CN110585371A - Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste - Google Patents
Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste Download PDFInfo
- Publication number
- CN110585371A CN110585371A CN201910788752.1A CN201910788752A CN110585371A CN 110585371 A CN110585371 A CN 110585371A CN 201910788752 A CN201910788752 A CN 201910788752A CN 110585371 A CN110585371 A CN 110585371A
- Authority
- CN
- China
- Prior art keywords
- parts
- spleen
- tonifying
- fried
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 239000003814 drug Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 77
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 44
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 44
- 240000000249 Morus alba Species 0.000 claims abstract description 44
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 44
- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 44
- 235000006545 Ziziphus mauritiana Nutrition 0.000 claims abstract description 39
- 235000008529 Ziziphus vulgaris Nutrition 0.000 claims abstract description 39
- 210000000952 spleen Anatomy 0.000 claims abstract description 39
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 25
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 25
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 25
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 25
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 24
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 24
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 23
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 23
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 23
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 23
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 23
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 23
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 23
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 23
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 23
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 23
- 241000234435 Lilium Species 0.000 claims abstract description 23
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 23
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 23
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 23
- 244000197580 Poria cocos Species 0.000 claims abstract description 23
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 23
- 239000000796 flavoring agent Substances 0.000 claims abstract description 19
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 230000000694 effects Effects 0.000 claims abstract description 15
- 244000088415 Raphanus sativus Species 0.000 claims abstract 4
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 3
- 239000000843 powder Substances 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 21
- 239000002674 ointment Substances 0.000 claims description 19
- 230000002936 tranquilizing effect Effects 0.000 claims description 14
- 235000005979 Citrus limon Nutrition 0.000 claims description 11
- 244000131522 Citrus pyriformis Species 0.000 claims description 11
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 10
- 229940085605 saccharin sodium Drugs 0.000 claims description 10
- 239000011812 mixed powder Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000013305 food Nutrition 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 238000005057 refrigeration Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 238000010411 cooking Methods 0.000 claims 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- -1 medicated liquor Substances 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 239000004576 sand Substances 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 abstract description 26
- 239000008280 blood Substances 0.000 abstract description 20
- 210000004369 blood Anatomy 0.000 abstract description 20
- 210000002784 stomach Anatomy 0.000 abstract description 16
- 210000000936 intestine Anatomy 0.000 abstract description 5
- 230000029087 digestion Effects 0.000 abstract description 4
- 230000003860 sleep quality Effects 0.000 abstract description 2
- 206010016766 flatulence Diseases 0.000 abstract 1
- 230000007958 sleep Effects 0.000 description 26
- 238000005728 strengthening Methods 0.000 description 22
- 241001092040 Crataegus Species 0.000 description 20
- 241000220259 Raphanus Species 0.000 description 20
- 208000024891 symptom Diseases 0.000 description 20
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 17
- 206010022437 insomnia Diseases 0.000 description 17
- 238000003745 diagnosis Methods 0.000 description 16
- 208000002173 dizziness Diseases 0.000 description 15
- 206010033557 Palpitations Diseases 0.000 description 14
- 230000002354 daily effect Effects 0.000 description 11
- 230000007812 deficiency Effects 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 9
- 230000004069 differentiation Effects 0.000 description 8
- 208000011580 syndromic disease Diseases 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 235000019789 appetite Nutrition 0.000 description 6
- 230000036528 appetite Effects 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 235000019525 fullness Nutrition 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 238000000540 analysis of variance Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 206010028372 Muscular weakness Diseases 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003326 hypnotic agent Substances 0.000 description 3
- 230000000147 hypnotic effect Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000002618 waking effect Effects 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 208000006083 Hypokinesia Diseases 0.000 description 2
- 235000001188 Peltandra virginica Nutrition 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 206010000059 abdominal discomfort Diseases 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 208000027905 limb weakness Diseases 0.000 description 2
- 231100000861 limb weakness Toxicity 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000036473 myasthenia Effects 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241001080798 Polygala tenuifolia Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000010340 Sleep Deprivation Diseases 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010043946 Tongue conditions Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013410 fast food Nutrition 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000021486 meal replacement product Nutrition 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000011726 slow pulse Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010017 yuan zhi Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a medicinal and edible traditional Chinese medicine composition for tonifying spleen, replenishing qi and soothing nerves, a spleen-tonifying qi-replenishing and soothing paste and a preparation method and application thereof, and the raw materials are as follows: 30-90 parts of fried Chinese yam, 10-40 parts of hawthorn, 10-40 parts of lily, 15-50 parts of poria cocos, 10-40 parts of fried radish seed, 10-40 parts of lotus seed, 10-40 parts of fried coix seed, 5-30 parts of spina date seed, 5-25 parts of fried malt, 5-25 parts of longan pulp, 5-25 parts of Chinese date, 5-25 parts of mulberry, 1-3 parts of longan pulp extract, 1-3 parts of Chinese date extract and 1-4 parts of mulberry extract, and the formula is matched, and the taste is adjusted by being assisted with proper flavoring agent combination to obtain the spleen-invigorating, qi-tonifying and nerve-soothing paste. The invention has the effects of tonifying qi and spleen, nourishing blood and moistening dryness, helping digestion and relieving flatulence, and nourishing heart and soothing nerves, and improves the sleep quality while preserving intestines and stomach.
Description
The technical field is as follows:
the invention belongs to the field of foods, and particularly relates to a spleen-tonifying qi-tonifying mind-tranquilizing medicine and food-homology Chinese medicinal composition, a spleen-tonifying qi-tonifying mind-tranquilizing paste and a preparation method and application thereof.
Technical Field
The modern life rhythm is increasingly accelerated, and people have become normal life when not eating on time or taking fast food with high salt and high fat frequently. In the past, the obesity rate of people is increased, and gastrointestinal diseases are frequent. The problems of weakness of intestines and stomach, inappetence, poor digestion function, frequent diarrhea and the like frequently occur. Anxiety can be easily generated while the body is penetrated, so that people who are in high-pressure life originally can bear heavy burden, and the sleep quality is seriously influenced. The problems that the time and the labor are consumed for nursing and conditioning in hospitals, the risk exists when people take medicines for a long time, the effect is slow when people take simple food therapy, and the like are all obstacles on the way of regulating intestines and stomach.
The invention provides medicinal and edible spleen-tonifying and qi-tonifying tranquilizing paste which is prepared from medicinal and edible medicinal materials such as Chinese yam, Chinese date, arillus longan and the like, has high safety, can regulate intestines and stomach and promote night sleep, and has the effect of replacing meals to achieve satiety. The spleen-invigorating, qi-tonifying and nerve-soothing paste is independently sealed and packaged, is safe and sterile, green and healthy, has a small volume, and is convenient to carry. The food can be used as both medicine and food, meets the requirements of the majority of people on conditioning intestines and stomach and replacing full meals, and prevents gastrointestinal diseases caused by excessive hunger.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine composition for strengthening spleen, tonifying qi and soothing nerves, a preparation method and application of a paste for strengthening spleen, tonifying qi and soothing nerves.
In order to achieve the above purpose of the invention, the following technical scheme is adopted:
a spleen-invigorating, qi-tonifying and mind-tranquilizing medicine-food homologous traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-90 parts of fried Chinese yam, 10-40 parts of hawthorn, 10-40 parts of lily, 15-50 parts of poria cocos, 10-40 parts of fried radish seed, 10-40 parts of lotus seed, 10-40 parts of fried coix seed, 5-30 parts of spina date seed, 5-25 parts of fried malt, 5-25 parts of longan pulp, 5-25 parts of Chinese date, 5-25 parts of mulberry, 1-3 parts of longan pulp extract, 1-3 parts of Chinese date extract and 1-4 parts of mulberry extract, wherein the parts are all parts by weight.
A preparation prepared from the traditional Chinese medicine composition is characterized in that appropriate auxiliary materials can be added into the traditional Chinese medicine composition for strengthening spleen, tonifying qi and soothing nerves to prepare any one of paste, tablets, pills, powder, wine, capsules and leachant.
A spleen-invigorating qi-tonifying tranquilizing paste comprises the following raw materials: 30-90 parts of fried Chinese yam, 10-40 parts of hawthorn, 10-40 parts of lily, 15-50 parts of poria cocos, 10-40 parts of fried radish seed, 10-40 parts of lotus seed, 10-40 parts of fried coix seed, 5-30 parts of spina date seed, 5-25 parts of fried malt, 5-25 parts of longan pulp, 5-25 parts of Chinese date, 5-25 parts of mulberry, 1-3 parts of longan pulp extract, 1-3 parts of Chinese date extract, 1-3 parts of mulberry extract and a combination of flavoring agents: 0.1-0.8% (w/v) of saccharin sodium, 1-7% (w/v) of lemon essence and 3-10% (w/v) of gelatin, wherein the parts are parts by weight.
The preparation method of the spleen-invigorating, qi-tonifying and nerve-soothing paste comprises the following steps:
(1) weighing the raw material medicines and crushing the raw material medicines into 60 meshes;
(2) uniformly mixing the medicinal material powder in the step (1) with the combined extract powder of the Chinese date extract, the longan extract and the mulberry extract;
(3) adding distilled water into the mixed powder in the step (2), and decocting with slow fire;
(4) adding 0.5% (w/v) of saccharin sodium and 5% (w/v) of lemon essence into the mixture cooked in the step (3), uniformly stirring, standing and cooling;
(5) and (4) when the mixture in the step (4) is cooled to room temperature, mixing the mixture with the gelatin which is heated to be just melted, uniformly stirring the mixture, placing the mixture in a refrigerator for refrigeration, taking out the mixture after shaping, and placing the mixture to room temperature to obtain the spleen-tonifying qi-tonifying and nerve-soothing paste.
The formula of the invention is that the inventor compounds a plurality of medicine-food homologous medicines according to the medical experience of many years, so that the synergistic effect is exerted. The formula comprises fried Chinese yam, hawthorn, lily, tuckahoe, fried radish seed, lotus seed, fried coix seed, spina date seed, fried malt, arillus longan, Chinese date and mulberry. The hawthorn fruit in the prescription has the effects of stimulating appetite and helping digestion, tonifying the longan pulp, tonifying the tuckahoe, tonifying the spleen and harmonizing the stomach, tonifying the spleen and checking diarrhea with the lotus seed, tonifying the liver and the kidney with the mulberry, reinforcing the kidney and replenishing vital essence with the Chinese yam, and tonifying the spleen and checking diarrhea with the coix seed, and has the efficacy of tonifying the spleen; the mulberry has the effects of tonifying deficiency and qi, the malt has the effect of promoting qi circulation and digestion, and the radish seed has the effects of lowering qi and reducing phlegm, and has the effect of tonifying qi; lily has the effects of clearing away heart-fire and soothing the nerves, spina date seed has the effects of calming the heart and soothing the nerves, and Chinese date has the effects of assisting sleep and soothing the nerves. The medicines in the formula have homology of medicine and food, the safety is high, and the traditional Chinese medicine composition can be used as a daily meal replacement product, can improve the gastrointestinal tract state of a patient to a certain extent, relieves anxiety, and promotes sleep.
The invention provides a preparation method through parameter optimization for ensuring better quality and sensory evaluation at lower cost, and the investigation indexes are color, smell and taste of the spleen-invigorating and qi-tonifying tranquilizing paste, and the preparation method comprises the following specific steps:
(1) determining the optimal medicinal material crushing particle size:
taking 4 parts of medicinal and edible traditional Chinese medicine composition according to the parts by weight, respectively, preparing the spleen-invigorating, qi-tonifying and nerve-soothing paste by crushing medicinal material powder which is sieved by a 40-mesh sieve, a 60-mesh sieve, an 80-mesh sieve and a 100-mesh sieve under the same operation condition, evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste from three aspects of color, smell and taste, and grading by adopting a grading system (percent system);
(2) determining the optimal decoction time:
taking 4 parts of medicinal and edible traditional Chinese medicine composition according to the parts by weight, respectively, adding distilled water of the same amount into mixed powder consisting of medicinal material powder, Chinese date extract, longan extract and mulberry extract powder under the same operation condition, and decocting for 5 minutes, 10 minutes, 15 minutes and 20 minutes respectively to prepare the spleen-invigorating, qi-tonifying and nerve-soothing paste. Evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste from color, smell and taste, and grading by adopting a grading system (percent system);
(3) determining the optimal combination ratio of the three medicinal material extracts:
weighing 16 parts of medicinal and edible traditional Chinese medicine composition according to the parts by weight, and respectively setting the longan pulp extract powder to 4 levels under the same operation conditions: 1 part, 2 parts, 3 parts and 4 parts; the jujube extract powder was 4 levels: 1 part, 2 parts, 3 parts and 4 parts; the mulberry extract powder was at 4 levels: 1.2 parts, 2.4 parts, 3.2 parts and 4 parts of the three extract powders are orthogonally combined for preparing the spleen-invigorating, qi-tonifying and nerve-soothing paste. Comprehensively scoring and evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste according to color, smell and taste (percent system);
(4) determining the optimal combination ratio of three flavoring agents:
weighing 16 parts of medicinal and edible traditional Chinese medicine composition raw materials according to the parts by weight, and respectively setting the saccharin sodium at 4 levels under the same operation condition: 0.1% (w/v), 0.5% (w/v), 0.8% (w/v), 1.0% (w/v); lemon essence is at 4 levels: 1% (w/v), 3% (w/v), 5% (w/v), 7% (w/v); gelatin was at 4 levels: 3% (w/v), 5.5% (w/v), 7.5% (w/v) and 10% (w/v), and orthogonally combining the three flavoring agents to prepare the spleen-invigorating and qi-tonifying tranquilization paste. And comprehensively scoring and evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste according to color, smell and taste (percent system).
Drawings
FIG. 1 is a bar graph showing different particle size scores of different herbs
FIG. 2 is a stacked bar graph of scores of different decoction times
Detailed Description
The invention is described in further detail below with reference to examples, to which again the following remarks apply: the following method is only a preparation process taking the spleen-invigorating and qi-tonifying tranquilizing paste as an example, does not cover and exhaust all formulations of the invention, and aims to use data to illustrate a preparation process and a quality control method of the traditional Chinese medicine composition.
Example 1: medicinal and edible traditional Chinese medicine composition of spleen-tonifying qi-tonifying tranquilizing paste
A medicinal and edible Chinese medicinal composition of a spleen-invigorating, qi-tonifying and nerve-soothing paste and parts by weight thereof are as follows: 30-90 parts of fried Chinese yam, 10-40 parts of hawthorn, 10-40 parts of lily, 15-50 parts of poria cocos, 10-40 parts of fried radish seed, 10-40 parts of lotus seed, 10-40 parts of fried coix seed, 5-30 parts of spina date seed, 5-25 parts of fried malt, 5-25 parts of longan pulp, 5-25 parts of Chinese date, 5-25 parts of mulberry, 1-3 parts of longan pulp extract, 1-3 parts of Chinese date extract and 1-4 parts of mulberry extract.
Example 2: medicinal and edible traditional Chinese medicine composition of spleen-tonifying qi-tonifying tranquilizing paste
A medicinal and edible Chinese medicinal composition of a spleen-invigorating, qi-tonifying and nerve-soothing paste and parts by weight thereof are as follows:
60 parts of fried Chinese yam, 20 parts of hawthorn, 20 parts of lily, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date, 12 parts of mulberry, 1 part of longan pulp extract, 1 part of Chinese date extract and 1.2 parts of mulberry extract.
Example 3: preparation method of spleen-invigorating, qi-tonifying and nerve-soothing paste
20 parts of lily, 60 parts of fried Chinese yam, 20 parts of hawthorn, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date and 12 parts of mulberry are crushed to be sieved by a 60-mesh sieve, and the crushed powder is uniformly mixed with 1 part of Chinese date extract powder, 1 part of longan extract powder and 1.2 parts of mulberry extract powder, 8-10 times of water is added for decoction, and the decoction is carried out for 10 minutes by slow fire in 300 watts, and the mixture is continuously stirred during the process. Adding saccharin sodium and lemon essence when the decoction is finished, standing and cooling to room temperature, adding the melted gelatin solution, refrigerating and shaping, taking out and standing to room temperature to obtain the spleen-invigorating and qi-tonifying tranquilizing paste.
Example 4: medicinal material crushing particle size investigation of spleen-tonifying qi-tonifying and nerve-soothing paste
Raw materials: 20 parts of lily, 60 parts of fried Chinese yam, 20 parts of hawthorn, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date, 12 parts of mulberry, 1 part of longan pulp extract, 1 part of Chinese date extract and 1.2 parts of mulberry extract.
(1) Respectively taking 4 parts of medicinal and edible traditional Chinese medicine composition according to the parts by weight, respectively crushing the raw medicinal materials, and sieving the crushed medicinal materials with 40-mesh, 60-mesh, 80-mesh and 100-mesh sieves;
(2) uniformly mixing the medicinal material powder in the step (1) with the Chinese date extract, the longan extract and the mulberry extract powder;
(3) adding 10 times of distilled water into the mixed powder in the step (2), and decocting with slow fire of 300 watts for 10 minutes respectively;
(4) adding a flavoring agent combination: 0.5 percent (w/v) of saccharin sodium, 5 percent (w/v) of lemon essence and 7.5 percent (w/v) of gelatin are used for seasoning to obtain the spleen-invigorating, qi-tonifying and nerve-soothing paste. And evaluating the color, the smell and the taste, scoring by adopting a scoring system (percent system), and drawing a stacking bar chart to analyze a scoring result.
As shown in FIG. 1, the optimal particle size of the herbs with the highest stacking score is 60 mesh.
Example 5: decoction time investigation of spleen-tonifying qi-tonifying tranquilizing paste
Raw materials: 20 parts of lily, 60 parts of fried Chinese yam, 20 parts of hawthorn, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date, 12 parts of mulberry, 1 part of longan pulp extract, 1 part of Chinese date extract and 1.2 parts of mulberry extract.
(1) Respectively taking 4 parts of medicinal and edible traditional Chinese medicine composition according to the parts by weight, crushing the raw medicinal materials, and sieving the crushed raw medicinal materials with a 60-mesh sieve;
(2) uniformly mixing the medicinal material powder in the step (1) with 1 part of jujube extract, 1 part of longan extract and 1.2 parts of mulberry extract powder respectively;
(3) adding 10 times of distilled water into the mixed powder in the step (2), and decocting with 300 watts over slow fire for 5 minutes, 10 minutes, 15 minutes and 20 minutes respectively;
(4) adding a flavoring agent combination into the mixture obtained in the step (3): 0.5 percent (w/v) of saccharin sodium, 5 percent (w/v) of lemon essence and 7.5 percent (w/v) of gelatin are used for seasoning to obtain the spleen-invigorating, qi-tonifying and nerve-soothing paste. The color, smell and taste are evaluated, a scoring system (a percentage system) is adopted for scoring, and a stacking bar chart is drawn to analyze the scoring result.
As shown in fig. 2, the optimal decoction time corresponding to the highest stacking score was 10 minutes.
Example 6: investigation on combination ratio of extracts of spleen-invigorating, qi-tonifying and nerve-soothing paste
Raw materials: 20 parts of lily, 60 parts of fried Chinese yam, 20 parts of hawthorn, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date and 12 parts of mulberry.
(1) Weighing the raw material medicines and crushing the raw material medicines into 60 meshes;
(2) uniformly mixing the medicinal material powder in the step (1) with combined extract powder of Chinese date extract, longan extract and mulberry extract which are respectively 4 levels in the table 1;
(3) adding distilled water into the mixed powder in the step (2), and decocting with slow fire;
(4) adding 0.5% (w/v) of saccharin sodium and 5% (w/v) of lemon essence into the mixture cooked in the step (3), uniformly stirring, standing and cooling;
(5) and (4) when the mixture in the step (4) is cooled to room temperature, mixing the mixture with the gelatin which is heated to be just melted, uniformly stirring the mixture, placing the mixture in a refrigerator for refrigeration, taking out the mixture after shaping, and placing the mixture to room temperature to obtain the spleen-tonifying qi-tonifying and nerve-soothing paste. And comprehensively scoring and evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste according to color, smell and taste (percent system).
Table 2 shows the results of orthogonal experiments on the combination ratios of the three extracts, table 3 shows the results of analysis of variance on the comprehensive scores of the combination ratios of the three extracts, and table 3 shows that the analysis of variance of the three extracts is significant, which indicates that the effects of the three extracts on the comprehensive scores are equivalent, and the optimal combination ratio of the three extracts is A1B1C1, namely 1 part of longan pulp extract, 1 part of jujube extract and 1.2 parts of mulberry extract, which is shown by combining the K-means of the 4 levels of the three extracts in table 2 with the comprehensive score.
TABLE 1 level table for three kinds of extracts combination ratio
TABLE 2 orthogonal experimental results of three extract combination ratios
TABLE 3 analysis results of the variance analysis of the composite score of three extracts
Example 7: investigation on combination ratio of three flavoring agents of spleen-tonifying qi-tonifying and nerve-soothing paste
Raw materials: 20 parts of lily, 60 parts of fried Chinese yam, 20 parts of hawthorn, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date and 12 parts of mulberry.
(1) Weighing the raw material medicines and crushing the raw material medicines into 60 meshes;
(2) uniformly mixing the medicinal material powder in the step (1) with combined extract powder of 1 part of Chinese date extract, 1 part of longan extract and 1.2 parts of mulberry extract;
(3) adding distilled water into the mixed powder in the step (2), and decocting with slow fire;
(4) and (3) adding the three flavoring agents shown in the table 4 into the mixture boiled in the step (3), uniformly stirring, placing in a refrigerator for refrigeration, taking out after shaping, and placing to room temperature to obtain the spleen-invigorating and qi-tonifying tranquilization paste. And comprehensively scoring and evaluating the finished product of the spleen-invigorating, qi-tonifying and nerve-soothing paste according to color, smell and taste (percent system).
Table 5 shows the results of orthogonal experiments on the combination ratios of the three flavoring agents, table 6 shows the results of analysis of variance on the comprehensive scores of the combination ratios of the three flavoring agents, and table 6 shows that the analysis of variance of lemon essence and gelatin in the three flavoring agents is significant, which indicates that the two flavoring agents have a greater influence on the comprehensive scores, and the optimal combination ratio of the three flavoring agents is A2B3C3, namely, 0.5% (w/v) of saccharin sodium, 5% (w/v) of lemon essence, and 7.5% (w/v) of gelatin, as shown by the combination of the K-means of the level 4 of the three flavoring agents in table 5 and the comprehensive score.
Table 4 level table for three flavouring agent combination ratio
TABLE 5 orthogonal experimental results of three flavor agents in combination ratio
TABLE 6 analysis results of comprehensive scoring and variance analysis of three flavoring agent combination ratios
Example 8: medicinal and edible traditional Chinese medicine composition spleen-tonifying qi-tonifying tranquilizing paste
Through a large number of clinical applications, the traditional Chinese medicine composition provided by the inventor treats diseases such as weakness of spleen and stomach, gastrointestinal discomfort, anxiety, insomnia and the like on the basis of strengthening spleen and replenishing qi and calming heart and tranquilizing mind, and has a good curative effect. The present invention will be further described with reference to specific examples.
Case one: wang A certain woman in age 38. Initial diagnosis in 2015, 7 months and 5 days. The main cause of insomnia is 'insomnia for 5 months'. The disease condition is aggravated in the last 1 month, even the night is not asleep, the memory is obviously reduced, the spirit is listened, and the mind is difficult to concentrate in the work. Initial diagnosis: dark and gloomy complexion, restlessness, insomnia, fright head, dizziness, myasthenia of limbs, palpitation, dry eyes, sweating and dry mouth. Poor appetite, yellow urine and loose stool. The tongue is pale red, the coating is thin and white, and the pulse is thready. "an Ding pian" taken orally once has poor effect and aggravates the disease. According to the clinical symptoms, tongue condition and pulse condition of the patient, it can be identified as qi and blood deficiency of the spleen and stomach. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
The prescription is as follows: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the sleep is improved obviously, the limbs are strong, there is no dizziness and palpitation, etc., the original prescription is ordered to continue to take for 2 months, and the follow-up symptoms disappear after 2 months.
Case two: shu somewhere, Man, 43 years old. Initial diagnosis is carried out in 2015 for 8-month and 12-year, insomnia is repeatedly cured for 1 year, dizziness and somnolence are caused after dinner, hypnotics are not taken, the patient can not fall asleep again after waking up nine times at night, rolling is repeatedly performed until the patient is clear, memory is reduced, heart force is pallid, poor appetite, limb weakness, dizziness and palpitation, one line of stool every day, stickiness and unsmooth, a pale red tongue, white fur and a thready pulse. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After continuously taking for 1 month, the sleep is improved obviously, the patient can sleep for more than 6 hours every day, the limbs are powerful, the patient has no symptoms such as dizziness, palpitation and the like, the patient is advised to continue taking the traditional prescription for 2 months, and the follow-up symptoms disappear after 2 months.
Case three: chen is certain, female, age 46. The initial diagnosis in 2015, 9 and 26 days, is accompanied by insomnia and sweating for 4 months. Pneumonia before 4 months, which causes menstrual disorder, and the menstrual cycle returns to normal after pneumonia is cured, but the patient has insomnia, can not fall asleep again after waking up, and has myasthenia of limbs, dizziness, palpitation, poor appetite, normal urine, loose stool, pale red tongue, thin and white fur, and thready and wiry pulse. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved, the patient can sleep for more than 5 hours every day, the limbs are strong, the patient has no symptoms such as dizziness, palpitation and the like, the patient is ordered to continue to take the medicine for 2 months, and the follow-up symptoms disappear after 2 months.
Case four: yuan Zhi, female, 24 years old. Initial diagnosis in 2015, 10 months and 28 days, repeated insomnia 1 year, aggravation 3 days. Patients have a history of sleep suboptimal since the time of high school, possibly due to learning stress, and gradually become more severe thereafter. Very poor night sleep in the last 1 year, repeated insomnia, difficult sleep, frequent waking, even more than ten times, headache, fullness in head, palpitation, vexation, memory decline, scanty menstruation, more serious recent times, even insomnia in all night, weakness of limbs, pale red tongue, thin tongue coating, and wiry and thready pulse. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved obviously, the patient can sleep for more than 6 hours every day, the limbs are strong, the patient has no symptoms of dizziness, fullness in the head, palpitation and the like, the patient is advised to continue to take the traditional formula for 2 months, the follow-up symptoms disappear after 2 months, and the memory is improved obviously compared with the prior art.
Case five: for male, age 54. Initial diagnosis in 2016, 2 months, 26 days: repeated insomnia was manifested for 20 years, aggravated for 1 week. Be difficult to fall asleep at night, sometimes difficult to wake up early and unable to fall asleep again. Sleep for only 1 hour nearly in 1 week, insomnia almost all night, dizziness, debilitation, stomach discomfort, limb weakness, cardiopalmus, shapeless stool, pale red tongue, marginal and tooth marks, thin and yellowish fur, and wiry and thready pulse. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 1 month of continuous administration, the second diagnosis: the sleep is improved obviously, the patient can sleep for more than 5 hours every day, the limbs are strong, the patient has no symptoms of dizziness, fullness in the head, palpitation and the like, the patient is advised to continue to take the traditional formula for 3 months, the follow-up symptoms disappear after 3 months, and the memory is improved obviously compared with the prior art.
Six cases: zhou somewhat, female, 35 years old. Insomnia was repeated for 3 years, and the initial diagnosis was made in 2016, 4, 9 months. The patient starts at home and gets back late, often waits for worry at home, gradually causes insomnia, easily wakes up after sleeping, can not fall asleep until 2-3 o' clock in the middle of the night, does not take hypnotics, is eye-cloth blood silk, dizziness and palpitation, worry about more and more, anorexia, loose stool, pale red tongue, thin and white fur and thin pulse. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved, the patient can sleep for more than 6 hours every day, the limbs are strong, the patient has no symptoms such as dizziness, fullness in the head and palpitation, the patient is advised to continue to take the medicine for 3 months, and the follow-up symptoms disappear after 3 months.
Case seven: huang Yi, woman, age 38. The initial diagnosis is given after 2016, 5 months and 7 days, because insomnia is repeated for 4 years. The patient insomnia starts from construction near a residence, is disturbed by noise, does not take hypnotics, generally sleeps for 3-5 hours from 10 o 'clock late to 3 o' clock next morning, even sleeps overnight, prefers to lie on the back, defecates for 2-3 times in 1 day and is loose. Also appeal for frequent micturition, palpitation, dizziness, asthenia, pale and dark tongue, thin and white fur, and thready pulse caused by long-term urine holding. Differentiation of syndromes based on the deficiency of spleen and stomach in both qi and blood. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved, the patient can sleep continuously for more than 6 hours every day, the limbs are strong, the patient has no symptoms such as dizziness, fullness in the head and palpitation, the patient is advised to continue taking the medicine for 2 months, and the follow-up symptoms disappear after 2 months.
Eight cases: wangzhi, female, 65 years old. The diagnosis is made 6 months and 15 days in 2016. The breast cancer operation is performed 1 month before. Pale complexion, insufficient sleep for 3 hours every night, dreaminess, dizziness, general debilitation, short breath, poor appetite, 1 time daily defecation, loose stool, limb paralysis, pale lips and tongue, tooth marks on the tongue edge, white fur, and thready and slow pulse. The syndrome differentiation is the deficiency of qi and blood of the spleen and stomach. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved, the sleep can be continuously performed for more than 6 hours every day, the complexion is changed to be ruddy, the symptoms of shortness of breath and hypodynamia are improved compared with the former symptoms, the original formula is ordered to continue to be taken for 2 months, and the follow-up symptoms disappear after 2 months.
Nine cases: ma Shi, male 49 years old, 2016, 10 months and 16 days. Insomnia is difficult to fall asleep for many days, and the average time for falling asleep is 2-3 hours per day, palpitation, short breath, mental fatigue, poor appetite, pale tongue with thin coating and weak pulse. The syndrome differentiation is the deficiency of qi and blood of the spleen and stomach. The prescription uses the ointment prescription for strengthening the spleen, tonifying qi and soothing the nerves, and has the functions of strengthening the spleen, tonifying qi, nourishing blood and soothing the nerves.
Prescription: 20g of lily, 60g of fried Chinese yam, 20g of hawthorn, 24g of poria cocos, 10g of fried radish seed, 20g of lotus seed, 20g of fried coix seed, 12g of spina date seed, 10g of fried malt, 15g of longan pulp, 15g of Chinese date and 15g of mulberry.
Making into ointment, three times daily, 10-20g each time.
After 2 weeks of continuous administration, the second diagnosis: the sleep is improved, the patient can sleep continuously for more than 5 hours every day, the symptoms of shortness of breath and hypodynamia are improved compared with the symptoms before, the patient is advised to continue to take the traditional formula for 2 months, and the follow-up symptoms disappear after 2 months.
Claims (10)
1. A spleen-invigorating, qi-tonifying and mind-tranquilizing medicine-food homologous traditional Chinese medicine composition is characterized by comprising the following raw materials: 30-90 parts of fried Chinese yam, 10-40 parts of hawthorn, 10-40 parts of lily, 15-50 parts of poria cocos, 10-40 parts of fried radish seed, 10-40 parts of lotus seed, 10-40 parts of fried coix seed, 5-30 parts of spina date seed, 5-25 parts of fried malt, 5-25 parts of longan pulp, 5-25 parts of Chinese date, 5-25 parts of mulberry, 1-3 parts of longan pulp extract, 1-3 parts of Chinese date extract and 1-4 parts of mulberry extract, wherein the parts are all parts by weight.
2. The spleen-invigorating, qi-tonifying and mind-tranquilizing medicine-food homologous traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials: 60 parts of fried Chinese yam, 20 parts of hawthorn, 20 parts of lily, 24 parts of poria cocos, 10 parts of fried radish seed, 20 parts of lotus seed, 20 parts of fried coix seed, 12 parts of spina date seed, 10 parts of fried malt, 10 parts of longan pulp, 10 parts of Chinese date, 12 parts of mulberry, 1 part of longan pulp extract, 1 part of Chinese date extract and 1.2 parts of mulberry extract, wherein the parts are all parts by weight.
3. The spleen-invigorating, qi-tonifying and mind-tranquilizing drug and food homologous traditional Chinese medicine composition according to any one of claims 1-2, wherein the fried Chinese yam, the fried radish seed, the fried coix seed and the fried malt are prepared by a single frying method: parching to brown, parching to carbon, and parching together: stir-frying with bran, rice, soil, sand, clam powder, and pulvis Talci.
4. The spleen-invigorating, qi-tonifying and mind-tranquilizing medicine-food homologous traditional Chinese medicine composition according to any one of claims 1-3, wherein the arillus longan extract, the jujube extract and the mulberry extract are extracts obtained by any one of water extraction, alcohol extraction and macroporous resin adsorption of raw medicinal materials.
5. The spleen-invigorating, qi-replenishing, and mind-tranquilizing drug-food homologous traditional Chinese medicine composition according to one of claims 1 to 4, characterized in that: making into any suitable dosage form of unguent, tablet, pill, powder, medicated liquor, capsule, and infusion by conventional method.
6. A spleen-invigorating, qi-replenishing and nerve-soothing paste, which is characterized by being prepared by taking the medicinal and edible traditional Chinese medicine composition as claimed in any one of claims 1 to 5 as a raw material and combining with a proper flavoring agent for flavoring.
7. The spleen-invigorating and qi-replenishing tranquilizing paste according to claim 6, wherein in the preparation process, the medicinal materials are crushed into medicinal material fine powder which is sieved by a 60-mesh sieve, and the medicinal material fine powder is uniformly mixed with the arillus longan extract, the jujube extract and the mulberry extract to obtain mixed powder.
8. The spleen-invigorating and qi-replenishing tranquilizing paste according to any one of claims 6 to 7, which is characterized in that the combination of the added flavoring agents during preparation is as follows: 0.1-0.8% (w/v) of saccharin sodium, 1-7% (w/v) of lemon essence and 3-10% (w/v) of gelatin.
9. The specific preparation method of the spleen-invigorating and qi-replenishing tranquilizing paste according to any one of claims 6 to 8, wherein 8 to 12 times of water is added to the mixed powder of the extract powder and the other medicinal material powder, and the mixture is boiled with slow fire at a power of 300 watts, with continuous stirring during the boiling for 10 minutes; adding saccharin sodium and lemon essence when cooking, stirring, standing, and cooling; and (3) when the mixture is cooled to room temperature, mixing the mixture with gelatin which is heated to be just melted, uniformly stirring, placing in a refrigerator for refrigeration, taking out after shaping, and placing to room temperature to obtain the spleen-invigorating, qi-tonifying and nerve-soothing paste.
10. Use of the Chinese medicinal composition according to one of claims 1 to 5 in the preparation of a Chinese medicinal composition having the effects of invigorating spleen, replenishing qi and tranquilizing mind.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910788752.1A CN110585371A (en) | 2019-08-26 | 2019-08-26 | Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910788752.1A CN110585371A (en) | 2019-08-26 | 2019-08-26 | Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110585371A true CN110585371A (en) | 2019-12-20 |
Family
ID=68855534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910788752.1A Pending CN110585371A (en) | 2019-08-26 | 2019-08-26 | Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110585371A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112106866A (en) * | 2020-10-15 | 2020-12-22 | 安徽珠峰生物科技有限公司 | Production formula and preparation method of Yijing granular tea |
CN112971082A (en) * | 2021-03-23 | 2021-06-18 | 山东利蒙药业有限公司 | Longan, lily and sea-buckthorn soup and production process thereof |
CN113854560A (en) * | 2021-09-26 | 2021-12-31 | 广州巨咖时代科技有限公司 | Weight-losing formula and preparation method |
CN114271491A (en) * | 2021-12-15 | 2022-04-05 | 重庆市中药研究院 | Medicinal and edible composition for improving insomnia as well as preparation method and application thereof |
CN115429860A (en) * | 2022-05-23 | 2022-12-06 | 山东中医药大学 | Fermented blood-nourishing nerve-soothing beverage and preparation process thereof |
CN117482188A (en) * | 2023-11-03 | 2024-02-02 | 江中食疗科技有限公司 | Medicinal and edible composition and preparation process thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101897799A (en) * | 2009-05-27 | 2010-12-01 | 北京因科瑞斯医药科技有限公司 | Drug composition with effect of improving sleep and preparation method thereof |
CN106620210A (en) * | 2016-11-23 | 2017-05-10 | 西宁志培知识产权咨询有限公司 | Preparation method of mind-tranquilizing substitute tea prepared by taking food plants as components |
-
2019
- 2019-08-26 CN CN201910788752.1A patent/CN110585371A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101897799A (en) * | 2009-05-27 | 2010-12-01 | 北京因科瑞斯医药科技有限公司 | Drug composition with effect of improving sleep and preparation method thereof |
CN106620210A (en) * | 2016-11-23 | 2017-05-10 | 西宁志培知识产权咨询有限公司 | Preparation method of mind-tranquilizing substitute tea prepared by taking food plants as components |
Non-Patent Citations (1)
Title |
---|
张小燕: "HPLC法测定小儿胃宝片中熊果酸的含量", 《陕西中医学院学报》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112106866A (en) * | 2020-10-15 | 2020-12-22 | 安徽珠峰生物科技有限公司 | Production formula and preparation method of Yijing granular tea |
CN112971082A (en) * | 2021-03-23 | 2021-06-18 | 山东利蒙药业有限公司 | Longan, lily and sea-buckthorn soup and production process thereof |
CN113854560A (en) * | 2021-09-26 | 2021-12-31 | 广州巨咖时代科技有限公司 | Weight-losing formula and preparation method |
CN114271491A (en) * | 2021-12-15 | 2022-04-05 | 重庆市中药研究院 | Medicinal and edible composition for improving insomnia as well as preparation method and application thereof |
CN115429860A (en) * | 2022-05-23 | 2022-12-06 | 山东中医药大学 | Fermented blood-nourishing nerve-soothing beverage and preparation process thereof |
CN115429860B (en) * | 2022-05-23 | 2023-08-04 | 山东中医药大学 | Fermented blood-nourishing nerve-soothing drink and preparation process thereof |
CN117482188A (en) * | 2023-11-03 | 2024-02-02 | 江中食疗科技有限公司 | Medicinal and edible composition and preparation process thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110585371A (en) | Spleen-tonifying qi-tonifying mind-tranquilizing medicine-food homologous traditional Chinese medicine composition and preparation method of spleen-tonifying qi-tonifying mind-tranquilizing paste | |
CN104839292A (en) | Nutrition and health care biscuit for stomach cold pain and preparation method | |
CN101773624A (en) | Traditional Chinese medicine composition for curing diabetes and preparation method thereof | |
CN103919008A (en) | Health porridge with spleen and kidney tonifying functions, and preparation method of health porridge | |
CN105475813A (en) | Qi-replenishing blood-nourishing nutritious congee and preparation method thereof | |
CN104207121B (en) | A kind of immunity that improves reduces by three high food therapeutic healths | |
CN104017701B (en) | The logical health-care white spirit of a kind of the five internal organs weighing apparatus | |
CN106343339A (en) | Nutrient composition and making method and application thereof | |
CN102526537A (en) | Medicinal composition for treating hyperglycemia | |
CN105733880A (en) | Composite hazelnut wine brewed from hazelnut meal | |
CN112336843A (en) | Zhuang medicine composition with functions of chest strengthening and breast enlarging, pills and preparation method and application of pills | |
CN104738437A (en) | Health soup capable of improving sleeping and manufacturing method thereof | |
CN105012732B (en) | Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof | |
CN104255922A (en) | Health care milk suitable for three-high crowd to drink and preparation method of milk | |
CN104687142A (en) | Formula and production method of ginseng soup stock for strengthening brain and tranquillizing | |
CN111328967A (en) | Method for preparing health porridge for hyperlipidemia patients | |
WO2018000726A1 (en) | Soup for treating insomnia and dysphoria, and preparation method therefor | |
CN105920271A (en) | Hypolipidemic composition and preparation method thereof | |
CN106665776A (en) | Traditional Chinese medicine pastries for conditioning yin deficiency constitutions | |
CN106343560A (en) | Nutrient composition and making method and application thereof | |
CN106173892A (en) | A kind of lung heat clearing health care can rush food coarse cereals flour and preparation method thereof | |
CN104397756A (en) | Health sausages containing bullfrog meat | |
CN105343567B (en) | Infant sleep-promoting formula | |
CN104645321A (en) | Sugar pills for promoting skeletal development of children and preparation method of sugar pills | |
CN113907337A (en) | Five-cereal meal powder and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191220 |