CN105597175B - A kind of haemodialysis equipment - Google Patents

A kind of haemodialysis equipment Download PDF

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Publication number
CN105597175B
CN105597175B CN201610106083.1A CN201610106083A CN105597175B CN 105597175 B CN105597175 B CN 105597175B CN 201610106083 A CN201610106083 A CN 201610106083A CN 105597175 B CN105597175 B CN 105597175B
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dialyzate
permeability
dialysis
inner tube
pipe
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CN201610106083.1A
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CN105597175A (en
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陈锋
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/166—Heating
    • A61M1/1664—Heating with temperature control

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention discloses a kind of haemodialysis equipment, including dialysis liquid bath, dialyzate ingress pipe, dialysis tubing, dialyzate delivery line and peristaltic pump, dialysis liquid bath is connected with dialyzate ingress pipe, the dialyzate ingress pipe port of export is connected with dialysis tubing respectively with the arrival end of dialyzate delivery line, dialyzate delivery line is connected with peristaltic pump, and peristaltic pump is connected with dialysis liquid bath；Dialysis tubing includes permeability inner tube, dialysis membrane and permeability outer tube, dialysis membrane is wrapped in outside permeability inner pipe wall, permeability outer tube sleeve is in permeability inner tube periphery, the arrival end and the port of export of permeability inner tube are arranged at the same side in permeability outer tube, the arrival end of permeability inner tube is connected with dialyzate ingress pipe, and the port of export of permeability inner tube is connected with dialyzate delivery line；The design is also latched including Y types.During the dialysis tubing of the design is placed in internal artery in dialysis, hemodialysis is completed in the blood vessel, hemodialysis is carried out again in vitro without blood is extracted out, on human blood-pressure without influence, more economical, safety.

Description

A kind of haemodialysis equipment
Technical field
The present invention relates to technical field of medical equipment, more particularly to a kind of haemodialysis equipment.
Background technology
The mainstream therapies for releasing oedema at present mainly include two kinds：1. drug diuresis：Make patient's hydrouria using medicine, So as to internal excessive moisture be excreted by the approach of " blood-kidney-urine "；2. extracorporeal blood dialysis：By patient body Interior blood is extracted out, by the filtering of extracorporal dialysis instrument, the excessive moisture in blood is filtered, and is left through the blood of " concentration " The purpose for releasing oedema so as to reach in vivo is fed back again.
Haemodialysis is also treatment acute and chronic Delayed graft function（Uremia）It is conventional with acute drugs poisoning and pesticide poisoning Method.Current China has up to ten million Chronic Renal Failure Patients needs to be sustained life with CHD every year, and has year by year The trend for increasing.Haemodialysis principle：Dialysis refers to that the solution of pellicle both sides passes through disperse, infiltration and ultrafiltration, instant Matter is flowed by the low side of a concentration lateral concentration high, and a hydrone effluent high by permeating the lateral osmotic pressure that forces down Dynamic process, is finally reached dynamic equilibrium.Haemodialysis is reached by the solution disperse and ultrafiltration between blood and dialyzate Therapeutic purposes.
The therapy of prior art is primarily present following shortcoming：1. drug diuresis method：Have the disadvantage largely using easy after medicine There is toxic and side effect and resistance phenomenon, or because critical patient is often associated with kidney failure, blocked the diuresis approach of appeal, cause profit Urine effect on driving birds is not good；2. extracorporeal blood dialysis process：(1) due to extracting blood out external, then feed back in patient body, period can make Drastically reduce or raise into blood volume in patient body, cause unstable blood pressure to even result in death；(2) extracorporal dialysis process is usual only Several hours can be continued, it is impossible to lasting, long-term, smoothly for patient gives excessive moisture；(3) extracorporal dialysis instrument is huge, It is difficult to transport, it is necessary to specially patient is delivered into dialysate chamber, or huge extracorporal dialysis machine is transported to patient bedside, increase is controlled Treat difficulty；(4) instrument price is expensive, up to hundreds thousand of or even millions of.
The content of the invention
Goal of the invention of the invention is：For above-mentioned problem, there is provided a kind of haemodialysis equipment.It is of the invention Dialysis tubing in haemodialysis equipment is placed in human body in artery in dialysis, directly completes haemodialysis in blood vessel in vivo, And blood need not be extracted out carries out hemodialysis through machine again in vitro, so that on human blood-pressure without influence, peace more more economical than external hemodialysis It is complete and wound is small.
In order to realize foregoing invention purpose, the technical solution adopted by the present invention is as follows：
A kind of haemodialysis equipment, including dialysis liquid bath, dialyzate ingress pipe, dialysis tubing, dialyzate delivery line and wriggling Pump, the dialysis liquid bath is connected with dialyzate ingress pipe entrance point, and the dialyzate ingress pipe port of export enters with dialyzate delivery line Mouth end is connected with dialysis tubing respectively, and the port of export of dialyzate delivery line is connected with peristaltic pump, and peristaltic pump passes through conduit and dialyzate Groove is connected；The dialysis tubing includes permeability inner tube, dialysis membrane and permeability outer tube, and the dialysis membrane is wrapped in permeability inner tube Outside tube wall, in permeability inner tube periphery, the arrival end and the port of export of the permeability inner tube are arranged at the permeability outer tube sleeve The same side in permeability outer tube, the arrival end of the permeability inner tube is connected with the port of export of dialyzate ingress pipe, permeability The port of export of inner tube is connected with the arrival end of dialyzate delivery line；The haemodialysis equipment is also latched including Y types, Y types lock One end be enclosed within permeability outer tube periphery, the two ends of bifurcated are respectively fitted over the periphery of dialyzate ingress pipe and dialyzate delivery line.
The operation principle of haemodialysis equipment of the present invention is：Before being dialysed to patient, puncture is first passed through, use seal wire Or during dialysis tubing is inserted in human body femoral artery or radial artery by sheath, dialysis tubing can retain a star in artery in vivo as needed Or so phase, then latched with Y types and dialyzate ingress pipe and dialyzate delivery line are connected with permeability outer tube, and by dialyzate Ingress pipe guides the arrival end of permeability inner tube into, and dialyzate delivery line is guided into the port of export of permeability inner tube, while connecting Other parts, open peristaltic pump, and dialyzate is input into the permeability inner tube of dialysis tubing by dialyzate ingress pipe in dialysis liquid bath, It is now the dialyzate of hyperosmosis in the permeability inner tube of dialysis tubing, blood enters outside permeability outer tube, i.e. permeability inner tube It is the relatively low blood of osmotic pressure（Moisture containing great quantities of spare）, across dialysis membrane, dialysis membrane only allows that molecular weight is less to interphase Hydrone passes through, and the most of macromolecule composition in blood can not pass through, the sustainable infiltration of the excessive moisture in such blood Enter in dialyzate, leave blood, and as dialyzate delivery line is transferred out in vitro, reach dialysis purpose；At the same time it is high in managing The dialyzate of concentration continues through flowing to update, and keeps permeable pressure head higher, reaches the effect of lasting dialysis.When needs stop When only dialysing, then peristaltic pump is closed, press from both sides locking button, lock is made up of flexible material, realizes the temporary transient cutout of dialyzate.
Further, the opposite side where the arrival end and the port of export of the permeability outer tube relative permeability inner tube also sets It is equipped with hard plastic material head.Hard plastic material head act as dialysis tubing insertion human vas in when, play a part of breakthrough, prevent pipe Head is excessively soft, inserts and does not enter blood vessel.
Further, it is provided with dialyzate flow speed control valve on the dialyzate ingress pipe.By set dialyzate flow speed control valve come Control the flow velocity of dialyzate, it is ensured that while dialytic efficiency, mitigate the pain of patient.
Further, the dialysis liquid bath peripheral hardware is equipped with temperature regulating device.The temperature of dialyzate is controlled by temperature regulating device, is protected The normal temperature demand of blood when barrier patient dialyses.
Further, the permeability inner tube includes straight tube and bend pipe, and straight tube and bend pipe are integrated, and bend pipe is in the shape of a spiral It is looped around straight tube periphery.The structure of permeability inner tube of the present invention can fully improve the contact area of blood and dialyzate, effectively carry The dialytic efficiency of blood high.
Further, the tube wall of the permeability outer tube is hollow out paliform, and the tube wall of the permeability inner tube is hollow out Latticed, the material of said inner tube and outer tube is polyureas amine ester.The polyureas amine ester that the present invention is used has stable chemical performance, raw Thing compatibility is good, and surface is smooth and elastic and the features such as good hydrophily.
Further, it is provided with lock on the dialyzate ingress pipe and dialyzate delivery line.
Further, it is provided with knob on the dialyzate ingress pipe and dialyzate delivery line.Knob auxiliary of the invention Dialysis tubing is kept completely separate with dialyzate ingress pipe and dialyzate delivery line.
Further, a diameter of 0.5 ~ 2mm of the permeability inner tube, a length of 200 ~ 300mm.
Further, a diameter of 3 ~ 5mm of the permeability outer tube, a length of 150 ~ 300mm.
The material of dialysis membrane of the present invention is polyether sulfone.Using biofacies compatibility and the more preferable new height of dialysis function The polyether sulphone hollow fibre film that molecular material is made, due to the effect of the oxygen-ether linkage in polyether sulfone materials molecular structure, its is hydrophilic Property and heat resistance, decay resistance further improve, during with contacting blood protein adsorption reduce, especially connect with strong oxidizer Free radical is no longer produced when tactile, the activation to complement is few, with more preferable convection current and disperse performance.
In sum, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
（1）Haemodialysis equipment of the present invention can realize internal haemodialysis, without blood is extracted out to enter through machine again in vitro Promoting circulation of blood thoroughly, without influence, the security of haemodialysis is substantially increased so as on human blood-pressure；
（2）Dialysis tubing in haemodialysis equipment of the present invention is a kind of portable, single use tubular member, is reached The purpose of beside sickbed dialysis, allows patient directly can on one's sick bed receive dialysis treatment, can be used to rescuing, severe treatment, and reduces Medical expense, it is safe, gentle, effective；
（3）Haemodialysis equipment of the invention has the advantages that reasonable in design, easy to use, is a kind of preferable blood Liquid dialysis utensil, can be widely used for clinic.
Brief description of the drawings
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein：
Fig. 1 is the structural representation of haemodialysis equipment of the present invention；
Fig. 2 is the annexation figure that haemodialysis equipment dialysis tubing of the present invention and dialyzate import and export pipe；
Fig. 3 is the structural representation of dialysis tubing of the present invention；
Fig. 4 is the partial enlarged drawing of present invention dialysis dialysis membrane and inner tube.
Wherein, 1- dialysis liquid bath；2- dialyzate ingress pipes；3- dialysis tubings；4- dialyzate delivery lines；5- peristaltic pumps；6- oozes Permeability outer tube；7- permeability inner tubes；8- dialysis membranes；9-Y types are latched；10- dialyzate flow speed control valves；11- hard plastic material heads；12- knobs； 13- is latched.
Specific embodiment
As shown in Fig. 1 ~ 4, a kind of haemodialysis equipment, including dialysis liquid bath 1, dialyzate ingress pipe 2, dialysis tubing 3, thoroughly Analysis liquid delivery line 4 and peristaltic pump 5, dialysis liquid bath 1 are connected with the entrance point of dialyzate ingress pipe 2, the port of export of dialyzate ingress pipe 2 and The arrival end of dialyzate delivery line 4 is connected with dialysis tubing 3 respectively, and the port of export of dialyzate delivery line 4 is connected with peristaltic pump 5, compacted Dynamic pump 5 is connected by conduit with dialysis liquid bath 1；Dialysis tubing 3 includes permeability inner tube 7, dialysis membrane 8 and permeability outer tube 6, dialysis Film 8 is wrapped in outside the tube wall of permeability inner tube 7, and permeability outer tube 6 is enclosed within the periphery of permeability inner tube 7, the arrival end of permeability inner tube 7 And the port of export is arranged at the same side in permeability outer tube 6, the arrival end of permeability inner tube 7 and the outlet of dialyzate ingress pipe 2 End connection, the port of export of permeability inner tube 7 is connected with the arrival end of dialyzate delivery line 4；Permeability inner tube 7 includes straight tube and curved Pipe, straight tube and bend pipe are connected as one, and bend pipe is looped around straight tube periphery in the shape of a spiral, and the tube wall of permeability inner tube 7 is hollow out It is latticed；Opposite side where the arrival end and the port of export of the relative permeability inner tube 7 of permeability outer tube 6 is additionally provided with duroplasts Head, the tube wall of permeability outer tube 6 is hollow out paliform；Haemodialysis equipment also includes that Y types latch one end set of 9, Y types lock 9 In the periphery of permeability outer tube 6, the two ends of bifurcated are respectively fitted over the periphery of dialyzate ingress pipe 2 and dialyzate delivery line 4, and will be saturating Analysis liquid ingress pipe 2 is guided into the arrival end of permeability inner tube 7, and dialyzate delivery line 4 is guided into the port of export of permeability inner tube 7； Lock 13 and knob 12 are provided with dialyzate ingress pipe 2 and dialyzate delivery line 4.Dialysis is provided with dialyzate ingress pipe 2 Liquid flow speed control valve 10, temperature regulating device is provided with outside dialysis liquid bath 1.
Further, the material of outer tube 6 and inner tube 7 is polyureas amine ester；The material of dialysis membrane 8 is polyether sulfone；Inner tube 7 it is straight Footpath is 0.5 ~ 2mm, a length of 200 ~ 300mm；A diameter of 3 ~ 5mm of the outer tube 6, a length of 150 ~ 300mm.
The application method of haemodialysis equipment of the present invention is：Before being dialysed to patient, puncture is first passed through, use seal wire Or sheath inserts in human body in artery dialysis tubing, then with Y types latch 9 by dialyzate ingress pipe 2 and dialyzate delivery line 4 with Permeability outer tube 6 is connected, and dialyzate ingress pipe 2 is guided into the arrival end of permeability inner tube 7, and dialyzate delivery line 4 is drawn To the port of export of permeability inner tube 7, while connecting other parts, peristaltic pump 5 is opened, dialyzate is by saturating in dialysis liquid bath 1 Analysis liquid ingress pipe 2 is input into the permeability inner tube 7 of dialysis tubing 3, is now hyperosmosis in the permeability inner tube 7 of dialysis tubing 3 Dialyzate, blood enters the outer blood relatively low for osmotic pressure of permeability outer tube 6, i.e. permeability inner tube 7（Moisture containing great quantities of spare）, Across dialysis membrane 8, dialysis membrane 8 only allows that the less hydrone of molecular weight passes through to interphase, the most of macromolecule in blood Composition can not pass through, and the excessive moisture in such blood is sustainable to infiltrate through dialyzate, leaves blood, and as dialyzate is led Outlet pipe 4 is transferred out in vitro, reaches dialysis purpose；At the same time the dialyzate of high concentration continues through flowing to update in managing, and protects Permeable pressure head higher is held, the effect of lasting dialysis is reached.When needing to stop dialysis, then peristaltic pump 5 is closed, and Y types are locked Button 9 or the folder of lock 13 are closed, and Y types lock 9 or lock 13 are made up of flexible material, realize the temporary transient cutout of dialyzate；To complete Separate, then by spin dialysis liquid ingress pipe 2 and the knob of dialyzate delivery line 4, auxiliary dialysate ingress pipe 2 and dialyzate are led Outlet pipe 4 is separated with the permeability inner tube 7 of dialysis tubing 3, disconnects the company of dialyzate ingress pipe 2 and dialyzate delivery line 4 and dialysis tubing 3 Connect.
Dialysis tubing 3 is placed in human body artery method in the present invention is prior art, dialyzate flow speed control valve 10 and temperature control Device is also prior art, is no longer described in detail herein.After dialyzate is circulated for several times in a device, osmotic pressure will be reduced, Abandoned by when water absorbing capacity drops to certain value, more renew penetrating fluid.
The invention is not limited in foregoing specific embodiment.The present invention is expanded to and any in this manual disclosed New feature or any new combination, and disclose any new method or process the step of or any new combination.

Claims (10)

1. a kind of haemodialysis equipment, including dialysis liquid bath, dialyzate ingress pipe, dialysis tubing, dialyzate delivery line and peristaltic pump, The dialysis liquid bath is connected with dialyzate ingress pipe entrance point, the arrival end of the dialyzate ingress pipe port of export and dialyzate delivery line It is connected with dialysis tubing respectively, the port of export of dialyzate delivery line is connected with peristaltic pump, peristaltic pump is connected by conduit with dialysis liquid bath Connect；Characterized in that, the dialysis tubing includes permeability inner tube, dialysis membrane and permeability outer tube, the dialysis membrane is wrapped in and oozes Outside permeability inner pipe wall, the permeability outer tube sleeve is in permeability inner tube periphery, the arrival end of the permeability inner tube and outlet End is arranged at the same side in permeability outer tube, and the arrival end of the permeability inner tube connects with the port of export of dialyzate ingress pipe Connect, the port of export of permeability inner tube is connected with the arrival end of dialyzate delivery line；The haemodialysis equipment is also locked including Y types Button, one end of Y types lock is enclosed within permeability outer tube periphery, and the two ends of bifurcated are respectively fitted over dialyzate ingress pipe and dialyzate is derived The periphery of pipe.
2. haemodialysis equipment according to claim 1, it is characterised in that the permeability outer tube relative permeability inner tube Arrival end and the port of export where opposite side be additionally provided with hard plastic material head.
3. haemodialysis equipment according to claim 1, it is characterised in that be provided with dialysis on the dialyzate ingress pipe Liquid flow speed control valve.
4. haemodialysis equipment according to claim 1, it is characterised in that the dialysis liquid bath peripheral hardware is equipped with temperature control dress Put.
5. haemodialysis equipment according to claim 1, it is characterised in that said inner tube includes straight tube and bend pipe, straight tube Connected as one with bend pipe, and bend pipe is looped around straight tube periphery in the shape of a spiral.
6. haemodialysis equipment according to claim 1, it is characterised in that the tube wall of the permeability outer tube is hollow out grid Columns, the tube wall of the permeability inner tube is that hollow out is latticed, and the material of said inner tube and outer tube is polyureas amine ester.
7. haemodialysis equipment according to claim 1, it is characterised in that the dialyzate ingress pipe and dialyzate are derived Lock is provided with pipe.
8. haemodialysis equipment according to claim 1, it is characterised in that the dialyzate ingress pipe and dialyzate are derived Knob is provided with pipe.
9. the haemodialysis equipment according to claim 1 to 8 any claim, it is characterised in that in the permeability A diameter of 0.5 ~ 2mm of pipe, pipe range is 200 ~ 300mm.
10. the haemodialysis equipment according to claim 1 to 8 any claim, it is characterised in that outside the permeability A diameter of 3 ~ 5mm of pipe, a length of 150 ~ 300mm.
CN201610106083.1A 2016-02-26 2016-02-26 A kind of haemodialysis equipment Active CN105597175B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610106083.1A CN105597175B (en) 2016-02-26 2016-02-26 A kind of haemodialysis equipment
US15/242,427 US10251993B2 (en) 2016-02-26 2016-08-19 Hemodialysis device

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Application Number Priority Date Filing Date Title
CN201610106083.1A CN105597175B (en) 2016-02-26 2016-02-26 A kind of haemodialysis equipment

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CN105597175B true CN105597175B (en) 2017-06-23

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CN108211029A (en) * 2018-03-19 2018-06-29 廖蕴华 A kind of animal peritoneal dialysis catheter

Citations (2)

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WO1999059655A1 (en) * 1998-05-19 1999-11-25 Transvivo, Inc. Apparatus and method for in vivo hemodialysis
US7481936B2 (en) * 2001-10-17 2009-01-27 Transvivo Inc. Method and apparatus for patient fluid management

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Publication number Priority date Publication date Assignee Title
US4950224A (en) * 1988-08-05 1990-08-21 Healthdyne, Inc. Apparatus and method for in vivo plasma separation
US5968004A (en) * 1997-09-23 1999-10-19 Matria Healthcare, Inc. Microporous membrane sheet plasma extraction catheter
US6899692B2 (en) * 2001-10-17 2005-05-31 Transvivo, Inc. Plasmapheresis filter device and catheter assembly
CN205698669U (en) * 2016-02-26 2016-11-23 陈锋 A kind of haemodialysis equipment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059655A1 (en) * 1998-05-19 1999-11-25 Transvivo, Inc. Apparatus and method for in vivo hemodialysis
US7481936B2 (en) * 2001-10-17 2009-01-27 Transvivo Inc. Method and apparatus for patient fluid management

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