CN110522738A - A kind of Lutein ester microcapsule preparation and its preparation method and application - Google Patents
A kind of Lutein ester microcapsule preparation and its preparation method and application Download PDFInfo
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- CN110522738A CN110522738A CN201910505870.7A CN201910505870A CN110522738A CN 110522738 A CN110522738 A CN 110522738A CN 201910505870 A CN201910505870 A CN 201910505870A CN 110522738 A CN110522738 A CN 110522738A
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- Prior art keywords
- lutein ester
- preparation
- ester microcapsule
- lutein
- microcapsule preparation
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- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 56
- 239000003094 microcapsule Substances 0.000 title claims abstract description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000004945 emulsification Methods 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 239000006210 lotion Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 14
- 229920002472 Starch Polymers 0.000 claims abstract description 13
- 235000019698 starch Nutrition 0.000 claims abstract description 13
- 239000008107 starch Substances 0.000 claims abstract description 13
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 10
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 10
- 239000003112 inhibitor Substances 0.000 claims abstract description 9
- 238000010008 shearing Methods 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 7
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 7
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 7
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000005469 granulation Methods 0.000 claims abstract description 6
- 230000003179 granulation Effects 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 5
- 238000004090 dissolution Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 7
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 7
- 229960005055 sodium ascorbate Drugs 0.000 claims description 7
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 229940046009 vitamin E Drugs 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- 238000000265 homogenisation Methods 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 230000036541 health Effects 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 239000004368 Modified starch Substances 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 claims 1
- 235000012680 lutein Nutrition 0.000 description 8
- 239000001656 lutein Substances 0.000 description 8
- 229960005375 lutein Drugs 0.000 description 8
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 8
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 8
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 8
- 239000003995 emulsifying agent Substances 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 6
- 238000013112 stability test Methods 0.000 description 6
- -1 carotenoid aliphatic ester Chemical class 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 230000005484 gravity Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000009818 secondary granulation Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 206010025421 Macule Diseases 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 241000206672 Gelidium Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 108010059642 isinglass Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052627 muscovite Inorganic materials 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 235000020748 rosemary extract Nutrition 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 235000005881 Calendula officinalis Nutrition 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241001674939 Caulanthus Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 240000000785 Tagetes erecta Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- KBPHJBAIARWVSC-TWGKZGRNSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-TWGKZGRNSA-N 0.000 description 1
- 229940107604 lutein esters Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention provides a kind of Lutein ester microcapsule preparation and its preparation method and application, the Lutein ester microcapsule preparation includes the raw material of following mass parts: 1 part of lutein ester, 4~12 parts of wall material, 0.5~3 part of low molecular weight carbohydrate, 0.1~0.4 part of water soluble antioxidant, 0.1~0.4 part of oil-soluble inhibitor, 5~20 parts of pure water；And the Xanthin micro-capsule preparation be 100% cross 40 meshes and sieve with 100 mesh sieve not more than 15% microcapsule powder.Preparation method includes: that wall material, lutein ester, water soluble antioxidant, oil-soluble inhibitor are added in pure water, and heating stirring dissolution carries out constant temperature high speed shearing emulsification later；In the solution emulsified be added low molecular weight carbohydrate be uniformly mixed, then carry out it is high-pressure homogeneous, obtain partial size be 0.2~2um lotion；Lotion is carried out to be spray-dried-secondary the granulation of starch embedding, obtains the Lutein ester microcapsule.
Description
Technical field
Present invention relates particularly to a kind of Lutein ester microcapsule preparations and its preparation method and application.
Background technique
Lutein ester (Lutein esters) is that the form combined with lutein and fatty acid is present in leaves of plants diameter and fruit
One of real carotenoid aliphatic ester.It is widely present in the plants such as marigold, wild cabbage corn, especially ten thousand longevity
Content is high in chrysanthemum.Lutein mainly exists in nature with free form, partially exists in the form of aliphatic ester, in human body
In in the form of aliphatic ester existing for lutein the lutein of free type can be hydrolyzed by the digestive juice that human pancreas secrete, through small
Intestinal mucosa is absorbed into blood circulation of human body, is finally deposited on the human bodies such as human body macula retinae area.Lutein mainly sinks
Product exists in skin, breast tissue, ovary and uterus, or even in breast milk and Neonates in human body macula retinae area
In have also discovered the presence of lutein.
Lutein ester is new raw-food material, can be made an addition in other food in addition to infant, to colour, improves food
Product color, while can be made functional health care food, be deposited in after being absorbed by the body in human eye's crystalline lens in, absorb big portion
Divide and inject intraocular blue light, reduces the injury to retina, promote lenticular oxidation resistance, resist the injury of free radical,
Eyes are protected, asthenopia is alleviated, delay or prevent the generation of cataract, old involutional macula disease sufferer is helped to improve view
Power.Meanwhile lutein ester also has and delays artery sclerosis, anticancer and the ability for improving human body cognition.
Lutein ester is fat-soluble pigment, there is multiple unsaturated double-bonds in structure, have height unsaturation, to temperature,
The factors such as illumination, oxygen, PH, reducing agent and oxidant are highly sensitive, therefore lutein ester needs low temperature, is protected from light and oxygen barrier preservation,
Microcapsules technology can be very good to solve the problems, such as lutein ester unstability and water-insoluble.
Publication number CN102389108A provides a kind of Lutein ester microcapsule powder and preparation method thereof, added filler
In water phase, filler is easy and wall material combines and forms empty pocket, reduces the embedding rate to core material, while needing to add oily mutually cream
The multiple auxiliary materials such as agent and aqueous emulsifier phase, will lead to the later period using label it is excessively complicated, be unfavorable for the use of product.Publication number
CN103735532A provides a kind of Lutein ester microcapsule and preparation method thereof, is not added with oil-soluble inhibitor and is added
Filler in water phase, the micro-capsule stability of formation is poor, while needing to add three kinds of emulsifiers, also will lead to the later period use
Label is excessively complicated, is unfavorable for the use of product.Publication number CN106262926A provide a kind of Lutein ester microcapsule and its
Preparation method, the oil-soluble inhibitor used are Rosmarinus officinalis extract, and Rosmarinus officinalis extract can only make as food additives
In production with meat product and grease, which limit the final use scope of Lutein ester microcapsule powder product, it is unfavorable for final
The use of product.Publication number CN107205456A provides the preparation method of a kind of lutein or Lutein ester microcapsule, adopts
It is substrate with isinglass, does not add emulsifier, reduce the product hollow structure formed by emulsification, reinforces product stability, but single
It is substrate with isinglass, limits the scope of application of final products, especially cannot be used for pure plant beverage, confectionary products
In.Publication number CN109305931A provides a kind of preparation method of Lutein ester microcapsule, divides oil water phase substance each in advance
Oil is mutually poured under the quick stirring state of water phase again from after dissolution, stirs evenly and homogeneous obtains homogenizing fluid, spraying secondary packet
Obtained microcapsule granule is buried, the advantage of the technique is secondary embedding, and product stability is enhanced, and shortcoming is in addition to using cream
Agent is formed outside hollow structure, and also auxiliary material used is excessive, and tag inventory is complicated, is unfavorable for the shortcomings that subsequent product uses.
Summary of the invention
In view of this, it is necessary in view of the problems of the existing technology, provide a kind of Lutein ester microcapsule preparation and its system
Preparation Method and application.The technical solution of the present invention is as follows:
First aspect, the present invention provide a kind of Lutein ester microcapsule preparation, the raw material including following mass parts: lutein
1 part of ester, 4~12 parts of wall material, 0.5~3 part of low molecular weight carbohydrate, 0.1~0.4 part of water soluble antioxidant, oil-soluble
0.1~0.4 part of antioxidant, 5~20 parts of pure water；And the Xanthin micro-capsule preparation crosses 40 meshes for 100% and crosses 100
Mesh is not more than 15% microcapsule powder.
Further, the wall material includes Arabic gum, modified starch.
Further, the low molecular weight carbohydrate be sucrose, it is glucose syrup, glucose, oligomeric maltose, oligomeric
The mixing of one or more of fructose, oligoisomaltose.
Further, the low molecular weight carbohydrate is preferably one of sucrose, glucose, oligofructose or several
Kind mixing.
Further, the low molecular weight carbohydrate is preferably sucrose.
Further, the water-soluble oxidizers include ascorbic acid, sodium ascorbate.
Further, the oil-soluble inhibitor includes vitamin E, BHT, BHA, ascorbyl palmitate.
The second aspect, the present invention provide a kind of preparation method of Lutein ester microcapsule preparation, include the following steps:
1) wall material, lutein ester, water soluble antioxidant, oil-soluble inhibitor are added in pure water, heating stirring
Dissolution carries out constant temperature high speed shearing emulsification later；
2) low molecular weight carbohydrate is added in the solution emulsified to be uniformly mixed, then carries out high-pressure homogeneous, obtains
The lotion for being 0.2~2um to partial size；
3) lotion is carried out being spray-dried-secondary the granulation of starch embedding, obtains the Lutein ester microcapsule.
Further, the heating temperature of the step 1) is 55~85 DEG C, and emulsification times are 20~60min.
Further, the heating temperature of the step 1) is 65~75 DEG C, and emulsification times are 30~50min.
Further, the heating temperature of the step 1) is preferably 75 DEG C, and emulsification times are preferably 45min.
Further, the high-pressure homogeneous condition of the step 2) are as follows: homogenization cycles 1~4 time, homogenization pressure 40~
100MPa。
Further, the high-pressure homogeneous condition of the step 2) is preferred are as follows: and homogenization cycles 3 times, homogenization pressure 60MPa.
Further, the spray drying condition of the step 3) are as follows: 110~120 DEG C of air temperature, charging rate 100~
150mL/min。
In terms of third, the present invention provide above-mentioned Lutein ester microcapsule preparation the food of preparation eye-protecting function, drug and
Application in health care product.
Advantage and beneficial effect of the invention is:
1, Lutein ester microcapsule preparation of the invention does not use emulsifier, does not form hollow structure, increases wall material to leaf
The embedding effect of flavine ester, and then the stability of lutein ester is improved, and Lutein ester microcapsule preparation of the invention is in temperature
Content retention after placing 6 months under the conditions of 25 DEG C of degree, humidity 75% is greater than 97%, in 40 DEG C of temperature, 75% condition of humidity
Content retention after lower placement 6 months is greater than 90%.
2, preparation process of the invention does not generate oily phase, and water phase separately produces row mixing and emulsifying again, it is only necessary to will be most of
Material is added in pure water, and low molecular weight carbohydrate is added in row again after heating emulsification shearing.
Detailed description of the invention
Fig. 1 is the SEM photograph of the Lutein ester microcapsule preparation of the embodiment of the present invention 1.
Fig. 2 is the SEM photograph of the Lutein ester microcapsule preparation of the embodiment of the present invention 2.
Fig. 3 is the SEM photograph of the Lutein ester microcapsule preparation of the embodiment of the present invention 3.
Fig. 4 is the SEM photograph of the Lutein ester microcapsule preparation of the embodiment of the present invention 4.
Fig. 5 is the SEM photograph of the Lutein ester microcapsule preparation of comparative example 1 of the present invention.
Specific embodiment
In the description of the present invention, it should be noted that the person that is not specified actual conditions in embodiment, according to normal conditions or
The condition that manufacturer suggests carries out.Reagents or instruments used without specified manufacturer is that can be obtained by commercially available purchase
Conventional products.
The present invention is described in further details with specific embodiment with reference to the accompanying drawing, described is to solution of the invention
It releases rather than limits.
Embodiment 1
By the lutein ester of 50g60% content, 250g capsul converted starch, sodium ascorbate 8g, vitamin E 8g add
Entering into the pure water inlet of 500g, after stirring at low speed, is heated to 75 DEG C, high speed shearing emulsification 30min forms uniform lotion,
50g white sugar is added, stirring and dissolving is uniform, with high pressure homogenizer 60Mpa homogeneous 3 times, obtains stable emulsion, Malvern 3000 surveys partial size
For 0.682um, lotion is carried out to be spray-dried-secondary the granulation of starch embedding, spray drying condition are as follows: 110 DEG C of inlet air temperature, into
Expect speed 120mL/min, obtain Lutein ester microcapsule preparation, measuring lutein ester content is 5.56%, specific gravity 0.62g/
cm3.The results are shown in Table 1 for stability test.SEM result is as shown in Figure 1.
Embodiment 2
By the lutein ester of 50g60% content, 500g capsul converted starch, sodium ascorbate 5g, vitamin E 10g
It is added in the pure water inlet of 800g, after stirring at low speed, is heated to 70 DEG C, high speed shearing emulsification 30min, form uniform cream
150g glucose is added in liquid, and stirring and dissolving is uniform, with high pressure homogenizer 70Mpa homogeneous 3 times, obtains stable emulsion, Malvern 3000
Survey partial size is 0.645um, carries out spray-dried starch to lotion and embeds secondary granulation, spray drying condition are as follows: inlet air temperature 110
DEG C, charging rate 120mL/min obtains Lutein ester microcapsule preparation, and surveying lutein ester content is 2.78%, and specific gravity is
0.55g/cm3.The results are shown in Table 1 for stability test.SEM result is as shown in Figure 2.
Embodiment 3
By the lutein ester of 50g60% content, 200g capsul converted starch, sodium ascorbate 15g, vitamin E 5g
It is added in the pure water inlet of 400g, after stirring at low speed, is heated to 65 DEG C, high speed shearing emulsification 40min, form uniform cream
100g glucose is added in liquid, and stirring and dissolving is uniform, with high pressure homogenizer 65Mpa homogeneous 3 times, obtains stable emulsion, Malvern 3000
Survey partial size is 0.645um, carries out spray-dried starch to lotion and embeds secondary granulation, spray drying condition are as follows: inlet air temperature 110
DEG C, charging rate 120mL/min obtains Lutein ester microcapsule preparation, and surveying lutein ester content is 5.16%, and specific gravity is
0.53g/cm3.The results are shown in Table 1 for stability test.SEM result is as shown in Figure 3.
Embodiment 4
By the lutein ester of 50g60% content, 350g capsul converted starch, sodium ascorbate 20g, vitamin E 10g
It is added in the pure water inlet of 500g, after stirring at low speed, is heated to 65 DEG C, high speed shearing emulsification 50min, form uniform cream
25g glucose is added in liquid, and stirring and dissolving is uniform, with high pressure homogenizer 55Mpa homogeneous 3 times, obtains stable emulsion, Malvern 3000
Survey partial size is 0.652um, carries out spray-dried starch to lotion and embeds secondary granulation, spray drying condition are as follows: inlet air temperature 110
DEG C, charging rate 120mL/min obtains Lutein ester microcapsule preparation, and surveying lutein ester content is 3.46%, and specific gravity is
0.54g/cm3.The results are shown in Table 1 for stability test.SEM result is as shown in Figure 4.
Comparative example 1
By the lutein ester of 50g60% content, 250g capsul converted starch, sodium ascorbate 8g, vitamin E 8g add
Entering into the pure water inlet of 500g, after stirring at low speed, is heated to 75 DEG C, high speed shearing emulsification 30min forms uniform lotion,
50g oligoisomaltose and 25g soybean lecithin is added, stirring and dissolving is uniform, with high pressure homogenizer 60Mpa homogeneous 3 times, obtains surely
Determine lotion, it is 0.622um that Malvern 3000, which surveys partial size, carries out spray-dried starch to lotion and embeds secondary granulation, spray drying
Condition are as follows: 110 DEG C of inlet air temperature, charging rate 120mL/min, obtain Lutein ester microcapsule preparation, survey lutein ester content
It is 5.12%, specific gravity 0.46g/cm3.The results are shown in Table 1 for stability test.SEM result is as shown in Figure 5.
From attached drawing 1-5 comparison as can be seen that when emulsifier is not added in attached drawing 1-4 granulation product, the sky brought into when not emulsifying
Gas does not form hollow structure after granulation is dry, and not remaining large quantity of air is inside particle, and Fig. 5 is after emulsifier processing is added
Manufactured particle, forms a large amount of hollow structures, and remaining has the air brought into when emulsification.Lutein ester is to oxygen sensitive, easily quilt
Oxidation, remaining air certainly will reduce the storage stability of particle.
The stability test result of 1 Examples 1 to 4 of table and comparative example 1
It can be seen that the Lutein ester microcapsule preparation of present aspect preparation in 25 DEG C of temperature, humidity 75% by the data of table 1
Under the conditions of place 6 months after content retention be greater than 97%, after being placed 6 months under the conditions of 40 DEG C of temperature, humidity 75%
Content retention is greater than 90%, and in contrast, comparative example 1 is the leaf that the preparation of emulsifier soybean lecithin is added using conventional method
Flavine ester microcapsule formulation, the content retention after placing 6 months under the conditions of 25 DEG C of temperature, humidity 75% are near
92.8%, the content retention after placing 6 months under the conditions of 40 DEG C of temperature, humidity 75% is down to 70.5%.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of Lutein ester microcapsule preparation, it is characterised in that: the raw material including following mass parts: 1 part of lutein ester, wall material 4
~12 parts, 0.5~3 part of low molecular weight carbohydrate, 0.1~0.4 part of water soluble antioxidant, oil-soluble inhibitor 0.1
~0.4 part, 5~20 parts of pure water；And the Xanthin micro-capsule preparation is crossed 40 meshes for 100% and is sieved with 100 mesh sieve not more than
15% microcapsule powder.
2. a kind of Lutein ester microcapsule preparation according to claim 1, it is characterised in that: the wall material includes Arab
Glue, modified starch.
3. a kind of Lutein ester microcapsule preparation according to claim 1, it is characterised in that: the low molecular weight carbon hydrate
Object is the mixing of one or more of sucrose, glucose syrup, glucose, oligomeric maltose, oligofructose, oligoisomaltose.
4. a kind of Lutein ester microcapsule preparation according to claim 1, it is characterised in that: the water-soluble oxidizers include
Ascorbic acid, sodium ascorbate.
5. a kind of Lutein ester microcapsule preparation according to claim 1, it is characterised in that: the oil-soluble inhibitor packet
Include vitamin E, BHT, BHA, ascorbyl palmitate.
6. a kind of preparation method of Lutein ester microcapsule preparation, feature described in Claims 1 to 5 any one claim
It is: includes the following steps:
1) wall material, lutein ester, water soluble antioxidant, oil-soluble inhibitor are added in pure water, heating stirring dissolution,
Constant temperature high speed shearing emulsification is carried out later；
2) low molecular weight carbohydrate is added in the solution emulsified to be uniformly mixed, then carries out high-pressure homogeneous, obtains grain
Diameter is the lotion of 0.2~2um；
3) lotion is carried out being spray-dried-secondary the granulation of starch embedding, obtains the Lutein ester microcapsule.
7. a kind of preparation method of Lutein ester microcapsule preparation according to claim 6, it is characterised in that: the step 1)
Heating temperature be 55~85 DEG C, emulsification times be 20~60min.
8. a kind of preparation method of Lutein ester microcapsule preparation according to claim 6, it is characterised in that: the step 2)
High-pressure homogeneous condition are as follows: homogenization cycles 1~4 time, 40~100MPa of homogenization pressure.
9. a kind of preparation method of Lutein ester microcapsule preparation according to claim 6, it is characterised in that: the step 3)
Spray drying condition are as follows: 110~120 DEG C of air temperature, 100~150mL/min of charging rate.
10. a kind of Lutein ester microcapsule preparation described in Claims 1 to 5 any one claim is in preparation eye-protecting function
Application in food, drug and health care product.
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| CN111387499A (en) * | 2020-04-17 | 2020-07-10 | 山东天音生物科技有限公司 | Lutein ester water-soluble particle and preparation method thereof |
| CN111838321A (en) * | 2020-08-18 | 2020-10-30 | 青岛大学 | Senile nutrition bag containing lutein and prebiotics and preparation method thereof |
| CN114504104A (en) * | 2022-01-23 | 2022-05-17 | 大连医诺生物股份有限公司 | Taste-masking instant lutein ester product, and preparation method and application thereof |
| CN114522149A (en) * | 2022-01-28 | 2022-05-24 | 肇庆市佰仕科生物科技有限公司 | Preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles |
| CN115160822A (en) * | 2022-07-26 | 2022-10-11 | 武汉星辰现代生物工程有限公司 | Production process of lutein ester |
| CN115251376A (en) * | 2022-07-28 | 2022-11-01 | 青岛康小鹿生物科技有限公司 | Lutein ester nano microcapsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111387499A (en) * | 2020-04-17 | 2020-07-10 | 山东天音生物科技有限公司 | Lutein ester water-soluble particle and preparation method thereof |
| CN111838321A (en) * | 2020-08-18 | 2020-10-30 | 青岛大学 | Senile nutrition bag containing lutein and prebiotics and preparation method thereof |
| CN114504104A (en) * | 2022-01-23 | 2022-05-17 | 大连医诺生物股份有限公司 | Taste-masking instant lutein ester product, and preparation method and application thereof |
| CN114522149A (en) * | 2022-01-28 | 2022-05-24 | 肇庆市佰仕科生物科技有限公司 | Preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles |
| CN115160822A (en) * | 2022-07-26 | 2022-10-11 | 武汉星辰现代生物工程有限公司 | Production process of lutein ester |
| CN115160822B (en) * | 2022-07-26 | 2023-08-15 | 武汉星辰现代生物工程有限公司 | Production process of lutein ester |
| CN115251376A (en) * | 2022-07-28 | 2022-11-01 | 青岛康小鹿生物科技有限公司 | Lutein ester nano microcapsule and preparation method thereof |
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