CN110604798A - Curcumin composition effervescent tablet - Google Patents
Curcumin composition effervescent tablet Download PDFInfo
- Publication number
- CN110604798A CN110604798A CN201910964757.5A CN201910964757A CN110604798A CN 110604798 A CN110604798 A CN 110604798A CN 201910964757 A CN201910964757 A CN 201910964757A CN 110604798 A CN110604798 A CN 110604798A
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- CN
- China
- Prior art keywords
- effervescent tablet
- traditional chinese
- chinese medicine
- parts
- curcumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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Abstract
The invention discloses a curcumin composition effervescent tablet, wherein the main medicine of the effervescent tablet is a traditional Chinese medicine extraction concentrated solution; the traditional Chinese medicine extract concentrated solution is prepared by extracting and concentrating 1-20 parts by weight of curcumin, 10-30 parts by weight of kudzu root, 5-20 parts by weight of cardamom and 10-20 parts by weight of hovenia dulcis thunb. In the effervescent tablet, a disintegrating agent consists of citric acid and sodium bicarbonate, and the mass ratio of the citric acid, the sodium bicarbonate, other auxiliary materials and the traditional Chinese medicine extract concentrated solution is 1:1:4: 2. The curcumin composition effervescent tablet disclosed by the invention has an obvious synergistic effect among components, and can help a body to improve liver function, help a human body to expel toxin, improve immunity, reduce the damage of alcohol to the human body, accelerate alcohol metabolism and reduce the damage of alcohol to the liver.
Description
Technical Field
The invention belongs to the field of health care products, and particularly relates to a curcumin composition effervescent tablet.
Background
Prolonged excessive drinking can cause significant injury to the patient in a short period of time and even death, either directly or indirectly. Prolonged excessive drinking can also cause cumulative harm to the patient, such as alcohol dependence, mental disorders, and induction of certain cancers. Under the background, the development of the liver-protecting and alcohol-dispelling product has very positive practical significance.
Curcumin is a chemical component extracted from rhizomes of plants of Zingiberaceae and Araceae, is a very rare pigment with diketone in plant kingdom, and is a diketone compound. Curcumin has various biological activities and pharmacological actions, and has preventing and treating effects on hyperlipidemia, cancer, senile dementia, diabetes, liver injury, etc.
Curcumin is commonly used as a natural pigment and an antioxidant in food and cosmetics, and is also a main component in food seasoning curry. The curcumin health-care products sold in the market at present are mostly produced in the United states and Japan, and the products comprise curcumin capsules, tablets, tea, functional beverages and the like, and have the main effects of relieving alcoholism and protecting liver.
Disclosure of Invention
The invention aims to provide a curcumin composition effervescent tablet for protecting liver and alleviating hangover.
The purpose of the invention is realized by the following technical scheme:
a curcumin composition effervescent tablet comprises main ingredient of Chinese medicinal extract concentrate;
the traditional Chinese medicine extract concentrated solution is prepared by extracting and concentrating 1-20 parts by weight of curcumin, 10-30 parts by weight of kudzu root, 5-20 parts by weight of cardamom and 10-20 parts by weight of hovenia dulcis thunb;
preferably, the extraction and concentration is to extract the raw materials of the traditional Chinese medicine by using an ethanol water solution with the volume fraction of 35-50%, evaporate the ethanol to obtain a traditional Chinese medicine extract water dispersion, and perform vacuum concentration to obtain a traditional Chinese medicine extract concentrated solution;
leaching for 2-3 times at 70-80 ℃ for 2.5-3.0 h each time;
the ethanol is evaporated, and the ethanol is preferably concentrated under reduced pressure at 70-80 ℃ until no ethanol smell exists;
the vacuum concentration is preferably carried out at the vacuum degree of-0.085-0.090 MPa and the temperature of 70-80 ℃;
preferably, in the effervescent tablet, the disintegrant consists of citric acid and sodium bicarbonate;
preferably, in the effervescent tablet, the mass ratio of the citric acid, the sodium bicarbonate and other auxiliary materials to the traditional Chinese medicine extract concentrated solution is 1:1:4: 2;
the other auxiliary materials are more than one of sucrose fine powder, cyclodextrin, starch or maltodextrin.
The preparation method of the curcumin composition effervescent tablet refers to the preparation method of the effervescent tablet in the prior art, and generally comprises the steps of mixing into acid granules, alkali granules, boiling and drying, granulating, tabletting and the like.
The kudzuvine root used in the effervescent tablet contains carbohydrate, vegetable protein, a plurality of vitamins and mineral substances, and in addition, contains flavonoid substances: daidzein and daidzin, and daidzein-4, 7-diglucoside, puerarin-7 xyloside, puerarin, radix Puerariae and isoflavone glycoside, etc., and can effectively antagonize lipid peroxidation damage of liver and testis caused by alcohol. The daidzin can decompose acetaldehyde toxicity, prevent reduction of brain inhibitory function of alcohol, inhibit absorption of alcohol by intestine and stomach, and promote metabolism and excretion of alcohol in blood.
The cardamom in the formula contains flavonoid compounds: quercetin, kaempferol, rhamnus limonin, Sasa albo-marginata, kaempferide, cardamom chalcone, raw pine flavanone, and diphenyl heptane compounds. It is suitable for patients with spleen and stomach qi stagnation, anorexia, food retention, chest distress, abdominal distention, belch, regurgitation, and thick and greasy tongue coating.
The semen Hoveniae contains a large amount of dihydromyricetin, glucose and organic acid, and has effects of expanding blood volume of human body, relieving alcoholism, relieving hangover and tranquilizing mind.
In the effervescent tablet, curcumin can relieve alcoholism and protect liver, and round cardamom can treat chest distress, abdominal distension, eructation and regurgitation. The kudzuvine root contains soyabean glycoside to decompose alcohol toxicity, the hovenia dulcis thunb contains a large amount of dihydromyricetin, glucose and organic acid to expand the blood volume of a human body, and the effects of sobering up and soothing the nerves are achieved, and the four have obvious synergistic effects.
Compared with the prior art, the invention has the following advantages and effects:
1. the curcumin composition effervescent tablet disclosed by the invention has an obvious synergistic effect among components, and can help a body to improve liver function, help a human body to expel toxin, improve immunity, reduce the damage of alcohol to the human body, accelerate alcohol metabolism and reduce the damage of alcohol to the liver.
2. The effervescent tablet adopts the traditional Chinese medicine extraction technology, and then adopts the methods of mixing, drying, granulating and tabletting, so that the active ingredients in all the raw materials can be fully extracted, and the trace element nutrition is not damaged. The preparation method is simple, the formula is simple, the raw material source is wide, the cost is low, and the prepared effervescent tablet has good taste, uniform bubbles and is not easy to agglomerate.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
In the following examples, 1 part by weight is 1 g.
Example 1
A method for preparing curcumin composition effervescent tablet comprises the following steps:
(1) weighing 10 parts of curcumin, 20 parts of kudzu root, 10 parts of round cardamom and 10 parts of hovenia dulcis thunb; respectively drying the weighed Chinese herbal medicines in an oven at the temperature of 80-85 ℃ for 2.5-4.0 h, then respectively crushing the dried Chinese herbal medicines for 35-50 s by using a crusher, sieving to obtain Chinese herbal medicine powder, adding the Chinese herbal medicine powder into 500mL of 40% ethanol solution, refluxing for 2h, controlling the temperature to be 70 ℃, carrying out suction filtration to obtain a filtrate A, repeatedly refluxing the obtained filter residue for 2h, carrying out suction filtration to obtain a filtrate B, combining the filtrates A, B, and carrying out reduced pressure concentration at the temperature of 70 ℃ until no ethanol smell exists, thereby obtaining an alcohol-free leaching solution;
(2) concentrating the alcohol-free leaching liquor for 20min under the conditions that the vacuum degree is-0.085-0.09 MPa and the temperature is 70 ℃ to fully concentrate the extracting solution to obtain a traditional Chinese medicine extracting concentrated solution;
(3) mixing the citric acid, the sodium bicarbonate, the auxiliary materials and the traditional Chinese medicine concentrated solution in a mass ratio of 1:1:4:2 to obtain acid granules, alkali granules, boiling, drying, granulating and tabletting to obtain the curcumin composition effervescent tablet.
Example 2
A method for preparing curcumin composition effervescent tablet comprises the following steps:
(1) weighing 1 part by weight of curcumin, 10 parts by weight of kudzu root, 20 parts by weight of round cardamom and 15 parts by weight of hovenia dulcis thunb; respectively drying the weighed Chinese herbal medicines in an oven at 80-85 ℃ for 2.5-4.0 h, then respectively crushing the dried Chinese herbal medicines for 35-50 s by using a crusher, sieving to obtain Chinese herbal medicine powder, adding the Chinese herbal medicine powder into 500mL of 50% ethanol solution, refluxing for 2.5h, controlling the temperature to be 80 ℃, carrying out suction filtration to obtain filtrate A, repeatedly refluxing the obtained filter residue for 2.5h, carrying out suction filtration to obtain filtrate B, combining the filtrates A, B, and carrying out reduced pressure concentration at 80 ℃ until no ethanol smell exists, thus obtaining an alcohol-free leaching solution;
(2) concentrating the alcohol-free leaching liquor for 20min under the conditions that the vacuum degree is-0.085-0.09 MPa and the temperature is 80 ℃ to fully concentrate the extracting solution to obtain a traditional Chinese medicine extracting concentrated solution;
(3) mixing the citric acid, the sodium bicarbonate, the auxiliary materials and the traditional Chinese medicine concentrated solution in a mass ratio of 1:1:4:2 to obtain acid granules, alkali granules, boiling, drying, granulating and tabletting to obtain the curcumin composition effervescent tablet.
Example 3
A method for preparing curcumin composition effervescent tablet comprises the following steps:
(1) weighing 20 parts of curcumin, 30 parts of kudzu root, 5 parts of round cardamom and 20 parts of hovenia dulcis thunb; respectively drying the weighed Chinese herbal medicines in an oven at the temperature of 80-85 ℃ for 2.5-4.0 h, then respectively crushing the dried Chinese herbal medicines for 35-50 s by using a crusher, sieving to obtain Chinese herbal medicine powder, adding the Chinese herbal medicine powder into 500mL of 35% ethanol solution, refluxing for 3h, controlling the temperature to be 75 ℃, carrying out suction filtration to obtain a filtrate A, repeatedly refluxing the obtained filter residue for 3h, carrying out suction filtration to obtain a filtrate B, combining the filtrates A, B, and carrying out reduced pressure concentration at the temperature of 75 ℃ until no ethanol smell exists, thereby obtaining an alcohol-free leaching solution;
(2) concentrating the alcohol-free leaching liquor for 20min under the conditions that the vacuum degree is-0.085-0.09 MPa and the temperature is 75 ℃ to fully concentrate the extracting solution to obtain a traditional Chinese medicine extracting concentrated solution;
(3) mixing the citric acid, the sodium bicarbonate, the auxiliary materials and the traditional Chinese medicine concentrated solution in a mass ratio of 1:1:4:2 to obtain acid granules, alkali granules, boiling, drying, granulating and tabletting to obtain the curcumin composition effervescent tablet.
Example 4
A method for preparing curcumin composition effervescent tablet comprises the following steps:
(1) weighing 15 parts of curcumin, 18 parts of kudzu root, 16 parts of round cardamom and 25 parts of hovenia dulcis thunb; respectively drying the weighed Chinese herbal medicines in an oven at 80-85 ℃ for 2.5-4.0 h, then respectively crushing the dried Chinese herbal medicines for 35-50 s by using a crusher, sieving to obtain Chinese herbal medicine powder, adding the Chinese herbal medicine powder into 500mL of 50% ethanol solution, refluxing for 2h, controlling the temperature to be 80 ℃, carrying out suction filtration to obtain a filtrate A, repeatedly refluxing the obtained filter residue for 2h, carrying out suction filtration to obtain a filtrate B, combining the filtrates A, B, and carrying out reduced pressure concentration at 80 ℃ until no ethanol smell exists, thereby obtaining an alcohol-free leaching solution;
(2) concentrating the alcohol-free leaching liquor for 20min under the conditions that the vacuum degree is-0.085-0.09 MPa and the temperature is 80 ℃ to fully concentrate the extracting solution to obtain a traditional Chinese medicine extracting concentrated solution;
(3) mixing the citric acid, the sodium bicarbonate, the auxiliary materials and the traditional Chinese medicine concentrated solution in a mass ratio of 1:1:4:2 to obtain acid granules, alkali granules, boiling, drying, granulating and tabletting to obtain the curcumin composition effervescent tablet.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (8)
1. A curcumin composition effervescent tablet is characterized in that the main drug is a concentrated solution extracted from traditional Chinese medicine;
the traditional Chinese medicine extract concentrated solution is prepared by extracting and concentrating 1-20 parts by weight of curcumin, 10-30 parts by weight of kudzu root, 5-20 parts by weight of cardamom and 10-20 parts by weight of hovenia dulcis thunb.
2. A curcumin composition effervescent tablet according to claim 1, characterized in that: in the effervescent tablet, a disintegrant consists of citric acid and sodium bicarbonate.
3. A curcumin composition effervescent tablet according to claim 2, characterized in that: in the effervescent tablet, the mass ratio of citric acid, sodium bicarbonate, other auxiliary materials and the traditional Chinese medicine extract concentrated solution is 1:1:4: 2.
4. A curcumin composition effervescent tablet according to claim 1, characterized in that: the extraction and concentration are carried out by leaching each traditional Chinese medicine raw material by using 35-50% by volume of ethanol water solution, evaporating to remove ethanol to obtain traditional Chinese medicine extract water dispersion, and then carrying out vacuum concentration to obtain traditional Chinese medicine extract concentrated solution.
5. A curcumin composition effervescent tablet according to claim 4, characterized in that: the leaching is carried out for 2.5-3.0 h each time at 70-80 ℃, and 2-3 times.
6. A curcumin composition effervescent tablet according to claim 4, characterized in that: the ethanol is evaporated and removed by vacuum concentration at 70-80 ℃ until no ethanol smell exists.
7. A curcumin composition effervescent tablet according to claim 4, characterized in that: the vacuum concentration is carried out under the vacuum degree of-0.085-0.090 MPa and the temperature of 70-80 ℃.
8. A curcumin composition effervescent tablet according to claim 3, characterized in that: the other auxiliary materials are more than one of sucrose fine powder, cyclodextrin, starch or maltodextrin.
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Application publication date: 20191224 |