CN110559208A - Bathing effervescent tablet containing hyaluronic acid - Google Patents
Bathing effervescent tablet containing hyaluronic acid Download PDFInfo
- Publication number
- CN110559208A CN110559208A CN201910975777.2A CN201910975777A CN110559208A CN 110559208 A CN110559208 A CN 110559208A CN 201910975777 A CN201910975777 A CN 201910975777A CN 110559208 A CN110559208 A CN 110559208A
- Authority
- CN
- China
- Prior art keywords
- hyaluronic acid
- kda
- derivatives
- sieving
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of cosmetics, and provides a hyaluronic acid-containing bath effervescent tablet which comprises the following raw materials in percentage by weight: 5-60% of hyaluronic acid and derivatives thereof, 5-20% of filler, 5-35% of acidic substances, 20-45% of alkaline substances, 0.5-3% of lubricant, 5-15% of glycerol, 1-5% of pentanediol, 0-10% of active substances, 0-1% of essence and 0-0.7% of pigment. The bath effervescent tablet prepared by the invention has high hyaluronic acid content, can accelerate the dissolution of hyaluronic acid by generating a large amount of bubbles after disintegration, increases the direct contact of hyaluronic acid and skin, and fully exerts the effects of moisturizing and replenishing water. The bath effervescent tablet disclosed by the invention has the advantages that the hyaluronic acid and the derivatives thereof are coated by the glycerol and the pentanediol, so that alkaline matters and acidic matters are isolated, a better anticorrosion effect is achieved, and the safety and the stability are improved.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to an effervescent tablet for bathing.
background
Hyaluronic acid is one of the main components constituting extracellular matrix and intercellular substance, and plays an important role in the form, structure, and function of skin. As hyaluronic acid has a good moisturizing effect and is a natural biomolecule widely existing in skin and other tissues, the hyaluronic acid is used in cosmetics from the 20 th century and the 80 th century and is known as an ideal natural intelligent moisturizing factor, and with the deepening of research, the hyaluronic acid is found to have the effects of nourishing, repairing damaged skin, removing free radicals and the like besides moisturizing performance. In addition, the skin care product containing hyaluronic acid has unique lubricity and film forming property, and when the skin care product containing hyaluronic acid is coated on skin, a layer of invisible breathable hydrated film is formed on the surface of the skin, so that the skin can generate good lubricating feeling and moistening feeling.
at present, most hyaluronic acid products on the market are cream products, the products have the defects of limited use positions, uneven coating and the like, and high-content hyaluronic acid is not easy to dissolve, so that the active ingredients cannot fully exert the effect. Effervescent tablets are widely used in the fields of pharmacy, beverages, daily chemicals and the like, organic acid and alkali type carbonate (hydrogen) are used as disintegrating agents, after the effervescent tablets are placed in water, the organic acid and the alkali type carbonate (hydrogen) react quickly, and a large amount of carbon dioxide gas is released, so that the effervescent tablets can disintegrate quickly, active ingredients in the effervescent tablets are released along with a large amount of foams generated by disintegration, the direct contact area with the skin is increased, and the defects of cream products are overcome.
In the prior art, hyaluronic acid has been used in bath effervescent tablet products, such as patent CN201610895203.0 and patent CN201611109007.2, the content of hyaluronic acid in the above patents is 0.5-2.0% and 0.5-3.0%, respectively, the addition amount is very small, and the moisturizing property is poor. However, high levels of hyaluronic acid tend to absorb moisture, causing reactions between the disintegrants, which can cause the effervescent tablet to mold and swell.
disclosure of Invention
Aiming at the problems that the existing high-content hyaluronic acid bath products are lacked and the high-content hyaluronic acid effervescent tablets are easy to deteriorate, the invention provides the high-content hyaluronic acid bath effervescent tablets which are high in disintegration speed and long in storage life.
The invention also aims to provide a preparation method of the bath effervescent tablet.
In order to achieve the purpose, the invention adopts the following technical scheme.
A bath effervescent tablet comprises the following raw materials in percentage by weight:
5-60% of hyaluronic acid and derivatives thereof, 5-20% of filler, 5-35% of acidic substances, 20-45% of alkaline substances, 0.5-3% of lubricant, 5-15% of glycerol, 1-5% of pentanediol, 0-10% of active substances, 0-1% of essence and 0-0.7% of pigment.
the weight ratio of the acid substance to the alkaline substance is 1-1.5: 1.
the content of the hyaluronic acid and the derivatives thereof is preferably 5 to 25%.
the volume ratio of the glycerol to the pentanediol is 5-11: 2.
the hyaluronic acid and the derivative thereof are selected from at least one of hyaluronic acid and salt thereof, hydrolyzed hyaluronic acid and salt thereof, cross-linked hyaluronic acid and salt thereof, acetylated hyaluronic acid and thiolated hyaluronic acid. Such salts include, but are not limited to, sodium, potassium, calcium, zinc, and lysine salts.
the molecular weight of the hyaluronic acid and the derivatives thereof is 2 kDa-3500 kDa. Preferably, the hyaluronic acid and the derivatives thereof are a combination of three molecular weight segments of 1200 kDa-2000 kDa, 300 kDa-1000 kDa and 2 kDa-200 kDa, the ratio of the three molecular weights ranging from 0.1 to 0.5: 1-5: 5-10.
the filler is at least one selected from starch, cellulose, saccharides and inorganic salts. Preferably, the starch is corn starch, potato starch, water caltrop powder, sweet potato starch and dextrin. The cellulose is at least one selected from microcrystalline cellulose, carboxymethyl cellulose, lignin, crude fiber, semi-crude fiber, ethyl cellulose and methyl cellulose. The inorganic salt is at least one selected from magnesium sulfate, anhydrous sodium sulfate, calcium chloride, zinc sulfate, calcium sulfate and calcium phosphate.
The alkali matter is selected from carbonate or bicarbonate, and the salt is sodium salt or potassium salt. The acidic substance is selected from weak organic acids such as tartaric acid, oxalic acid, benzoic acid, salicylic acid, citric acid, malic acid and citric acid.
the lubricant is selected from at least one of polyethylene glycol, sodium lauryl sulfate or magnesium lauryl sulfate.
the active substance is a substance for improving skin, and the improving effect can be whitening, moisturizing, antioxidation, wrinkle resistance and the like. Such as vitamin C, arbutin, plant extract, active polypeptide, saccharide isomer, etc.
The preparation method of the bath effervescent tablet containing hyaluronic acid comprises the following steps:
(1) Dissolving the pigment in water, selectively adding the pigment into the acid substance, and uniformly stirring to obtain slurry A;
(2) adding a lubricant into the slurry A, selectively adding essence, fully and uniformly mixing, drying and sieving to obtain a material B;
(3) Adding the filler into the material B, and uniformly stirring to obtain a material C;
(4) Sieving hyaluronic acid and its derivatives, adding into wrapping liquid containing glycerol and pentanediol, dispersing, adding alkaline substance, optionally adding active substance, stirring, drying, and sieving to obtain material D;
(5) Adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) and (4) putting the material E into a forming die, pressing and forming, and curing at normal temperature to obtain a finished product.
In the steps (2) and (4), the aperture of the sieve is 20 meshes.
In the step (6), the curing time is 20-30 h.
the invention has the following advantages:
The bath effervescent tablet with high hyaluronic acid content and no preservative is prepared, and a large amount of bubbles are generated after the effervescent tablet is disintegrated, so that the dissolution of hyaluronic acid is accelerated, the direct contact of hyaluronic acid with skins of various parts of a body is increased, and the moisturizing and hydrating effects of the hyaluronic acid are fully exerted. The bath effervescent tablet disclosed by the invention has the advantages that the hyaluronic acid and the derivatives thereof are coated by the glycerol and the pentanediol, so that the contact between the hyaluronic acid and the derivatives thereof and air and water is isolated, the antiseptic effect is achieved, and the safety is improved. The alkaline matter and the acidic matter are also isolated by wrapping, so that the stability is improved, and the storage time of the effervescent tablet is prolonged. The bath effervescent tablet is added with the inorganic salt filler, and the inorganic salt can lock water after absorbing water, so that the contact of alkaline matters and water is reduced, the effervescent tablet is prevented from disintegrating, and the storage stability is improved.
Detailed Description
The present invention will be further illustrated with reference to the following examples, but the present invention is not limited to the following examples.
EXAMPLE 1 preparation of hyaluronic acid-containing effervescent bath tablets
(1) Adding 0.02g of rose glycoside pigment into 4g of purified water, dissolving at 25 ℃, adding 30g of citric acid, and uniformly stirring to obtain slurry A;
(2) adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) adding 15g of corn starch into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 20g of sodium bicarbonate, 0.1g of hyaluronic acid with the molecular weight of 2000 kDa, 2g of hyaluronic acid with the molecular weight of 500 kDa and 5g of hyaluronic acid with the molecular weight of 3 kDa through a 20-mesh sieve, adding 2mL of glycerol and pentanediol solution of 5mL, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) Adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
Example 2
(1) adding 0.02g of rose glycoside pigment into 2g of purified water, dissolving at 25 ℃, adding 37g of citric acid, and uniformly stirring to obtain slurry A;
(2) adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) Adding 21g of dextrin into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 28.5g of sodium bicarbonate, 0.1g of hyaluronic acid with molecular weight of 2000 kDa, 1g of hyaluronic acid with molecular weight of 500 kDa and 5g of hyaluronic acid with molecular weight of 3 kDa through a 20-mesh sieve, adding 3mL of glycerol and pentanediol solution of 8mL, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
Example 3
(1) Adding 0.02g of rose glycoside pigment into 3.5g of purified water, dissolving at 25 ℃, adding 30g of citric acid, and uniformly stirring to obtain slurry A;
(2) Adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) Adding 15g of dextrin into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 20g of sodium bicarbonate, 0.1g of hyaluronic acid with the molecular weight of 2000 kDa, 2g of hyaluronic acid with the molecular weight of 500 kDa and 5g of hyaluronic acid with the molecular weight of 3 kDa through a 20-mesh sieve, adding 11mL of glycerol and 2mL of pentanediol solution, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) and (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
Comparative example 1
(1) adding 0.02g of rose glycoside pigment into 4g of purified water, dissolving at 25 ℃, adding 30g of citric acid, and uniformly stirring to obtain slurry A;
(2) adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) Adding 15g of corn starch into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 20g of sodium bicarbonate, 0.1g of hyaluronic acid with molecular weight of 2000 kDa, 2g of hyaluronic acid with molecular weight of 500 kDa and 5g of hyaluronic acid with molecular weight of 3 kDa through a 20-mesh sieve, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) and (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
comparative example 2
(1) adding 0.02g of rose glycoside pigment into 4g of purified water, dissolving at 25 ℃, adding 30g of citric acid, and uniformly stirring to obtain slurry A;
(2) adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) adding 15g of corn starch into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 20g of sodium bicarbonate, 0.1g of hyaluronic acid with the molecular weight of 2000 kDa, 2g of hyaluronic acid with the molecular weight of 500 kDa and 5g of hyaluronic acid with the molecular weight of 3 kDa through a 20-mesh sieve, adding 5mL of polyethylene glycol-200 and 2mL of pentanediol solution, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) Adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) and (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
comparative example 3
(1) adding 0.02g of rose glycoside pigment into 4g of purified water, dissolving at 25 ℃, adding 10g of citric acid, and uniformly stirring to obtain slurry A;
(2) adding 0.5g of sodium lauryl sulfate into the slurry A, adding 0.02g of jasmine essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) adding 15g of corn starch into the material B, and uniformly stirring to obtain a material C;
(4) sieving 20g of sodium bicarbonate, 0.1g of hyaluronic acid with the molecular weight of 2000 kDa, 2g of hyaluronic acid with the molecular weight of 500 kDa and 5g of hyaluronic acid with the molecular weight of 3 kDa through a 20-mesh sieve, adding 2mL of glycerol and pentanediol solution of 5mL, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (3) putting the material E into a forming die, pressing and forming, and curing for 24 hours at normal temperature to obtain a finished product.
example 4 product stability test
the samples of example 1, example 2, example 3, comparative example 1, comparative example 2 and comparative example 3 were placed in a petri dish, and 5 samples were packed in aluminum foil bags, and then plastic-sealed, and placed in a constant temperature and humidity chamber under test conditions of 45 ± 0.5 ℃ and 75 ± 5% RH, and the conditions of the initial, month-1 and month-3 samples were observed, respectively, and the results are shown in table 1.
TABLE 1 storage stability test
the test simulates the 2-year state under normal storage conditions through a storage test of 3 months at higher temperature and humidity, and as can be seen from table 1, the states of examples 1 to 3 are stable in the storage test of 3 months, and the color change and the bag expansion phenomenon caused by mildew do not occur; while comparative example 1, which did not use the coating liquid, showed significant mold and bag expansion at month 1, comparative example 2, which used polyethylene glycol instead of glycerin in the original coating liquid, showed slight bag expansion at month 1, and mold and bag expansion at month 3. If the ratio of alkaline matter is higher than that of acidic matter, the effervescent tablet is more prone to absorb moisture, and the shelf life is shortened.
example 5
(1) adding 0.01g of rose glycoside pigment into 4g of purified water, dissolving at 25 ℃, adding 20g of citric acid and 20g of tartaric acid, and uniformly stirring to obtain slurry A;
(2) adding 1g of magnesium lauryl sulfate into the slurry A, adding 0.05g of rose essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) adding 8g of corn starch and 2g of zinc sulfate into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 30g of sodium bicarbonate, 0.25g of hyaluronic acid with the molecular weight of 1200 kDa, 2.5g of hyaluronic acid with the molecular weight of 300 kDa and 25g of hyaluronic acid with the molecular weight of 3 kDa through a 20-mesh sieve, adding 4mL of glycerol and pentanediol solution of 12mL, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (3) putting the material E into a forming die, performing compression molding, and curing at normal temperature for 24 hours to obtain a near-milky finished product which can be completely disintegrated in a bubbling manner within 30s without precipitation. The tablets were stored for 3 months under the conditions of reference example 4 without mildew and without bag bloating.
example 6
(1) Adding 0.2g of cochineal carmine into 2g of purified water, dissolving at 25 ℃, adding 23g of tartaric acid, and uniformly stirring to obtain slurry A;
(2) adding 1g of magnesium lauryl sulfate into the slurry A, adding 0.1g of rose essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) Adding 10g of corn starch into the material B, and uniformly stirring to obtain a material C;
(4) Sieving 23g of sodium bicarbonate, 0.5g of hyaluronic acid with the molecular weight of 1200 kDa, 1g of hyaluronic acid with the molecular weight of 300 kDa and 7g of hyaluronic acid with the molecular weight of 2 kDa through a 20-mesh sieve, adding 3mL of glycerol and pentanediol solution of 7.5mL, adding 8g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) and (3) putting the material E into a forming die, performing compression forming, and curing at normal temperature for 24 hours to obtain a light orange red finished product which can be completely disintegrated in a effervescent manner within 30s without precipitation. The tablets were stored for 3 months under the conditions of reference example 4 without mildew and without bag bloating.
example 7
(1) adding 0.1g of cochineal carmine into 3g of purified water, dissolving at 25 ℃, adding 23g of tartaric acid, and uniformly stirring to obtain slurry A;
(2) Adding 1g of magnesium lauryl sulfate into the slurry A, adding 0.1g of rose essence, fully and uniformly mixing, drying, and sieving by a 20-mesh sieve to obtain a material B;
(3) Adding 16g of corn starch and 3g of sodium sulfate into the material B, and uniformly stirring to obtain a material C;
(4) sieving 23g of sodium bicarbonate, 0.1g of hyaluronic acid with the molecular weight of 1500 kDa, 5g of hyaluronic acid with the molecular weight of 300 kDa and 5g of hyaluronic acid with the molecular weight of 10 kDa through a 20-mesh sieve, adding 3mL of glycerol and pentanediol solution of 8mL, adding 5g of vitamin C, uniformly stirring, drying and sieving to obtain a material D;
(5) Adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (3) putting the material E into a forming die, performing compression forming, and curing at normal temperature for 24 hours to obtain a light orange red finished product which can be completely disintegrated in a effervescent manner within 30s without precipitation. The tablets were stored for 3 months under the conditions of reference example 4 without mildew and without bag bloating.
Claims (10)
1. the bath effervescent tablet is characterized by comprising the following raw materials in percentage by weight:
5-60% of hyaluronic acid and derivatives thereof, 5-20% of filler, 5-35% of acidic substances, 20-45% of alkaline substances, 0.5-3% of lubricant, 5-15% of glycerol, 1-5% of pentanediol, 0-10% of active substances, 0-1% of essence and 0-0.7% of pigment.
2. the effervescent bath tablet of claim 1, wherein the hyaluronic acid and its derivatives are present in an amount of 5-25%.
3. The effervescent bath tablet of claim 1, wherein the glycerin to pentanediol volume ratio is 5-11: 2.
4. The effervescent bath tablet of claim 1, wherein the hyaluronic acid and its derivatives are selected from at least one of hyaluronic acid and its salts, hydrolyzed hyaluronic acid and its salts, cross-linked hyaluronic acid and its salts, acetylated hyaluronic acid, and thiolated hyaluronic acid.
5. the effervescent bath tablet of claim 1, wherein the molecular weight of the hyaluronic acid and its derivatives is 2 kDa-3500 kDa; preferably 1200 kDa-2000 kDa, 300 kDa-1000 kDa and 2 kDa-200 kDa in terms of mass ratio of the three molecular weight segments: 1-5: 5-10 in combination.
6. The effervescent bath tablet of claim 1, wherein the filler is selected from at least one of starch, cellulose, sugars, and inorganic salts;
The alkaline matter is selected from sodium carbonate salt, potassium carbonate salt, sodium bicarbonate salt or potassium bicarbonate salt; the acid is selected from organic weak acid;
The lubricant is selected from at least one of polyethylene glycol, sodium lauryl sulfate or magnesium lauryl sulfate;
The active matter is at least one of vitamin C, arbutin, plant extract, active polypeptide or saccharide isomer.
7. a process for the preparation of effervescent bath tablets as claimed in any one of claims 1 to 6, comprising the steps of:
(1) dissolving the pigment in water, selectively adding the pigment into the acid substance, and uniformly stirring to obtain slurry A;
(2) Adding a lubricant into the slurry A, selectively adding essence, fully and uniformly mixing, drying and sieving to obtain a material B;
(3) adding the filler into the material B, and uniformly stirring to obtain a material C;
(4) sieving hyaluronic acid and its derivatives, adding into wrapping liquid containing glycerol and pentanediol, dispersing, adding alkaline substance, optionally adding active substance, stirring, drying, and sieving to obtain material D;
(5) Adding the material D into the material C, and uniformly stirring to obtain a material E;
(6) And (4) putting the material E into a forming die, pressing and forming, and curing at normal temperature to obtain a finished product.
8. The process according to claim 7, wherein the weight ratio of the acidic substance to the basic substance in the steps (1) and (4) is 1-1.5: 1.
9. The method according to claim 7, wherein the size of the sieved mesh in steps (2) and (4) is 20 mesh.
10. the method according to claim 7, wherein in the step (6), the curing time is 20 to 30 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910975777.2A CN110559208B (en) | 2019-10-15 | 2019-10-15 | Bathing effervescent tablet containing hyaluronic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910975777.2A CN110559208B (en) | 2019-10-15 | 2019-10-15 | Bathing effervescent tablet containing hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110559208A true CN110559208A (en) | 2019-12-13 |
| CN110559208B CN110559208B (en) | 2022-09-23 |
Family
ID=68784765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910975777.2A Active CN110559208B (en) | 2019-10-15 | 2019-10-15 | Bathing effervescent tablet containing hyaluronic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110559208B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1436536A (en) * | 2002-02-07 | 2003-08-20 | 张晓崧 | Effervescent tablet with hyaluronic acid as effective component |
| CN106109265A (en) * | 2016-08-02 | 2016-11-16 | 山东华熙海御生物医药有限公司 | A kind of hyaluronic acid moisture-keeping composition and its preparation method and application |
| CN106309401A (en) * | 2016-10-14 | 2017-01-11 | 杭州惠博士生物科技有限公司 | Bathing effervescent tablets for preventing and treating skin diseases |
| CN107095833A (en) * | 2016-02-23 | 2017-08-29 | 欧诗漫生物股份有限公司 | A kind of face cleaning composition |
| CN109528509A (en) * | 2018-11-06 | 2019-03-29 | 广东轻工职业技术学院 | A kind of moisture-proof effervesce bath balls and preparation method thereof |
-
2019
- 2019-10-15 CN CN201910975777.2A patent/CN110559208B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1436536A (en) * | 2002-02-07 | 2003-08-20 | 张晓崧 | Effervescent tablet with hyaluronic acid as effective component |
| CN107095833A (en) * | 2016-02-23 | 2017-08-29 | 欧诗漫生物股份有限公司 | A kind of face cleaning composition |
| CN106109265A (en) * | 2016-08-02 | 2016-11-16 | 山东华熙海御生物医药有限公司 | A kind of hyaluronic acid moisture-keeping composition and its preparation method and application |
| CN106309401A (en) * | 2016-10-14 | 2017-01-11 | 杭州惠博士生物科技有限公司 | Bathing effervescent tablets for preventing and treating skin diseases |
| CN109528509A (en) * | 2018-11-06 | 2019-03-29 | 广东轻工职业技术学院 | A kind of moisture-proof effervesce bath balls and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110559208B (en) | 2022-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6113944B2 (en) | Freeze-dried molded product, production method thereof, and use thereof | |
| CN104800120B (en) | A kind of anti-ageing filling microgroove facial treatment essence liquid | |
| CN107496278A (en) | Carnosine snow face frost | |
| CN105476876A (en) | Novel deuterium-depleted lotion and preparation method thereof | |
| JP6646993B2 (en) | Foaming skin external preparation | |
| CN106619325A (en) | Anti-glycation facial mask containing Poria extract | |
| CN109730953A (en) | A kind of hyaluronic acid (sodium hyaluronate) stoste and preparation method thereof | |
| CN111450008A (en) | Whitening cream and preparation method thereof | |
| CN106580837A (en) | Whitening and moisture supplementing mask | |
| CN108635311B (en) | Raw material for hydrogen-rich mask and hydrogen-rich mask | |
| CN103340779A (en) | Young skin activating lotion | |
| CN106727042A (en) | A kind of tender white MASQUE APAISANT HYDRATANT containing Margarita extract | |
| CN110393703A (en) | A kind of lyophilized excipient of ascorbic acid and preparation method thereof | |
| CN104771340B (en) | A kind of facial mask of anti-ageing filling microgroove | |
| CN105616174B (en) | A kind of microballoon being enclosed with whitening active ingredients and its preparation method and a kind of Skin whitening care cosmetics | |
| KR101279020B1 (en) | A Cosmetic Composition increased viscosity and Carbon Dioxide of occur quantity | |
| CN104703583A (en) | Modified hyaluronic acid derivatives and use thereof | |
| CN110559208B (en) | Bathing effervescent tablet containing hyaluronic acid | |
| TW201244742A (en) | External agent kit | |
| CN101961299B (en) | Chinese herbal medicinal gel cosmetic and preparation method thereof | |
| CN111743850A (en) | Edible ampelopsis grossedentata hydrogel mask and preparation method thereof | |
| CN109718140A (en) | One main laminaria bioactivity facial mask effervescent tablet and preparation method thereof | |
| CN107485598B (en) | It is a kind of to thicken pearl toner and preparation method thereof certainly | |
| CN201019920Y (en) | Sea crystal intelligence face pack | |
| CN105853315A (en) | Face cream containing green tea concentrate essence and preparation method of face cream |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230627 Address after: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee after: BLOOMAGE BIOTECH Co.,Ltd. Address before: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee before: BLOOMAGE BIOTECH Co.,Ltd. Patentee before: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. |