CN110585368A - Pharmaceutical composition for losing weight and preparation thereof - Google Patents

Pharmaceutical composition for losing weight and preparation thereof Download PDF

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Publication number
CN110585368A
CN110585368A CN201910961634.6A CN201910961634A CN110585368A CN 110585368 A CN110585368 A CN 110585368A CN 201910961634 A CN201910961634 A CN 201910961634A CN 110585368 A CN110585368 A CN 110585368A
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fine powder
parts
sieve
pharmaceutical composition
drying
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鞠振宇
陈爱萍
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Ningbo Helin Health Technology Co Ltd
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Ningbo Helin Health Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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Abstract

The pharmaceutical composition for losing weight is characterized by comprising the following components: 15-40 parts of raw coix seeds, 5-20 parts of bitter almonds, 5-20 parts of wrinkled gianthyssop herb, 5-20 parts of fermented soybeans, 5-20 parts of chicory, 5-30 parts of poria cocos, 5-20 parts of Pu' er tea and 5-20 parts of lotus leaves, and by means of a modern extraction technology, effective components in an original prescription can be extracted, and the taking dosage is reduced; the semisolid and solid preparations with stable property, good taste and convenient taking are prepared by modern preparation technology and novel auxiliary materials, and the clinical compliance is effectively improved.

Description

Pharmaceutical composition for losing weight and preparation thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for losing weight and a preparation thereof.
Background
The main clinical application form of the current traditional Chinese medicine preparation is still decoction, however, the common people lack the professional knowledge of traditional Chinese medicine, and often cannot correctly process (such as special processing such as wrapping and decocting, melting and the like) and decoct the medicine, so that the medicine components are difficult to effectively extract, and the decoction is sometimes generated when the people are burnt and cooked. In addition, the traditional Chinese medicine decoction always has the problems of thick and black appearance and poor taste, the clinical compliance (especially for teenagers and children) is seriously influenced, and the liquid preparation form also causes the problems of inconvenient transportation and carrying and the stability of the active ingredients. How to convert the traditional Chinese medicine decoction into a semisolid and solid preparation with good color, smell and taste by using the modern pharmaceutical technology becomes a problem to be solved urgently.
The traditional Chinese medicine decoction has the advantages of thick and black appearance, inconvenience in carrying, large taking dosage, poor taste and poor stability, is not beneficial to storage of effective components, and further influences the exertion of clinical curative effect; the traditional Chinese medicine prescription is prepared into a preparation form which is convenient to carry and take, stable in property and good in compliance by adopting a novel pharmaceutical technology and novel auxiliary materials, and the traditional Chinese medicine prescription is beneficial to improving the acceptance of patients and improving the curative effect of the prescription.
Disclosure of Invention
The invention provides a pharmaceutical composition for losing weight and a preparation thereof, which can extract effective components in the original prescription and reduce the dosage by the modern extraction technology; the semisolid and solid preparations with stable property, good taste and convenient taking are prepared by modern preparation technology and novel auxiliary materials, and the clinical compliance is effectively improved.
The technical scheme adopted by the invention for solving the problems is as follows: a pharmaceutical composition for reducing weight comprises the following components: 15-40 parts of raw coix seeds, 5-20 parts of bitter almonds, 5-20 parts of wrinkled gianthyssop herbs, 5-20 parts of fermented soybeans, 5-20 parts of chicory, 5-30 parts of poria cocos, 5-20 parts of Pu' er tea and 5-20 parts of lotus leaves.
The preparation method comprises the following steps:
(1) adding 5-15 times of water, soaking for 0.5-1 hour, decocting for 0.5-2 hours each time, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(2) adding 5-15 times of 30-85% ethanol, refluxing for 0.5-2 hours, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(3) adding 5-15 times of 30-85% ethanol, soaking for 4-72 hours at 20-65 ℃, extracting for 1-3 times, and separating the soaking solution by adopting a centrifugal or filtering mode;
(4) pulverizing into coarse powder, adding a small amount of 30-85% ethanol to wet the powder, filling a percolation cylinder, adding 5-15 times of 30-85% ethanol, soaking for 4-12 hours, percolating, and taking percolate.
The buccal tablet of the pharmaceutical composition is prepared by any one of the following modes:
(1) recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, uniformly mixing, preparing a soft material by using 80-100% ethanol, preparing granules by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, uniformly mixing, tabletting, wherein the hardness of the tablet is more than 8, wherein the medicinal powder is 40-80%, the dextrin or soluble starch is 10-60%, the mannose is 5-30%, the lactose is 0-50%, the xylitol is 0-50%, the sweetener is 0-5%, and the magnesium stearate is 0.5-3%;
(2) recovering the solvent from the extracting solution, and concentrating to obtain an extract with the density of 1.05-1.45 g/ml; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, mixing uniformly, granulating by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, mixing uniformly, tabletting, wherein the hardness of the tablet is more than 8, wherein the extract accounts for 10-40%, the dextrin or soluble starch accounts for 60-80%, the mannose accounts for 5-30%, the lactose accounts for 0-50%, the xylitol accounts for 0-50%, the sweetener accounts for 0-5%, and the magnesium stearate accounts for 0.5-3%.
The pharmaceutical composition orally disintegrating tablet is prepared by the following method: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; adding the fine powder of croscarmellose sodium, the fine powder of crospovidone, the fine powder of flavoring agent, the fine powder of dextrin or soluble starch and the fine powder of magnesium stearate, uniformly mixing, and tabletting to obtain the tablet, wherein the medicinal powder is 20-40%, the croscarmellose sodium is 5-25%, the crospovidone is 5-25%, the flavoring agent is 1-5%, the dextrin or soluble starch is 20-70%, and the magnesium stearate is 0.5-3%.
5. The weight-loss pharmaceutical composition according to claim 2, wherein the pharmaceutical composition chewable tablet is prepared by: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; mixing the medicinal powder with anhydrous lactose fine powder, citric acid fine powder and flavoring agent fine powder, adding 80-95% ethanol to prepare a soft material, sieving with a No. 2 sieve to prepare granules, drying at 40 ℃, grading with a No. 2 sieve, adding magnesium stearate fine powder, and tabletting to obtain tablets with the hardness of more than 8, wherein the medicinal powder accounts for 30-50%, the anhydrous lactose accounts for 50-85%, the citric acid accounts for 0-5%, the flavoring agent accounts for 1-25%, and the magnesium stearate accounts for 0.5-3%.
The pharmaceutical composition chewable tablet is prepared by the following method: recovering solvent from the above extractive solution, concentrating, drying, pulverizing into fine powder, mixing with 0.5-2 times of dextrin or soluble starch, and dividing into A, B parts; dissolving sodium carbonate or sodium bicarbonate with 85-90% ethanol, spraying into powder A as wetting agent, sieving with No. 1 sieve or No. 2 sieve for granulating, drying at 60 deg.C, and sieving with No. 1 sieve or No. 2 sieve; dissolving citric acid or citric acid in 85-95% ethanol solution, spraying into powder B as wetting agent, sieving with No. 1 sieve or No. 2 sieve, granulating, drying at 60 deg.C, and sieving with No. 1 sieve or No. 2 sieve; mixing the two kinds of granules uniformly, and quickly packaging, wherein the medicinal powder is 20-60%, the dextrin or soluble starch is 30-60%, the citric acid or tartaric acid is 1-10%, and the sodium carbonate or sodium bicarbonate is 1-10%. And controlling the ambient humidity to be less than 40%.
The pharmaceutical composition oral gel is prepared by the following method: recovering the solvent from the extracting solution, and concentrating to the density of 1.05-1.45 g/ml; adding water to the carrageenin or the gelatin or the agar for swelling for 20min, heating and melting the carrageenin or the gelatin or the agar in a water bath at 90 ℃, adding the liquid medicine, uniformly stirring, adding the flavoring agent, stirring to dissolve, sub-packaging by heating, and cooling, wherein the extracting solution is 50-80%, the purified water is 0-30%, the carrageenin or the gelatin or the agar is 3-10%, and the flavoring agent is 1-5%.
The oral pellet of the pharmaceutical composition is prepared by the following steps: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; sieving microcrystalline cellulose with 80 mesh sieve, mixing with the extract fine powder, making into soft mass, extruding, rolling, drying, and sieving. Wherein the dosage of the microcrystalline cellulose is 40-70%, the aperture of the sieve plate is 1.0mm, the extrusion speed is 30r/min, the rounding speed is 50Hz, the rounding time is 6min, and the drying is carried out.
The medicinal soft extract is prepared by the following steps: and recovering the solvent from the extracting solution, concentrating the extracting solution to obtain clear paste with the density of 1.20-1.28 g/ml, adding 150-250 g of brown sugar into every 100g of clear paste, heating to melt, uniformly mixing, and concentrating the mixture to obtain the sugar-free beverage with the relative density of 1.35-1.45.
The medicinal composition tea bag is prepared by the following steps: mixing and crushing 5-15 parts of wrinkled gianthyssop herb, 5-15 parts of chicory, 5-15 parts of Pu' er tea and 5-15 parts of lotus leaf, sieving by a No. 1 sieve, adding 2-6 times of water into 20-40 parts of raw coix seed, 5-15 parts of bitter apricot seed, 5-15 parts of fermented soybean and 5-25 parts of poria cocos, soaking for 0.5-1 hour, decocting for 0.5-2 hours, extracting for 1 time, combining extracting solutions, concentrating, spraying the concentrated solution onto mixed powder of the four medicines such as the wrinkled gianthyssop herb, uniformly mixing, drying and subpackaging tea bags.
Detailed Description
Example 1
A pharmaceutical composition for reducing weight comprises the following components: 15-40 parts of raw coix seeds, 5-20 parts of bitter almonds, 5-20 parts of wrinkled gianthyssop herbs, 5-20 parts of fermented soybeans, 5-20 parts of chicory, 5-30 parts of poria cocos, 5-20 parts of Pu' er tea and 5-20 parts of lotus leaves.
The preparation method comprises the following steps:
(1) adding 5-15 times of water, soaking for 0.5-1 hour, decocting for 0.5-2 hours each time, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(2) adding 5-15 times of 30-85% ethanol, refluxing for 0.5-2 hours, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(3) adding 5-15 times of 30-85% ethanol, soaking for 4-72 hours at 20-65 ℃, extracting for 1-3 times, and separating the soaking solution by adopting a centrifugal or filtering mode;
(4) pulverizing into coarse powder, adding a small amount of 30-85% ethanol to wet the powder, filling a percolation cylinder, adding 5-15 times of 30-85% ethanol, soaking for 4-12 hours, percolating, and taking percolate.
The buccal tablet of the pharmaceutical composition is prepared by any one of the following modes:
(1) recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, uniformly mixing, preparing a soft material by using 80-100% ethanol, preparing granules by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, uniformly mixing, tabletting, wherein the hardness of the tablet is more than 8, wherein the medicinal powder is 40-80%, the dextrin or soluble starch is 10-60%, the mannose is 5-30%, the lactose is 0-50%, the xylitol is 0-50%, the sweetener is 0-5%, and the magnesium stearate is 0.5-3%;
(2) recovering the solvent from the extracting solution, and concentrating to obtain an extract with the density of 1.05-1.45 g/ml; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, mixing uniformly, granulating by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, mixing uniformly, tabletting, wherein the hardness of the tablet is more than 8, wherein the extract accounts for 10-40%, the dextrin or soluble starch accounts for 60-80%, the mannose accounts for 5-30%, the lactose accounts for 0-50%, the xylitol accounts for 0-50%, the sweetener accounts for 0-5%, and the magnesium stearate accounts for 0.5-3%.
Example 2
The process for preparing orally disintegrating tablets of the pharmaceutical composition comprises the steps of preparing an extract as in example 1, recovering the solvent from the extract, concentrating, drying, and pulverizing into fine powder; adding croscarmellose sodium fine powder, crospovidone fine powder, correctant fine powder, dextrin or soluble starch, and magnesium stearate fine powder, mixing, and tabletting. Wherein the medicine powder is 20-40%, the croscarmellose sodium is 5-25%, the crospovidone is 5-25%, the flavoring agent is 1-5%, the dextrin or soluble starch is 20-70%, and the magnesium stearate is 0.5-3%.
Example 3
The process for preparing chewable tablets of the pharmaceutical composition, the preparation of the extract is the same as that of example 1, the above extract is processed by recovering the solvent, concentrating, drying and pulverizing into fine powder; mixing the medicinal powder with anhydrous lactose fine powder, citric acid fine powder, and taste corrective fine powder (such as sucrose, mannitol, xylitol, etc.), adding 80-95% ethanol to make soft mass, sieving with No. 2 sieve to make granule, drying at 40 deg.C, sieving with No. 2 sieve, adding magnesium stearate fine powder, and tabletting to obtain tablet with hardness of more than 8. Wherein the medicine powder is 30-50%, the anhydrous lactose is 50-85%, the citric acid is 0-5%, the flavoring agent is 1-25%, and the magnesium stearate is 0.5-3%.
Example 4
A method for preparing effervescent granule of pharmaceutical composition comprises recovering solvent from the above extractive solution, concentrating, drying, pulverizing into fine powder, mixing with 0.5-2 times of dextrin or soluble starch, and dividing into A, B parts; dissolving sodium carbonate or sodium bicarbonate with 85-90% ethanol, spraying into powder A as wetting agent, sieving with No. 1 sieve, granulating, drying at 60 deg.C, and grading with No. 1 sieve; dissolving citric acid or citric acid in 85-95% ethanol solution, spraying into powder B as wetting agent, sieving with No. 1 sieve, granulating, drying at 60 deg.C, and grading with No. 1 sieve; mixing the above two kinds of granules, and rapidly packaging. Wherein the medicinal powder is 20-60%, the dextrin or soluble starch is 30-60%, the citric acid or tartaric acid is 1-10%, and the sodium carbonate or sodium bicarbonate is 1-10%. And controlling the ambient humidity to be less than 40%. Or recovering solvent from the above extractive solution, concentrating, drying, pulverizing into fine powder, mixing with 0.5-2 times of dextrin or soluble starch, and dividing into A, B parts; dissolving sodium carbonate or sodium bicarbonate with 85-90% ethanol, spraying into powder A as wetting agent, sieving with No. 2 sieve, granulating, drying at 60 deg.C, and grading with No. 2 sieve; dissolving citric acid or citric acid in 85-95% ethanol solution, spraying into powder B as wetting agent, sieving with No. 2 sieve, granulating, drying at 60 deg.C, and grading with No. 2 sieve; mixing the above two kinds of granules, tabletting with a tabletting machine, and rapidly packaging. Wherein the medicinal powder is 20-60%, the dextrin or soluble starch is 30-60%, the citric acid or tartaric acid is 1-10%, and the sodium carbonate or sodium bicarbonate is 1-10%. And controlling the ambient humidity to be less than 40%.
Example 5
The preparation method of the buccal film agent of the pharmaceutical composition is the same as the preparation method of the embodiment 1, the extracting solution is recovered, concentrated, dried and crushed into fine powder; dissolving polyvinyl alcohol in glycerol aqueous solution, adding the medicinal powder, dispersing uniformly, coating, drying at 60-80 deg.C, and cutting. Wherein the medicinal powder is 0-10%, the polyvinyl alcohol is 0-25%, and the glycerol is 0-10%.
Example 6
The preparation method of the oral gel of the pharmaceutical composition comprises the steps of preparing an extracting solution in the same way as in example 1, recovering a solvent from the extracting solution, and concentrating the solvent until the density is 1.05-1.45 g/ml; swelling Carrageenan or gelatin or agar with water for 20min, heating in 90 deg.C water bath for melting, adding the medicinal liquid, stirring, adding correctant (such as aspartame, acesulfame potassium, stevioside, etc.), stirring for dissolving, packaging under heating, and cooling. Wherein the extract is 50-80%, the purified water is 0-30%, the carrageenan or gelatin or agar is 3-10%, and the flavoring agent is 1-5%.
Example 7
A method for preparing oral micropill of pharmaceutical composition comprises preparing extractive solution as in example 1, recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; sieving microcrystalline cellulose with 80 mesh sieve to obtain fine powder, mixing with the extract fine powder, adding 80-95% ethanol to make soft mass, extruding, rolling, drying, and sieving. Wherein the dosage of the microcrystalline cellulose is 40-70%, the aperture of the sieve plate is 1.0mm, the extrusion speed is 30r/min, the rounding speed is 50Hz, the rounding time is 6min, and the drying is carried out at 60 ℃.
Example 8
The preparation method of the medicinal composition soft extract is the same as that of the extract in the example 1, and the extract is recovered with the solvent and concentrated into clear paste with the density of 1.20-1.28 g/ml. Adding 150-250 g of brown sugar into every 100g of the clear paste, heating to melt, uniformly mixing, and concentrating until the relative density is 1.35-1.45 (55-60 ℃).
5-15 parts of wrinkled gianthyssop herb, 5-15 parts of chicory, 5-15 parts of Pu' er tea and 5-15 parts of lotus leaf are mixed and crushed, and screened by a No. 1 sieve. 20-40 parts of raw coix seeds, 5-15 parts of bitter almonds, 5-15 parts of fermented soybeans and 5-25 parts of poria cocos are added with 2-6 times of water, soaked for 0.5-1 hour, decocted for 0.5-2 hours each time, extracted for 1 time, the extracting solutions are combined and concentrated to the concentration of 1-2g decoction pieces/ml. Spraying the concentrated solution onto the mixed powder of herba Agastaches, mixing, oven drying at 40-60 deg.C, and packaging.

Claims (10)

1. The pharmaceutical composition for losing weight is characterized by comprising the following components: 15-40 parts of raw coix seeds, 5-20 parts of bitter almonds, 5-20 parts of wrinkled gianthyssop herbs, 5-20 parts of fermented soybeans, 5-20 parts of chicory, 5-30 parts of poria cocos, 5-20 parts of Pu' er tea and 5-20 parts of lotus leaves.
2. The weight-loss pharmaceutical composition as claimed in claim 1, which is prepared by any one of the following methods:
(1) adding 5-15 times of water, soaking for 0.5-1 hour, decocting for 0.5-2 hours each time, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(2) adding 5-15 times of 30-85% ethanol, refluxing for 0.5-2 hours, extracting for 1-3 times, and separating decoction by adopting a centrifugal or filtering mode;
(3) adding 5-15 times of 30-85% ethanol, soaking for 4-72 hours at 20-65 ℃, extracting for 1-3 times, and separating the soaking solution by adopting a centrifugal or filtering mode;
(4) pulverizing into coarse powder, adding a small amount of 30-85% ethanol to wet the powder, filling a percolation cylinder, adding 5-15 times of 30-85% ethanol, soaking for 4-12 hours, percolating, and taking percolate.
3. The weight-losing pharmaceutical composition according to claim 2, wherein the pharmaceutical composition buccal tablet is prepared by any one of the following ways:
(1) recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, uniformly mixing, preparing a soft material by using 80-100% ethanol, preparing granules by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, uniformly mixing, tabletting, wherein the hardness of the tablet is more than 8, wherein the medicinal powder is 40-80%, the dextrin or soluble starch is 10-60%, the mannose is 5-30%, the lactose is 0-50%, the xylitol is 0-50%, the sweetener is 0-5%, and the magnesium stearate is 0.5-3%;
(2) recovering the solvent from the extracting solution, and concentrating to obtain an extract with the density of 1.05-1.45 g/ml; adding dextrin or soluble starch, mannose fine powder, lactose fine powder, xylitol fine powder and sweetener fine powder, mixing uniformly, granulating by using a No. 2 sieve, drying at 40 ℃, granulating by using a No. 2 sieve, adding magnesium stearate fine powder, mixing uniformly, tabletting, wherein the hardness of the tablet is more than 8, wherein the extract accounts for 10-40%, the dextrin or soluble starch accounts for 60-80%, the mannose accounts for 5-30%, the lactose accounts for 0-50%, the xylitol accounts for 0-50%, the sweetener accounts for 0-5%, and the magnesium stearate accounts for 0.5-3%.
4. The weight-loss pharmaceutical composition according to claim 2, wherein the pharmaceutical composition orally disintegrating tablet is prepared by: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; adding the fine powder of croscarmellose sodium, the fine powder of crospovidone, the fine powder of flavoring agent, the fine powder of dextrin or soluble starch and the fine powder of magnesium stearate, uniformly mixing, and tabletting to obtain the tablet, wherein the medicinal powder is 20-40%, the croscarmellose sodium is 5-25%, the crospovidone is 5-25%, the flavoring agent is 1-5%, the dextrin or soluble starch is 20-70%, and the magnesium stearate is 0.5-3%.
5. The weight-loss pharmaceutical composition according to claim 2, wherein the pharmaceutical composition chewable tablet is prepared by: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; mixing the medicinal powder with anhydrous lactose fine powder, citric acid fine powder and flavoring agent fine powder, adding 80-95% ethanol to prepare a soft material, sieving with a No. 2 sieve to prepare granules, drying at 40 ℃, grading with a No. 2 sieve, adding magnesium stearate fine powder, and tabletting to obtain tablets with the hardness of more than 8, wherein the medicinal powder accounts for 30-50%, the anhydrous lactose accounts for 50-85%, the citric acid accounts for 0-5%, the flavoring agent accounts for 1-25%, and the magnesium stearate accounts for 0.5-3%.
6. The weight-loss pharmaceutical composition according to claim 2, wherein the pharmaceutical composition chewable tablet is prepared by: recovering solvent from the above extractive solution, concentrating, drying, pulverizing into fine powder, mixing with 0.5-2 times of dextrin or soluble starch, and dividing into A, B parts; dissolving sodium carbonate or sodium bicarbonate with 85-90% ethanol, spraying into powder A as wetting agent, sieving with No. 1 sieve or No. 2 sieve for granulating, drying at 60 deg.C, and sieving with No. 1 sieve or No. 2 sieve; dissolving citric acid or citric acid in 85-95% ethanol solution, spraying into powder B as wetting agent, sieving with No. 1 sieve or No. 2 sieve, granulating, drying at 60 deg.C, and sieving with No. 1 sieve or No. 2 sieve; mixing the two kinds of granules uniformly, and quickly packaging, wherein the medicinal powder is 20-60%, the dextrin or soluble starch is 30-60%, the citric acid or tartaric acid is 1-10%, the sodium carbonate or sodium bicarbonate is 1-10%, and the environmental humidity is controlled to be less than 40%.
7. The weight-loss pharmaceutical composition as claimed in claim 2, wherein the pharmaceutical composition oral gel is prepared by the following method: recovering the solvent from the extracting solution, and concentrating to the density of 1.05-1.45 g/ml; adding water to the carrageenin or the gelatin or the agar for swelling for 20min, heating and melting the carrageenin or the gelatin or the agar in a water bath at 90 ℃, adding the liquid medicine, uniformly stirring, adding the flavoring agent, stirring to dissolve, sub-packaging by heating, and cooling, wherein the extracting solution is 50-80%, the purified water is 0-30%, the carrageenin or the gelatin or the agar is 3-10%, and the flavoring agent is 1-5%.
8. The weight-losing pharmaceutical composition according to claim 2, wherein the pharmaceutical composition oral pellet is prepared by: recovering solvent from the above extractive solution, concentrating, drying, and pulverizing into fine powder; sieving microcrystalline cellulose with 80 mesh sieve, mixing with the extract fine powder, making into soft mass, extruding, rolling, drying, and sieving. Wherein the dosage of the microcrystalline cellulose is 40-70%, the aperture of the sieve plate is 1.0mm, the extrusion speed is 30r/min, the rounding speed is 50Hz, the rounding time is 6min, and the drying is carried out.
9. The weight-losing pharmaceutical composition according to claim 2, wherein the pharmaceutical soft extract is prepared by: and recovering the solvent from the extracting solution, concentrating the extracting solution to obtain clear paste with the density of 1.20-1.28 g/ml, adding 150-250 g of brown sugar into every 100g of clear paste, heating to melt, uniformly mixing, and concentrating the mixture to obtain the sugar-free beverage with the relative density of 1.35-1.45.
10. The weight-losing pharmaceutical composition according to claim 2, wherein the pharmaceutical composition tea bag is prepared by: mixing and crushing 5-15 parts of wrinkled gianthyssop herb, 5-15 parts of chicory, 5-15 parts of Pu' er tea and 5-15 parts of lotus leaf, sieving by a No. 1 sieve, adding 2-6 times of water into 20-40 parts of raw coix seed, 5-15 parts of bitter apricot seed, 5-15 parts of fermented soybean and 5-25 parts of poria cocos, soaking for 0.5-1 hour, decocting for 0.5-2 hours, extracting for 1 time, combining extracting solutions, concentrating, spraying the concentrated solution onto mixed powder of the four medicines such as the wrinkled gianthyssop herb, uniformly mixing, drying and subpackaging tea bags.
CN201910961634.6A 2019-10-10 2019-10-10 Pharmaceutical composition for losing weight and preparation thereof Pending CN110585368A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103446514A (en) * 2012-05-30 2013-12-18 杨启红 Traditional Chinese medicine composition for treating facial chlorosis
CN105535881A (en) * 2015-12-10 2016-05-04 辽宁中医药大学 Medicinal food recipe for phlegm-dampness constitution

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103446514A (en) * 2012-05-30 2013-12-18 杨启红 Traditional Chinese medicine composition for treating facial chlorosis
CN105535881A (en) * 2015-12-10 2016-05-04 辽宁中医药大学 Medicinal food recipe for phlegm-dampness constitution

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
许明德等: "祛湿饮治疗亚健康50例临床观察", 《四川中医》 *

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