CN110496247B - 一种骨再生材料的制备方法 - Google Patents
一种骨再生材料的制备方法 Download PDFInfo
- Publication number
- CN110496247B CN110496247B CN201910874191.7A CN201910874191A CN110496247B CN 110496247 B CN110496247 B CN 110496247B CN 201910874191 A CN201910874191 A CN 201910874191A CN 110496247 B CN110496247 B CN 110496247B
- Authority
- CN
- China
- Prior art keywords
- chitosan
- carotenoid
- bone
- polyethylene oxide
- regeneration material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000010478 bone regeneration Effects 0.000 title claims abstract description 27
- 239000000463 material Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000002121 nanofiber Substances 0.000 claims abstract description 69
- 229920001661 Chitosan Polymers 0.000 claims abstract description 50
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 50
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims abstract description 49
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 42
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims abstract description 39
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims abstract description 39
- 229940030275 epigallocatechin gallate Drugs 0.000 claims abstract description 39
- 239000002609 medium Substances 0.000 claims abstract description 38
- 230000008468 bone growth Effects 0.000 claims abstract description 37
- 235000021466 carotenoid Nutrition 0.000 claims abstract description 37
- 150000001747 carotenoids Chemical class 0.000 claims abstract description 37
- 239000003102 growth factor Substances 0.000 claims abstract description 36
- 239000002502 liposome Substances 0.000 claims abstract description 29
- 238000002791 soaking Methods 0.000 claims abstract description 29
- 238000006243 chemical reaction Methods 0.000 claims abstract description 27
- 238000009987 spinning Methods 0.000 claims abstract description 25
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 20
- 238000004108 freeze drying Methods 0.000 claims abstract description 20
- 238000001035 drying Methods 0.000 claims abstract description 16
- 238000004880 explosion Methods 0.000 claims abstract description 16
- 238000005406 washing Methods 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 230000003213 activating effect Effects 0.000 claims abstract description 9
- 239000001963 growth medium Substances 0.000 claims abstract description 8
- 230000007935 neutral effect Effects 0.000 claims abstract description 5
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 17
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 17
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 12
- 238000009832 plasma treatment Methods 0.000 claims description 12
- 230000001133 acceleration Effects 0.000 claims description 9
- 230000006196 deacetylation Effects 0.000 claims description 9
- 238000003381 deacetylation reaction Methods 0.000 claims description 9
- -1 polyoxyethylene Polymers 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 102000008143 Bone Morphogenetic Protein 2 Human genes 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 8
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 6
- 235000013793 astaxanthin Nutrition 0.000 claims description 6
- 239000001168 astaxanthin Substances 0.000 claims description 6
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 6
- 229940022405 astaxanthin Drugs 0.000 claims description 6
- 150000003904 phospholipids Chemical class 0.000 claims description 6
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 5
- 235000012661 lycopene Nutrition 0.000 claims description 5
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 5
- 229960004999 lycopene Drugs 0.000 claims description 5
- 239000001751 lycopene Substances 0.000 claims description 5
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 2
- 230000035876 healing Effects 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 36
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 210000000988 bone and bone Anatomy 0.000 description 8
- 239000010408 film Substances 0.000 description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 7
- 235000012000 cholesterol Nutrition 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 235000010445 lecithin Nutrition 0.000 description 7
- 229940067606 lecithin Drugs 0.000 description 7
- 239000000787 lecithin Substances 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000002390 rotary evaporation Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- 206010061363 Skeletal injury Diseases 0.000 description 2
- 150000001746 carotenes Chemical class 0.000 description 2
- 235000005473 carotenes Nutrition 0.000 description 2
- 239000012792 core layer Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000001700 effect on tissue Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000009818 osteogenic differentiation Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
- D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0092—Electro-spinning characterised by the electro-spinning apparatus characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/626—Liposomes, micelles, vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910874191.7A CN110496247B (zh) | 2019-09-17 | 2019-09-17 | 一种骨再生材料的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910874191.7A CN110496247B (zh) | 2019-09-17 | 2019-09-17 | 一种骨再生材料的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110496247A CN110496247A (zh) | 2019-11-26 |
CN110496247B true CN110496247B (zh) | 2021-09-10 |
Family
ID=68591977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910874191.7A Active CN110496247B (zh) | 2019-09-17 | 2019-09-17 | 一种骨再生材料的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110496247B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111494723B (zh) * | 2020-04-22 | 2021-10-12 | 苏州大学附属第一医院 | 一种微环境响应性免疫调控促神经再生微纳米纤维的制备方法 |
CN113209385B (zh) * | 2021-04-21 | 2022-04-22 | 华南理工大学 | 一种纳米硒复合纤维组织工程支架及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1238061C (zh) * | 2004-05-12 | 2006-01-25 | 天津大学 | 壳聚糖纳米超细纤维膜材料及其制备方法 |
WO2012048188A1 (en) * | 2010-10-07 | 2012-04-12 | Drixel University | Electrospun mineralized chitosan nanofibers crosslinked with genipin for bone tissue enginering |
CN103167868B (zh) * | 2010-10-14 | 2016-08-03 | 株式会社爱茉莉太平洋 | 包覆有脂质的水凝胶粒子及其制备方法 |
GB201101669D0 (en) * | 2011-01-31 | 2011-03-16 | Ip Science Ltd | Carotenoid particles and uses thereof |
CN103394114B (zh) * | 2013-07-03 | 2016-08-10 | 东华大学 | 一种医用敷料用壳聚糖基超细纤维载体材料的制备方法 |
CN103757743B (zh) * | 2013-12-25 | 2017-06-30 | 中国科学院化学研究所 | 包载脂质体的核壳纳米纤维 |
US10898608B2 (en) * | 2017-02-02 | 2021-01-26 | Nanofiber Solutions, Llc | Methods of improving bone-soft tissue healing using electrospun fibers |
CN110141527B (zh) * | 2019-06-14 | 2021-12-28 | 南通大学 | 一种营养角蛋白面膜的制备方法 |
-
2019
- 2019-09-17 CN CN201910874191.7A patent/CN110496247B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN110496247A (zh) | 2019-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Meinel et al. | Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications | |
CN111479771B (zh) | 纳米纤维结构及其使用方法 | |
Lu et al. | Nerve guidance conduits with hierarchical anisotropic architecture for peripheral nerve regeneration | |
US20110202125A1 (en) | Artificial stent and its preparation method | |
WO2020015046A1 (zh) | 一种具有天然抗菌药物缓释功能的医用缝合线及其制备方法 | |
US20130045266A1 (en) | Method for preparing polymeric biomaterials having immobilized drug delivery system comprising bioactive molecules loaded particle carrier | |
EP2797633B1 (en) | A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite | |
CN110496247B (zh) | 一种骨再生材料的制备方法 | |
CN108066815A (zh) | 一种骨植入材料及其制备方法和应用 | |
JP2020520344A (ja) | フィブロインを含むナノファイバーならびにヒドロゲルおよび前記ナノファイバーを含むシステム | |
EP2052740A1 (en) | Crosslinked gelatin gel multilayered structure, carrier for bioactive factor, preparation for release of bioactive factor, and their production methods | |
CN110975008B (zh) | 一种具有电刺激和促血管生成作用的神经修复载药系统的制备方法 | |
Luo et al. | In vivo evaluation of porous lithium-doped hydroxyapatite scaffolds for the treatment of bone defect | |
CN115487337A (zh) | 一种皮肤修复用敷料贴及其制备方法 | |
KR20160056345A (ko) | 나노 캐리어를 포함하는 생체 이식용 임플란트 및 이의 제조방법 | |
JP6429490B2 (ja) | コラーゲン線維架橋多孔体 | |
CN116096311A (zh) | 用导管桥接外周神经间隙以增强神经再生 | |
CN211156651U (zh) | 一种羊膜隐形接触镜 | |
CN102671243A (zh) | 一种负载季铵化壳聚糖/siRNA复合粒子的皮肤再生材料及其制备方法 | |
CN114425102A (zh) | 一种诱导皮肤组织再生的亲水性静电纺植入物 | |
CN110101901B (zh) | 硅酸铜中空微球复合纤维支架及其制备方法和用途 | |
CN114059350A (zh) | 一种天然长效抗菌抗炎蚕丝缝合线及其制备方法 | |
KR101725374B1 (ko) | 생체분자 및/또는 약물이 고정되어 있는 천연고분자 기반 섬유 패치 및 그 제조방법 | |
US20220090299A1 (en) | Nanofiber and nanowhisker-based transfection platforms | |
CN108744046A (zh) | 一种三明治式复合膜支架 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230508 Address after: Room 801, 85 Kefeng Road, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Dayu Chuangfu Technology Co.,Ltd. Address before: 226019 Jiangsu city of Nantong province sik Road No. 9 Patentee before: NANTONG University |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240612 Address after: Room 201, 2nd Floor, Building H, No. 7 Xiaoyang Road, Tanzhou Town, Zhongshan City, Guangdong Province, 528400 Patentee after: Zhongshan Xujia Biotechnology Co.,Ltd. Country or region after: China Address before: Room 801, 85 Kefeng Road, Huangpu District, Guangzhou City, Guangdong Province Patentee before: Guangzhou Dayu Chuangfu Technology Co.,Ltd. Country or region before: China |