CN110559474A - Liquid wound dressing, method for the production thereof and use thereof - Google Patents
Liquid wound dressing, method for the production thereof and use thereof Download PDFInfo
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- CN110559474A CN110559474A CN201910846021.8A CN201910846021A CN110559474A CN 110559474 A CN110559474 A CN 110559474A CN 201910846021 A CN201910846021 A CN 201910846021A CN 110559474 A CN110559474 A CN 110559474A
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- wound dressing
- liquid wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Abstract
a liquid wound dressing and a preparation method and application thereof belong to the technical field of medical dressings and preparation thereof. The method comprises the following steps: adding ethanol less than 20% and ethyl acetate less than 80% weighed according to the mass percentage into a reaction container with a heating device and a stirring device, and uniformly stirring to obtain a mixed solvent; adding polyvinyl butyral which is weighed by mass percent and is less than 20% into a mixed solvent, and heating and stirring uniformly to obtain a mixed solution; and adding the polylactic acid which is weighed according to the mass percentage and is less than 20 percent into the mixed solution, heating and uniformly stirring to obtain the liquid wound dressing. The application method comprises applying or spraying liquid wound dressing on wound after debridement treatment, slightly washing with cold water, and forming film for 10-12s to cover wound. The comfort is well embodied, the transparency is ensured, and the raw materials are easy to obtain and are cheap; the process is simple and has no harsh process requirements; the protection of the wound can be instantly generated.
Description
Technical Field
the invention belongs to the technical field of medical dressings and preparation thereof, and particularly relates to a liquid wound dressing, and a preparation method and a use method thereof.
background
Since wounds caused by situations such as cuts, abrasions, bruises, falls, contusions and the like are inevitably encountered in daily life, it is not uncommon to perform necessary treatments of wounds, such as debridement and hemostasis and application of medical dressings to wounds.
in recent years, with the remarkable increase of self-care consciousness of families, common people are generally equipped with various conventional care products such as a wound dressing, an iodophor, an alcohol sprayer, a medical cotton ball or cotton swab, a forceps, a thermometer, a sphygmomanometer, a blood glucose meter, various test papers, and the like. The wound dressing is suitable for self-treatment of mild small wounds or household autonomous treatment, and the trouble of going to and from hospitals is eliminated, so that the wound dressing is more and more concerned and favored by people as a common nursing article. It is due to the foregoing that various medical dressings come in transit.
The conventional wound covering has the functions of covering a wound and stopping bleeding, but has the problems of poor air permeability, poor comfort and poor compliance, and can cause pain in the removing process. Because the liquid adhesive bandage has the advantages of good air permeability, film feeling, transparency, water resistance and the like, the liquid adhesive bandage has a good application prospect compared with the traditional adhesive bandage such as a bundy (benzalkonium chloride) adhesive bandage.
The film forming time of the liquid dressing in the prior art is usually within five minutes, wherein the film forming speed of the cellulose nitrate liquid dressing is the fastest, and the wound can be covered within thirty seconds, so that the wound can be covered within a very short time.
technical information related to liquid wound dressings is found in published chinese patent documents, such as that CN100471528C recommends "liquid wound dressing having wound healing promoting, antibacterial functions" and that CN105126107A provides "a liquid wound dressing", and so on.
Typically, the liquid wound dressing and the preparation method thereof introduced in CN106943619A are composed of the following components in percentage by mass: 60-97% of polyethylene glycol, 1-25% of glycerol, 1-10% of seaweed extract and 1-10% of aloe gel. The CN106943619A has the double functions of promoting wound healing and inhibiting bacteria, which is known in the 0010 paragraph of the specification, and has the advantages of low cost, no toxic or side effect, safety and practicability. However, most of aloe gel is prepared by extracting high-purity aloe leaves, and aloe has a certain sensitization rate, so that the probability of sensitization exists for different people; since the seaweed extract is an extract of kelp, spirulina, laver, undaria pinnatifida, eucheuma, and gelidium amansii, although it is a purely natural marine product category, it is relatively expensive, and thus if it is applied to a liquid wound dressing, there is a risk of losing the economical efficiency of the dressing. In addition, CN106943619A No. 0009 indicates that the main component is fucoidan extract, the fucoidan extract is a complex mixture, the structure of fucoidan is very complex, on one hand, fucoidan of different species of brown algae has different chemical compositions, and besides fucose and sulfate, other monosaccharides (mannose, galactose, glucose, etc.) and uronic acid, and some have acetyl groups and proteins, on the other hand, fucoidan of different species of brown algae has different structures, and fucoidan obtained by different extraction methods may have different structural inclusion, so there is an increasing difference before the production of batches; all the components pointed out in the patent are polyethylene glycol, glycerol, seaweed extract (main components) and aloe gel, the four components are easily soluble in water and are more easily changed into water when the temperature is slightly increased, so that the patent cannot block water when in use, cannot wash hot water after forming a film, and cannot block bacteria, the invention focuses on promoting wound healing and inhibiting bacteria, but the saccharides and the seaweed extract are generally nutrient components for bacterial breeding, so that the bacteria blocking effect is reduced due to the increase of time, and the water blocking performance is not realized; in addition, the film forming time of the patent is 4 to 7min, which is not favorable for quick covering of the wound, and the operation is very inconvenient because the film forming time needs to be long. Technically, the patent needs to sterilize and then bottle, so that the risk of bacterial contamination is increased.
Disclosure of Invention
The invention provides a liquid wound dressing which is beneficial to avoiding cracking and edge warping of a film layer, avoiding skin tightness so as to embody good comfort, avoiding turbidity when meeting water and conveniently embodying low cost.
The invention also aims to provide a preparation method of the liquid wound dressing, which has short process steps and non-rigorous process elements, meets the requirement of industrial scale-up production, and can ensure that the technical effect of the liquid wound dressing is comprehensively embodied.
It is a further object of the present invention to provide a method of using a liquid wound dressing which is easy and quick to use and which takes a short time to form a film.
In order to embody the primary task of the invention, the technical scheme provided by the invention is as follows: a liquid wound dressing comprises the following raw materials in percentage by mass:
In a specific embodiment of the present invention, the liquid wound dressing comprises the following raw materials by mass:
in another specific embodiment of the present invention, the liquid wound dressing comprises the following raw materials by mass:
In another specific embodiment of the present invention, the liquid wound dressing comprises the following raw materials by mass:
In another specific embodiment of the present invention, the liquid wound dressing comprises the following raw materials by mass:
in another specific embodiment of the present invention, the liquid wound dressing comprises the following raw materials by mass:
in a more specific embodiment of the present invention, the polylactic acid has a molecular weight of 2000 to 3 ten thousand; the molecular weight of the polyvinyl butyral is 4-20 ten thousand.
In order to embody another task of the present invention, the technical solution provided by the present invention is: a method of making a liquid wound dressing comprising the steps of:
A) Preparing a mixed solvent, adding ethanol which is less than 20 percent and ethyl acetate which is less than 80 percent and is weighed according to the mass percentage into a reaction container with a heating device and a stirring device, and uniformly stirring to obtain the mixed solvent;
B) preparing a mixed solution, adding polyvinyl butyral (accounting for less than 20 mass percent) which is weighed according to the mass percent into the mixed solvent obtained in the step A), and heating and uniformly stirring to obtain a mixed solution;
C) preparing a finished product, adding the polylactic acid which is weighed according to the mass percentage and is less than 20% into the mixed solution obtained in the step B), and continuously heating and uniformly stirring to obtain the liquid wound dressing.
in yet another specific embodiment of the present invention, the temperature of said heating in step B) and said continuing heating in step C) is 35-45 ℃; the reaction vessel in the step A) is a reaction kettle; the stirring speed in the steps A), B) and C) is 600-2500rpm, and the stirring time is 50-85min respectively.
In order to embody and complete another task of the invention, the invention provides the following technical scheme: a method for using the liquid wound dressing includes such steps as applying or spraying the liquid wound dressing on the wound, flushing it with cold water for 10-12s to form a film for covering the wound.
the technical scheme provided by the invention has the technical effects that: because the raw material selection and the proportion of the provided liquid wound dressing are reasonable, the film layer can be prevented from cracking and warping in the actual use process, the skin can not be tightly felt, the good comfort can be embodied, the liquid at the wound can not be turbid, the transparency can be ensured, the raw materials are easy to obtain and are cheap; the preparation process is simple and has no harsh technological requirements, so that the technical effect of the liquid wound dressing can be reflected comprehensively and truly, and the requirement of industrial amplification production can be met; the provided using method is convenient to use and the film forming time is only 10-12s, so that the wound can be protected immediately.
Detailed Description
example 1:
A) Preparing a mixed solvent, namely adding 15% of ethanol weighed according to the mass percentage and 61% of ethyl acetate weighed according to the mass percentage into a reaction vessel, namely a reaction kettle, provided with a heating device and a stirring device, and uniformly stirring, wherein the stirring speed, namely the stirring speed of the stirring device, is 2500rpm, and the stirring time is 80min, so as to obtain the mixed solvent;
B) Preparing a mixed solution, adding 20% of polyvinyl butyral with the molecular weight of 4 ten thousand, which is weighed according to the mass percentage, into the mixed solvent obtained in the step A), namely, adding into the reaction kettle, and uniformly stirring at the heating temperature of the heating device in the step A) of 40 ℃, wherein the stirring speed, namely, the stirring speed of the stirring device in the step A), is 2500rpm, and the stirring time is 80min, so as to obtain the mixed solution;
C) preparing a finished product, adding 4% of polylactic acid with the molecular weight of 3 ten thousand weighed according to the mass percentage into the mixed solution obtained in the step B), namely adding into the reaction kettle, and uniformly stirring at the continuous heating temperature of the heating device in the step A) of 40 ℃, wherein the stirring speed is 2500rpm of the stirring device in the step A), and the stirring time is 80min, so as to obtain the finished product, namely the liquid wound dressing, and then filling, sterilizing and packaging.
example 2:
A) preparing a mixed solvent, adding 2% of ethanol weighed according to the mass percentage and 80% of ethyl acetate weighed according to the mass percentage into a reaction vessel (a reaction kettle) provided with a heating device and a stirring device, and uniformly stirring, wherein the stirring speed (the stirring speed of the stirring device) is 600rpm, and the stirring time is 85min to obtain the mixed solvent;
B) preparing a mixed solution, adding 3% of polyvinyl butyral with the molecular weight of 20 ten thousand, which is weighed according to the mass percentage, into the mixed solvent obtained in the step A), namely, adding into the reaction kettle, and uniformly stirring at the heating temperature of the heating device in the step A) of 35 ℃, wherein the stirring speed, namely, the stirring speed of the stirring device in the step A), is 600rpm, and the stirring time is 85min, so as to obtain the mixed solution;
C) Preparing a finished product, adding 15% of polylactic acid with the molecular weight of 2000 weighed according to the mass percentage into the mixed solution obtained in the step B), namely adding into the reaction kettle, and uniformly stirring at the continuous heating temperature of the heating device in the step A) of 35 ℃, wherein the stirring speed is 600rpm of the stirring device in the step A), and the stirring time is 85min, so as to obtain the finished product, namely the liquid wound dressing, and then filling, sterilizing and packaging.
example 3:
A) preparing a mixed solvent, namely adding 20% of ethanol weighed according to the mass percentage and 40% of ethyl acetate weighed according to the mass percentage into a reaction vessel, namely a reaction kettle, provided with a heating device and a stirring device, and uniformly stirring, wherein the stirring speed, namely the stirring speed of the stirring device, is 2000rpm, and the stirring time is 82min, so as to obtain the mixed solvent;
B) preparing a mixed solution, adding 20% of polyvinyl butyral with the molecular weight of 12 ten thousand, which is weighed according to the mass percentage, into the mixed solvent obtained in the step A), namely, adding into the reaction kettle, and uniformly stirring at the heating temperature of the heating device in the step A) of 45 ℃, wherein the stirring speed, namely the stirring speed of the stirring device in the step A), is 2000rpm, and the stirring time is 82min, so as to obtain the mixed solution;
C) Preparing a finished product, adding 20% of polylactic acid with the molecular weight of 15000 weighed according to the mass percentage into the mixed solution obtained in the step B), namely adding into the reaction kettle, and uniformly stirring at the continuous heating temperature of the heating device in the step A) of 45 ℃, wherein the stirring speed is 2000rpm of the stirring device in the step A), and the stirring time is 82min, so as to obtain the finished product, namely the liquid wound dressing, and then filling, sterilizing and packaging.
Example 4:
A) preparing a mixed solvent, namely adding 10% of ethanol weighed according to the mass percentage and 65% of ethyl acetate weighed according to the mass percentage into a reaction vessel, namely a reaction kettle, provided with a heating device and a stirring device, and uniformly stirring, wherein the stirring speed, namely the stirring speed of the stirring device, is 1200rpm, and the stirring time is 84min, so as to obtain the mixed solvent;
B) Preparing a mixed solution, namely adding 15% of polyvinyl butyral with the molecular weight of 8 ten thousand, which is weighed according to the mass percentage, into the mixed solvent obtained in the step A), namely, adding into the reaction kettle, and uniformly stirring at the heating temperature of the heating device in the step A) of 38 ℃, wherein the stirring speed, namely the stirring speed of the stirring device in the step A), is 1200rpm, and the stirring time is 84min, so as to obtain the mixed solution;
C) preparing a finished product, adding 10% of polylactic acid with the molecular weight of 25000 ten thousand weighed according to the mass percentage into the mixed solution obtained in the step B), namely adding into the reaction kettle, and uniformly stirring at the continuous heating temperature of the heating device in the step A) of 38 ℃, wherein the stirring speed, namely the stirring speed of the stirring device in the step A), is 1200rpm, and the stirring time is 84min, so that the finished product, namely the liquid wound dressing, is obtained, and then filling, sterilizing and packaging are carried out.
use example:
the liquid wound dressing obtained in any of the above examples 1 to 4 is applied, i.e., spread or sprayed, to the debrided wound and then gently rinsed with cold water such as tap water or the like for 10 to 12 seconds to form a film covering the wound.
The liquid wound dressings obtained from examples 1 to 4 above were used with the technical effects shown in the following table.
the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention are intended to be included therein.
evaluation of water-blocking performance of the liquid wound dressings of examples:
1. experimental Material
Liquid wound dressing prepared in example 3
② distilled water
③ release paper
Coating machine
water resistance measuring instrument
2. experimental methods
coating a film with the thickness of 0.3mm on the release surface of release paper by using a coating machine, washing with cold water to form the film, removing the film, drying in an oven at 55 ℃ to obtain a sample film to be tested, and testing according to the water resistance test method 3 in YY-T0471.3-2004 contact wound dressing test method part 3 water resistance test method.
3. The experimental results show that the liquid wound dressing prepared in example 3 has good water resistance.
comfort performance evaluation of the example liquid wound dressings:
1. Experimental Material
Liquid wound dressings prepared in examples 1, 2, 3 and 4
② release paper
③ coating machine
tensile machine
2. The experimental method comprises the following steps:
The liquid wound dressings prepared in the embodiments 1, 2, 3 and 4 were respectively coated on a release surface of a release paper by a coater to form a film with a thickness of 0.3mm, a length of the film was not less than 20cm, a width of the film was not less than 10cm, the film was washed with cold water to form a film, the film was peeled off, dried in an oven at 55 ℃ to obtain a sample film to be tested, which was tested according to the method 3.2.3 in comfort of part 4 of the YY-T0471.4-2004 contact wound dressing test method, and the result was calculated according to 3.2.4.2.
3. the experimental results are as follows:
comfort calculation results: example 1 was 3.85%, example 2 was 3.92% permanent set, example 3 was 3.9%, and example 4 was 3.88%.
Claims (10)
1. The liquid wound dressing is characterized by comprising the following raw materials in percentage by mass:
The polylactic acid is less than 20 percent;
Polyvinyl butyral less than 20%;
Ethyl acetate is less than 80 percent;
the ethanol is less than 20 percent.
2. the liquid wound dressing according to claim 1, characterized in that the liquid wound dressing comprises the following raw materials in percentage by mass:
4-20% of polylactic acid;
3-20% of polyvinyl butyral;
30-80% of ethyl acetate;
2-20% of ethanol.
3. The liquid wound dressing according to claim 2, characterized in that the liquid wound dressing comprises the following raw materials in percentage by mass:
4% of polylactic acid;
20% of polyvinyl butyral;
61% of ethyl acetate;
15% of ethanol.
4. the liquid wound dressing according to claim 2, characterized in that the liquid wound dressing comprises the following raw materials in percentage by mass:
15% of polylactic acid;
3% of polyvinyl butyral;
80% of ethyl acetate;
And 2% of ethanol.
5. the liquid wound dressing according to claim 2, characterized in that the liquid wound dressing comprises the following raw materials in percentage by mass:
20% of polylactic acid;
20% of polyvinyl butyral;
40% of ethyl acetate;
20% of ethanol.
6. the liquid wound dressing according to claim 2, characterized in that the liquid wound dressing comprises the following raw materials in percentage by mass:
10% of polylactic acid;
polyvinyl butyral 15%;
65% of ethyl acetate;
10 percent of ethanol.
7. a liquid wound dressing according to any of claims 1 to 6, characterised in that the polylactic acid has a molecular weight of 2000-3 ten thousand; the molecular weight of the polyvinyl butyral is 4-20 ten thousand.
8. A method of making a liquid wound dressing according to claim 1, comprising the steps of:
A) preparing a mixed solvent, adding ethanol which is less than 20 percent and ethyl acetate which is less than 80 percent and is weighed according to the mass percentage into a reaction container with a heating device and a stirring device, and uniformly stirring to obtain the mixed solvent;
B) preparing a mixed solution, adding polyvinyl butyral (accounting for less than 20 mass percent) which is weighed according to the mass percent into the mixed solvent obtained in the step A), and heating and uniformly stirring to obtain a mixed solution;
C) Preparing a finished product, adding the polylactic acid which is weighed according to the mass percentage and is less than 20% into the mixed solution obtained in the step B), and continuously heating and uniformly stirring to obtain the liquid wound dressing.
9. The method of preparing a liquid wound dressing according to claim 8, characterized in that the temperature of the heating in step B) and the continued heating in step C) is 35-45 ℃; the reaction vessel in the step A) is a reaction kettle; the stirring speed in the steps A), B) and C) is 600-2500rpm, and the stirring time is 50-85min respectively.
10. A method of using the liquid wound dressing according to claim 1, wherein the liquid wound dressing is applied or sprayed on the debrided wound and then gently rinsed with cold water to form a film covering the wound over a period of 10-12 seconds.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910846021.8A CN110559474A (en) | 2019-09-09 | 2019-09-09 | Liquid wound dressing, method for the production thereof and use thereof |
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| CN201910846021.8A CN110559474A (en) | 2019-09-09 | 2019-09-09 | Liquid wound dressing, method for the production thereof and use thereof |
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| CN110559474A true CN110559474A (en) | 2019-12-13 |
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Application publication date: 20191213 |