Fig. 5 is a schematic diagram of a control circuit of the physiotherapy instrument.
FIG. 6A shows the effect of deep sea concentrate on inhibiting the enzymatic activity of matrix metalloproteinase-1.
FIG. 6B shows the effect of deep sea concentrate on inhibiting the enzymatic activity of matrix metalloproteinase-3.
FIG. 7 is the effect of deep ocean concentrate on increasing collagen secretion.
[ detailed description ] embodiments
The invention provides a method for improving the appearance of a deep sea concentrate skin physiotherapy formula.
Described in the invention "The deep sea water is sea water 200-1500 m below sea level, preferably 500-700 m below sea level, and each 100g of the sea water solution contains calcium 1000-1500 mg, magnesium 1400-2100 mg, sodium 2000-4000 mg, potassium 1400-2100 mg, sulfate radical less than 6.5 wt% and specific weight of 1.17-1.32g/cm3A solution of marine minerals of (a).
The "deep sea concentrate" in the invention refers to liquid or powder produced by concentrating deep sea water. The deep sea concentration process includes fiber filtering system, ultrafiltering system, reverse sea water permeating system, low temperature vacuum evaporating and concentrating system and/or centrifuging.
The deep sea concentrate has a hardness of 80000-420000 mg/l, a salinity of 380-430 ‰, a magnesium concentration of 6500-110000 mg/l, and a sodium concentration of 3800-30000 mg/l. The deep ocean concentrate of the present invention is rich in various minerals including, but not limited to, trace elements such as calcium (Ca), potassium (K), iron (Fe), zinc (Zn), molybdenum (Mo), manganese (Mn), lithium (Li), strontium (Sr), copper (Cu), silicon (Si), etc. In one embodiment, the composition of the concentrate is shown in table one, but the concentrate of the present invention is not limited thereto since the detection unit does not complete the complete element detection.
Ingredients of epi-I, deep sea concentrate
| Formulation 1 | |
Formulation 1 | |
||
| Potassium salt | 0.53％ | 1.4％ | HCO3 | N/A | N/A |
| Calcium carbonate | 13.9ppm | 8.92ppm | Carbonate salt | N/A | N/A |
| Titanium (IV) | 0.03ppm | N.D. | Aluminium | N.D. | N.D. |
| Vanadium oxide | 2.21ppm | 0.54ppm | Antimony (Sb) | N.D. | N.D. |
| Manganese oxide | N.D. | N.D. | Arsenic (As) | 1.52ppm | 0.13ppm |
| Iron | 0.09ppm | 0.04ppm | Beryllium (beryllium) | N.D. | N.D. |
| Copper (Cu) | 0.03ppm | 0.02ppm | Boron | 235.1ppm | 0.31ppm |
| Zinc | 0.53ppm | N.D. | Chromium (III) | 0.30ppm | 0.14ppm |
| Bromine compound | N.D. | N.D. | Cobalt | 0.22ppm | 0.03ppm |
| Strontium salt | N.D. | N.D. | Molybdenum (Mo) | 0.59ppm | 0.29ppm |
| Lead (II) | N.D. | N.D. | Nickel (II) | 0.26ppm | 0.07ppm |
| Cadmium (Cd) | N.D. | N.D. | Mercury | N.D. | N.D. |
| Magnesium alloy | 9.1％ | 4.6％ | Barium salt | N.D. | N.D. |
| Selenium | N.D. | N.D. | Fluorine | N.D. | N.D. |
| Lithium ion source | 29.74ppm | 9.3ppm | Iodine | 3.8ppm | 1.0ppm |
| Sodium salt | 0.53％ | 10％ | SO4 | N.D. | N.D. |
The "fibrous membrane" as used herein refers to a face membrane of ultra-fine long fibers.
The term "impregnated fiber membrane" as used herein refers to a fiber membrane impregnated with the skin treatment formulation and the deep ocean concentrate, which is a mixture of the deep ocean concentrate and the skin treatment formulation.
The skin physical therapy formula refers to a general gel state formula product and a formula used in a treatment course in a beauty-related institution. For example, skin whitening products, moisturizing products, wrinkle removing products, wound healing products, quick healing treatment products and the like can improve the appearance of skin.
The "mixture of the deep sea concentrate and the skin treatment formula" or "mixture of the first agent and the second agent" of the invention means that after the fiber membrane is soaked in the skin treatment formula and the deep sea concentrate, the deep sea concentrate is mixed in the skin treatment formula, namely the fiber membrane contains a mixture of the deep sea concentrate and the skin treatment formula.
However, deep ocean concentrates can cause skin treatment formulations to deteriorate, destabilize and disintegrate after a period of time after the deep ocean concentrate is mixed into the skin treatment formulation. Therefore, the fibrous membrane of the present invention is applied to the surface of the affected part after being impregnated with the second agent and then the first agent, and is used within 10 days, preferably within 9 days, 8 days, 7 days, 6 days, 5 days, 4 days, 3 days, 2 days, 1 day, and most preferably within 12 hours, 6 hours, 3 hours, 2 hours, and 1 hour after the completion of the impregnation.
After the deep sea concentrate is mixed into the skin physiotherapy formula, the skin physiotherapy formula is obviously deteriorated after only 10 days. In addition, the deep ocean concentrate can cause unknown sediments and floating matters in the skin physiotherapy formula, and the ions of the deep ocean concentrate can generate chemical changes with components if the deep ocean concentrate is mixed in the skin physiotherapy formula for a period of time, so that the effect of the original skin physiotherapy formula on skin is reduced, and even derivatives which can possibly harm the skin are generated.
The manner of impregnation of the fiber film is not particularly limited, and a general method may be used, for example, impregnation of the fiber film into a wrap bag containing a skin treatment formulation, and addition of the deep sea concentrate into the wrap bag to impregnate the fiber film into the deep sea concentrate. The time for soaking the fiber membrane in the skin treatment formulation is not particularly limited, but because the fiber membrane must be used as soon as possible after soaking in the concentrate to avoid deterioration of the quality of the skin treatment formulation, the fiber membrane should not be soaked in the concentrate to an excessive length, usually within 15 minutes, preferably within 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3 minutes, and most preferably within 10 minutes. The impregnated fibrous membrane should not be left for too long, but is usually applied to the affected area within 15 minutes, preferably within 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3 minutes, and most preferably within 10 minutes. It is also desirable to apply the physiotherapy instrument to the impregnated fibrous membrane as soon as possible after the impregnated fibrous membrane has been applied to the affected area surface, typically within 15 minutes, preferably within 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3 minutes, most preferably within 10 minutes.
As described above, the infiltrated fiber membrane must be applied to the affected part as soon as possible and introduced using a physical therapy instrument as soon as possible to prevent quality change of a physical therapy formulation for skin.
After the fiber membrane is soaked into the skin physiotherapy formula and the deep sea concentrate, the deep sea concentrate is mixed with the skin physiotherapy formula and can generate phase transfer immediately, so that molecules of the care product become small, and the deep sea concentrate and the skin physiotherapy formula are matched with a physiotherapy instrument to enable the mixture of the deep sea concentrate and the skin physiotherapy formula to easily penetrate through the sebum membrane and reach the dermis layer.
The method of use of this example was to impregnate the fibrous membrane with 0.4 grams per square centimeter of skin treatment formulation and then 0.4 grams per square centimeter of deep ocean concentrate, depending on the size of the fibrous membrane. And applying a physiotherapy instrument on the surface soaked with the fiber membrane, wherein the current applied by the physiotherapy instrument per square centimeter is 0.1 mA-0.8 mA, and the application time per square centimeter is 15-30 seconds.
Example 1.56 human face test results
The test subjects were 20-85 years old, women 37, men 19, and subjects who wanted to improve facial appearance, the age of the test subjects being shown in Table I.
TABLE I, tester age
| Age (year of old) | Ratio of |
| 20-29 | 7％ |
| 30-39 | 20％ |
| 40-49 | 31％ |
| 50-59 | 20％ |
| 60-69 | 20％ |
| 70-79 | 0％ |
| More than 80 | 2％ |
In one embodiment, the fibrous membrane is placed in a skin treatment formulationAnd pouring the deep sea concentrate into the preservative film to enable the fiber film to be soaked in the skin physiotherapy formula and then soaked in the deep sea concentrate to obtain the soaked fiber film. The infiltrated fiber membrane comprises a mixture of a deep ocean concentrate and a skin treatment formulation, wherein the effective concentration of the deep ocean concentrate is at least greater than or equal to 1.25 (v/v)%. Taking out the soaked fiber membrane, immediately applying the soaked fiber membrane on the surface of the face, and applying a physiotherapy instrument on the soaked fiber membrane, wherein the current applied by the physiotherapy instrument is changed according to the size of the fiber membrane, the current applied per square centimeter is 0.1-0.8 mA, and the application time is 15-30 seconds/cm of the affected part fiber membrane2。
The results are shown in Table two, Table three and FIGS. 2 to 4. Wherein, after the application, the fine lines on the face are improved, and the appearance problems of eye bags, drooping eyes, crow's feet, drooping eyelids, eyebrow lines, statue lines, puppet lines, chin lines, double chin, neck lines, black eye circles, acne scars which can be improved by invasive treatment in the prior art are also improved.
Fig. 2A shows the eye before the method of the invention, fig. 2B shows the eye change after the method of the invention, and fig. 2C shows the eye change one day after the method of the invention. In FIG. 2B, there are improvements in periocular fine lines, under-eye puffiness, drooping of the tail, crow's feet, drooping of the eyelids, and eyebrow lines. In fig. 2C, there was a further improvement in periocular fine lines, under-eye puffiness, drooping tail, crow's feet, drooping eyelids, and brow marks.
Fig. 2D is the eye prior to use of the method of the invention, fig. 2E is the eye change after use of the method of the invention, and fig. 2F is the eye change one day after use of the method of the invention. In FIG. 2E, there are improvements in periocular fine lines, under-eye puffiness, drooping tail, crow's feet, drooping eyelids, and eyebrow lines. In FIG. 2F, there was a further improvement in periocular fine lines, under-eye puffiness, drooping tail, crow's feet, drooping eyelids, and brow marks.
Figures 3A-3C show comparative before and after use of the method of use of the present invention for whole faces showing changes in the whole face. Fig. 3A is before use, fig. 3B is the fourth day after use, and fig. 3C is the fifth day after use. In fig. 3B, fine lines, under-eye puffiness, drooping eye tails, crow's feet, drooping eyelids, eyebrow lines, statuary lines, puppet lines, chin lines, double chin lines, neck lines, and dark circles have been improved. In fig. 3C, the pouch, the drooping of the tail, the chin line, and the chin are further improved significantly, and the cheeks are pulled up significantly.
Fig. 3D and 3E are comparison diagrams showing the use method of the present invention before and after use of the face, showing changes in the whole face. Fig. 3D is before use and fig. 3E is after use. In fig. 3E, fine lines, under-eye puffiness, drooping eye tails, crow's feet, drooping eyelids, eyebrow lines, statuary lines, puppet lines, chin lines, double chin, neck lines, black eye circles, especially chin lines, and both sides of cheeks have a significant lifting effect.
Figures 4A-4B show a comparison of the method of use of the present invention before and after use on the face showing the change in neck laxity (i.e., double chin). Fig. 4A is before use and fig. 4B is after use. In fig. 4B, the neck relaxation is significantly improved, and the jaw pulling effect is significantly improved.
Table two, 56 human face test results
TABLE III, 56 human face test results
EXAMPLE 2 Physiotherapy equipment
The using method of the present invention is used in combination with a physiotherapy instrument, which can use a general commercially available physiotherapy instrument, preferably, referring to the schematic control circuit diagram of the physiotherapy instrument in fig. 5, the physiotherapy instrument comprises a power supply device and a sensor, wherein the power supply device comprises an outer surface and an inner surface; the external surface of the power supply device comprises an operation panel, a power supply device and a control device, wherein the operation panel is arranged on the side surface of the physiotherapy instrument so as to provide a control instruction and regulate and control direct current output by the power supply device, and the direct current is combined by positive electricity and negative electricity with different intensities and different time proportions; a sensor connection hole for externally connecting the sensor, the sensor connection hole further having a stable current detection circuit 127 electrically connected to the control circuit and the sensor connection hole for amplifying a voltage of the stimulus current; and a power input end arranged on the other side of the physiotherapy instrument for providing power to the power supply device, wherein the power input end is further provided with a plurality of safety circuits 125 which are electrically connected with the control circuit and the power input end for controlling different voltages of the power supply; wherein, the control circuit is arranged in the power supply device, the control circuit is electrically connected with the operation panel to obtain the control instruction, the power supply is obtained by the power supply input end, and the direct current is output through the sensor connecting hole, the device comprises a fixed actual measurement human body circuit 126 for controlling different intensities of the direct current; and a switching valve circuit which controls the positive and negative electricity of the direct current by the selection of the control instruction; the sensor is externally connected with the sensor connecting hole of the power supply device through a wire, and is provided with a discharging end with a specific area interface, so that the direct current outputs the stimulation current through the sensor.
Example 3 inhibition of collagen loss
Referring to FIG. 6A, FIG. 6B, Table III and Table IV, the inventor's research institute of the present invention investigated the inhibition of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) by deep ocean concentrates using in vitro experiments. Matrix metalloproteinase-1 and matrix metalloproteinase-3 are two of the known collagen catabolic enzymes, and in order to regulate important factors of photoaging, exposure of fibroblasts to ultraviolet rays of sunlight causes massive expression of matrix metalloproteinase, so that extracellular matrix (ECM) is degraded, namely MMP-1 and MMP-3 are responsible for degradation and loss of collagen in dermal tissue. This experiment confirmed that the deep sea concentrate has the function of inhibiting collagen loss, and NNGH (N-Isobutyl-N- (4-methoxyphenylsulfonyl) glycolic acid) is an MMP (matrix metalloproteinase) inactivating drug, and as can be seen from the experimental data in FIGS. 6A and 6B, the deep sea concentrate at a concentration of 0.5% can relatively inhibit matrix metalloproteinase-1 activity by 4.92% and matrix metalloproteinase-3 activity by 2.18% compared with the NNGH inhibition rate (VS.NNGH). The concentration of 1% of the marine deep concentrate inhibited matrix metalloproteinase-1 activity by 15.13% and matrix metalloproteinase-3 activity by 8.12%. The 2% concentration of the deep sea concentrate inhibited matrix metalloproteinase-1 activity by up to 23.93% and matrix metalloproteinase-3 activity by 27.71%. The experiment shows that the deep sea concentrate can effectively inhibit the enzyme activity of matrix metalloproteinase-1 and matrix metalloproteinase-3, and compared with the NNGH inhibition rate, the effect of inhibiting the activity of the matrix metalloproteinase-1 and the matrix metalloproteinase-3 is as high as 50%. The deep sea concentrate has the effect of inhibiting the loss of collagen, promotes skin cells to show a better health state, and is beneficial to the addition effect of all effective components aiming at the skin cells.
TABLE IV inhibition of matrix metalloproteinase-1
TABLE V inhibition of matrix metalloproteinase-3
Example 4 increasing collagen secretion
Referring to fig. 7, where n is 8, the mean standard deviation of the bar graph is p <0.05, the experiment shows the amount of collagen secreted by the deep sea concentrate with different concentrations, using the deep sea concentrate with concentration of 0-1% in combination with vitamin C.
Example 5 electronic State
The skin care formulation is mixed with the deep ocean concentrate to produce microparticle cell surface electrodes and their electrical charges (not shown), and the time ratio of the direct current positive and negative current application is designed according to the ratio.
All of the features disclosed in the present application may be implemented in any combination. Each feature disclosed in this specification may be replaced by an alternative feature serving the same, equivalent, or similar purpose. Thus, unless expressly stated otherwise, each feature disclosed is one example only of a generic series of equivalent or similar features.
[ notation ] to show
125 safety circuit
126 fixed actual measurement human body circuit
127 stable current detection circuit
Claims (11)
1. A use method of a skin physiotherapy formula of a deep sea concentrate is characterized by comprising the following steps:
(a) providing a first agent that is a deep ocean concentrate;
(b) providing a second dose, said second dose being a dermatological treatment formulation;
(c) providing a fiber membrane, and soaking the fiber membrane in the second agent and then in the first agent to form a soaked fiber membrane;
(d) immediately applying the infiltrated fiber membrane on the surface of the affected part;
(e) applying a physiotherapy instrument on the infiltrated fiber membrane, wherein the current applied by the physiotherapy instrument per square centimeter is 0.1 mA-0.8 mA, and the application time per square centimeter is 15-30 seconds;
wherein the first and second agents are caused to rapidly penetrate the sebaceous membrane to the dermal layer and to stimulate collagen proliferation by the step (e).
2. Use according to claim 1, characterized in that:
wherein the second agent is used in an amount of 0.4 g per square centimeter, depending on the size of the fibrous membrane.
3. Use according to claim 1, characterized in that:
wherein, in the infiltrated fiber membrane, the effective concentration of the first agent is greater than or equal to 1.25 (v/v)%.
4. Use according to claim 1, characterized in that:
wherein, in the step (d), the impregnated fiber membrane is applied to the surface of the affected part within 10 minutes.
5. Use according to claim 1, characterized in that:
wherein, in the step (e), the physiotherapy instrument is applied to the infiltrated fiber membrane within 10 minutes.
6. Use according to claim 1, characterized in that:
wherein the magnesium concentration of the first agent is 6500-110000 mg/l.
7. Use according to claim 1, characterized in that:
wherein the first agent has a sodium concentration of 3800-30000 mg/l, a potassium concentration of 400-18000 mg/l and a calcium concentration of 100-500 mg/l.
8. Use according to claim 1, characterized in that:
wherein the hardness of the first agent is 80000-420000 mg/l, and the salinity is 380-430 per mill.
9. Use according to claim 1, characterized in that:
wherein, each 100g of the first agent contains 1000-1500 mg of calcium, 1400-2100 mg of magnesium, 2000-4000 mg of sodium, 1400-2100 mg of potassium and sulfate radical less than 6.5 wt%, and the specific gravity is 1.17-1.32g/cm3A solution of marine minerals of (a).
10. Use according to claim 1, characterized in that:
wherein the second agent is whitening product, moisturizing product, wrinkle removing product, wound healing product, medical or cosmetic introducing product, and collagen proliferation promoting product.
11. Use according to claim 1, characterized in that:
wherein, the physiotherapy instrument comprises a power supply device and a sensor, the power supply device comprises an outer surface and an inner device,
the outer surface of the feeding device comprises:
the operation panel is arranged on the side surface of the physiotherapy instrument so as to provide a control instruction and regulate and control the direct current output by the power supply device, and the direct current is combined by positive electricity and negative electricity with different intensities and different time proportions;
the sensor connecting hole is used for being externally connected with the sensor and provided with a stable current detection circuit, and the stable current detection circuit is electrically connected with the control circuit and the sensor connecting hole and used for amplifying the voltage of the stimulating current; and
a power input end arranged at the other side of the physiotherapy instrument for providing power to the power supply device, the power input end is provided with a plurality of safety circuits electrically connected with the control circuit and the power input end for controlling different voltages of the power supply,
wherein the control circuit is provided in the interior of the power feeding device, the control circuit is electrically connected to the operation panel to obtain the control command and the power input terminal to obtain the power supply, and outputs the direct current via the sensor connection hole,
the control circuit includes:
fixing an actually measured human body circuit for controlling different intensities of the direct current; and
and the switch valve circuit is selected by the control instruction to control the positive electricity and the negative electricity of the direct current, the sensor is externally connected with the sensor connecting hole of the power supply device by an electric wire and is provided with a discharging end with a specific area interface, so that the direct current outputs the stimulation current through the sensor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW107122672A TWI712425B (en) | 2018-06-29 | 2018-06-29 | Skin physiotherapy formula of deep sea water concentrate for mature skin appearance improvement and the use thereof |
| TW107122672 | 2018-06-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110652472A true CN110652472A (en) | 2020-01-07 |
| CN110652472B CN110652472B (en) | 2023-04-07 |
Family
ID=69028811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811563016.8A Active CN110652472B (en) | 2018-06-29 | 2018-12-20 | Method for improving aging appearance of human body by using skin physiotherapy formula of deep sea concentrate |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110652472B (en) |
| TW (1) | TWI712425B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114425057A (en) * | 2020-10-15 | 2022-05-03 | 苏珍仪 | Care composition and use thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040267189A1 (en) * | 2001-10-24 | 2004-12-30 | Daniela Mavor | Device and method for controlled delivery of active substance into the skin |
| CN1787760A (en) * | 2003-06-17 | 2006-06-14 | 黄胜英 | Advanced handable skin care device and operating method thereof |
| TW200927182A (en) * | 2007-12-24 | 2009-07-01 | Stone & Resource Ind R & D Ct | Essence concentrate and lotion using deep seawater as its carrier |
| CN106999705A (en) * | 2014-09-29 | 2017-08-01 | Elc 管理有限责任公司 | The targeting of skin-care and treatment thing in facial mask or patch form using micro-current is delivered with personalized |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2768456B2 (en) * | 1995-12-22 | 1998-06-25 | 株式会社ジャパンギャルズ | Makeup mask |
| US9522267B2 (en) * | 2012-02-08 | 2016-12-20 | Derma Dream Group Ltd | Transdermal delivery device |
-
2018
- 2018-06-29 TW TW107122672A patent/TWI712425B/en active
- 2018-12-20 CN CN201811563016.8A patent/CN110652472B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040267189A1 (en) * | 2001-10-24 | 2004-12-30 | Daniela Mavor | Device and method for controlled delivery of active substance into the skin |
| CN1787760A (en) * | 2003-06-17 | 2006-06-14 | 黄胜英 | Advanced handable skin care device and operating method thereof |
| TW200927182A (en) * | 2007-12-24 | 2009-07-01 | Stone & Resource Ind R & D Ct | Essence concentrate and lotion using deep seawater as its carrier |
| CN106999705A (en) * | 2014-09-29 | 2017-08-01 | Elc 管理有限责任公司 | The targeting of skin-care and treatment thing in facial mask or patch form using micro-current is delivered with personalized |
Non-Patent Citations (1)
| Title |
|---|
| 陈华新等: "《水疗健康300问》", 31 October 2013 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114425057A (en) * | 2020-10-15 | 2022-05-03 | 苏珍仪 | Care composition and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI712425B (en) | 2020-12-11 |
| CN110652472B (en) | 2023-04-07 |
| TW202000178A (en) | 2020-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101100631B1 (en) | A topical composition comprising particulates comprising a first conductive material and a second conductive material | |
| KR101100630B1 (en) | A method of manufacturing a composition comprising particulates for administering electricity to a human | |
| US6544401B1 (en) | Biomimetic water solutions and compositions, their use as and in health and beauty care products and the methods to prepare them | |
| CN105055285B (en) | A kind of skin-nourishing liquid and preparation method thereof | |
| CN104473966A (en) | Electricity-generating particulates and the use thereof | |
| US20070190175A1 (en) | Skin care composition for dermatological disorders | |
| JP2007521238A (en) | Sponge-based therapeutic compositions for the treatment and prevention of skin diseases | |
| WO2014015443A1 (en) | Use of electrolysis water produced with the aid of diamond electrodes for the hydration, firming and care of skin, for the treatment of dermatoses, sunburn and general wounds | |
| CN105662899A (en) | Skincare product having functions of repairing scar and resisting wrinkle and preparation method thereof | |
| CN107693456A (en) | A kind of natural tea pasta frost and preparation method thereof | |
| CN108888562A (en) | A kind of eye mask and preparation method thereof | |
| CN106562891A (en) | Multifunctional anti-aging face application agent composition | |
| KR20050120751A (en) | Laser ionization therapy system and method | |
| CN110652472B (en) | Method for improving aging appearance of human body by using skin physiotherapy formula of deep sea concentrate | |
| CN111388349A (en) | Facial mask containing moisturizing and whitening essence and preparation method thereof | |
| IL122776A (en) | Gel composition for skin care and protection and a method for preparation thereof | |
| KR102114286B1 (en) | Cosmetic composition comprising enzyme-treated extract of agave syrup as active ingredient | |
| KR100762288B1 (en) | Bath liquid with high moisturizing and high amounts of minerals comprising deep sea water | |
| CN115429738B (en) | Acne-removing, repairing and reviving essence and preparation method thereof | |
| CN104287982B (en) | Dandruff removal composition for adjusting oil balance of scalp | |
| KR20180110357A (en) | Cosmetic composition for preventing oxidative stress comprising nephrite water and nephrite powder | |
| CN113827511A (en) | Anti-light damage plant seed oil transparent microemulsion composition and preparation method thereof | |
| KR100811594B1 (en) | Composites and preparation method of toothpsate containing sulfur salts produced the andes mountains | |
| JPH1160481A (en) | Iontophoretic liquid for skin preparation for external use | |
| CN108653164A (en) | It is a kind of to nourish quantum ion nutrient solution repaired and preparation method thereof and application for human body surface cell |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220614 Address after: 7/F, No. 6, 189 Lane, Yuxi Street, Yonghe District, New North City, Taiwan, China Applicant after: Su Zhenyi Address before: 7/F, No. 6, 189 Lane, Yuxi Street, Yonghe District, New North City, Taiwan, China Applicant before: Luo Yingming Applicant before: Su Zhenyi |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |