CN110496064A - A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol - Google Patents
A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol Download PDFInfo
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- CN110496064A CN110496064A CN201910896075.5A CN201910896075A CN110496064A CN 110496064 A CN110496064 A CN 110496064A CN 201910896075 A CN201910896075 A CN 201910896075A CN 110496064 A CN110496064 A CN 110496064A
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- water
- cannabidiol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol, belong to chemical product technical field sheet.The toothpaste includes following raw material (being calculated in mass percent): water-soluble cannabidiol (0.5% ~ 5%), rubbing agent (40% ~ 60%), thickener (1% ~ 5%), surfactant (1% ~ 5%), preservative (0.1% ~ 0.5%), moisturizer (10% ~ 50%), essence (0.5% ~ 5%), sweetener (0.01% ~ 0.1%), surplus is water.Inventing the toothpaste is to have effects that anti-inflammatory, analgesic, antibacterial type toothpaste.
Description
Technical field
The present invention relates to a kind of daily chemical products, belong to chemical product technical field.More particularly to a kind of containing water-soluble hemp two
Toothpaste of phenol and preparation method thereof.
Background technique
With the change of eating habit, the oral health for increasing let us of especially high sugar, gourmet foods intake
Problem is increasingly severe.Up to 97% adult perplexs by different degrees of oral problem, calculus dentalis, saprodontia, gum
Problem, sensitivity of tooth, implication, tooth stain, plaque constitute the big oral problem of Chinese most common 7.It as the saying goes that " having a toothache is not
Disease, pain get up to want human life ", swelling and aching of gum not only will affect our normal living and studying work, also will affect our drink
It eats and speaks；And most of oral problem, such as implication, tooth stain are all caused by bacterium.Toothpaste is people's daily cleaning oral cavity, protects
Protect oral health necessary product, therefore develop it is a can anti-inflammatory, analgesic, and can bacteriostasis antibiosis the effect of type toothpaste extremely have
Necessity is beneficial to daily maintenence, relieves pain and deteriorates with oral problem.
Cannabidiol (Cannabidiol, abbreviation CBD) is the pure natural components extracted from cannabis plants, is in hemp
Non- additive ingredient, cannabidiol played by the double inhibition to cyclooxygenase and lipoxygenase analgesic and anti-inflammatory work
With pain stop and anti-inflammation effect is stronger.There are also certain antibacterial actions for cannabidiol: cannabidiol has staphylococcus and streptococcus
Certain inhibitory activity, minimum inhibitory concentration range are 1~5 μ g/mL.Therefore performance anti-inflammatory in toothpaste is added in cannabidiol to stop
Bitterly, antibacterial action one-stop can solve the problems, such as cleaning oral cavity and caring.
Although have been reported that cannabidiol is applied to dental care products in the prior art, such as:
CN109925246A discloses a kind of toothpaste and preparation method containing industrial hemp floral leaf extract, by high-purity cannabidiol
Toothpaste is added in oil or cannabidiol crystal, which has antibacterial anti-inflammatory, analgesic efficacy.But cannabidiol used in the invention
Oil or cannabidiol crystal be practically insoluble in water, be not easy to be absorbed by the body, it is difficult to effectively play cannabidiol anti-inflammatory analgetic and
Antibacterial effect.Therefore cannabidiol water solubility problems are solved, and cannabidiol is added in toothpaste and effectively plays anti-inflammatory analgetic, resist
Bacterium effect, is the technical problem to be solved in the present invention.
Summary of the invention
The present invention is to be embedded using carrier to cannabidiol, is allowed to form inclusion compound, is made into molecular capsule, solves
The water-soluble problem of cannabidiol, and a kind of preparation method of the toothpaste of containing water-soluble cannabidiol is provided, containing water-soluble is big
The toothpaste of numb diphenol can effectively play anti-inflammatory analgetic, antibacterial effect, prevention and alleviation oral health issue.
To achieve the above object, technical scheme is as follows:
A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol, the toothpaste are made of raw material below (with quality hundred
Score meter): water-soluble cannabidiol (0.5% ~ 5%), rubbing agent (40% ~ 60%), thickener (1% ~ 5%), surfactant (1% ~
5%), preservative (0.1% ~ 0.5%), moisturizer (10% ~ 50%), essence (0.5% ~ 5%), sweetener (0.01% ~ 0.1%), surplus are
Water.
In the present invention, it is preferred to be formed and (be calculated in mass percent) by raw material below: water-soluble cannabidiol 1% ~
2%, rubbing agent 50%, thickener 2%, surfactant 2%, preservative 0.2%, moisturizer 20%, essence 1%, sweetener 0.1%, it is remaining
Amount is water.
In the present invention, the rubbing agent is one or both of hydrated silica, aluminium hydroxide mixture；The thickening
Agent is carboxymethyl cellulose；The surfactant is sodium lauryl sulfonate；The preservative is sodium benzoate；The moisturizer
For one or both of glycerol, propylene glycol mixture；The essence is Mint Essence or lemon extract；The sweetener is wood
Sugar alcohol, water are deionized water.
In the present invention, water-soluble cannabidiol the preparation method is as follows:
1. high-purity C BD dissolution of crystals is heated to 30 ~ 60 DEG C of acceleration dissolutions when necessary with 2 ~ 5 times of ethyl alcohol, it is cold after dissolving completely
But spare to room temperature.
2. any one in alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-β-cyclodextrin is pure with 1 ~ 5 times
Water or alcohol-water dissolve by heating, it is to be dissolved completely after by step, 1. the solution is added thereto, be uniformly mixed.
3. the preparation of inclusion compound: in 2. mixed liquor merging closed container that step is prepared, at supersonic generator ultrasound
Manage 1 ~ 4h, 3000 ~ 5000W of ultrasonic power, 25 ~ 70 DEG C of temperature；After ultrasonic treatment, depressurized using Rotary Evaporators dense
Contracting removes most of solvent and moisture.The material being disposed is transferred in vacuum oven, is dried in vacuo 60 ~ 120h, very
Reciprocal of duty cycle -0.08MPa, 35 ~ 75 DEG C of temperature.
The content of cannabidiol is not less than 90% in the water solubility cannabidiol.
Preparing the preparation method of the toothpaste of containing water-soluble cannabidiol a kind of, steps are as follows:
1. weighing various components according to the ratio, surfactant, preservative are dissolved in water, are put into mixing kettle, by sweetener, thickening
Agent, moisturizer sequentially add above-mentioned solution, 100 revs/min of stirring 30min.
2. essence, rubbing agent, water-soluble cannabidiol are added in said mixture, lower 500 revs/min of vacuum state are stirred
2h is mixed, lotion is obtained.
3. being packed after standing 20min.
Compared with prior art, beneficial effects of the present invention are as follows:
Toothpaste of the invention joined water-soluble cannabidiol, anti-inflammatory analgetic, antibacterial, long-time service can effectively can prevent
With extenuate the oral problems such as swelling and aching of gum.
Specific embodiment
The present invention is further explained in the light of specific embodiments, but not limited to the examples.
Embodiment 1
(1) preparation of water-soluble cannabidiol
1. accurately weighing 100g cannabidiol solid powder (99% or more purity) and 1L single necked round bottom flask being added in 500g ethyl alcohol
In, stir 30min, dissolve cannabidiol solid sufficiently, it is to be dissolved completely after be cooled to room temperature it is spare.
2. accurately weighing 200g alpha-cyclodextrin and 600g level-one purified water being added in 2L single necked round bottom flask, flask is set
In 40 DEG C of water-baths, 30min is stirred, is substantially dissolved in alpha-cyclodextrin in water, forms clear solution；It is to be dissolved completely after will
1. the solution is added at one time wherein step, continues to stir 10min.
3. inclusion: 2. mixed liquor that step is prepared is transferred in supersonic generator, seals with rubber stopper bottleneck, ultrasound
4h, ultrasonic power 3000W are handled, temperature is 35 DEG C.After ultrasonic treatment, it is concentrated under reduced pressure using Rotary Evaporators (true
Reciprocal of duty cycle -0.1MPa, temperature 70 C), remove most of ethyl alcohol and moisture.The crude product formed after vacuum concentration, solid mass are smash
It is broken into powder, is laid in surface plate, vacuum oven is placed in, is dried in vacuo 72h(vacuum degree -0.08MPa, 35 DEG C of temperature).
(2) preparation of the toothpaste of containing water-soluble cannabidiol
1. preparing 100g toothpaste, various components are weighed according to the ratio.2g sodium lauryl sulfonate, 0.2g sodium benzoate are dissolved in water, it will
0.1g xylitol, 2g carboxymethyl cellulose, 20g glycerol sequentially add, 100 revs/min of stirring 30min.
2. 2g water solubility cannabidiol obtained in 1g Mint Essence, step (1), 50g hydrated silica are added above-mentioned mixed
It closes in object, the lower 500 revs/min of stirrings 2h of vacuum state obtains lotion.
3. being packed after standing 20min.
Embodiment 2
(1) the preparation method is the same as that of Example 1 for water-soluble cannabidiol.
(2) preparation of the toothpaste of containing water-soluble cannabidiol
1. preparing 100g toothpaste, various components are weighed according to the ratio, and 2g sodium lauryl sulfonate, 0.2g sodium benzoate are dissolved in water, it will
0.1g xylitol, 2g carboxymethyl cellulose, 20g propylene glycol sequentially add, 100 revs/min of stirring 30min.
2. by 1g water solubility cannabidiol obtained in 1g lemon extract, step (1), 30g hydrated silica, 20g hydroxide
Aluminium is added in said mixture, and the lower 500 revs/min of stirrings 2h of vacuum state obtains lotion.
3. being packed after standing 20min.
Embodiment 3: the experiment to swelling and aching of gum effect of the toothpaste of containing water-soluble cannabidiol
(1) experimental article: the toothpaste prepared by embodiment 1.
(2) experimental subjects: 50 suffer from the volunteer of swelling and aching of gum.Daily using twice, Brushing time is no less than
Two minutes, use such as table 1 of result after 10 days.
1 toothpaste anti-inflammatory analgesic effect of table
Containing water-soluble cannabidiol toothpaste anti-inflammatory analgetic effective percentage of the invention illustrates that anti-inflammatory analgesic effect is preferable, for a long time up to 70%
Using the oral problems such as gum analgesic, implication can be reduced.
Above embodiments are only the explanations that makes an explanation to the present invention, do not carry out any limit to protection scope of the present invention
System.To those skilled in the art, all same embodiments done without departing from the technology of the present invention spirit or change exist
Within protection scope of the present invention.
Claims (6)
1. a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol, the toothpaste are made of raw material below (with quality
Percentage meter): water-soluble cannabidiol (0.5% ~ 5%), rubbing agent (40% ~ 60%), thickener (1% ~ 5%), surfactant (1%
~ 5%), preservative (0.1% ~ 0.5%), moisturizer (10% ~ 50%), essence (0.5% ~ 5%), sweetener (0.01% ~ 0.1%), surplus
For water.
2. a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that institute
Stating rubbing agent is one or both of hydrated silica, aluminium hydroxide mixture；The thickener is carboxymethyl cellulose；It is described
Surfactant is sodium lauryl sulfonate；The preservative is sodium benzoate；The moisturizer is one of glycerol, propylene glycol
Or two kinds of mixtures；The essence is Mint Essence or lemon extract；The sweetener is xylitol, and water is deionized water.
3. a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that institute
The content of cannabidiol in water-soluble cannabidiol is stated not less than 90%.
4. a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that packet
Include following steps:
Various components are weighed according to the ratio, surfactant, preservative are dissolved in water, are put into mixing kettle, by sweetener, thickening
Agent, moisturizer sequentially add above-mentioned solution, stir 30min；
Essence, water-soluble cannabidiol, rubbing agent are added in mixture obtained by step (1), 2h is stirred under vacuum state, obtains
Lotion；
It is packed after standing 20min.
5. a kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that institute
The preparation method for stating water-soluble cannabidiol includes the following steps:
(1) high-purity cannabidiol crystal (purity is 99% or more) dissolution is heated to 30 DEG C ~ 60 when necessary with 2 ~ 5 times of ethyl alcohol
DEG C accelerate dissolution, dissolution completely after be cooled to room temperature it is spare；
(2) by 1 ~ 5 times of pure water of any one in alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-β-cyclodextrin or
Alcohol-water dissolve by heating, it is to be dissolved completely after step (1) described solution is added thereto, be uniformly mixed；
(3) preparation of inclusion compound: by the mixed liquor merging closed container of step (2) preparation, supersonic generator is ultrasonically treated 1
~ 4h, 3000 ~ 5000W of ultrasonic power, after ultrasonic treatment, are concentrated under reduced pressure using Rotary Evaporators, are gone by 25 ~ 70 DEG C of temperature
Except most of solvent and moisture.
6. the material being disposed is transferred in vacuum oven, it is dried in vacuo 60 ~ 120h, vacuum degree -0.08MPa, temperature
35 ~ 75 DEG C to get cannabidiol inclusion compound (water solubility).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910896075.5A CN110496064A (en) | 2019-09-22 | 2019-09-22 | A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910896075.5A CN110496064A (en) | 2019-09-22 | 2019-09-22 | A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol |
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| Publication Number | Publication Date |
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| CN110496064A true CN110496064A (en) | 2019-11-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910896075.5A Withdrawn CN110496064A (en) | 2019-09-22 | 2019-09-22 | A kind of toothpaste and preparation method thereof of containing water-soluble cannabidiol |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020128767A1 (en) * | 2018-12-19 | 2020-06-25 | Artiss Joseph D | Cannabinoid-containing composition |
| CN114159496A (en) * | 2020-09-10 | 2022-03-11 | 云南康恩贝植物研究院有限公司 | Hemp leaf extract and preparation method and application thereof |
-
2019
- 2019-09-22 CN CN201910896075.5A patent/CN110496064A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020128767A1 (en) * | 2018-12-19 | 2020-06-25 | Artiss Joseph D | Cannabinoid-containing composition |
| US11660283B2 (en) | 2018-12-19 | 2023-05-30 | Joyn Botanicals Ltd. | Cannabinoid-containing composition |
| CN114159496A (en) * | 2020-09-10 | 2022-03-11 | 云南康恩贝植物研究院有限公司 | Hemp leaf extract and preparation method and application thereof |
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Application publication date: 20191126 |