CN110573609A - 双分化或多分化类器官 - Google Patents

双分化或多分化类器官 Download PDF

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Publication number
CN110573609A
CN110573609A CN201880027801.3A CN201880027801A CN110573609A CN 110573609 A CN110573609 A CN 110573609A CN 201880027801 A CN201880027801 A CN 201880027801A CN 110573609 A CN110573609 A CN 110573609A
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tissue
cells
ventral
differentiation
tissues
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Chinese (zh)
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J.诺布里奇
J.A.巴格利
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Imba Molikul Institute Of Biotechnology
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Imba Molikul Institute Of Biotechnology
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Priority to CN202411042018.8A priority Critical patent/CN119101651A/zh
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
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    • C12N2502/00—Coculture with; Conditioned medium produced by
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201880027801.3A 2017-04-25 2018-04-25 双分化或多分化类器官 Pending CN110573609A (zh)

Priority Applications (1)

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CN202411042018.8A CN119101651A (zh) 2017-04-25 2018-04-25 双分化或多分化类器官

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17168051.5A EP3395942A1 (en) 2017-04-25 2017-04-25 Bi- or multi-differentiated organoid
EP17168051.5 2017-04-25
PCT/EP2018/060559 WO2018197544A1 (en) 2017-04-25 2018-04-25 Bi- or multi-differentiated organoid

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US (1) US20210095260A1 (enExample)
EP (2) EP3395942A1 (enExample)
JP (1) JP7248590B2 (enExample)
KR (1) KR102692498B1 (enExample)
CN (2) CN110573609A (enExample)
AU (1) AU2018260183B2 (enExample)
CA (1) CA3061412A1 (enExample)
SG (1) SG11201909470TA (enExample)
WO (1) WO2018197544A1 (enExample)

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CN116129193A (zh) * 2023-02-27 2023-05-16 重庆大学附属肿瘤医院 一种类器官生长预测方法、系统及设备
CN118530833A (zh) * 2024-04-02 2024-08-23 武汉大学 一种同步共分化的多组织或多类器官模型及其构建方法

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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
EP3658666A4 (en) * 2017-07-28 2021-04-28 Memorial Sloan-Kettering Cancer Center PRODUCTION OF A TOPOGRAPHICAL ORGANIZATION IN A THREE-DIMENSIONAL TISSUE CULTURE
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
AU2018379993A1 (en) * 2017-12-04 2020-07-02 Axosim, Inc. Cell systems using spheroids and methods of making and using the same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
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JP7726489B2 (ja) * 2021-01-15 2025-08-20 国立大学法人 東京大学 神経回路組織の神経活動の観察装置およびこれを用いた物質のスクリーニング方法
DE102021132190A1 (de) * 2021-12-07 2023-06-22 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Biokompatible Strukturen zur Verbindung und Kultivierung von biologischem Material
HUP2200189A2 (hu) * 2022-05-30 2023-12-28 Biotalentum Tudasfejlesztoe Kft Új, riportert stabilan expresszáló humán indukált pluripotens õssejt
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116129193A (zh) * 2023-02-27 2023-05-16 重庆大学附属肿瘤医院 一种类器官生长预测方法、系统及设备
CN116129193B (zh) * 2023-02-27 2024-06-11 重庆大学附属肿瘤医院 一种类器官生长预测方法、系统及设备
CN118530833A (zh) * 2024-04-02 2024-08-23 武汉大学 一种同步共分化的多组织或多类器官模型及其构建方法
CN118530833B (zh) * 2024-04-02 2024-11-29 武汉大学 一种同步共分化的多组织或多类器官模型及其构建方法

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CN119101651A (zh) 2024-12-10
JP2020517283A (ja) 2020-06-18
EP3615661A1 (en) 2020-03-04
AU2018260183B2 (en) 2024-09-19
JP7248590B2 (ja) 2023-03-29
SG11201909470TA (en) 2019-11-28
KR20190141231A (ko) 2019-12-23
EP3395942A1 (en) 2018-10-31
CA3061412A1 (en) 2018-11-01
AU2018260183A1 (en) 2019-10-31
KR102692498B1 (ko) 2024-08-05
WO2018197544A1 (en) 2018-11-01
US20210095260A1 (en) 2021-04-01

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