CN110596109A - Artificial spleen design chip - Google Patents
Artificial spleen design chip Download PDFInfo
- Publication number
- CN110596109A CN110596109A CN201910931985.2A CN201910931985A CN110596109A CN 110596109 A CN110596109 A CN 110596109A CN 201910931985 A CN201910931985 A CN 201910931985A CN 110596109 A CN110596109 A CN 110596109A
- Authority
- CN
- China
- Prior art keywords
- plate
- pressing plate
- groove
- fixing block
- fixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000952 spleen Anatomy 0.000 title claims abstract description 27
- 238000007789 sealing Methods 0.000 claims abstract description 19
- 208000001848 dysentery Diseases 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 abstract description 29
- 239000008280 blood Substances 0.000 abstract description 29
- 239000011664 nicotinic acid Substances 0.000 abstract description 2
- 238000007689 inspection Methods 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000002158 endotoxin Substances 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 238000004159 blood analysis Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 108700043460 bacteria ModE Proteins 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Prostheses (AREA)
Abstract
The invention discloses an artificial spleen type design chip which comprises a luer male connector, a luer female connector, a first upper fixing block, an upper pressing plate, a middle clamping plate, a lower pressing plate, a sealing ring, a first lower fixing seat, a second lower fixing seat and a second upper fixing block, wherein an upper passing groove and a lower passing groove are formed in the middle clamping plate, a through groove for communicating the upper passing groove and the lower passing groove is formed between the upper passing groove and the lower passing groove, plate fixing holes and plate positioning holes distributed in a rectangular array are formed in the middle clamping plate, the upper pressing plate and the lower pressing plate are respectively arranged on the upper side and the lower side of the middle clamping plate, plate fixing holes and plate positioning holes are formed in the upper pressing plate and the lower pressing plate, through openings are formed in the upper pressing plate and the lower pressing plate, and a first upper fixing block, a first lower fixing seat, a first upper fixing block and a first lower fixing seat are arranged on the. This multilayer bonding blood is examined and is treated chip carries out bionic design to biological spleen, has the function of blood treatment and inspection, is fit for generally using widely.
Description
Technical Field
The invention belongs to the technical field of blood examination equipment, and particularly relates to an artificial spleen design chip.
Background
Blood is a red opaque viscous liquid that flows in human blood vessels and the heart. The blood consists of blood plasma and blood cells, the bacterial infection is acute systemic infection caused by invasion of pathogenic bacteria or conditional pathogenic bacteria into blood circulation to grow and reproduce and produce toxins and other metabolites, and is clinically characterized by chills, hyperpyrexia, rash, arthralgia and hepatosplenomegaly, and part of the bacterial infection can have infective shock and migratory focus. Acute systemic infection caused by invasion of pathogenic microorganisms into the blood from wounds or infected lesions in vivo.
The existence of bacteria in blood is an important index in blood examination, the existing blood bacteria mode mostly adopts a slide to clamp the blood and observe the blood through a microscope, and the slide is difficult to apply in a closed blood circuit.
Disclosure of Invention
The invention aims to provide an artificial spleen design chip to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: an artificial spleen design chip comprises a Ruhr male connector, a Ruhr female connector, a first upper fixing block, an upper pressing plate, a middle clamping plate, a lower pressing plate, a sealing ring, a first lower fixing seat, a second lower fixing seat and a second upper fixing block, wherein the outer contour of the middle clamping plate is of a rectangular plate-shaped structure, the middle clamping plate is provided with an upper passing groove and a lower passing groove, a plurality of groups of through grooves which are distributed in a linear array and are communicated with the upper passing groove and the lower passing groove are arranged between the upper passing groove and the lower passing groove, the middle clamping plate is provided with plate fixing holes and plate positioning holes which are distributed in a rectangular array, the upper pressing plate and the lower pressing plate are respectively arranged on the upper side and the lower side of the middle clamping plate, the upper pressing plate and the lower pressing plate are respectively provided with plate fixing holes and plate positioning holes, and the upper pressing;
one end of the upper pressing plate, the lower pressing plate and the middle clamping plate is provided with a first upper fixing block and a first lower fixing base, the first upper fixing block is provided with screw counter bores which are distributed in a rectangular array and penetrate through the first upper fixing block, block positioning holes are arranged among the screw counter bores, a bent groove is arranged in the first upper fixing block, one end, adjacent to the upper pressing plate, of the bent groove is provided with a sealing ring groove, a sealing ring is arranged in the sealing ring groove, one side, away from the upper pressing plate, of the bent groove is internally provided with a luer male connector, the lower side of the first upper fixing block is provided with a first lower fixing base, the first lower fixing base is internally provided with seat threaded holes distributed in a rectangular array, the first lower fixing base is provided with a positioning shaft, the bent groove is arranged in the first lower fixing base, one end, adjacent to the lower pressing plate, of the bent groove is provided with a sealing ring groove, the other end, the shape of the second upper fixing block and the shape of the first upper fixing block are in a symmetrical relation and the same as the corresponding relation of the upper pressing plate, the shape of the second lower fixing seat and the shape of the first lower fixing seat are in a symmetrical relation and the same as the corresponding relation of the lower pressing plate, and the connection mode of the second lower fixing seat and the second upper fixing block is the same as that of the first lower fixing seat and the first upper fixing block.
Preferably, the depth of the upper passing groove is zero six millimeters, and the depth of the lower passing groove is zero three or four millimeters.
Preferably, the plate fixing holes and the plate positioning holes are in a mutually symmetrical relationship by taking the middle clamping plate as an axis, and the plate fixing holes and the plate positioning holes on the middle clamping plate correspond to the plate fixing holes and the plate positioning holes on the upper pressing plate and the lower pressing plate.
Preferably, the through grooves are long strips, the inner spaces at the two ends of the through grooves are semicircular surfaces, the length of each through groove is two millimeters, the width of each through groove is three millimeters at zero point, the distance between every two adjacent through grooves is four millimeters at zero point, and the depth of each through groove is three millimeters at zero point.
Preferably, the upper passing groove and the lower passing groove are both provided with inlets and outlets, the runners of the upper passing groove and the lower passing groove are distributed into one-to-two, two-to-four, four-to-eight and eight-to-sixteen, the runners are symmetrical and parallel to each other, and the width of the runner divided into sixteen equal parts is two millimeters.
Preferably, the through hole in the upper pressing plate corresponds to the upper through groove adjacent to the through hole, the bent grooves in the first upper fixing block and the second upper fixing block correspond to the positions of the through holes, the through hole in the lower pressing plate corresponds to the lower through groove adjacent to the through hole, and the bent grooves in the first lower fixing seat and the second lower fixing seat correspond to the positions of the bent grooves.
Preferably, the luer male connectors are provided with luer female connectors corresponding to the specifications of the luer male connectors.
Preferably, the positioning shaft corresponds to the adjacent plate positioning hole and the positioning hole, the positioning shaft on the lower fixing seat penetrates through the plate positioning hole in the lower pressing plate, the middle clamping plate and the upper pressing plate adjacent to the positioning shaft and the positioning hole in the upper fixing block, the seat threaded hole corresponds to the adjacent plate fixing hole and the screw counter bore in position, a hexagonal screw is arranged in the screw counter bore, the hexagonal screw penetrates through the screw counter bore and the plate fixing hole in the adjacent lower pressing plate, the middle clamping plate and the upper pressing plate and stretches into the seat threaded hole in the lower fixing seat, the first upper fixing block and the first lower fixing seat are connected with each other through an inner hexagonal screw, and the second upper fixing block and the second lower fixing seat are connected with each other through an inner hexagonal screw.
The invention has the technical effects and advantages that: the artificial spleen design chip determines the relative position relation among an upper pressure plate, a middle splint and a lower pressure plate through a positioning shaft, blood and a physiological saline pipeline are led into the middle splint through a luer connector by fixing a hexagon socket screw, a first upper fixing block, a second upper fixing block, a first lower fixing seat and a second lower fixing seat, the physiological saline is mixed in a through groove in the middle splint, the transparent upper pressure plate, the lower pressure plate and the middle splint have excellent light transmittance, the mixture of the blood and the physiological saline in the middle splint is observed through a microscope, the difference can be observed through the microscope to determine whether abnormal cells or germs and the like exist in the blood, the chip is used for helping a doctor to determine the disease condition of a detected person, a treatment scheme is determined, the chip has wide application prospect in the field of medical treatment, for example, a patient needing hemodialysis, the chip can be directly connected in series into a blood loop of dialysis equipment, blood in the loop can be observed in a light-transmitting mode in real time, the blood state of a patient can be observed visually, the chip can be applied to multiple aspects in clinical treatment of blood diseases, and structurally, the structure carries out bionic design on human spleen, and potential applications are pathogen (bacteria, fungi, parasites and the like), endotoxin and circulating tumor cells are enriched or pathogen (bacteria, fungi, parasites and the like), endotoxin and circulating tumor cells are subjected to blood purification.
Drawings
FIG.1 is a schematic structural view of the present invention;
FIG. 2 is an exploded view of the present invention;
FIG. 3 is a schematic view of a luer female coupling structure of the present invention;
FIG. 4 is a schematic view of a luer male connector of the present invention;
FIG. 5 is a top view of the first upper fixing block according to the present invention;
FIG. 6 is a view showing the lower structure of the first upper fixing block according to the present invention;
FIG. 7 is a schematic view of the structure of the upper platen of the present invention;
FIG. 8 is a schematic view of the upper surface structure of the middle splint of the present invention;
FIG. 9 is an enlarged view of the structure of FIG. 8 at A in accordance with the present invention;
FIG. 10 is a schematic view of the lower surface of the middle splint of the present invention;
FIG. 11 is a schematic view of the lower splint of the present invention;
FIG. 12 is a schematic view of the seal ring of the present invention;
FIG. 13 is a schematic view of a first lower fixing base according to the present invention;
FIG. 14 is a schematic view of a second lower fixing base according to the present invention;
FIG. 15 is a view showing an upper side structure of a second upper fixing block according to the present invention;
fig. 16 is a view showing the lower side structure of a second upper fixing block according to the present invention;
FIG. 17 is a schematic top view of a through slot of the present invention;
fig. 18 is a cross-sectional dimension view of the through-slot of the present invention.
In the figure: the locking device comprises a 1-luer female connector, a 2-luer male connector, a 3-first upper fixing block, a 4-upper pressing plate, a 5-middle clamping plate, a 501-upper through groove, a 502-through groove, a 503-lower through groove, a 6-lower pressing plate, a 7-sealing ring, a 8-first lower fixing seat, a 9-second lower fixing seat, a 10-second upper fixing block, a 11-bent groove, a 12-sealing ring groove, a 13-positioning hole, a 14-screw counter bore, a 15-positioning shaft, a 16-seat threaded hole, a 17-plate positioning hole, a 18-plate fixing hole and a 19.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides an artificial spleen design chip as shown in figures 1-18, which comprises a luer male connector 2, a luer female connector 1, a first upper fixing block 3, an upper pressure plate 4, a middle clamping plate 5, a lower pressure plate 6, a sealing ring 7, a first lower fixing seat 8, a second lower fixing seat 9 and a second upper fixing block 10, wherein the outer contour of the middle clamping plate 5 is in a rectangular plate-shaped structure, the middle clamping plate 5 is provided with an upper passing groove 501 and a lower passing groove 503, a plurality of groups of through grooves 502 which are distributed in a linear array and are communicated up and down are arranged between the upper passing groove 501 and the lower passing groove 503, the middle clamping plate 5 is provided with plate fixing holes 18 and plate positioning holes 17 which are distributed in a rectangular array, the upper pressure plate 4 and the lower pressure plate are respectively arranged on the upper side and the lower side of the middle clamping plate 5, the upper pressure plate 4 and the lower pressure plate 6 are both provided with the plate fixing holes 18 and the plate positioning holes, the upper pressing plate 4 and the lower pressing plate 6 are also provided with through openings 19;
one end of the upper pressing plate 4, one end of the lower pressing plate 6 and one end of the middle clamping plate 5 are provided with a first upper fixing block 3 and a first lower fixing seat 8, the first upper fixing block 3 is provided with screw counter bores 14 which are distributed in a rectangular array and penetrate through the first upper fixing block 3, block positioning holes 13 are arranged between the screw counter bores 14, a bent groove 11 is arranged inside the first upper fixing block 3, one end, adjacent to the upper pressing plate 4, of the bent groove 11 is provided with a sealing ring groove 12, a sealing ring 7 is arranged inside the sealing ring groove 12, one side, away from the upper pressing plate 4, of the bent groove 11 is internally provided with a luer male connector 2, the lower side of the first upper fixing block 3 is provided with a first lower fixing seat 8, seat threaded holes 16 which are distributed in a rectangular array are arranged inside the first lower fixing seat 8, a positioning shaft 15 is arranged on the first lower fixing seat 8, a bent groove 11 is arranged inside the first lower fixing seat 8, one, the other end of the upper pressing plate 4, the lower pressing plate 6 and the middle clamping plate 5 is provided with a second upper fixing block 10 and a second lower fixing block 9, the second upper fixing block 10 and the first upper fixing block 3 are in a symmetrical relationship and are identical to the corresponding relationship of the upper pressing plate 4, the second lower fixing block 9 and the first lower fixing block 8 are in a symmetrical relationship and are identical to the corresponding relationship of the lower pressing plate 6, and the second lower fixing block 9 and the second upper fixing block 10 are identical to the first lower fixing block 8 and the first upper fixing block 3.
Specifically, the depth of the upper passing groove 501 is zero six millimeters, and the depth of the lower passing groove 503 is zero three or four millimeters.
Specifically, the plate fixing holes 18 and the plate positioning holes 17 are in a mutually symmetrical relationship with the middle clamping plate 5 as an axis, the plate fixing holes 18 and the plate positioning holes 17 on the middle clamping plate 5 correspond to the plate fixing holes 18 and the plate positioning holes 17 on the upper clamping plate 4 and the lower clamping plate 6, and the hole positions are correspondingly used for determining the position relationship among the upper clamping plate 4, the middle clamping plate 5 and the lower clamping plate 6.
Specifically, the through groove 502 is long, the inner spaces at the two ends of the through groove 502 are semicircular surfaces, the length of the through groove 502 is two millimeters, the width of the through groove 502 is three millimeters at zero point, the distance between the adjacent through grooves 502 is four millimeters at zero point, and the depth of the through groove 502 is three millimeters at zero point.
Specifically, the upper passing groove 501 and the lower passing groove 503 are both provided with inlets and outlets, the flow channels of the upper passing groove 501 and the lower passing groove 503 are distributed into two in one, four in two, eight in four and sixteen in eight, the flow channels are symmetrical and parallel to each other, and the flow channel width divided into sixteen equal parts is two millimeters.
Specifically, the through hole 19 in the upper pressure plate 4 corresponds to the upper through groove 501 adjacent thereto, the curved grooves 11 in the first upper fixing block 3 and the second upper fixing block 10 correspond to the positions thereof, the through hole 19 in the lower pressure plate 6 corresponds to the lower through groove 503 adjacent thereto, and the curved grooves 11 in the first lower fixing seat 8 and the second lower fixing seat 9 correspond to the positions thereof.
Specifically, the luer male connectors 2 are provided with luer female connectors 1 corresponding to the specifications of the luer male connectors.
Specifically, the positioning shaft 15 corresponds to the adjacent plate positioning hole 17 and the positioning hole 13, the positioning shaft 15 on the lower fixing seat penetrates through the plate positioning hole 17 in the lower pressing plate 6, the middle pressing plate 5 and the upper pressing plate 4 adjacent to the positioning shaft and the positioning hole 13 on the upper fixing block, the seat threaded hole 16 corresponds to the adjacent plate fixing hole 18 and the screw counter bore 14 in position, a hexagonal screw is arranged inside the screw counter bore 14, the hexagonal screw penetrates through the screw counter bore 14 and the adjacent plate fixing hole 18 in the lower pressing plate 6, the middle pressing plate 5 and the upper pressing plate 4 and extends into the seat threaded hole 16 in the lower fixing seat, the first upper fixing block 3 and the first lower fixing seat 8 are connected with each other through an inner hexagonal screw, and the second upper fixing block 10 and the second lower fixing seat 9 are connected with each other through an inner hexagonal screw.
Specifically, the artificial spleen chip comprises an upper pressing plate 4 and a lower pressing plate 6, wherein a middle clamping plate 5 is clamped by the upper pressing plate 4 and the lower pressing plate 6, a first upper fixing block 3 and a first lower fixing block 8 are fixed at one end of the middle clamping plate, a second upper fixing block 10 and a second lower fixing block 9 are fixed at the other end of the middle clamping plate, a positioning shaft 15 on the first lower fixing block 8 and the second lower fixing block 9 penetrates through a plate positioning hole 17 in the upper pressing plate 4, the lower pressing plate 6 and the middle clamping plate 5 above the positioning shaft, the protruding parts of the positioning shaft extend into positioning holes 13 in the first upper fixing block 3 and the second upper fixing block 10 above the positioning shaft, so that the positions of the upper pressing plate 4, the lower pressing plate 6 and the middle clamping plate 5 are determined, an inner hexagonal screw penetrates through a screw counter bore 14 and is screwed into a seat threaded hole 16, the first upper fixing block 3, the second upper fixing block 10, the first lower fixing block 8, the second lower fixing block 9, the upper pressing plate 4, the lower pressing, blood and saline pipelines are respectively connected with a luer on one side of the middle splint 5, the blood and the saline enter the upper passing groove 501 and the lower passing groove 503 through the luer, the bent grooves 11 in the first upper fixing block 3 and the second upper fixing block 10 and are mixed in the through groove 502 inside the upper passing groove 501 and the lower passing groove 503, the sealing ring 7 is used for filling gaps and preventing the blood or the saline from seeping out, the two sets of luer on the lower side are used for removing blood mixtures inside the upper passing groove 501, the lower passing groove 503 and the through groove 502, the upper pressing plate 4, the lower pressing plate 6 and the middle splint 5 are all made of transparent polymer materials, and light can pass through the upper pressing plate 4, the lower pressing plate and the middle splint 5 so as to be convenient for observing cells and bacteria inside the microscope; in order to effectively remove the magnetized phage-bound pathogenic bacteria and endotoxin from the blood of sepsis patients, the blood purification rate was several liters/hour, and the blood was not damaged and diluted. Inspired by the inspiration of the microstructure of the biological spleen, an extracorporeal blood purification system is developed, namely the chip. The chip is composed of two adjacent rectangular runners. One serves as a vascular access (2mm x 0.6mm x 27 mm; the flow rate through which blood flows can be as high as 1.25L/h.) the other (2mm x 0.34mm x 27mm) flows through saline at intermittent (5min on and 60min) or slow flow rates (0-0.1L/h), the vascular access and the saline through access are two sets of access connected and formed by luer connectors, and the structure is similar to the venous sinus of the spleen. In the spleen, the phage-bound pathogens are cleared from the blood by macrophages resident in the spleen, when blood flow slows down as they filter through the cleft between adjacent endothelial cells, flowing from the medullary and marginal zone of the blood stream into the venous sinus. Similarly, the artificial spleen contains a series of open rectangular slits (2 mm. times.0.34 mm), i.e., through-ports 502, which provide direct access to blood channels and saline-infused sinus channels (FIG.1 c). We base the sizing of the channels and slits on previous artificial spleen designs. In order to improve the separation and purification efficiency under the blood flow velocity, an inflow channel in the artificial spleen is branched four times, then is connected with sixteen magnetic separation channels, and finally is converged into an outflow channel (FIG.1c), and the structure is designed to simulate the human spleen and has potential applications of pathogen (bacteria, fungi, parasites and the like), endotoxin and circulating tumor cell enrichment or pathogen (bacteria, fungi, parasites and the like), endotoxin and circulating tumor cell blood purification.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (8)
1. The utility model provides an artifical spleen class design chip, includes luer male joint (2), luer female joint (1), first fixed block (3) of going up, top board (4), well splint (5), holding down plate (6), sealing washer (7), first fixing base (8), second fixing base (9) and second go up fixed block (10), its characterized in that: the outer contour of the middle clamping plate (5) is of a rectangular plate-shaped structure, an upper passing groove (501) and a lower passing groove (503) are formed in the middle clamping plate (5), a plurality of groups of through grooves (502) which are distributed in a linear array and are communicated with each other are formed between the upper passing groove (501) and the lower passing groove (503), plate fixing holes (18) and plate positioning holes (17) which are distributed in a rectangular array are formed in the middle clamping plate (5), an upper pressing plate (4) and a lower pressing plate are respectively arranged on the upper side and the lower side of the middle clamping plate (5), the upper pressing plate (4) and the lower pressing plate (6) are respectively provided with the plate fixing holes (18) and the plate positioning holes (17), and the upper pressing plate (4) and the lower pressing plate (6) are further provided with passing openings (19);
the sealing device is characterized in that one end of the upper pressing plate (4), the lower pressing plate (6) and the middle clamping plate (5) is provided with a first upper fixing block (3) and a first lower fixing seat (8), the first upper fixing block (3) is provided with screw counter bores (14) which are distributed in a rectangular array and penetrate through the first upper fixing block (3), block positioning holes (13) are formed between the screw counter bores (14), a bent groove (11) is formed inside the first upper fixing block (3), one end, adjacent to the upper pressing plate (4), of the bent groove (11) is provided with a sealing ring groove (12), a sealing ring (7) is arranged inside the sealing ring groove (12), one side, far away from the upper pressing plate (4), of the bent groove (11) is internally provided with a Ruhr male connector (2), the lower side of the first upper fixing block (3) is provided with the first lower fixing seat (8), and seat threaded holes (16) which are distributed in the rectangular, a positioning shaft (15) is arranged on the first lower fixed seat (8), a curved groove (11) is arranged in the first lower fixed seat (8), one end of the curved groove (11) adjacent to the lower pressure plate (6) is provided with a sealing ring groove (12), the other ends of the upper pressure plate (4), the lower pressure plate (6) and the middle splint (5) are provided with a second upper fixed block (10) and a second lower fixed seat (9), the shapes of the second upper fixing block (10) and the first upper fixing block (3) are in a symmetrical relationship and have the same corresponding relationship with the upper pressure plate (4), the shapes of the second lower fixing seat (9) and the first lower fixing seat (8) are in a symmetrical relation and are the same as the corresponding relation of the lower pressing plate (6), and the connection mode of the second lower fixing seat (9) and the second upper fixing block (10) is the same as that of the first lower fixing seat (8) and the first upper fixing block (3).
2. The artificial spleen design chip of claim 1, wherein: the depth of the upper passing groove (501) is zero six millimeters, and the depth of the lower passing groove (503) is zero three or four millimeters.
3. The artificial spleen design chip of claim 1, wherein: the plate fixing holes (18) and the plate positioning holes (17) are in a mutually symmetrical relationship by taking the middle clamping plate (5) as an axis, and the plate fixing holes (18) and the plate positioning holes (17) on the middle clamping plate (5) correspond to the plate fixing holes (18) and the plate positioning holes (17) on the upper pressing plate (4) and the lower pressing plate (6).
4. The artificial spleen design chip of claim 1, wherein: the through grooves (502) are long, the inner spaces at two ends of each through groove (502) are semicircular surfaces, the length of each through groove (502) is two millimeters, the width of each through groove (502) is three millimeters to four millimeters, the distance between every two adjacent through grooves (502) is four millimeters to three millimeters, and the depth of each through groove (502) is three millimeters to four millimeters.
5. The artificial spleen design chip of claim 1, wherein: the upper passing groove (501) and the lower passing groove (503) are both provided with inlets and outlets, the runners of the upper passing groove (501) and the lower passing groove (503) are distributed into two in one, four in two, eight in four and sixteen in eight, the runners are symmetrical and parallel to each other, and the width of the runner divided into sixteen equal parts is two millimeters.
6. The artificial spleen design chip of claim 1, wherein: the upper pressing plate is characterized in that a through hole (19) in the upper pressing plate (4) is adjacent to an upper through groove (501), bent grooves (11) in a first upper fixing block (3) and a second upper fixing block (10) are corresponding to the positions of the bent grooves, a through hole (19) in the lower pressing plate (6) is adjacent to a lower through groove (503), and bent grooves (11) in a first lower fixing seat (8) and a second lower fixing seat (9) are corresponding to the positions of the bent grooves.
7. The artificial spleen design chip of claim 1, wherein: and the luer male connectors (2) are provided with luer female connectors (1) corresponding to the specification of the luer male connectors.
8. The artificial spleen design chip of claim 1, wherein: the positioning shaft (15) corresponds to the adjacent plate positioning hole (17) and the positioning hole (13), a positioning shaft (15) on the lower fixing seat penetrates through a plate positioning hole (17) in the lower pressing plate (6), the middle clamping plate (5) and the upper pressing plate (4) adjacent to the positioning shaft and a positioning hole (13) on the upper fixing block, seat screw hole (16) correspond rather than adjacent board fixed orifices (18) and screw counter bore (14) position, the inside hexagonal screw that is provided with of screw counter bore (14), the hexagonal screw passes screw counter bore (14) and adjacent holding down plate (6), the board fixed orifices (18) in well splint (5) and top board (4) stretch into down inside seat screw hole (16) in the fixing base, first fixed block (3) and first fixing base (8) are through interior hexagonal screw interconnect on going up, fixed block (10) and second fixing base (9) are through interior hexagonal screw interconnect on the second.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910931985.2A CN110596109A (en) | 2019-09-29 | 2019-09-29 | Artificial spleen design chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910931985.2A CN110596109A (en) | 2019-09-29 | 2019-09-29 | Artificial spleen design chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110596109A true CN110596109A (en) | 2019-12-20 |
Family
ID=68864586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910931985.2A Pending CN110596109A (en) | 2019-09-29 | 2019-09-29 | Artificial spleen design chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110596109A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100750511B1 (en) * | 2006-05-29 | 2007-08-20 | 주식회사 뉴하트바이오 | Artificial renal microchip using electrospun nano web and polydimethysiloxane layer |
| CN103439514A (en) * | 2013-08-05 | 2013-12-11 | 徐州工程学院 | Pesticide and veterinary drug multi-residue detection method based on microarray detection chip |
| CN104524652A (en) * | 2015-01-29 | 2015-04-22 | 中国科学技术大学 | Artificial liver in-vitro working platform |
| WO2016077067A2 (en) * | 2014-10-27 | 2016-05-19 | President And Fellows Of Harvard College | Magnetic capture of a target from a fluid |
| CN105999448A (en) * | 2016-07-29 | 2016-10-12 | 武汉仝干医疗科技股份有限公司 | Four-in-one plush linear artificial liver reactor |
| US20170252701A1 (en) * | 2016-03-03 | 2017-09-07 | Micromedics Inc. | Biomimetically Designed Modular Microfluidic-Based Capillaries & Lymphatic Units for Kidney & Liver Dialysis Systems, Organ Bio-Reactors and Bio-Artificial Organ Support Systems |
| US20190209408A1 (en) * | 2018-01-09 | 2019-07-11 | Amnion Life, LLC | Systems, methods, and devices for artificial placentas and amniotic bed incubators |
| CN210775240U (en) * | 2019-09-29 | 2020-06-16 | 清科医疗器械(深圳)有限公司 | Artificial spleen design chip |
-
2019
- 2019-09-29 CN CN201910931985.2A patent/CN110596109A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100750511B1 (en) * | 2006-05-29 | 2007-08-20 | 주식회사 뉴하트바이오 | Artificial renal microchip using electrospun nano web and polydimethysiloxane layer |
| CN103439514A (en) * | 2013-08-05 | 2013-12-11 | 徐州工程学院 | Pesticide and veterinary drug multi-residue detection method based on microarray detection chip |
| WO2016077067A2 (en) * | 2014-10-27 | 2016-05-19 | President And Fellows Of Harvard College | Magnetic capture of a target from a fluid |
| CN104524652A (en) * | 2015-01-29 | 2015-04-22 | 中国科学技术大学 | Artificial liver in-vitro working platform |
| US20170252701A1 (en) * | 2016-03-03 | 2017-09-07 | Micromedics Inc. | Biomimetically Designed Modular Microfluidic-Based Capillaries & Lymphatic Units for Kidney & Liver Dialysis Systems, Organ Bio-Reactors and Bio-Artificial Organ Support Systems |
| CN105999448A (en) * | 2016-07-29 | 2016-10-12 | 武汉仝干医疗科技股份有限公司 | Four-in-one plush linear artificial liver reactor |
| US20190209408A1 (en) * | 2018-01-09 | 2019-07-11 | Amnion Life, LLC | Systems, methods, and devices for artificial placentas and amniotic bed incubators |
| CN210775240U (en) * | 2019-09-29 | 2020-06-16 | 清科医疗器械(深圳)有限公司 | Artificial spleen design chip |
Non-Patent Citations (2)
| Title |
|---|
| JOO H KANG 等: "An extracorporeal blood-cleansing device for sepsis therapy", 《NATURE MEDICINE》, vol. 20, no. 10, 14 September 2014 (2014-09-14), pages 1212 - 1215 * |
| 柏青: "滤血、贮血的免疫器官", 健康必读, no. 05, 31 May 2003 (2003-05-31), pages 27 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7297270B2 (en) | Hollow fiber filter for extracorporeal blood circuit | |
| CN210775240U (en) | Artificial spleen design chip | |
| CN106621510B (en) | Soft material polymer precision filter for transfusion and manufacturing method thereof | |
| MX2012010876A (en) | Catheter with tapering surfaces. | |
| TWI815547B (en) | Integrated membrane oxygenator | |
| CN110596109A (en) | Artificial spleen design chip | |
| CN102078646A (en) | Polyether sulfone hollow fiber blood dialyzer | |
| CN104083819A (en) | Precise liquid medicine filter for medical infusion set | |
| CN204563304U (en) | Be applicable to the single use disinfectant cap of Needleless barotropic joint | |
| CN107929833B (en) | Backflow-preventing negative pressure drainage device | |
| CN201969096U (en) | PES hollow cored fibre hemodialyzer | |
| CN204017041U (en) | A kind of medical Transfusion device precision liquid medicine filter | |
| CN209173059U (en) | Haemodialysis equipment | |
| CN113289103A (en) | Hemodialyzer | |
| CN208130195U (en) | A kind of drainage system for wound | |
| CN205759038U (en) | A kind of pump-free type ECMO | |
| CN205903473U (en) | Disposable hemodialysis pipeline | |
| CN219230938U (en) | Clamping device for hemodialysis room nursing pipeline of nephrology department | |
| CN217245767U (en) | Negative pressure drainage device convenient to carry and observe | |
| CN211050424U (en) | Can replace hemodialysis pipe hemostatic clamp | |
| CN210904331U (en) | Hemodialyzer for high-flux hemodialysis | |
| CN206089679U (en) | Stem cells collection device | |
| CN215779006U (en) | Negative pressure type fixing splint | |
| CN215821885U (en) | ECMO & CRRT pressure balancing appearance | |
| CN215083056U (en) | Self-circulation joint of machine in CRRT patient suspension treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |