CN110650801B - 液体的离心气动式切换 - Google Patents

液体的离心气动式切换 Download PDF

Info

Publication number
CN110650801B
CN110650801B CN201880031223.0A CN201880031223A CN110650801B CN 110650801 B CN110650801 B CN 110650801B CN 201880031223 A CN201880031223 A CN 201880031223A CN 110650801 B CN110650801 B CN 110650801B
Authority
CN
China
Prior art keywords
liquid
fluid
chamber
downstream
fluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880031223.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN110650801A (zh
Inventor
英格玛·施瓦兹
尼尔斯·泡斯特
史蒂芬·泽纳尔
马克·凯勒
托拜厄斯·哈特森劳伯
弗兰克·施韦默尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hann-Schickard-Gesellschaft fuer Angewandte Forschung eV
Original Assignee
Hann-Schickard-Gesellschaft fuer Angewandte Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hann-Schickard-Gesellschaft fuer Angewandte Forschung eV filed Critical Hann-Schickard-Gesellschaft fuer Angewandte Forschung eV
Publication of CN110650801A publication Critical patent/CN110650801A/zh
Application granted granted Critical
Publication of CN110650801B publication Critical patent/CN110650801B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201880031223.0A 2017-03-10 2018-03-05 液体的离心气动式切换 Active CN110650801B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102017204002.5 2017-03-10
DE102017204002.5A DE102017204002B4 (de) 2017-03-10 2017-03-10 Zentrifugo-pneumatisches schalten von flüssigkeit
PCT/EP2018/055344 WO2018162413A1 (de) 2017-03-10 2018-03-05 Zentrifugo-pneumatisches schalten von flüssigkeit

Publications (2)

Publication Number Publication Date
CN110650801A CN110650801A (zh) 2020-01-03
CN110650801B true CN110650801B (zh) 2021-11-02

Family

ID=61563410

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880031223.0A Active CN110650801B (zh) 2017-03-10 2018-03-05 液体的离心气动式切换

Country Status (7)

Country Link
US (1) US11141728B2 (es)
EP (1) EP3592463B1 (es)
CN (1) CN110650801B (es)
DE (1) DE102017204002B4 (es)
ES (1) ES2864739T3 (es)
PL (1) PL3592463T3 (es)
WO (1) WO2018162413A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109894175B (zh) * 2019-04-11 2024-05-17 石家庄禾柏生物技术股份有限公司 一种流体控制模块
DE102019007512A1 (de) * 2019-10-29 2021-04-29 Lilian Labs GmbH Mikrofluidische Vorrichtung zur Aufnahme von Flüssigkeiten und zugehöriges Verfahren
US12023689B2 (en) * 2020-04-24 2024-07-02 Quommni Technologies Limited Fluidics device, apparatus, and method for partitioning fluid
DE102020207628B4 (de) 2020-06-19 2023-01-19 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Leiten eines flüssigkeitsflusses auf eine aktive festphase
DE102020210404B4 (de) 2020-08-14 2022-07-14 SpinDiag GmbH Verfahren zum Betrieb eines Analysegeräts, Verwendung einer Kartusche und Analysegerät
WO2022243369A1 (en) * 2021-05-20 2022-11-24 Blusense Diagnostics Aps Microfluidic device with improved venting structure
DE102021208891B3 (de) 2021-08-13 2022-10-13 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Unterdruckschalten von Flüssigkeit
DE102022203875B3 (de) 2022-04-20 2023-06-15 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Handhabung zweier flüssigkeitsvolumina
DE102023202639A1 (de) 2023-03-23 2024-09-26 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikmodul, Fluidhandhabungsvorrichtung und Verfahren mit vorübergehendem Druckausgleich in einer Pneumatikkammer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101437615A (zh) * 2004-12-21 2009-05-20 法斯特拉克公司 用于诊断化验的试样盒
CN104169590A (zh) * 2012-02-23 2014-11-26 哈恩-席卡德应用研究学会 用于泵送液体的流控模块、装置和方法
US9433940B2 (en) * 2012-02-13 2016-09-06 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053311A2 (en) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US9182384B2 (en) 2007-11-08 2015-11-10 Panasonic Healthcare Holdings Co., Ltd. Analyzing device and analyzing method using same
DE102008003979B3 (de) 2008-01-11 2009-06-10 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikvorrichtung, Fluidikmodul und Verfahren zum Handhaben einer Flüssigkeit
SE533562C2 (sv) * 2009-03-06 2010-10-26 Alfa Laval Corp Ab Centrifugalseparator
US9186672B2 (en) 2011-04-18 2015-11-17 The Regents Of The Univeristy Of California Microfluidic device for whole blood sample preparation
JP6257521B2 (ja) 2011-12-08 2018-01-10 バイオサーフィット、 ソシエダッド アノニマ 逐次分注および沈降速度の指標の決定
DE102013203293B4 (de) 2013-02-27 2016-01-21 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Leiten einer Flüssigkeit durch einen ersten oder zweiten Auslasskanal
DE102013215002B3 (de) 2013-07-31 2014-11-06 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Bewegen von Flüssigkeit in einem zentrifugalen System unter Verwendung von Unterdruck
DE102013218978B3 (de) 2013-09-20 2014-11-06 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren, die Rückschlüsse über die Viskosität einer Probe ermöglichen
DE102013219929B4 (de) 2013-10-01 2015-07-30 Albert-Ludwigs-Universität Freiburg Fluidikmodul, Vorrichtung und Verfahren zum Aliquotieren einer Flüssigkeit
DE102014224664B3 (de) * 2014-12-02 2015-10-08 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und verfahren zur tropfenerzeugung
DE102016207845B4 (de) 2016-05-06 2018-04-12 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidhandhabungsvorrichtung und Verfahren zur Fluidhandhabung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101437615A (zh) * 2004-12-21 2009-05-20 法斯特拉克公司 用于诊断化验的试样盒
US9433940B2 (en) * 2012-02-13 2016-09-06 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
CN104169590A (zh) * 2012-02-23 2014-11-26 哈恩-席卡德应用研究学会 用于泵送液体的流控模块、装置和方法

Also Published As

Publication number Publication date
EP3592463A1 (de) 2020-01-15
US20190388886A1 (en) 2019-12-26
WO2018162413A1 (de) 2018-09-13
PL3592463T3 (pl) 2021-09-13
DE102017204002B4 (de) 2019-05-23
EP3592463B1 (de) 2021-01-27
US11141728B2 (en) 2021-10-12
DE102017204002A1 (de) 2018-09-13
CN110650801A (zh) 2020-01-03
ES2864739T3 (es) 2021-10-14

Similar Documents

Publication Publication Date Title
CN110650801B (zh) 液体的离心气动式切换
EP2688674B1 (en) Control of liquid flow sequence on microfluidic device
US11285479B2 (en) Device and method for handling liquid
US10906041B2 (en) Fluid handling method to switch a valve device or to temporarily counteract a flow
JP6418581B2 (ja) 流体モジュール、液体を分取するためのデバイス及び方法
US8865005B2 (en) Jet deflection device
US20020150512A1 (en) Capillary microvalve
JP4927817B2 (ja) 多数の弁を備えるマイクロ流体装置
JP4752546B2 (ja) 遠心分離デバイス及び遠心分離方法
US11458472B2 (en) Liquid flow control
JP4911514B2 (ja) マイクロチップ、液体分注方法
KR100705361B1 (ko) 모세관 유동 제어 모듈 및 이를 구비한 랩온어칩
JP7250697B2 (ja) 毛細管駆動型流体システムの計量機構およびそのための方法
JP2008538319A (ja) 分離用構造体
US20060281192A1 (en) Method for mixing fluids in microfluidic systems
EP3313559A1 (en) Valve-less mixing method and mixing device

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant