CN110497671A - A kind of high-barrier composite layer medical infusion bags and its production method - Google Patents

A kind of high-barrier composite layer medical infusion bags and its production method Download PDF

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Publication number
CN110497671A
CN110497671A CN201910722079.1A CN201910722079A CN110497671A CN 110497671 A CN110497671 A CN 110497671A CN 201910722079 A CN201910722079 A CN 201910722079A CN 110497671 A CN110497671 A CN 110497671A
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layer
barrier
medical infusion
mixture
infusion bags
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Granted
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CN110497671B (en
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龙浩
龙潜
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Anhui Tianrun Medical New Material Co Ltd
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Anhui Tianrun Medical New Material Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D22/00—Producing hollow articles
    • B29D22/003—Containers for packaging, storing or transporting, e.g. bottles, jars, cans, barrels, tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/302—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising aromatic vinyl (co)polymers, e.g. styrenic (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/306—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl acetate or vinyl alcohol (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/42—Layered products comprising a layer of synthetic resin comprising condensation resins of aldehydes, e.g. with phenols, ureas or melamines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/10—Coating on the layer surface on synthetic resin layer or on natural or synthetic rubber layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/20—Inorganic coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/306—Resistant to heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B32B2307/7244—Oxygen barrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B32B2307/7246—Water vapor barrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B32B2307/7265—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/752—Corrosion inhibitor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Laminated Bodies (AREA)

Abstract

The present invention relates to a kind of high-barrier composite layer medical infusion bags and its production method, which is respectively as follows: the second barrier layer, the first barrier layer, central core, weathering layer from inside to outside.Production method mainly comprises the steps that S1, preparation center layer material；S2, weather-proof layer material is prepared；S3, the second barrier material of preparation；It is S4, central core and weathering layer is compound；Pellumina is plated on S5, in the composite central layer surface；It is S6, the coated surface of Coating Materials and the second barrier layer is compound；S7, medical infusion bags are made in composite material.The barrier property of infusion bag prepared by the present invention is high, and substance can not enter in bag body in air, and medical fluid and bag body do not react, the good weatherability of transfusion flexible bag.

Description

A kind of high-barrier composite layer medical infusion bags and its production method
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of high-barrier composite layer medical infusion bags and its producer Method.
Background technique
Substantially there are several types of glass infusion bottle, plastic infusion bottle, PVC transfusion flexible bags, infusion film for the type of infusion bag Bag.
Traditional glass active conveying bottle and plastic infusion bottle due to due to bottle body itself be it is solid, need air to enter bottle body In, the medical fluid of the inside, which can just smoothly flow out, to be come, this will lead to the meetings such as bacterium, dust in air and medical fluid contact, leads to medical fluid It may be contaminated, both infusion bottles are gradually eliminated.
PVC infusion film bag solves the defect that infusion bottle needs air inlet, but PVC material is not sufficiently stable, part medical fluid meeting It is reacted with PVC, it is contaminated to cause medical fluid, while the barrier property of the material is relatively low.
Patent No. CN101411672B patent of invention discloses a kind of medical infusion soft bag and its manufacturing method, the infusion film Bag one-pass molding, when infusion, does not need air and enters bag body, but the infusion material is single substance, polypropylene material therein The pollution of medical fluid can be caused into the liquid.
Patent No. CN103893012A patent of invention discloses a kind of compound transfusion flexible bag, which can empty medical fluid, And bag body is not reacted with medical fluid, barrier property is preferable, but the weatherability of bag body is general.
Therefore, the present invention is directed to develop a kind of transfusion flexible bag of high obstructing performance, substance can not enter in bag body in air, And medical fluid and bag body do not react, the good weatherability of transfusion flexible bag.
Summary of the invention
The present invention provides a kind of high-barrier composite layer medical infusion bags:
The high-barrier meets a layer medical infusion bags and is divided into four layers, is respectively as follows: the second barrier layer, the first barrier from inside to outside Layer, central core, weathering layer, the second barrier layer be polyvinylidene chloride, polyethylene terephthalate mixing material, with a thickness of 20-25um, the first barrier layer are pellumina, and with a thickness of 5-10um, central core is polyethylene, polystyrene mixing material, thickness Degree is 60-70um, and weathering layer is the mixture of phenolic resin, polyethylene, polyvinyl alcohol, with a thickness of 25-30um.
Polyvinylidene chloride quality accounts for the 70-80% of the second barrier layer mixing material, and polyethylene terephthalate accounts for The 20-30% of two barrier layer mixing materials；Polyethylene quality accounts for the 60-70% of central core mixing material, and polystyrene quality accounts for The 30-40% of central core mixing material；Phenolic resin quality accounts for the 30-40% of weathering layer mixture, and polyethylene quality accounts for weather-proof The 20-30% of layer mixture, polyvinyl alcohol quality account for the 40-50% of weathering layer mixture.
The present invention provides a kind of production method of high-barrier composite layer medical infusion bags: the production method shares seven steps It is rapid:
S1, preparation center layer material；
S2, weather-proof layer material is prepared；
S3, the second barrier material of preparation；
It is S4, central core and weathering layer is compound；
Pellumina is plated on S5, in the composite central layer surface；
It is S6, the coated surface of Coating Materials and the second barrier layer is compound；
S7, medical infusion bags are made in composite material.
Further, the preparation of the center step S1 layer material weighs polyethylene, polystyrene according to prescription quality, so After be uniformly mixed, feed the mixture into reaction kettle, then heat the mixture to 240-250 DEG C, mixture melts, by mold It is put into baking oven and is preheated to 90-100 DEG C, then by the mixture injection mold of thawing, make mold natural at room temperature It is cooling, obtain center layer material.
Further, the preparation of the weather-proof layer material of step S2, by phenolic resin, polyethylene, polyvinyl alcohol according to formula matter Amount weighs, and is then uniformly mixed and is added in reaction kettle, is then heated to 240-250 DEG C to melting, mold is put into baking oven in advance Then heat will allow mold natural cooling at room temperature, obtain weather-proof in the copolymer injection mold of thawing to 90-100 DEG C Layer material.
Further, the preparation of the second barrier material of step S3, by polyvinylidene chloride, polyethylene terephthalate It weighs according to prescription quality, is then uniformly mixed, feed the mixture into reaction kettle, then heat the mixture to 260-270 DEG C, mixture melts, and mold is put into baking oven and is preheated to 90-100 DEG C, then by the mixture injection mold of thawing, allows Mold natural cooling at room temperature obtains the second barrier material.
Further, step S4 central core and weathering layer is compound, and central core and weathering layer are stacked together, then pressed Flat to make bubble-free between two layers, compound heat under the conditions of 0.5-1Mpa in pressure, combined temp is 240-250 DEG C, multiple Closing the time is 3-5 seconds.
Further, step S5 composite material center layer surface plates pellumina, first puts composite material into vacuum coating In machine, composite material center layer surface is set by coated surface, selecting the aluminium oxide that purity is 99.99% is raw material, is closed true Empty plated film gate is extracted the air in vacuum coating equipment out, then heated oxide aluminium, and heating temperature is 1150-1200 DEG C, to oxygen After change aluminium is sublimed into oxidation aluminum steam, stop heating, and open cooling system, oxidation aluminum vapor deposition is formed on the composite Pellumina.
Further, the coated surface of step S6 Coating Materials and the second barrier layer are compound, and Coating Materials is lain in work On platform, keep plated film face-up, the second barrier layer is covered on Coating Materials, carry out smooth, makes corrugationless between the two, gas Bubble, then compound heat under the conditions of 0.5-1Mpa in pressure, combined temp is 260-270 DEG C, recombination time 3-5 Second, obtain high-barrier composite material.
Further, in step S7 high-barrier medical infusion bag preparation, by high-barrier composite material obtained in S6 cut out It is cut into required shape, heat treatment sealing is carried out to periphery, heat treatment temperature is 270-280 DEG C, and carries out irrigation liquid, then close Envelope.
Wherein, present invention is characterized in that increasing weathering layer on the outside of central core, it is phenolic resin, polyethylene, gathers The mixing material of vinyl alcohol, polyethylene, the mixing material of polyvinyl alcohol are big, resistance to good barrier properties for gases, mechanical strength Mill property is good, but weatherability is general, to polyethylene, polyvinyl alcohol mixing material in a certain proportion of phenolic resin is added, can To enhance the mixing material weatherability of polyethylene, polyvinyl alcohol, because the heat resistance of phenolic resin, flame resistance and water resistance are very It is good, therefore by phenolic resin and polyethylene, polyvinyl alcohol, obtained material can be placed for a long time, and performance is hardly sent out Changing protects the inner layer material of infusion bag using the material as weather resistant materials, can store medicine for a long time Liquid.
Central core is polyethylene, polystyrene mixing material, which is the basic material of infusion bag, and the material is odorless It is nontoxic, there are certain flexibility and intensity.
The pellumina plated on the inside of central core is first layer barrier material, which can obstruct center layer material Monomer enters the internal layer of infusion bag, while can stop the invasion of oxygen, nitrogen and hydrone, and the inside of pellumina is poly- inclined Dichloroethylene, polyethylene terephthalate mixing material, the mixing material are the second barrier layer, have heat-resisting, corrosion-resistant, gas The characteristics of close property is good, safe and non-toxic, discord medical fluid reaction.
Beneficial effect
1. the present invention devises a kind of high-barrier composite layer medical infusion bags, which is soft dress infusion bag, is being infused In the process, air does not pollute medical fluid, and medical fluid can drain, which has two layers of barrier material, can obstruct very well Evil substance enters medical fluid, and pollution-free to medical fluid, and the infusion bag can use for a long time.
2. first layer barrier layer can obstruct central core material monomer, oxygen, nitrogen and hydrone in air are obstructed, the Two barrier layers further serve as barrier action, and heat-resisting, corrosion-resistant, safe and non-toxic, pollution-free to medical fluid.
3. weathering layer shields to the internal material of infusion bag, it is able to extend the holding time of infusion bag, is improved defeated The shelf-life of liquid bag.
Detailed description of the invention
Fig. 1 is material layer schematic diagram of the invention；
Fig. 2 is schematic diagram of the invention；
Specific embodiment
1-2 and process of the invention and operating procedure are made in conjunction with the embodiments further detailed with reference to the accompanying drawings Explanation.
Embodiment 1
Polyethylene and polystyrene are weighed by mass percentage, and wherein polyethylene accounts for the 65% of mixture gross mass, polyphenyl Ethylene accounts for the 35% of mixture heavy amount, is then uniformly mixed, feeds the mixture into reaction kettle, then heats the mixture to 240-250 DEG C, mixture melts, and mold is put into baking oven and is preheated to 90-100 DEG C, and the mixture of thawing is then injected mould In tool, mold natural cooling at room temperature is allowed, obtain center layer material.
Phenolic resin, polyethylene and polyvinyl alcohol are weighed by mass percentage, and wherein phenolic resin accounts for mixture gross mass 35%, polyethylene accounts for the 25% of mixture heavy amount, and polyvinyl alcohol accounts for the 40% of mixture gross mass, be then uniformly mixed, Phenolic resin, polyethylene, polyvinyl alcohol are added in reaction kettle, 240-250 DEG C is then heated to melting, mold is put into It is preheated to 90-100 DEG C in baking oven, then will allow mold natural cooling at room temperature in the copolymer injection mold of thawing, Obtain weather-proof layer material.
Polyvinylidene chloride, polyethylene terephthalate are weighed by mass percentage, and wherein polyvinylidene chloride accounts for mixed The 75% of object gross mass is closed, polyethylene terephthalate accounts for the 25% of mixture heavy amount, is then uniformly mixed, by mixture It is added in reaction kettle, then heats the mixture to 260-270 DEG C, mixture melts, and mold is put into baking oven and is preheated to 90- 100 DEG C, then it will allow mold natural cooling at room temperature, and obtain the second barrier layer in the mixture injection mold of thawing Material.
Central core and weathering layer are stacked together, then flattening makes bubble-free between two layers, is 0.5-1Mpa in pressure Under the conditions of heat it is compound, combined temp be 240-250 DEG C, recombination time be 3-5 seconds.
First composite material is put into vacuum coating equipment, sets coated surface to the center level of composite material, is selected pure Degree is raw material for 99.99% aluminium oxide, closes vacuum coating gate, and the air in vacuum coating equipment is extracted out, is then heated Aluminium oxide, heating temperature are 1150-1200 DEG C, after aluminium to be oxidized is sublimed into oxidation aluminum steam, stop heating, and open cooling system System, oxidation aluminum vapor deposition form pellumina on the composite.
Coating Materials is laid flat on the table, keeps plated film face-up, the second barrier layer is covered on Coating Materials, into Row is smooth, makes corrugationless between the two, bubble, then carries out heating compound, combined temp under the conditions of pressure is 0.5-1Mpa It is 260-270 DEG C, recombination time is 3-5 seconds, obtains high-barrier composite material.
High-barrier composite material obtained in S6 is cut into required shape, heat treatment sealing is carried out to periphery, is heat-treated Temperature is 270-280 DEG C, and carries out irrigation liquid, is then sealed.
Gas barrier property test, intensity experiment and weather resistance test, each test are carried out to gained infusion bag and do three Secondary, results are averaged, and test result is shown in Table 1.
Table 1
Steam penetrating capacity g/ (m2*24h) 0.485
Nitrogen transit dose cm3/(m2*24h*0.1Mpa) 0.328
Oxygen transit dose cm3/(m2*24h*0.1Mpa) 0.355
Carbon dioxide transit dose cm3/(m2*24h*0.1Mpa) 0.498
Heat seal strength (N/15mm) 40
100 DEG C for 24 hours (weatherability test) Bag body without cracking, without deformation, without gas leak phenomenon
From the data in table 1, it can be seen that steam penetrating capacity is lower than 0.5g/ (m2* for 24 hours), nitrogen transit dose, oxygen transit dose and two Carbonoxide transit dose is respectively as follows: 0.328,0.355 and 0.498cm3/(m2* * 0.1Mpa for 24 hours), heat seal strength 40N/15mm, State Food and Drug Administration's national drug packing container standard (YBB00112005) is reached.

Claims (10)

1. a kind of high-barrier composite layer medical infusion bags, it is characterised in that: the high-barrier meets a layer medical infusion bags and is divided into four Layer, is respectively as follows: the second barrier layer, the first barrier layer, central core, weathering layer from inside to outside, and the second barrier layer is to gather inclined two chloroethene Alkene, polyethylene terephthalate mixing material, with a thickness of 20-25um, the first barrier layer is pellumina, with a thickness of 5- 10um, central core is polyethylene, polystyrene mixing material, and with a thickness of 60-70um, weathering layer is phenolic resin, polyethylene, gathers The mixture of vinyl alcohol, with a thickness of 25-30um.
2. a kind of high-barrier composite layer medical infusion bags as described in claim 1, it is characterised in that: polyvinylidene chloride quality The 70-80% of the second barrier layer mixing material is accounted for, polyethylene terephthalate accounts for the 20- of the second barrier layer mixing material 30%；Polyethylene quality accounts for the 60-70% of central core mixing material, and polystyrene quality accounts for the 30- of central core mixing material 40%；Phenolic resin quality accounts for the 30-40% of weathering layer mixture, and polyethylene quality accounts for the 20-30% of weathering layer mixture, gathers Vinyl alcohol quality accounts for the 40-50% of weathering layer mixture.
3. a kind of production method of high-barrier composite layer medical infusion bags as described in claim 1, it is characterised in that: the producer Method shares seven steps:
S1, preparation center layer material；
S2, weather-proof layer material is prepared；
S3, the second barrier material of preparation；
It is S4, central core and weathering layer is compound；
Pellumina is plated on S5, in the composite central layer surface；
It is S6, the coated surface of Coating Materials and the second barrier layer is compound；
S7, medical infusion bags are made in composite material.
4. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S1 Polyethylene, polystyrene are weighed according to prescription quality, are then uniformly mixed, feed the mixture by the preparation of center layer material In reaction kettle, 240-250 DEG C is then heated the mixture to, mixture melts, and mold is put into baking oven and is preheated to 90-100 DEG C, then it will allow mold natural cooling at room temperature, and obtain center layer material in the mixture injection mold of thawing.
5. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S2 The preparation of weather-proof layer material weighs phenolic resin, polyethylene, polyvinyl alcohol according to prescription quality, is then uniformly mixed and is added In reaction kettle, 240-250 DEG C is then heated to melting, mold is put into baking oven and is preheated to 90-100 DEG C, then will be melted Copolymer injection mold in, allow mold natural cooling at room temperature, obtain weather-proof layer material.
6. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S3 Polyvinylidene chloride, polyethylene terephthalate are weighed according to prescription quality, are then mixed by the preparation of the second barrier material It closes uniformly, feeds the mixture into reaction kettle, then heat the mixture to 260-270 DEG C, mixture melts, and mold is put into It is preheated to 90-100 DEG C in baking oven, then will allow mold natural cooling at room temperature in the mixture injection mold of thawing, Obtain the second barrier material.
7. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S4 Central core and weathering layer it is compound, central core and weathering layer are stacked together, then flattening makes bubble-free between two layers, is pressing Power is compound heat under the conditions of 0.5-1Mpa, and combined temp is 240-250 DEG C, and recombination time is 3-5 seconds.
8. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S5 Composite material center layer surface plates pellumina, first puts in vacuum coating equipment composite material into, sets compound for coated surface Material center layer surface, selecting the aluminium oxide that purity is 99.99% is raw material, vacuum coating gate is closed, by vacuum coating equipment In air extraction, then heated oxide aluminium, heating temperature is 1150-1200 DEG C, after aluminium to be oxidized is sublimed into oxidation aluminum steam, Stop heating, and open cooling system, oxidation aluminum vapor deposition forms pellumina on the composite.
9. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step S6 The coated surface of Coating Materials and the second barrier layer are compound, and Coating Materials is laid flat on the table, keep plated film face-up, by second Barrier layer is covered on Coating Materials, carries out smooth, is made corrugationless between the two, bubble, is then 0.5-1Mpa item in pressure Carry out heating under part it is compound, combined temp be 260-270 DEG C, recombination time be 3-5 seconds, obtain high-barrier composite material.
10. a kind of production method of high-barrier composite layer medical infusion bags as claimed in claim 3, it is characterised in that: step High-barrier composite material obtained in S6 is cut into required shape by the preparation of high-barrier medical infusion bag in S7, to periphery into Row heat treatment sealing, heat treatment temperature is 270-280 DEG C, and carries out irrigation liquid, is then sealed.
CN201910722079.1A 2019-08-06 2019-08-06 High-barrier composite layer medical infusion bag and production method thereof Active CN110497671B (en)

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CN107042128A (en) * 2015-12-15 2017-08-15 雷迪奥米特医学公司 Accommodate the bag of reference fluid
CN207044842U (en) * 2017-05-11 2018-02-27 南通富华医用包装有限公司 A kind of composite membrane for blood product packaging bag
CN108501483A (en) * 2016-05-18 2018-09-07 张�杰 Outer complex pocket infusion bag

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102414023A (en) * 2009-05-19 2012-04-11 赢创罗姆有限公司 Transparent, weather-resistant barrier foil, production thereof by means of lamination, extrusion lamination or extrusion coating
CN103118649A (en) * 2010-10-01 2013-05-22 富士胶片株式会社 Infusion bag and exterior film
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