CN110639008A - External medicament for treating gynecological vaginal diseases and preparation method thereof - Google Patents
External medicament for treating gynecological vaginal diseases and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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Abstract
The invention discloses an external medicament for treating gynecological vaginal diseases and a preparation method thereof. The invention discloses a gynecological health-care, clean-keeping and therapeutic product prepared by selected medicinal materials according to the technical requirements of biological product preparation, which contains laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, the main components of the product belong to active protein, have good regulation, repair and nutrition effects on tissue cells, are easy to be absorbed by skin mucosa, have the effects of cleaning the gynecological vagina, sterilizing and disinfecting, and have the effect of treating cervical erosion, vaginitis and pelvic inflammation. The medicine does not contain chemical synthetic drugs and anaphylactic substances, has no irritation to vaginal mucosa cells, and does not produce toxic or side effects on the metabolic capability of vaginal mucosa cell tissues.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to an external medicament for treating gynecological vaginal diseases and a preparation method thereof.
Background
The physiological structural characteristics of the female vagina determine that the vagina is very easy to be infected by exogenous viruses and pathogenic bacteria, so that many women suffer from gynecological vaginal diseases of different degrees, such as vulvitis, cervicitis, bacterial vaginosis, mycotic vaginitis, trichomonas vaginitis, non-specific vaginitis and the like. In recent decades, gynecological vaginal diseases have become common diseases and frequently encountered diseases seriously harming female health, according to relevant statistics, the number of patients suffering from gynecological vaginal diseases in the world currently accounts for more than 40% of female adult population, women use gynecological medicines for more than 5-8 times per year on average, and among various gynecological diseases affecting female health, vaginal diseases caused by gynecological unclean are one disease with the highest occurrence frequency of female diseases and the first disease harming female health, so that the use amount of medicines related to female health care and sanitation in the market is increased year by year.
The gynecological vaginal diseases are diseases of vaginal cell mucosa tissue injury caused by infection of women caused by exogenous viruses, pathogen bacteria and other factors, and the female vaginal epidermis tissue cells are cells with secretion capacity and have the functions of secreting self-cleaning substances, secreting estrogen, secreting endocrine hormone, secreting immune components, secreting lubricating fluid and the like.
At present, the medicines for cleaning and health care of the gynecological vagina and preventing and treating the gynecological vagina diseases in the field are not few, particularly, some Chinese and western medicine preparations also form quite unique curative effect advantages in clinical practice, but because the incidence rate of the gynecological vagina diseases is high and the pathological mechanism is relatively complex, some existing medicine preparations cannot completely meet the requirements of clinic and market in the curative effect aspect, some chemical medicines have the anti-inflammatory and antibacterial effects, but the problem of reducing the irritation to vaginal mucosa cells is not considered, so that the medicine obviously has irritation side effects on the vaginal mucosa cells; although some lotion and emulsion cleans the vagina, a large amount of vaginal mucosal cell secretion can be washed away after long-term use, so that not only is the gynecological dryness caused, but also bacteria and viruses are more easily infected because the vagina is protected by losing mucosal secretion; in addition, in the aspect of medicament dosage forms, except for lotion and emulsion, the medicaments for treating gynecological vaginal diseases at home and abroad mainly comprise tablets, hard capsules and suppositories, and the medicaments of the tablets, the hard capsules and the suppositories contain high impurities which have great damage to the secretion function of vaginal mucosa cells. In summary, in the technical field, the development of a drug which can effectively protect the secretion function of vaginal mucosa cells and eliminate the irritation of the drug and has the anti-inflammatory or antibacterial effect is expected to be used in gynecological vagina in future and is an important index for delaying female vaginal cell aging.
Disclosure of Invention
The present invention aims at providing one kind of externally applied medicine for treating women's vagina diseases and its preparation process.
The invention realizes the purpose through the following technical scheme:
an external medicament for treating gynecological vaginal diseases comprises laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, and comprises the following specific components in parts by weight: 9-21 parts of laminin, 11-18 parts of fibronectin, 3-7 parts of serum protein, 1-4 parts of small molecule active peptide, 5-11 parts of superoxide dismutase, 7-14 parts of propolis, 4-12 parts of zedoary turmeric oil and 8-13 parts of lithospermum extract.
In the present invention, it is preferable that the laminin is 21 parts, the fibronectin is 18 parts, the serum protein is 7 parts, the small molecule active peptide is 4 parts, the superoxide dismutase is 11 parts, the propolis is 14 parts, the zedoary turmeric oil is 12 parts, and the lithospermum extract is 13 parts.
In the present invention, it is preferable that 9 parts of the laminin, 11 parts of the fibronectin, 3 parts of the serum protein, 1 part of the small molecule active peptide, 5 parts of the superoxide dismutase, 7 parts of the propolis, 4 parts of the zedoary turmeric oil, and 8 parts of the lithospermum extract are included.
In the present invention, it is preferable that 15 parts of the laminin, 13 parts of the fibronectin, 5 parts of the serum protein, 3 parts of the small molecule active peptide, 8 parts of the superoxide dismutase, 11 parts of the propolis, 7 parts of the zedoary turmeric oil, and 9 parts of the lithospermum extract are included.
A preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the standby liquid is stirred by a centrifugal pump at the rotating speed of: 1800 plus material 3000 r/s, stirring for 10-18 min, and sealing in a sterile bottle according to the specification requirement, namely the external medicament aqua.
A method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the mixed solution is firstly put into a refrigerator with the temperature of-23 ℃ for freezing for 2 h-6 h, and then transferred into a vacuum freeze dryer for drying for 7 h-13 h to obtain dry powder, namely the freeze-dried powder of the external medicament.
A preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: and (2) freezing the mixed solution in a refrigerator at the temperature of-25 ℃ for 2 to 5 hours, then unfreezing at the temperature of-4 ℃ to 0 ℃, adding 13 parts by weight of carbomer 940, uniformly mixing, and then transferring to a vacuum freeze dryer for drying for 1 to 3 hours to obtain the gel, namely the external medicament gel.
A preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: accurately weighing the required formula amount, and uniformly mixing superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract to obtain a mixed solution for later use;
s2: adding a certain amount of polyvinyl alcohol into the mixed solution, uniformly mixing, adding into a batching tank, and heating to ensure that the temperature of the finished product liquid in the batching tank is 130-150 ℃ to obtain the finished product liquid;
s3: filtering the obtained finished product liquid through a filtering system under the condition of keeping the temperature at 130-150 ℃, and then cooling to normal temperature to obtain a mixture liquid;
s4: adding laminin, fibronectin, serum protein and micromolecular active peptide into the mixture, uniformly mixing, filling by filling equipment, and performing irradiation sterilization to obtain the external medicament dressing.
The invention has the beneficial effects that:
the invention discloses a gynecological health-care, clean-keeping and therapeutic product prepared by selected medicinal materials according to the technical requirements of biological product preparation, which contains laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, the main components of the product belong to active protein, have good regulation, repair and nutrition effects on tissue cells, are easy to be absorbed by skin mucosa, have the effects of cleaning the gynecological vagina, sterilizing and disinfecting, and have the effect of treating cervical erosion, vaginitis and pelvic inflammation. The medicine does not contain chemical synthetic drugs and anaphylactic substances, has no irritation to vaginal mucosa cells, and does not produce toxic or side effects on the metabolic capability of vaginal mucosa cell tissues.
Detailed Description
The invention is further illustrated below:
an external medicament for treating gynecological vaginal diseases comprises laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, and comprises the following specific components in parts by weight: 9-21 parts of laminin, 11-18 parts of fibronectin, 3-7 parts of serum protein, 1-4 parts of small molecule active peptide, 5-11 parts of superoxide dismutase, 7-14 parts of propolis, 4-12 parts of zedoary turmeric oil and 8-13 parts of lithospermum extract.
The first embodiment is as follows:
21 parts of laminin, 18 parts of fibronectin, 7 parts of serum protein, 4 parts of small molecule active peptide, 11 parts of superoxide dismutase, 14 parts of propolis, 12 parts of zedoary turmeric oil and 13 parts of lithospermum extract.
Example two:
9 parts of laminin, 11 parts of fibronectin, 3 parts of serum protein, 1 part of small molecule active peptide, 5 parts of superoxide dismutase, 7 parts of propolis, 4 parts of zedoary turmeric oil and 8 parts of lithospermum extract.
Example three:
15 parts of laminin, 13 parts of fibronectin, 5 parts of serum protein, 3 parts of small molecule active peptide, 8 parts of superoxide dismutase, 11 parts of propolis, 7 parts of zedoary turmeric oil and 9 parts of lithospermum extract.
Preparation method of external medicament embodiment one:
a preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the standby liquid is stirred by a centrifugal pump at the rotating speed of: 1800 plus material 3000 r/s, stirring for 10-18 min, and sealing in a sterile bottle according to the specification requirement, namely the external medicament aqua.
Preparation method of external medicament example two:
a method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the mixed solution is firstly put into a refrigerator with the temperature of-23 ℃ for freezing for 2 h-6 h, and then transferred into a vacuum freeze dryer for drying for 7 h-13 h to obtain dry powder, namely the freeze-dried powder of the external medicament.
Preparation method of external medicament example three:
a preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: after the laminin, fibronectin, serum protein, small molecular active peptide and superoxide dismutase are subjected to membrane sterilization, the laminin, fibronectin, serum protein, small molecular active peptide and superoxide dismutase are uniformly mixed with the propolis, the zedoary turmeric oil and the lithospermum extract to obtain a mixed solution for later use;
s2: and (2) freezing the mixed solution in a refrigerator at the temperature of-25 ℃ for 2 to 5 hours, then unfreezing at the temperature of-4 ℃ to 0 ℃, adding 13 parts by weight of carbomer 940, uniformly mixing, and then transferring to a vacuum freeze dryer for drying for 1 to 3 hours to obtain the gel, namely the external medicament gel.
Preparation method of external medicament example four:
a preparation method of an external medicament for treating gynecological vaginal diseases comprises the following steps:
s1: accurately weighing the required formula amount, and uniformly mixing superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract to obtain a mixed solution for later use;
s2: adding a certain amount of polyvinyl alcohol into the mixed solution, uniformly mixing, adding into a batching tank, and heating to ensure that the temperature of the finished product liquid in the batching tank is 130-150 ℃ to obtain the finished product liquid;
s3: filtering the obtained finished product liquid through a filtering system under the condition of keeping the temperature at 130-150 ℃, and then cooling to normal temperature to obtain a mixture liquid;
s4: adding laminin, fibronectin, serum protein and micromolecular active peptide into the mixture, uniformly mixing, filling by filling equipment, and performing irradiation sterilization to obtain the external medicament dressing.
In conclusion, the gynecological health-care, cleaning and therapeutic product prepared by the selected medicinal materials according to the technical requirements of biological product preparation contains laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, the main components of the product belong to active protein, the product has good regulation, repair and nutrition effects on tissue cells, is easy to be absorbed by skin mucosa, has the effects of cleaning gynecological vagina, sterilizing and disinfecting, and has the effect of treating cervical erosion, vaginitis and pelvic inflammation. The medicine does not contain chemical synthetic drugs and anaphylactic substances, has no irritation to vaginal mucosa cells, and does not produce toxic or side effects on the metabolic capability of vaginal mucosa cell tissues.
As will be realized, the invention is capable of other and different modifications and its several details are capable of modifications in various obvious respects, all without departing from the spirit and scope of the present invention.
Claims (8)
1. An external medicament for treating gynecological vaginal diseases is characterized by comprising laminin, fibronectin, serum protein, small molecular active peptide, superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract, wherein the specific components are in parts by weight: 9-21 parts of laminin, 11-18 parts of fibronectin, 3-7 parts of serum protein, 1-4 parts of small molecule active peptide, 5-11 parts of superoxide dismutase, 7-14 parts of propolis, 4-12 parts of zedoary turmeric oil and 8-13 parts of lithospermum extract.
2. The external medicament for treating the gynecological vaginal diseases according to claim 1, characterized in that the laminin 21 parts, the fibronectin 18 parts, the serum protein 7 parts, the small molecule active peptide 4 parts, the superoxide dismutase 11 parts, the propolis 14, the zedoary turmeric oil 12 and the lithospermum extract 13 are used.
3. The external medicament for treating the gynecological vaginal diseases according to claim 1, characterized in that the laminin is 9 parts, the fibronectin is 11 parts, the serum protein is 3 parts, the small molecule active peptide is 1 part, the superoxide dismutase is 5 parts, the propolis is 7 parts, the zedoary turmeric oil is 4 parts, and the lithospermum extract is 8 parts.
4. The external medicament for treating the gynecological vaginal diseases according to claim 1, characterized in that 15 parts of laminin, 13 parts of fibronectin, 5 parts of serum protein, 3 parts of small molecule active peptide, 8 parts of superoxide dismutase, 11 parts of propolis, 7 parts of zedoary turmeric oil and 9 parts of lithospermum extract.
5. A method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the standby liquid is stirred by a centrifugal pump at the rotating speed of: 1800 plus material 3000 r/s, stirring for 10-18 min, and sealing in a sterile bottle according to the specification requirement, namely the external medicament aqua.
6. A method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: the mixed solution is firstly put into a refrigerator with the temperature of-23 ℃ for freezing for 2 h-6 h, and then transferred into a vacuum freeze dryer for drying for 7 h-13 h to obtain dry powder, namely the freeze-dried powder of the external medicament.
7. A method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, performing membrane sterilization on laminin, fibronectin, serum protein, small molecule active peptide and superoxide dismutase, and uniformly mixing with propolis, zedoary turmeric oil and radix Arnebiae extract to obtain a mixed solution for later use;
s2: and (2) freezing the mixed solution in a refrigerator at the temperature of-25 ℃ for 2 to 5 hours, then unfreezing at the temperature of-4 ℃ to 0 ℃, adding 13 parts by weight of carbomer 940, uniformly mixing, and then transferring to a vacuum freeze dryer for drying for 1 to 3 hours to obtain the gel, namely the external medicament gel.
8. A method for preparing an external medicament for treating gynecological vaginal diseases, which comprises the external medicament for treating gynecological vaginal diseases as claimed in any one of claims 1 to 4, comprising the steps of:
s1: accurately weighing the required formula amount, and uniformly mixing superoxide dismutase, propolis, zedoary turmeric oil and lithospermum extract to obtain a mixed solution for later use;
s2: adding a certain amount of polyvinyl alcohol into the mixed solution, uniformly mixing, adding into a batching tank, and heating to ensure that the temperature of the finished product liquid in the batching tank is 130-150 ℃ to obtain the finished product liquid;
s3: filtering the obtained finished product liquid through a filtering system under the condition of keeping the temperature at 130-150 ℃, and then cooling to normal temperature to obtain a mixture liquid;
s4: adding laminin, fibronectin, serum protein and micromolecular active peptide into the mixture, uniformly mixing, filling by filling equipment, and performing irradiation sterilization to obtain the external medicament dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911116537.3A CN110639008A (en) | 2019-11-16 | 2019-11-16 | External medicament for treating gynecological vaginal diseases and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911116537.3A CN110639008A (en) | 2019-11-16 | 2019-11-16 | External medicament for treating gynecological vaginal diseases and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110639008A true CN110639008A (en) | 2020-01-03 |
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| CN201911116537.3A Withdrawn CN110639008A (en) | 2019-11-16 | 2019-11-16 | External medicament for treating gynecological vaginal diseases and preparation method thereof |
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Application publication date: 20200103 |