CN110604296A

CN110604296A - Health buccal tablet containing natamycin and preparation method thereof

Info

Publication number: CN110604296A
Application number: CN201910968051.6A
Authority: CN
Inventors: 许宸华; 陈卫良; 李波
Original assignee: Wei Day (shandong) Biological Technology Co Ltd
Current assignee: Wei Day (shandong) Biological Technology Co Ltd
Priority date: 2019-10-12
Filing date: 2019-10-12
Publication date: 2019-12-24

Abstract

The health buccal tablet containing natamycin comprises, by mass, 300 ~ 550 parts of passion fruit, 200 ~ 500 parts of pitaya flower, 1 ~ 5 parts of natamycin, 30 ~ 70 parts of xylo-oligosaccharide, 40 ~ 80 parts of honey and 170 ~ 300 parts of tabletting auxiliary materials, wherein the composition extract and the fruit powder are prepared by uniformly mixing the fruit powder, the natamycin and xylo-oligosaccharide powder by weight, adding the honey, the lactose and the composition extract A to prepare soft material particles, drying the soft material particles, adding magnesium stearate to uniformly tabletting, and drying the tabletting.

Description

Health buccal tablet containing natamycin and preparation method thereof

Technical Field

The invention relates to an oral care potion, in particular to a natamycin-containing health buccal tablet and a preparation method thereof.

Background

Dental caries is a progressive lesion of hard tooth tissue caused by the compounding and acting of various factors in the oral cavity, and is represented by the evolution process of inorganic demineralization and organic matter decomposition from color change to substantial lesion formation along with the development of the course of disease. Dental caries is a bacterial disease and therefore it can be secondary to pulpitis and periapical inflammation and can even cause inflammation of the alveolar bone and jaw bone. The secondary infection of dental caries can form focus, and can cause or add other diseases of the whole body such as arthritis, cardia periostitis, chronic kidney and various eye diseases. Dental caries should be mainly prevented for health care.

Fluoride anticariogenic has been known for over 40 years and includes drinking water with fluorine, fluorine-containing milk or fluorine-containing salt, topical fluorine (including fluorine)

Fluorine toothpaste, fluorine-containing gel, fluorine-containing mouth wash) and the like, and fluoride can reduce the caries rate of people to different degrees, so that fluoride is known as an effective caries prevention measure in the world currently. The oral medical community has proposed that fluoride anticaries is one of the major achievements in oral preventive medicine in the 20 th century, but the measurement of fluoride on human body's profit and disadvantage has been the subject of controversy in the oral medical field so far. It appears that the use of fluorine formulations has significant limitations, such as dental fluorosis, etc. Therefore, the search for new, safe and effective fluorine-free preparations is receiving increasing attention from researchers in the field of caries prevention and treatment.

At present, some antibacterial agents are used for preventing and treating dental caries, and a long-term use of broad-spectrum antibacterial agents and chemical synthetic drugs destroys the ecological balance of the oral cavity while removing pathogenic bacteria in the oral cavity. Meanwhile, long-term use of antibacterial drugs may cause side effects such as edema, hypertension, induction and aggravation of infection, and the like. Moreover, antibiotic drugs are susceptible to drug resistance when applied topically, and long-term topical application can cause dysbacteriosis and fungal infection. This is particularly true in children. If the traditional Chinese medicine with antibacterial effect is used, the ecological balance of the oral cavity can not be damaged while the pathogenic bacteria are inhibited. Meanwhile, the natural returning and the green therapy are accepted by more people due to the special curative effect and safety of the traditional Chinese medicine. In recent years, the research on the pharmacology and mechanism of applying traditional Chinese medicine to the prevention and treatment of dental caries has been paid attention and attention by scholars at home and abroad, and has made a better progress. Therefore, the development of a convenient and practical medicament for preventing and treating the decayed teeth has become necessary.

The passion fruit has the effects of exciting and strengthening after being used as a medicine. The pulp is juicy, and can be added with calcium bicarbonate and sugar to make aromatic and delicious beverage, or added into other beverage to improve quality of beverage. Although the nutritional value of the passion fruit is high, the passion fruit developed at present is only used as an additive for making beverages or a taste modifier for other products, the utilization rate of the passion fruit is low at present, only the inner pulp is utilized, and the outer part of the shell is discarded as garbage. At present, no product which completely develops the medicinal and nutritional values of the passion fruit exists, and no buccal tablet which takes the passion fruit as the main raw material exists in the market.

The pitaya flower is a perennial fleshy herb climbing plant, the main edible part is a flower container, the dried product of the flower container is a good product in vegetables, and the content of the nutrient components in each 100g of the dried product of the pitaya flower is as follows: 9.570g of water, 1.812g of protein, 2.785g of crude fiber, 1.547g of ash, 961.27mg of calcium and 328.45mg of phosphorus, at least 13 amino acids are contained, and the amino acids comprise a plurality of amino acids essential to human bodies. And also contains Cu, N, Cr, Cd, Ca, Zn and other elements which have important effects on human body. The pitaya flower not only can be eaten by people as a food material, but also has rich medicinal efficacy. The traditional Chinese medicine believes that the medicine has sweet and cool nature and taste, enters lung and has the effects of clearing heat and phlegm, removing accumulated heat, clearing phlegm-fire and the like. The pitaya flower has the effects of clearing heat and moistening lung, and has a close relation with the attribute of the pitaya flower, the pitaya flower is sweet in taste, slightly cold in nature and capable of entering lung channels, so that the pitaya flower can help to clear heat phlegm, remove accumulated heat and regulate phlegm fire, effectively moisten lung and clear lung, can help to relieve cough and reduce phlegm, has a certain auxiliary treatment effect on respiratory diseases such as cough, thick yellow phlegm bronchitis and the like, has a good relieving effect on constipation caused by vigorous heat in a body due to the heat of the pitaya flower.

Natamycin is a tetraene antibiotic extracted from NATALENSIS streptomycete, polyene is a plane macrolide ring structure, can interact with sterol compounds with high affinity, the action mechanism is that hydrophobic parts, namely double bond parts of macrolide are combined with whole sterol molecules by van der waals force to form a polyene sterol compound, the permeability of cell membranes is changed to form water pores, and important substances such as amino acid, electrolyte and the like in fungal cells are exuded, so that the fungi die. Hygiene and skin spot experiments show that natamycin has no anaphylactic reaction and is difficult to generate resistance by microorganisms; natamycin approved in 1996 in China as a food preservative for cheese, meat products, Cantonese moon cakes, surfaces of cakes, fruit juice puree, surfaces of easily mildewed food processing vessels and the like.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a natamycin-containing health buccal tablet and a preparation method thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows:

a health buccal tablet containing natamycin comprises the following raw materials, by mass, 300 36550 parts of passion fruit, 200 ~ parts of pitaya flower, 1 ~ parts of natamycin, 30 ~ parts of xylo-oligosaccharide, 40 ~ parts of honey and 170 ~ parts of tabletting auxiliary materials.

The passion fruit is superfine powder with 500 ~ 1000 meshes of fruit shell pulp and 500 ~ 1000 meshes of pitaya flower.

The tabletting adjuvant is one or more of lactose, microcrystalline cellulose, sodium carboxymethylcellulose, magnesium stearate and silica gel micropowder.

The tabletting auxiliary material comprises, by mass, 40 ~ 300 parts of lactose, 35 ~ 400 parts of microcrystalline cellulose, 3.5 ~ 15 parts of sodium carboxymethyl cellulose, 0.35 ~ 10 parts of magnesium stearate and 1 ~ 35 parts of aerosil.

The preparation method of the health buccal tablet containing natamycin comprises the following specific preparation steps:

(1) peeling the fruit shell to obtain fruit pulp, crushing the passion fruit pulp and the pitaya flower respectively, mixing, adding 60-80% ethanol for extraction for 2 times, filtering, recovering ethanol from filtrate, and concentrating to obtain an extract with a relative density of 1.10-1.15/60 ℃ to obtain a composition extract A;

(2) separating water from the separated pulp by a freeze drying technology, controlling the total content of the residual water to be between 11 and 17 percent, repeatedly crushing the dried pulp into superfine powder by crushing, and sieving by a 500-mesh sieve to obtain fruit powder B for later use;

(3) uniformly mixing the fruit powder B, the natamycin and the xylo-oligosaccharide powder in parts by weight, sieving the mixture by a 500-mesh sieve, adding the honey, the lactose and the composition extract A, continuously stirring the mixture to fully mix the raw materials, repeatedly adding the composition extract A for 3 times to prepare soft material granules, drying the soft material granules at the drying temperature of 40-50 ℃ to obtain soft material granules with the water content of 10-15%, sieving the granules by a 20-30-mesh sieve, adding the magnesium stearate in parts by weight, uniformly tabletting, drying the tablets, controlling the temperature to be 40-50 ℃, controlling the tabletting weight to be 500-800 mg, and finally locking the water content to be below 5%.

And (3) controlling the drying temperature of the passion fruit powder B extracted in the step (2) to be between-10 ℃ and-15 ℃.

The buccal tablet is prepared by concentrating the buccal tablet, can relieve sub-fatigue to the maximum extent and is convenient to carry, and the buccal tablet considers the absorptivity of mucous membranes in the oral cavity, has a better curative effect than various prepared juices, is healthier than compound juice, and contains fewer additives. The natamycin is added as a bacteriostatic agent in the oral cavity, the natamycin in the invention is added as a preservative and is used as an oral bacteriostatic agent, and the residence time of the buccal tablets in the oral cavity leaves sufficient room for the natamycin to inhibit bacteria in the oral cavity, so that the harm of the buccal tablets to teeth in the oral cavity is avoided; the invention has the advantages of low cost, suitability for industrial production, and strong sterilization and inhibition effects on natamycin, especially on candidiasis (commonly called thrush) in oral cavity. The xylo-oligosaccharide is selected in the invention in order to reduce the generation of dental caries to the maximum extent, the dental caries is caused by the erosion of oral microorganisms, particularly streptococcus, and the xylo-oligosaccharide added in the invention is not a proper action substrate of the oral microorganisms, so that the dental caries is not caused, and the growth of oral bacteria is inhibited. The addition of xylo-oligosaccharide not only increases the taste of the product, but also prevents the occurrence of dental caries, and the xylo-oligosaccharide in the invention has the outstanding characteristics of acid resistance, good thermal stability and difficult fermentation, and compared with other oligosaccharides, the xylo-oligosaccharide has very good stability. Even when heated to 100 ℃ under acidic conditions (pH = 2.5-7), the functional oligosaccharides are not substantially decomposed, while some functional oligosaccharides are easily decomposed under acidic conditions, thereby causing a decrease in the proliferation activity of bifidobacteria and losing the health-care effect.

Detailed Description

Example 1

A health buccal tablet containing natamycin comprises, by mass, 300 ~ 550 parts of passion fruit, 200 ~ 500 parts of pitaya flower, 1 ~ 5 parts of natamycin, 30 ~ 70 parts of xylo-oligosaccharide, 40 ~ 80 parts of honey, 170 ~ 300 parts of tabletting auxiliary materials, wherein the passion fruit is superfine powder with 500 ~ 1000 meshes of fruit shell pulp, the pitaya flower is superfine powder with 500 ~ 1000 meshes of 500, the tabletting auxiliary materials are one or more of lactose, microcrystalline cellulose, sodium carboxymethylcellulose, magnesium stearate and aerosil, and the tabletting auxiliary materials comprise, by mass, 40 ~ 300 parts of lactose, 35 ~ 400 parts of microcrystalline cellulose, 3.5 ~ 15 parts of sodium carboxymethylcellulose, 0.35 ~ 10 parts of magnesium stearate and 1 ~ 35 parts of aerosil.

(1) peeling a fruit shell to obtain a pulp, crushing the pulp of the passion fruit and the pitaya flower respectively, mixing 30 parts by mass of the pulp of the passion fruit and 200 parts by mass of the pitaya flower, adding 60-80% ethanol for extraction for 2 times, filtering, recovering ethanol from filtrate, and concentrating the filtrate to obtain an extract with the relative density of 1.25-1.40/60 ℃, thereby obtaining a composition extract A;

(2) separating water from the separated pulp by a freeze drying technology, controlling the drying temperature of passion fruit powder B to be between-10 ℃ and-15 ℃, controlling the total content of the residual water to be between 13% and 17%, repeatedly crushing the dried pulp into superfine powder by crushing, and sieving by a 500-mesh sieve to obtain fruit powder B for later use;

(3) uniformly mixing the fruit powder B, the natamycin and the xylo-oligosaccharide powder in parts by weight, sieving the mixture by a 500-mesh sieve, adding the honey, the lactose and the composition extract A, continuously stirring the mixture to fully mix the raw materials, repeatedly adding the composition extract A for 3 times to prepare soft material granules, drying the soft material granules at the drying temperature of 40-50 ℃ to obtain soft material granules with the water content of 10-15%, sieving the granules by a 20-30-mesh sieve, adding the magnesium stearate in parts by weight, and uniformly tabletting, wherein the components are in parts by weight: 220 parts of composition extract A, 300 parts of passion fruit powder B, 1.5 parts of natamycin, 55 parts of xylooligosaccharide powder, 70 parts of honey, 40 parts of lactose and 7 parts of magnesium stearate, and then tabletting is dried, the temperature is controlled to be 40-50 ℃, the tabletting weight is controlled to be 500-800 mg, and the final water content is locked below 5%.

Example 2

(1) peeling a fruit shell to obtain a pulp, crushing the pulp of the passion fruit and the pitaya flower respectively, mixing 50 parts by mass of the pulp of the passion fruit and 200 parts by mass of the pitaya flower, adding 60-80% ethanol for extraction for 2 times, filtering, recovering ethanol from filtrate, and concentrating the filtrate to obtain an extract with the relative density of 1.10-1.15/60 ℃ to obtain a composition extract A;

(2) separating water from the separated pulp by a freeze drying technology, controlling the drying temperature of passion fruit powder B to be between-10 ℃ and-15 ℃, controlling the total content of the residual water to be between 11 percent and 14 percent, repeatedly crushing the dried pulp into superfine powder by crushing, and sieving by a 500-mesh sieve to obtain fruit powder B for later use;

(3) uniformly mixing the fruit powder B, the natamycin and the xylo-oligosaccharide powder in parts by weight, sieving the mixture by a 500-mesh sieve, adding the honey, the lactose and the composition extract A, continuously stirring the mixture to fully mix the raw materials, repeatedly adding the composition extract A for 3 times to prepare soft material granules, drying the soft material granules at the drying temperature of 40-50 ℃ to obtain soft material granules with the water content of 10-15%, sieving the granules by a 20-30-mesh sieve, adding the magnesium stearate in parts by weight, and uniformly tabletting, wherein the components are in parts by weight: 200 parts of composition extract A, 280 parts of passion fruit powder B, 1.7 parts of natamycin, 60 parts of xylooligosaccharide powder, 65 parts of honey, 50 parts of lactose and 10 parts of sodium carboxymethylcellulose, then drying the tabletting, controlling the temperature to be 40-50 ℃, controlling the weight of the tabletting to be 500-800 mg, and finally locking the water content to be below 4%.

The pitaya flower is rich in nutrition and can well improve the immunity of a human body. The pitaya flower contains various trace elements and at least 13 amino acids, so that extremely rich nutrition can be supplemented for a body, and the body immunity can be improved by eating the pitaya flower frequently.

The content of phosphorus in the pitaya flower is high, the phosphorus is an important component forming a nervous system, the phosphorus has the effect of maintaining acid-base balance in a body and participates in fat and sugar metabolism, and the content of calcium in the pitaya flower is 961.27mg/kg, which is a good source of calcium. Calcium has good effects in forming and maintaining bones, and preventing infantile bones and osteoporosis.

The passion fruit is rich, sweet and sour, and delicious, and can promote the production of body fluid to quench thirst; refreshing, loosening bowel to relieve constipation, and preventing carcinoma of large intestine; tonifying kidney, strengthening body constitution, removing toxic substance, and caring skin; relieving alcoholism, protecting liver, and relieving fatigue; has effects in lowering blood pressure, blood sugar and cholesterol; oral ulcer, periodontitis, and pharyngolaryngitis; has effects in treating colitis and gastrointestinal diseases; regulating blood sugar, and preventing diabetes; the bone is strengthened and the osteoporosis is relieved; improving immunity, and preventing diseases. The passion fruit is a natural tranquilizer and has the effects of relaxing and calming nerves; can be used for treating insomnia, inducing natural sleep and deep sleep, and eliminating headache and dizziness; it also can relieve headache, gastralgia, frequent micturition, palpitation, muscle spasm, tetany, and pain caused by anxiety, stress, depression, and nervous tension. Lycopene in passion fruit can remove free radicals, block nitrosamine formation, and has the effects of preventing and resisting cancer, preventing cardiovascular diseases, enhancing immunity and delaying aging. Passion fruit has a complex role in the central nervous system. The nikkic acid contained in the eggplants is necessary for cell respiration and participates in a plurality of metabolic processes in the body, and the nikkic acid plays roles of resisting pellagra, preventing mental depression and the like, so people with high working and mental stress need to eat the nikkic acid regularly. The passion fruit can be used for treating insomnia, inducing natural sleep and deep sleep, and eliminating headache, dizziness and other phenomena; relieving anxiety, depression, albizia, headache, frequent micturition, and palpitation caused by nervous tension; improving muscle spasm, convulsion, and pain caused by nervous tension; relieve all discomfort caused by nervous tension and extreme anxiety; improve extreme depressed mood and excessive anxiety.

Claims

1. The health-care buccal tablet containing natamycin is characterized by comprising the following raw materials, by mass, 300 ~ 550 parts of passion fruit, 200 ~ 500 parts of pitaya flower, 1 ~ 5 parts of natamycin, 30 ~ 70 parts of xylo-oligosaccharide, 40 ~ 80 parts of honey and 170 ~ 300 parts of tabletting auxiliary materials.

2. The natamycin-containing health buccal tablet as claimed in claim 1, wherein the passion fruit is ultramicro powder with a shell pulp of 500 ~ 1000 meshes 1000, and the pitaya flower is ultramicro powder with a shell pulp of 500 ~ 1000 meshes 1000.

3. The natamycin-containing health buccal tablet as claimed in claim 1, wherein the tabletting excipients are one or more of lactose, microcrystalline cellulose, sodium carboxymethyl cellulose, magnesium stearate and aerosil.

4. The natamycin-containing health buccal tablet as claimed in claim 1, wherein the tabletting excipients comprise, by mass, 40 ~ 300 parts of lactose, 35 ~ 400 parts of microcrystalline cellulose, 3.5 ~ 15 parts of sodium carboxymethylcellulose, 0.35 ~ 10 parts of magnesium stearate and 1 ~ 35 parts of aerosil.

5. The preparation method of the natamycin-containing health buccal tablet according to claim 1, 2, 3 or 4 is characterized by comprising the following steps:

6. The preparation method of the natamycin-containing health buccal tablet as claimed in claim 5, wherein the drying temperature of the passion fruit powder B extracted in the step (2) is controlled between-10 ℃ and-15 ℃.