CN102078646A - Polyether sulfone hollow fiber blood dialyzer - Google Patents
Polyether sulfone hollow fiber blood dialyzer Download PDFInfo
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- CN102078646A CN102078646A CN 201110024273 CN201110024273A CN102078646A CN 102078646 A CN102078646 A CN 102078646A CN 201110024273 CN201110024273 CN 201110024273 CN 201110024273 A CN201110024273 A CN 201110024273A CN 102078646 A CN102078646 A CN 102078646A
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- dialyzer
- polyether sulfone
- dialyser
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Abstract
The invention relates to a polyether sulfone hollow fiber blood dialyzer, which consists of a dialyzer blood cover protective sleeve, a dialyzer blood cover, a dialyzate joint, a dialyzer shell, a polyether sulfone hollow fiber membrane bundle, a sealing ring, sealing rubber, a dialyzate blocking plate and an anti-rotation bracket. The dialyzer is prepared from a high polymer material polyether sulfone hollow fiber membrane with higher biocompatibility and a better dialyzing function, so that the dialyzer has higher convection and dispersion performance; the dialyzate blocking plate adopts an eddy current technology, and the concentration of dialyzate outside a dialyzing membrane is more uniform and convection and dispersion effects are increased under the stirring action of eddy current, so that dialyzing efficiency is improved; the anti-rotation bracket can effectively prevent bacterial pollution; meanwhile, liquid in the dialyzer can be prevented from flowing out randomly when the dialyzer is flatly placed.
Description
Technical field
The present invention relates to a kind of haemodialysis equipment of polyether sulfone hollow-fibre membrane, this dialyser can carry out hemodiafiltration when the clinical treatment kidney disease, belong to technical field of medical instruments.
Technical background
Its structure of hemodialyzer of clinical treatment kidney disease is to install and use the cellulose hollow fiber film in the dialyser shell at present, and two ends are fixed with resin glue.Shell one end at dialyser has the blood inlet, and the other end has the blood liquid outlet, distolateral the dialysis solution inlet is arranged at one of shell, and another is distolateral the dialysis solution liquid outlet.This dialyser is when clinical use, and the blood pump of patients'blood by dialysis machine draws from tremulous pulse that the blood inlet of dialyser is made hollow-fibre membrane by cellulosic material after the dialyser outlet is got back in the patient body after the pipeline of dialysing is connected to.But because the biocompatibility of cellulose hollow fiber fibrous membrane is not high; Patient intravital in some molecule be difficult to remove, as B2M, this class material is detained the people that long-term dependence dialysis is survived and has very big harm in blood; Because of there being great amount of hydroxy group to exist, be easy to cause that complement activation makes the intravital leukopenia of patient in the fiber, cause the dialysis syndrome.
The dialysis solution of conventional dialysis device outlet at present generally is the blocking solution plate that faces dialysis fluid chamber, the normal employing symmetric form design of conventional dialysis device blocking solution plate, because of dialysis procedure liquid stream direction becomes symmetric form, the flow velocity on liquid stream both sides is under the bump that liquidates of hydrone, dialysate flow rate tends to impaired, particularly at the place, the hollow fiber bundle back side over against the dialysis solution mouth, flow velocity is very low.The low flow velocity of dialysis solution often makes with the inner blood constituent exchange of hollow fibre insufficient, influences the effect of convection current and disperse, reduces dialytic efficiency.
The conventional dialysis device generally is cylindric, and medical personnel are in the clinical manipulation process, and dialyser lies low and rolls easily when placing, can cause the dialysis solution mouth by germ contamination, if in the dialyser liquid is arranged, also make the temporary flow of liquid of dialyser come out easily, make troubles to medical personnel.
Summary of the invention
The objective of the invention is to overcome above-mentioned existing disadvantages of background technology part, and a kind of hemodialyzer that adopts the polyether sulfone hollow-fibre membrane is provided.
The present invention implements in the following manner:
A kind of polyether sulfone hollow fibre hemodialyzer comprises dialyser blood blood inlet; Dialyser blood lid; The dialysis solution outlet; The dialyser shell; Hollow fiber membrane bundle; Sealing ring; Sealing compound; The dialysis solution import; The blood outlet is characterized in that hollow fiber membrane bundle adopts macromolecular material polyether sulfone hollow-fibre membrane to make, and dialysis solution import one side that passes in and out sap cavity at dialyser is provided with the blocking solution plate, and the blocking solution plate has adopted the vortex patern liquid barrier.
For preventing to be flowed out, on the shell of dialyser liquid in-out mouth, increased an anti-rotation supporting structure by liquid in germ contamination and the dialyser.
The present invention has following characteristics:
1, uses of the harm of cellulose hollow fiber film in order to solve to the patient, the polyether sulfone hollow-fibre membrane that we have adopted biocompatibility and the better novel high polymer material of dialysis function to make, because the effect of the oxygen-ether linkage in the polyether sulfone materials molecular structure, its hydrophilic and thermostability, decay resistance further improve, protein adsorption reduces when contacting with blood, especially when contacting, no longer produce basic free radical with strong oxidizer, activation to complement is few, has better convection current and disperse performance.
2, enter liquid eddy current direction and reduce the impact of liquid circlewise in the dialysis chamber in order to change dialysis solution to dialyzer, we have adopted exclusive dialysis solution eddy-current technique, and import one side that dialyser is passed in and out sap cavity is designed to blocking solution and changes the dialysis solution blocking solution plate of flow direction function.When dialysis solution entered dialyser, because the effect of blocking solution plate, liquid rotated into the dialyser inner chamber with blocking solution plate angle, because " stirring " of eddy current effect, make the outer dialysate concentration of dialyzer more even, dialysis solution has fully with dialyzer and contacts, and has improved dialytic efficiency.
Dialysis solution eddy-current technique of the present invention can be realized following effect:
1) effectively reduces the dialysis solution tunnel phenomenon, make the dialysis solution distribution and flow more even;
2) " stirring " of eddy current effect makes the outer dialysate concentration of dialyzer more even, increases convection current and dispersion effect, improves the clearance rate of medium and small molecule toxin;
3) dialysis solution is fully contacted with dialyzer, effectively increase contact area, the solute clearance rate is high and stable;
4) compare with the dialyser of no vortex technology, carbamide/flesh liver/phosphate/vitamin B12 clearance rate improves 5%～9%.Be the influence of checking eddy current to clearance rate, (test condition is super: filter flow velocity Q to have done corresponding test
F=10mL/min, blood flow Q
B=300mL/min, dialysate flow Q
D=500mL/min.), data contrast situation sees Table 1, and the result has the feelings dialyser carbamide/flesh liver/phosphate/vitamin B12 clearance rate of eddy current can improve 5%～9% from checking;
5) test shows that the eddy current dialyser has certain anticoagulation function.
3, for prevent dialyser after the flushing since the round influence of in put procedure, arbitrarily rolling of shell use, we have increased an anti-rotation supporting structure on the shell of dialyser liquid in-out mouth, prevent that the dialysis solution interface from contacting generation and infecting phenomenon with other article, can prevent that the liquid of dialyser inside from flowing out simultaneously.
Description of drawings
Fig. 1: polyether sulfone hemodialyzer plane graph of the present invention;
Fig. 2: polyether sulfone hemodialyzer axonometric chart of the present invention;
Fig. 3: polyether sulfone hemodialyzer cut-away view of the present invention;
Fig. 4: the vortex patern blocking solution of the present invention composition that hardens.
The specific embodiment
See Fig. 1,2,3,4 for details.The present invention implements in the following manner: a kind of hemodialyzer that adopts the polyether sulfone hollow-fibre membrane comprises dialyser blood inlet 1; Dialyser blood lid 2; Dialysis solution outlet 3; Dialyser shell 4; Hollow fiber membrane bundle 5; Sealing ring 6; Sealing compound 7; Dialysis solution import 10; Blood outlet 11, above-mentioned hollow fiber membrane bundle 5 adopts macromolecular material polyether sulfone hollow-fibre membranes to make, and is provided with blocking solution plate 8 in dialysis solution import 10 1 sides of dialyser, and blocking solution plate 8 has adopted the vortex patern liquid barrier.For preventing to be flowed out, increased an anti-rotation supporting structure 9 at the reverse side of dialyser liquid in-out mouth by liquid in germ contamination and the dialyser.
Claims (2)
1. a polyether sulfone hollow fibre hemodialyzer comprises dialyser blood blood inlet (1); Dialyser blood lid (2); Dialysis solution outlet (3); Dialyser shell (4); Hollow fiber membrane bundle (5); Sealing ring (6); Sealing compound (7); Dialysis solution import (10); Blood outlet (11), it is characterized in that hollow fiber membrane bundle (5) adopts macromolecular material polyether sulfone hollow-fibre membrane to make, dialysis solution import (10) one sides at dialyser turnover sap cavity are provided with blocking solution plate (8), and blocking solution plate (8) has adopted the vortex patern liquid barrier.
2. polyether sulfone hollow fibre hemodialyzer according to claim 1 is characterized in that being provided with anti-rotation supporting structure (9) on the shell of dialyser liquid in-out mouth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110024273 CN102078646A (en) | 2011-01-22 | 2011-01-22 | Polyether sulfone hollow fiber blood dialyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110024273 CN102078646A (en) | 2011-01-22 | 2011-01-22 | Polyether sulfone hollow fiber blood dialyzer |
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| CN102078646A true CN102078646A (en) | 2011-06-01 |
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| CN 201110024273 Pending CN102078646A (en) | 2011-01-22 | 2011-01-22 | Polyether sulfone hollow fiber blood dialyzer |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104349833A (en) * | 2012-11-22 | 2015-02-11 | 甘布罗伦迪亚股份公司 | Capillary dialyzers |
| CN106039445A (en) * | 2016-08-17 | 2016-10-26 | 上海佩尼医疗科技发展有限公司 | Super-miniature dialyzer for clinical animal research and method for manufacturing super-miniature dialyzer |
| CN107050545A (en) * | 2017-01-16 | 2017-08-18 | 东华大学 | The board-like haemodialyser of one kind stacking |
| CN110573237A (en) * | 2017-04-13 | 2019-12-13 | 甘布罗伦迪亚股份公司 | Optimized hemodialyzer for blood purification |
| CN111359042A (en) * | 2020-03-18 | 2020-07-03 | 江西洪达医疗器械集团有限公司 | Hollow fiber hemodialyzer |
| CN112245691A (en) * | 2019-07-22 | 2021-01-22 | 巴克斯特医疗保健股份有限公司 | Method and system for preparing dialysate from raw water |
| CN113633840A (en) * | 2020-05-11 | 2021-11-12 | 苏州佳世达电通有限公司 | Hemodialyzer and hemodialysis system using same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169319A (en) * | 1996-06-21 | 1998-01-07 | 彭罗民 | Filter for blood dialysis |
| CN1777471A (en) * | 2003-04-23 | 2006-05-24 | 旭化成医疗有限公司 | Body fluid treating device of hollow fiber membrane type |
| CN201969096U (en) * | 2011-01-22 | 2011-09-14 | 江西三鑫医疗科技股份有限公司 | PES hollow cored fibre hemodialyzer |
-
2011
- 2011-01-22 CN CN 201110024273 patent/CN102078646A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169319A (en) * | 1996-06-21 | 1998-01-07 | 彭罗民 | Filter for blood dialysis |
| CN1777471A (en) * | 2003-04-23 | 2006-05-24 | 旭化成医疗有限公司 | Body fluid treating device of hollow fiber membrane type |
| CN201969096U (en) * | 2011-01-22 | 2011-09-14 | 江西三鑫医疗科技股份有限公司 | PES hollow cored fibre hemodialyzer |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104349833A (en) * | 2012-11-22 | 2015-02-11 | 甘布罗伦迪亚股份公司 | Capillary dialyzers |
| CN106039445A (en) * | 2016-08-17 | 2016-10-26 | 上海佩尼医疗科技发展有限公司 | Super-miniature dialyzer for clinical animal research and method for manufacturing super-miniature dialyzer |
| CN106039445B (en) * | 2016-08-17 | 2019-01-04 | 上海佩尼医疗科技发展有限公司 | A kind of superminiature dialyzer and its manufacturing method for clinical zooscopy |
| CN107050545A (en) * | 2017-01-16 | 2017-08-18 | 东华大学 | The board-like haemodialyser of one kind stacking |
| CN107050545B (en) * | 2017-01-16 | 2023-12-29 | 东华大学 | Laminated plate type hemodialysis device |
| CN110573237A (en) * | 2017-04-13 | 2019-12-13 | 甘布罗伦迪亚股份公司 | Optimized hemodialyzer for blood purification |
| CN112245691A (en) * | 2019-07-22 | 2021-01-22 | 巴克斯特医疗保健股份有限公司 | Method and system for preparing dialysate from raw water |
| CN111359042A (en) * | 2020-03-18 | 2020-07-03 | 江西洪达医疗器械集团有限公司 | Hollow fiber hemodialyzer |
| CN113633840A (en) * | 2020-05-11 | 2021-11-12 | 苏州佳世达电通有限公司 | Hemodialyzer and hemodialysis system using same |
| CN113633840B (en) * | 2020-05-11 | 2024-05-17 | 苏州佳世达电通有限公司 | Hemodialysis ware and use its hemodialysis system |
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Application publication date: 20110601 |