CN110575460A - external patch for improving immunity and preparation method thereof - Google Patents

external patch for improving immunity and preparation method thereof Download PDF

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CN110575460A
CN110575460A CN201910906512.7A CN201910906512A CN110575460A CN 110575460 A CN110575460 A CN 110575460A CN 201910906512 A CN201910906512 A CN 201910906512A CN 110575460 A CN110575460 A CN 110575460A
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parts
weight
patch
micro powder
immunity
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佘建华
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Veterinary Medicine (AREA)
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  • Alternative & Traditional Medicine (AREA)
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Abstract

The invention discloses an external patch for improving immunity and a preparation method thereof, wherein the effective components of the external patch are prepared from the following raw material medicines in parts by weight: musk 30-40 parts and white mustard seed 15-20 parts. Based on years of clinical research and guided by modern medical theory, the musk and the white mustard seed are compatible, the components are mutually influenced, the synergistic effect is obtained, the external patch which is safe and effective, has no toxic or side effect and effectively improves the immunity of the organism is provided for people, the acupuncture points of the patch are stimulated and treated at intervals, the aim of strengthening the body can be really achieved, and the external patch has the advantages of good effect, quick response, obvious curative effect and convenience in use. The invention has simple components and low cost.

Description

external patch for improving immunity and preparation method thereof
Technical Field
The invention relates to the technical field of medicines, in particular to an external patch for improving immunity and a preparation method thereof.
Background
Under the same environment, some people are sick and others are innoxious because of different immunity (resistance) of different people. Immunity is the body's own defense mechanism, and is the body's ability to recognize and destroy any foreign body (virus, bacteria, etc.) that invades from the outside, and to treat aged, damaged, dead, denatured self-cells, and to recognize and treat mutant cells and virus-infected cells in the body. Modern immunology considers that immunity is the physiological response of the human body to recognize and eliminate "isohexia". Immunocompromised bodies are susceptible to infection or cancer; when the immune system cannot normally exert a protective effect, the immune system is very easy to cause infection of bacteria, viruses, fungi and the like, so the most direct expression of low immunity is that the immune system is easy to cause diseases. Because the body consumption is aggravated due to frequent illness, people with low immunity have the manifestations of weak constitution, malnutrition, listlessness, fatigue, weakness, appetite reduction, sleep disorder and the like, and the occurrence of illness, injection and medication becomes a common thing; the curative effect is not obvious, it is easy to repeat and the recovery is slow. This causes physical and intellectual development failure and also induces serious diseases. When the immune function is disordered or the immune system is not healthy, the following problems, such as cold, tonsillitis, asthma, bronchitis, pneumonia, diarrhea and the like, can occur repeatedly. Particularly, the problem of influencing the curative effect in the treatment of bronchial diseases, asthma, allergic diseases and neoplastic diseases is that the repeated diseases caused by low immunity cause the physician and the patient to have a dilemma instead of prescription. Only by improving the immunity of patients can the ideal effect be achieved.
The acupoint application therapy is a non-invasive pain acupoint therapy for treating diseases by grinding the medicines into fine powder, blending the fine powder with water, vinegar, wine, egg white, honey, vegetable oil, cooling oil, liquid medicine or even saliva into paste, or preparing the paste, pill or cake from solidified grease (such as vaseline) and vinegar, rice and jujube paste, or decocting the decoction of the traditional Chinese medicines into paste, or dispersing the medicine powder on the plaster and directly applying the plaster to acupoints and affected parts. It is an important component of Chinese medicine therapeutics, is a unique and effective treatment method summarized by the working people in China in long-term struggle with diseases, and has a very long development history after undergoing the development processes of practice, cognition, re-practice and re-cognition for countless times.
in the prior art, external patches for improving immunity exist. For example, CN101317969A discloses a Zusanli acupoint patch for enhancing immunity, which is characterized in that: collecting semen Trigonellae, Aspongopus, carapax et Plastrum Testudinis, radix Acanthopanacis Senticosi, Polygoni Multiflori radix, radix Aconiti lateralis Preparata, fructus Psoraleae, herba Epimedii, and rhizoma Gastrodiae, extracting to obtain concentrated solution, making into extract powder, mixing with Camphora, Borneolum Syntheticum, Margarita powder, and infrared ray powder, stirring, mixing with matrix gel, and spreading on cloth. CN104800818A discloses a traditional Chinese medicine emplastrum for improving body immunity in summer-heat and a preparation method thereof, belonging to the field of formulas and preparation methods of medicines for improving body immunity. The traditional Chinese medicine composition is used for people who suffer from repeated cold, rhinitis, chronic cough, rheumatism, weakness and sickliness and the like caused by low body immunity due to insufficient yang qi by using different traditional Chinese medicines in the three-volt stage on the theoretical basis of 'treating winter diseases in summer'. The plaster comprises raw materials, wherein the raw materials comprise artificial musk, asarum, euphorbia kansui, semen brassicae, rhizoma corydalis, pericarpium zanthoxyli, prepared monkshood, musk and unprocessed pinellia ternate. The preparation method comprises the following steps: pulverizing the raw materials into 200 mesh fine powder, adding fresh succus Zingiberis recens into the fine powder while stirring, packaging, and making into Chinese medicinal patch. The use method comprises the following steps: the application is carried out on the 1 st day of each volt in the three-volt period for three times. The product has the advantages of accurate administration dosage, convenient use, better compliance of patients, lower cost and good long-term curative effect, and is recognized by the public. CN106110278A discloses a medicinal composition acupoint plaster for improving primordial yang and enhancing immunity and its preparation method, wherein folium Artemisiae Argyi, rhizoma Zingiberis recens, Carthami flos, Ginseng radix, cortex Cinnamomi, fructus evodiae, herba asari, semen Sinapis Albae, Mirabilitum crystallina, radix et rhizoma Rhei, radix Ampelopsis, fructus Gardeniae, rhizoma Drynariae, fructus Psoraleae, flos Caryophylli, fructus Foeniculi, rhizoma Cyperi, fructus Amomi, fructus Cnidii, Galla chinensis, fructus Schisandrae chinensis, fructus Piperis, Hippocampus, cornu Cervi, carapax Trionycis, Vinegar calcined Magnetitum, rice vinegar powder, bamboo vinegar powder, radix Morindae officinalis, Cistanchis herba, Corni fructus, Cistanchis herba, and Os Draconis are pulverized, stirred at a certain proportion, extracted and concentrated to obtain a thick paste, the medicinal plaster is prepared by using medical pressure-sensitive adhesive or plaster adhesive or membrane patch, cataplasma, etc. as carrier, and can also be directly applied to corresponding acupuncture points, or used in combination with the high-efficiency simple smokeless self-heating multipurpose synergistic patch, and can stimulate qi of channels and collaterals, dredge channels and collaterals, regulate qi and blood, and regulate yin-yang balance of viscera.
however, in the process of implementing the embodiments of the present application, the inventors of the present application found that the above-mentioned technology has at least the following technical problems: the existing external patch for improving the immunity needs a plurality of traditional Chinese medicines for compatibility and combination, has the problems of complex components, high cost, difficult preparation and the like, takes effect slowly, has a long treatment period, and is not suitable for low-income people.
disclosure of Invention
In order to make up for the defects of the prior art, the invention provides an external patch for improving immunity and a preparation method thereof, and the external patch has the advantages of simple components, low price, quick response, convenient use and no side effect after long-term use.
The technical problem to be solved by the invention is realized by the following technical scheme:
The external patch for improving the immunity comprises the following active ingredients in parts by weight: musk 30-40 parts and white mustard seed 15-20 parts.
Further, the effective components are prepared from the following raw material medicines in parts by weight: musk 35 parts and white mustard seed 18 parts.
further, the external patch also comprises auxiliary materials.
further, the auxiliary materials comprise the following components in parts by weight: 18-24 parts of glycerin, 23-35 parts of beeswax, 20-40 parts of lanolin, 5-15 parts of azone and 5-15 parts of ammonium leaf oil.
The invention also provides a preparation method of the external patch for improving the immunity, which comprises the following steps:
S1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
s2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
s3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
s4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
S5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
The invention has the following beneficial effects:
based on years of clinical research and guided by modern medical theory, the musk and the white mustard seed are compatible, the components are mutually influenced, the synergistic effect is obtained, the external patch which is safe and effective, has no toxic or side effect and effectively improves the immunity of the organism is provided for people, the acupuncture points of the patch are stimulated and treated at intervals, the aim of strengthening the body can be really achieved, and the external patch has the advantages of good effect, quick response, obvious curative effect and convenience in use. The invention has simple components and low cost.
the external patch for improving the immunity is an external medicine for treating low immunity, and is suitable for people who suffer from repeated cold, rhinitis, chronic cough, rheumatism, asthma, tumor, weakness, sickliness and the like caused by low body immunity due to yang qi deficiency.
the preparation method provided by the invention has the advantages of simple flow, convenience in operation and high efficiency, can fully exert the effects of the raw materials, effectively retains the nutritional ingredients of the raw materials, reduces the ineffective ingredients in the medicine, has good product stability, is safe, does not have toxic or side effect, and is easy for industrial production.
Detailed Description
the present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
Example 1
the external patch for improving the immunity comprises the following active ingredients in parts by weight: musk 35 parts and white mustard seed 18 parts; the external patch also comprises an auxiliary material, wherein the auxiliary material comprises the following components in parts by weight: 20 parts of glycerin, 30 parts of beeswax, 30 parts of lanolin, 10 parts of azone and 10 parts of ammonium leaf oil.
the preparation method of the external patch for improving the immunity comprises the following steps:
S1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
s2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
s3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
S4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
S5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
example 2
The external patch for improving the immunity comprises the following active ingredients in parts by weight: musk 30 parts and white mustard seed 15 parts; the external patch also comprises an auxiliary material, wherein the auxiliary material comprises the following components in parts by weight: 18 parts of glycerin, 23 parts of beeswax, 20 parts of lanolin, 5 parts of azone and 5 parts of ammonium leaf oil.
the preparation method of the external patch for improving the immunity comprises the following steps:
s1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
S2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
s3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
S4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
s5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
Example 3
the external patch for improving the immunity comprises the following active ingredients in parts by weight: 40 parts of musk and 20 parts of white mustard seed; the external patch also comprises an auxiliary material, wherein the auxiliary material comprises the following components in parts by weight: 24 parts of glycerin, 35 parts of beeswax, 40 parts of lanolin, 15 parts of azone and 15 parts of ammonium leaf oil.
The preparation method of the external patch for improving the immunity comprises the following steps:
s1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
S2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
S3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
S4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
s5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
example 4
the external patch for improving the immunity comprises the following active ingredients in parts by weight: 32 parts of musk and 19 parts of white mustard seed; the external patch also comprises an auxiliary material, wherein the auxiliary material comprises the following components in parts by weight: 20 parts of glycerin, 23 parts of beeswax, 40 parts of lanolin, 8 parts of azone and 5-15 parts of ammonium leaf oil.
The preparation method of the external patch for improving the immunity comprises the following steps:
S1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
S2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
s3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
s4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
S5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
The above-mentioned embodiments only express the embodiments of the present invention, and the description is more specific and detailed, but not understood as the limitation of the patent scope of the present invention, but all the technical solutions obtained by using the equivalent substitution or the equivalent transformation should fall within the protection scope of the present invention.

Claims (5)

1. the external patch for improving the immunity is characterized in that the effective components are prepared from the following raw material medicines in parts by weight: musk 30-40 parts and white mustard seed 15-20 parts.
2. the patch for external use for improving immunity according to claim 1, wherein the active ingredients are prepared from the following raw material medicines in parts by weight: musk 35 parts and white mustard seed 18 parts.
3. The patch for external use for enhancing immunity according to claim 1, wherein said patch for external use further comprises an auxiliary material.
4. the patch for external use for improving immunity according to claim 3, wherein the auxiliary material consists of the following components in parts by weight: 18-24 parts of glycerin, 23-35 parts of beeswax, 20-40 parts of lanolin, 5-15 parts of azone and 5-15 parts of ammonium leaf oil.
5. a method of preparing a patch for external use for enhancing immunity as claimed in any one of claims 1 to 4, comprising the steps of:
S1, mixing the musk and the white mustard seed in parts by weight, and mechanically crushing into 10-20-mesh micro powder;
S2, placing the micro powder obtained in the step S1 in a percolation cylinder, continuously adding 75% ethanol solution for percolation, and collecting leachate and the micro powder after percolation for later use; the weight of the added 75 percent ethanol solution is 3 to 6 times of the weight of the micro powder;
s3, taking out the micro powder obtained after the percolation in the step S2, drying, and continuously crushing the micro powder into fine powder of 200 meshes and 400 meshes;
S4, concentrating the leachate obtained in the step S2, and then mixing and stirring the leachate and the fine powder obtained in the step S3 uniformly to obtain a mixture;
s4, putting the auxiliary materials in parts by weight into a water bath kettle at 100 ℃, carrying out water bath to a molten state, taking out, putting to 50 ℃, and mixing according to the weight ratio of the mixture: adding the auxiliary materials into the mixture prepared in the step S3 according to the mass ratio of 1: 9, and uniformly mixing to prepare the ointment;
S5, degassing the ointment, coating the ointment on a back lining, covering a film, drying, slicing and preparing the external patch.
CN201910906512.7A 2019-09-24 2019-09-24 external patch for improving immunity and preparation method thereof Pending CN110575460A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN111937868A (en) * 2020-07-30 2020-11-17 韩兆清 A Chinese medicinal composition for preventing and controlling new coronary pneumonia and influenza

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CN105031331A (en) * 2015-07-07 2015-11-11 梁慕瑾 Navel patch for treating dysmenorrhoea and preparation method thereof

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CN105031331A (en) * 2015-07-07 2015-11-11 梁慕瑾 Navel patch for treating dysmenorrhoea and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111937868A (en) * 2020-07-30 2020-11-17 韩兆清 A Chinese medicinal composition for preventing and controlling new coronary pneumonia and influenza

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Application publication date: 20191217