CN110638894A - Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof Download PDFInfo
- Publication number
- CN110638894A CN110638894A CN201911064171.XA CN201911064171A CN110638894A CN 110638894 A CN110638894 A CN 110638894A CN 201911064171 A CN201911064171 A CN 201911064171A CN 110638894 A CN110638894 A CN 110638894A
- Authority
- CN
- China
- Prior art keywords
- parts
- premature ejaculation
- chinese medicine
- traditional chinese
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating impotence and premature ejaculation, which comprises the following components in parts by mass: 95-105 parts of epimedium, 95-105 parts of morinda officinalis, 95-105 parts of pepper, 95-105 parts of gardenia, 95-105 parts of teasel root, 195-205 parts of achyranthes bidentata, 95-105 parts of notopterygium root and 115-125 parts of wormwood. Meanwhile, the invention discloses a preparation method of the traditional Chinese medicine composition for treating impotence and premature ejaculation. The invention also discloses application of the traditional Chinese medicine composition for treating impotence and premature ejaculation in preparing foot bath liquid.
Description
Technical Field
The invention belongs to the field of preparation of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating impotence and premature ejaculation, and a preparation method and application thereof.
Background
Impotence (ED), Premature Ejaculation (PE) are common sexual dysfunctional diseases in adult males. With the acceleration of modern society rhythm, the increase of study, life and working pressure, and because of environmental pollution, the factor such as bad life style increase leads to impotence, the incidence and the rate of seeing a doctor of premature ejaculation improve year by year, because impotence is also called "sexuality can" and has definitional definitions of discriminativity, have brought huge physiology and psychological pressure to the patient.
At present, most of the medicinal preparations for treating the diseases at home and abroad are drugs for promoting and tonifying yang or vasodilators influencing NO metabolism, and when the medicinal preparations are used temporarily, the medicinal preparations can help people to exhaust primordial qi and damage the health of human bodies. There are also many Chinese patent drugs available, but these drugs still have the following problems: firstly, most of the medicines are taken at the moment and have no effect when the medicines are stopped; in addition, the existing medicines can take effect only after being taken due to external stimulation and enhancement of subjective desire. These drugs have short-term effects, and can only solve a problem of short time, and cannot achieve the purpose of regulating the endocrine and nervous systems of the human body. Therefore, it is necessary to develop a new medicine which has reliable curative effect, less adverse reaction and convenient use and treats both principal and secondary aspect of disease.
Disclosure of Invention
The invention designs and develops a traditional Chinese medicine composition for treating impotence and premature ejaculation, which adopts epimedium, morinda officinalis, pepper, gardenia, Chinese teasel root, achyranthes root, notopterygium root and wormwood as raw materials and can effectively treat the impotence and premature ejaculation.
The invention designs and develops a preparation method of a traditional Chinese medicine composition for treating impotence and premature ejaculation, and the extract is obtained in the preparation process, so that the effective components of the medicine are fully released and exerted, and the absorption of each component is promoted.
The invention designs and develops application of a traditional Chinese medicine composition for treating impotence and premature ejaculation, and the application of the traditional Chinese medicine composition for preparing foot bath liquid for treating impotence and premature ejaculation.
The technical scheme provided by the invention is as follows:
a Chinese medicinal composition for treating impotence and premature ejaculation comprises:
the traditional Chinese medicine composition comprises the following components in parts by weight:
95-105 parts of epimedium, 95-105 parts of morinda officinalis, 95-105 parts of pepper, 95-105 parts of gardenia, 95-105 parts of teasel root, 195-205 parts of achyranthes bidentata, 95-105 parts of notopterygium root and 115-125 parts of wormwood.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight:
100 parts of epimedium, 100 parts of morinda officinalis, 100 parts of pepper, 100 parts of gardenia, 100 parts of teasel root, 200 parts of achyranthes root, 100 parts of notopterygium root and 120 parts of wormwood.
A preparation method of a traditional Chinese medicine composition for treating impotence and premature ejaculation is used for preparing the traditional Chinese medicine composition and comprises the following steps:
step one, weighing component medicinal materials such as epimedium, morinda officinalis, pepper, gardenia, teasel root, achyranthes, notopterygium root and wormwood according to parts by weight, and processing the component medicinal materials into powder;
step two, adding water to the powdery material for multiple times for extraction, filtering, and combining to obtain an extracting solution;
step three, concentrating the extracting solution into extract;
and step four, adding auxiliary materials into the extract to prepare a gel or an oral preparation.
Preferably, in the step one, the method for processing the component medicinal materials into the powdery material comprises the following steps:
and putting the component medicinal materials into a grinder to be ground into powder, and sieving the powder through a 100-mesh sieve to obtain the powdery material.
Preferably, in the second step, water is added for extraction twice;
wherein, 10 times of water is added into the powdery material for the first time to be decocted for 2 hours; adding 6 times of water into the residue for decocting for 1 hr.
Preferably, in the third step, the density ratio of the extract to the extracting solution is 1.2: 1.
Preferably, the oral dosage form is: tablet, capsule, microcapsule, granule, pill, powder, oral liquid, dripping pill, sustained release preparation or controlled release preparation.
Preferably, the auxiliary materials added for preparing the oral dosage form are as follows: one or more of diluent, disintegrant, excipient, binder, lubricant, surfactant, filler, preservative, stabilizer, flavoring agent, thickener and cosolvent.
Preferably, the auxiliary materials added for preparing the gel comprise: carbomer, diethanolamine, and sodium benzoate.
The application of the traditional Chinese medicine composition for treating impotence and premature ejaculation is characterized in that the traditional Chinese medicine composition in the form of gel is added into water to be dissolved to obtain foot bath liquid.
The invention has the beneficial effects that:
the traditional Chinese medicine composition selects eight traditional Chinese medicinal materials of epimedium, morinda officinalis, pepper, gardenia, Chinese teasel root, achyranthes root, notopterygium root and wormwood as raw materials, has the effects of nourishing yin and tonifying yang, strengthening kidney and calming heart, tonifying primordial qi, nourishing blood and producing sperm, is mainly used for treating impotence, premature ejaculation and sexual function decline, has the effects of building up body and resisting fatigue, has mild medicinal properties and obvious curative effect, and treats both principal and secondary aspect of disease.
The prepared extract in the preparation process can effectively and fully release and exert the pharmaceutical ingredients, promotes the absorption of the ingredients, has no toxic or side effect, and is safe and reliable.
The preparation method is simple, mature in process, natural in raw materials, convenient to use, environment-friendly and suitable for large-scale production.
Detailed Description
The present invention is described in further detail below to enable those skilled in the art to practice the invention with reference to the description.
The invention provides a traditional Chinese medicine composition for treating impotence and premature ejaculation, which comprises the following components in parts by mass:
95-105 parts of epimedium, 95-105 parts of morinda officinalis, 95-105 parts of pepper, 95-105 parts of gardenia, 95-105 parts of teasel root, 195-205 parts of achyranthes bidentata, 95-105 parts of notopterygium root and 115-125 parts of wormwood.
As a further optimization, the traditional Chinese medicine composition comprises the following components in parts by mass:
100 parts of epimedium, 100 parts of morinda officinalis, 100 parts of pepper, 100 parts of gardenia, 100 parts of teasel root, 200 parts of achyranthes root, 100 parts of notopterygium root and 120 parts of wormwood.
The weight parts of the invention are units of gram, two, kilogram and the like.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating impotence and premature ejaculation, which is used for preparing the traditional Chinese medicine composition and comprises the following steps:
step one, weighing component medicinal materials such as epimedium, morinda officinalis, pepper, gardenia, teasel root, achyranthes, notopterygium root and wormwood according to parts by weight, and processing the component medicinal materials into powder;
step two, adding water to the powdery material for multiple times for extraction, filtering, and combining to obtain an extracting solution;
step three, concentrating the extracting solution into extract;
and step four, adding auxiliary materials into the extract to prepare a gel or an oral preparation.
Wherein the oral dosage form is: tablet, capsule, microcapsule, granule, pill, powder, oral liquid, dripping pill, sustained release preparation or controlled release preparation.
The auxiliary materials added for preparing the oral preparation are as follows: one or more of diluent, disintegrant, excipient, binder, lubricant, surfactant, filler, preservative, stabilizer, flavoring agent, thickener and cosolvent.
The auxiliary materials added for preparing the gel comprise: carbomer, diethanolamine, and sodium benzoate.
In another embodiment, in the step one, the method for processing the component medicinal materials into the powdery material comprises the following steps: and putting the medicinal materials of epimedium, morinda officinalis, pepper, gardenia, Chinese teasel root, achyranthes root, notopterygium root and wormwood into a crusher, crushing into powder, and sieving by a 100-mesh sieve to obtain the powdery material.
In another embodiment, in the second step, water extraction is performed twice, and the two extracts are obtained after filtration and combination. The specific process comprises the following steps:
extracting for the first time: adding 10 times of water into the powdery material, decocting for 2h at 100 ℃, and filtering to obtain a first extracting solution; and (3) second extraction: adding 6 times of water into the residue after the first extraction and filtration, decocting for 1h at 100 ℃, and filtering to obtain a second extraction solution; thereafter, the first extract is combined with
And combining the second extracting solution to obtain the final extracting solution.
In another embodiment, in the third step, the extracting solution is concentrated into an extract, wherein the density ratio of the extract to the extracting solution is 1.2: 1.
The application of the traditional Chinese medicine composition for treating impotence and premature ejaculation is characterized in that the traditional Chinese medicine composition in the form of gel is added into water to be dissolved to obtain foot bath liquid.
Example 1
(1) Respectively weighing the following raw material medicaments in part by weight: 95g of epimedium, 95g of morinda officinalis, 95g of pepper, 95g of gardenia, 95g of teasel root, 195g of achyranthes root, 95g of notopterygium root and 115g of wormwood, wherein the raw materials are traditional Chinese medicine decoction pieces; crushing the raw material medicaments into powder in a crusher, and sieving the powder by a 100-mesh sieve to obtain a powdery material;
(2) adding water into the powdery material obtained in the step (1) for extraction twice, wherein the first time is as follows: adding 10 times of water, and decocting for 2h at 100 deg.C; and (3) for the second time: adding 6 times of water into the residue after the first extraction and filtration, decocting for 1h at 100 ℃, filtering, and combining the two decoctions;
(3) concentrating the decoction obtained in the step (2) to obtain an extract with the relative density of 1.2;
(4) and (4) adding carbomer, diethanol amine, sodium benzoate and the like into the extract obtained in the step (3) to prepare a gel.
The using method comprises the following steps: taking 25g of gel each time, adding 45 ℃ water to dissolve, soaking feet for 15-30 minutes, 1 time every day, and 7 days as a treatment course.
Example 2
(1) Respectively weighing the following raw material medicaments in part by weight: 100g of epimedium, 100g of morinda officinalis, 100g of pepper, 100g of gardenia, 100g of Chinese teasel root, 200g of achyranthes root, 100g of notopterygium root and 120g of wormwood; the raw material medicaments are Chinese medicinal decoction pieces; crushing the raw material medicaments into powder in a crusher, and sieving the powder by a 100-mesh sieve to obtain a powdery material;
(2) adding water into the powdery material obtained in the step (1) for extraction twice, wherein the first time is as follows: adding 10 times of water, and decocting for 2h at 100 deg.C; and (3) for the second time: and (3) for the second time: adding 6 times of water into the residue after the first extraction and filtration, decocting for 1h at 100 ℃, filtering, and combining the two decoctions;
(3) concentrating the decoction obtained in the step (2) to obtain an extract with the relative density of 1.2;
(4) and (4) adding a proper amount of starch into the extract obtained in the step (3), granulating, and tabletting to obtain a finished product.
The taking method comprises the following steps: orally taking 8 tablets at a time, 2 times a day, 15 days as a treatment course, and treating 2 treatment courses in total; other related medicines and other treatments are stopped taking during the taking period.
Example 3
(1) Respectively weighing the following raw material medicaments in part by weight: 105g of epimedium, 105g of morinda officinalis, 105g of pepper, 105g of gardenia, 105g of teasel root, 205g of achyranthes root, 105g of notopterygium root and 125g of wormwood, wherein the raw materials are Chinese herbal pieces; crushing the raw material medicaments into powder in a crusher, and sieving the powder by a 100-mesh sieve to obtain a powdery material;
(2) adding water into the powdery material obtained in the step (1) for extraction twice, wherein the first time is as follows: adding 10 times of water, and decocting for 2h at 100 deg.C; and (3) for the second time: adding 6 times of water into the residue after the first extraction and filtration, decocting for 1h at 100 ℃, filtering, and combining the two decoctions;
(3) concentrating the decoction obtained in the step (2) to obtain an extract with the relative density of 1.2; then drying, crushing and sieving by a 100-mesh sieve to obtain fine powder;
preparing soft materials from the fine powder obtained in the step (3) by using purified water, preparing pills, and preparing 400 pills to obtain finished products.
The taking method comprises the following steps: orally taking 8 pills at a time, 2 times a day, 15 days as a treatment course, and treating 2 treatment courses in total; other related medicines and other treatments are stopped taking during the taking period.
Test example 1
100 clinical reports of the invention for treating impotence and premature ejaculation are as follows:
100 patients are hospital outpatient clinic patients, the maximum age is 51 years old, the minimum age is 27 years old, wherein, 27-30 years old is 19 cases, and 31-40 years old is 38 cases; 41 cases are 41 cases at age of 41-50, 2 cases above age of 50, the shortest disease course is 2 months, and the longest disease course is 8 years. The patient selection criteria were established according to the first edition of the guidelines for clinical research of new drugs in Chinese medicine (1993). The clinical manifestations of the patient are impotence, premature ejaculation, dizziness, tinnitus, amnesia, drowsiness, soreness and weakness of the waist and knees.
Diagnostic criteria: the penis can not erect or erect and can not complete the intercourse.
The treatment method comprises the following steps:
all patients used the gel prepared according to the formula in the embodiment 1 of the invention, 25g of the gel is dissolved in water at 45 ℃, 3 times a day, 7 days are a treatment course, and 4 treatment courses are total; other related medicines and other treatments are stopped taking during the taking period.
The judgment standard of the curative effect is as follows:
made according to the first edition of clinical research guidelines for new drugs in Chinese medicine (1993).
And (3) curing: the treatment lasts for 1 month, the penile erection is more than 90 degrees, and 75 percent of intercourse chances can be successful;
the effect is shown: after treatment, the erection is more than 90 degrees, and 50 percent of intercourse chances can be successful;
the method has the following advantages: after treatment, the erection is improved, and over 25 percent of intercourse chance can be successfully treated;
and (4) invalidation: all indexes before and after the administration are not improved.
As a result:
58 cases are cured, 25 cases are obviously effective, 6 cases are effective, 11 cases are ineffective, and the total effective rate is 89%.
Test example 2
100 clinical reports of the invention for treating impotence and premature ejaculation are as follows:
100 patients are hospital outpatient clinic patients, the maximum age is 51 years old, the minimum age is 27 years old, wherein 27-30 years old are 18 patients, and 31-40 years old are 36 patients; 44 cases are 41-50 years old, 2 cases are more than 50 years old, the shortest disease course is 2 months, and the longest disease course is 8 years. The patient selection criteria were established according to the first edition of the guidelines for clinical research of new drugs in Chinese medicine (1993). The clinical manifestations of the patient are impotence, premature ejaculation, dizziness, tinnitus, amnesia, drowsiness, soreness and weakness of the waist and knees.
Diagnostic criteria: the penis can not erect or erect and can not complete the intercourse.
The treatment method comprises the following steps:
all patients take the tablets prepared according to the formula in the embodiment 2 of the invention, and the tablets are orally taken, 8 tablets are taken at a time, 2 times a day, 15 days are taken as a treatment course, and 2 treatment courses are totally treated; other related medicines and other treatments are stopped taking during the taking period.
The judgment standard of the curative effect is as follows:
made according to the first edition of clinical research guidelines for new drugs in Chinese medicine (1993).
And (3) curing: the treatment lasts for 1 month, the penile erection is more than 90 degrees, and 75 percent of intercourse chances can be successful;
the effect is shown: after treatment, the erection is more than 90 degrees, and 50 percent of intercourse chances can be successful;
the method has the following advantages: after treatment, the erection is improved, and over 25 percent of intercourse chance can be successfully treated;
the medicine is ineffective, and all indexes before and after the medicine is taken are not improved.
As a result:
59 cases are cured, 24 cases are obviously effective, 7 cases are effective, 10 cases are ineffective, and the total effective rate is 90%.
Test example 3
100 clinical reports of the invention for treating impotence and premature ejaculation are as follows:
100 patients are hospital outpatient clinic patients, the maximum age is 51 years old, the minimum age is 27 years old, wherein 27-30 years old 15 cases, 31-40 years old 39 cases; 45 cases aged 41-50 years, 1 case aged 50 years, the shortest disease course is 2 months, and the longest disease course is 8 years. The patient selection criteria were established according to the first edition of the guidelines for clinical research of new drugs in Chinese medicine (1993). The clinical manifestations of the patient are impotence, premature ejaculation, dizziness, tinnitus, amnesia, drowsiness, soreness and weakness of the waist and knees.
Diagnostic criteria: the penis can not erect or erect and can not complete the intercourse.
The treatment method comprises the following steps:
all patients take pills prepared according to the formula in the embodiment 3 of the invention, and the pills are orally taken, 8 pills are taken at a time, 2 times a day, 15 days are taken as a treatment course, and 2 treatment courses are totally treated; other related medicines and other treatments are stopped taking during the taking period.
The judgment standard of the curative effect is as follows:
made according to the first edition of clinical research guidelines for new drugs in Chinese medicine (1993).
And (3) curing: the treatment lasts for 1 month, the penile erection is more than 90 degrees, and 75 percent of intercourse chances can be successful;
the effect is shown: after treatment, the erection is more than 90 degrees, and 50 percent of intercourse chances can be successful;
the method has the following advantages: after treatment, the erection is improved, and over 25 percent of intercourse chance can be successfully treated;
the medicine is ineffective, and all indexes before and after the medicine is taken are not improved.
As a result:
57 cases are cured, 25 cases are obviously effective, 8 cases are effective, 10 cases are ineffective, and the total effective rate is 90%.
The test examples show that the traditional Chinese medicine composition for treating impotence and premature ejaculation with different dosage forms prepared in the embodiments of the invention can effectively treat impotence and premature ejaculation.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (10)
1. The traditional Chinese medicine composition for treating impotence and premature ejaculation is characterized by comprising the following components in parts by mass:
95-105 parts of epimedium, 95-105 parts of morinda officinalis, 95-105 parts of pepper, 95-105 parts of gardenia, 95-105 parts of teasel root, 195-205 parts of achyranthes bidentata, 95-105 parts of notopterygium root and 115-125 parts of wormwood.
2. The traditional Chinese medicine composition for treating impotence and premature ejaculation as claimed in claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight:
100 parts of epimedium, 100 parts of morinda officinalis, 100 parts of pepper, 100 parts of gardenia, 100 parts of teasel root, 200 parts of achyranthes root, 100 parts of notopterygium root and 120 parts of wormwood.
3. A method for preparing a traditional Chinese medicine composition for treating impotence and premature ejaculation, which is used for preparing the traditional Chinese medicine composition of any one of claims 1 to 2, and is characterized by comprising the following steps:
step one, weighing component medicinal materials such as epimedium, morinda officinalis, pepper, gardenia, teasel root, achyranthes, notopterygium root and wormwood according to parts by weight, and processing the component medicinal materials into powder;
step two, adding water to the powdery material for multiple times for extraction, filtering, and combining to obtain an extracting solution;
step three, concentrating the extracting solution into extract;
and step four, adding auxiliary materials into the extract to prepare a gel or an oral preparation.
4. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 3, wherein in the step one, the method for processing the component medicinal materials into powder comprises:
and putting the component medicinal materials into a grinder to be ground into powder, and sieving the powder through a 100-mesh sieve to obtain the powdery material.
5. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 3 or 4, wherein in the second step, water extraction is performed twice;
wherein, 10 times of water is added into the powdery material for the first time to be decocted for 2 hours; adding 6 times of water into the residue for decocting for 1 hr.
6. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 5, wherein in the third step, the density ratio of the extract to the extracting solution is 1.2: 1.
7. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 6, wherein the oral dosage form is: tablet, capsule, microcapsule, granule, pill, powder, oral liquid, dripping pill, sustained release preparation or controlled release preparation.
8. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 7, wherein the adjuvants added in the preparation of oral dosage form are: one or more of diluent, disintegrant, excipient, binder, lubricant, surfactant, filler, preservative, stabilizer, flavoring agent, thickener and cosolvent.
9. The method for preparing a Chinese medicinal composition for treating impotence and premature ejaculation as claimed in claim 8, wherein the adjuvants added for preparing the gel comprise: carbomer, diethanolamine, and sodium benzoate.
10. The application of the traditional Chinese medicine composition for treating impotence and premature ejaculation, which is prepared by the preparation method of the traditional Chinese medicine composition for treating impotence and premature ejaculation as claimed in any one of claims 3, 4, 5, 6 or 9, is characterized in that the traditional Chinese medicine composition in the form of gel is added into water for dissolving to obtain foot bath liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911064171.XA CN110638894A (en) | 2019-11-04 | 2019-11-04 | Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911064171.XA CN110638894A (en) | 2019-11-04 | 2019-11-04 | Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110638894A true CN110638894A (en) | 2020-01-03 |
Family
ID=68995328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911064171.XA Pending CN110638894A (en) | 2019-11-04 | 2019-11-04 | Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110638894A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700887A (en) * | 2019-01-25 | 2019-05-03 | 张掖市金盛中药饮片有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating impotence and premature ejaculation |
-
2019
- 2019-11-04 CN CN201911064171.XA patent/CN110638894A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700887A (en) * | 2019-01-25 | 2019-05-03 | 张掖市金盛中药饮片有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating impotence and premature ejaculation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107496701B (en) | Formula for producing sperms and treating impotence and premature ejaculation | |
| CN1245187C (en) | Medicine for treating eye disease caused by visceral disease | |
| CN108310311A (en) | A kind of element culturing fixed folder strengthening yang and invigorating kidney Chinese medicine composition and preparation method | |
| US20200268826A1 (en) | Application Method of Dendrobium Candidum in Preparing Medicine for Treating Hypertension | |
| CN105663607A (en) | Traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN104288228A (en) | Traditional Chinese medicine composite for treating pain in neck, shoulders, waist and legs | |
| CN103599409B (en) | One treats prosopalgic Chinese medicine composition | |
| CN112494569B (en) | Traditional Chinese medicine composition for improving immunity and preparation method and application thereof | |
| CN110638894A (en) | Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method and application thereof | |
| CN112704699A (en) | Traditional Chinese medicine composition for treating climacteric syndrome and application thereof | |
| CN109700887A (en) | A kind of Chinese medicine composition and preparation method thereof for treating impotence and premature ejaculation | |
| CN103520289B (en) | A kind of Chinese medicine composition for the treatment of constipation and its preparation method and application | |
| CN111265609A (en) | Traditional Chinese medicine composition for adjuvant treatment of true myopia and preparation method thereof | |
| CN104324186A (en) | Traditional Chinese medicine prescription for treating climacteric syndrome, and preparation methods of capsule and ointment of traditional Chinese medicine prescription | |
| CN104147156A (en) | Beverage containing kidney-tonifying traditional Chinese medicine composition and preparation method thereof | |
| CN114712466B (en) | Medicine with weight-reducing and beautifying effects and preparation method thereof | |
| CN115177690B (en) | Traditional Chinese medicine composition for treating osteoarthritis and preparation method thereof | |
| CN102743499A (en) | Chinese medicinal herb drug for treating soft tissue internal injury blood stasis and cerebral hemorrhage | |
| CN102579617A (en) | Traditional Chinese medicine capsule for treating chronic neck, shoulder, waist and leg pains and processing method of same | |
| CN102526544B (en) | Oral powder Chinese medicine formula for treating lumbar disc herniation and osteoproliferation | |
| CN105412395A (en) | Traditional Chinese medicine composition for treating hyperostosis and preparation method thereof | |
| CN105641295A (en) | Traditional Chinese medicine composition and application thereof to treatment of rheumatic arthritis | |
| CN113116905A (en) | A composition for improving male sexual function and continuously improving sexual dysfunction, and its preparation method | |
| CN115671245A (en) | External compound traditional Chinese medicine preparation for preventing and treating cerebral infarction | |
| CN102727575A (en) | Medicine for treating hypertension, hyperlipidemia and hyperglycemia and preparation method of medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200103 |