CN110470617A - It can recognize chip and detection method and its application - Google Patents
It can recognize chip and detection method and its application Download PDFInfo
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- CN110470617A CN110470617A CN201810448601.7A CN201810448601A CN110470617A CN 110470617 A CN110470617 A CN 110470617A CN 201810448601 A CN201810448601 A CN 201810448601A CN 110470617 A CN110470617 A CN 110470617A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3129—Determining multicomponents by multiwavelength light
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The present invention relates to field of chemical detection, a kind of recognizable chip, water quality many reference amounts detection device and detection method and its application are disclosed.The chip has multiple reaction tanks, and multiple reaction tanks are arranged in using the center of the recognizable chip to be correspondingly arranged on the label for determining detection signal with the reaction tank on more than one circumference in the center of circle.Recognizable chip light path of the invention is simple, and operation difficulty is low, can meet the requirement of multi-signal while detection.
Description
Technical field
The present invention relates to field of chemical detection, and in particular to a kind of recognizable chip and detection method and its application.
Background technique
One of developing direction of modern age instrument is miniaturization, integrated, portability.No matter in life science, chemical
The appearance of field or field of environment protection, micro-total analysis system (microTAS) has had resulted in revolutionary variation.It is micro- complete
The purpose of analysis is that function is integrated, sample preparation, separation, purifying, the reaction, prison that will need to realize in laboratory originally
The integration of the sophisticated functions such as survey focuses on the micro analytical device even chip of credit card-sized, therefore also referred to as " chip is real
Test room ".
Micro-total analysis technology is proposed the nineties in last century by Manz etc., has benefited from the phases such as micro electro mechanical processing, biochemistry
The development of pass technology has been increasingly becoming the cutting edge technology of analytical chemistry.It is with a series of spies for being different from traditional technology
Point: 1) effective heat and mass and characteristic dimension is small, thus processing speed is fast, high-efficient；2) reagent loss is small；3) equipment size
Small, light-weight, function integrated-type height；4) individual equipment is at low cost when producing in enormous quantities.It is widely applied rapidly in these advantages
In fields such as drug screening, high-flux sequence, molecular diagnosis, environment monitorings, portability and function integration are especially on site
In detection application, the scene that can not be popularized or be limited for laboratory test provides solution.Above-mentioned scene includes but unlimited
In: Emergent detection, water quality on-site test, biochemical analysis patient survey etc. certainly after accident.
The method detected to reaction signal on chip mainly has optical detection, Electrochemical Detection, Mass Spectrometer Method etc..Its
Middle optical detection includes fluorescence, absorbance, chemiluminescence, infrared spectroscopy, ultraviolet spectra, refractive index detection etc.；Electrochemical Detection
Including ampere, conductance, potentiometric detection etc.；Mass Spectrometer Method includes LC-MS spectrometry and Matrix assisted laser desorption ionization
Mass Spectrometer Method etc..Wherein optical detection due to high sensitivity, it is contactless do not influence reaction itself, noise it is smaller and specific good
The advantages that more favored.
As the necessary component of micro-total analysis technology, when being applied to on-site test scene, detection technique on chip
It should also be as developing towards micromation, portability, simple operation direction, such as hand-held spectrophotometer, the Raman of POS machine size
Spectrometer, infrared spectroscopy are even emerged with direct photographic analysis of smart phone etc. one after another.Simultaneously as the object of on-site test
Often more than one, multi-parameter, multiple target objects detect simultaneously becomes great demand.In view of this, how will there is multi-parameter detection
The micro-total analysis chip of function is organically combined with small-sized spectral analysis technique and is examined on site as the application of micro-total analysis Technique Popularizing
Survey scene major issue to be solved.
Currently, having been able to realize single sample introduction, more reactions while carry out, the method one of use by chip design people
As be that differential responses (being limited in differential responses pond) are distributed on the different spatial position of chip, read when or will inspection
Survey optical path is moved to differential responses Chi Chu and reads each reaction tank signal one by one, or obtains the signal of chip entirety, data analysis
The independent analysis of each signal of Shi Jinhang.The former requires the movement of light path, is not easy to be accurately positioned, and reading error is larger and is not easy
Operation, the latter be not suitable for then infrared spectroscopy, absorbance etc. can not Signal averaging analysis method.
Summary of the invention
The purpose of the invention is to overcome the problems, such as that chip detecting equipment application of the existing technology is limited, one is provided
The recognizable chip of kind and detection method and its application, the present invention are needed by can recognize that the label being arranged on chip can easily identify
The detection mode wanted, detection process is easy to operate, and the detection of a variety of methods can be rapidly completed.
To achieve the goals above, one aspect of the present invention provides a kind of recognizable chip, which has multiple reaction tanks,
Multiple reaction tanks are arranged in using the center of the recognizable chip as on more than one circumference in the center of circle, with the reaction tank
It is correspondingly arranged on the label for determining detection signal.
Preferably, the label being provided with for determining detection signal is respectively corresponded with each reaction tank.
Preferably, the recognizable chip is circle.
Preferably, the multiple reaction tank is arranged in using the center of the recognizable chip as on the circumference in the center of circle.
Preferably, the reaction tank is divided into multiple groups, and every group of reaction tank has multiple reaction tanks, every group of multiple reaction tanks
It is separately positioned on using the center of the recognizable chip as on one in one group of concentric circles in center of circle circumference.
Preferably, fixation member is provided at the center of the recognizable chip, the fixation member is used for can by described in
Identification chip is fixed on detection means, and the recognizable chip can be rotated in detection device.
Preferably, the chip is glass-chip, quartz chip or high molecular material chip.
Second aspect of the present invention provides a kind of water quality many reference amounts detection device based on recognizable chip, the water quality many reference amounts
Detection device includes chip-detecting apparatus, and is capable of fixing the above-mentioned recognizable chip on the chip-detecting apparatus, and
The recognizable chip can be rotated in the chip-detecting apparatus.
Preferably, there is signal identification component and more than one detection part, the signal in the chip-detecting apparatus
Identification component be used for detect on the recognizable chip for determine detection signal label, the detection part and it is described can
The label for determining detection signal on identification chip is corresponding.
Preferably, the recognizable chip can be by driving either manually or by the driving part in chip-detecting apparatus
It is rotated around the center of the recognizable chip.
Preferably, the detection part is chromaticity sensing section, absorbance detection component, fluorescence signal detection part, draws
One of graceful signal detecting part and infrared spectroscopy detection part are a variety of.
Preferably, which further includes sample introduction component, the driving part for driving chip rotation, signal
One of acquisition component, data processor, data output component and data transfer component are a variety of.
Third aspect present invention provides a kind of detection method, this method comprises: using above-mentioned recognizable chip or above-mentioned
Water quality many reference amounts detection device, by rotating the sample detection in the recognizable chip progress differential responses pond.
Fourth aspect present invention provides above-mentioned recognizable chip, above-mentioned water quality many reference amounts detection device or above-mentioned detection
Application of the method in environmental pollution analyte detection, in-vitro diagnosis or micro-total analysis chip field.
Under the scene for needing the optical signalling in the reaction tank to positions multiple on chip to measure, existing fixation
Chip, mobile light path method and obtain the method for entire chip signal that there are reading errors be big, method for detecting is limited etc.
Problem.The invention proposes a kind of fixed axis of rotation and optical path position, by rotary chip to reaction tank test one by one can
Identification chip, the beneficial effect that can achieve have:
1) detection mode of needs is easily identified by the label being arranged on chip, test is quick, accurate, repeatable
By force；
2) reading for realizing different location signal in turn, is rotated by chip, without the physical location of mobile test optical path,
Mechanical position is reduced, space is saved, while being reduced due to measurement error caused by positioning；
3) reading while can realizing multi-parameter in a short time；
4) allow using absorbance method, Raman spectroscopy, infra-red sepectrometry, ultraviolet spectroscopy, chemoluminescence method, fluorescence
The multiple spectrums analysis method such as method, chromatmetry, is not limited by analysis method；
5) due to acquiring signal one by one using for single reaction pond, method is integrally read simultaneously with chip (such as to chip
Entirety is taken pictures) ratioing signal intensity is high, noise is low.
6) detection that a chip can be completed in a short time a variety of different Testing index, detection process operation is used only
Simplicity, accuracy is high, is conducive to the miniaturization and portability of detection device, is applicable to the demand of a variety of detection scenes.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of recognizable chip of the invention；
Fig. 2 is the structural schematic diagram that another kind of the invention can recognize chip；
Fig. 3 is the structural schematic diagram of water quality many reference amounts detection device of the invention.
Description of symbols
1, light source 2, branch optical fiber
3, spectroscopy equipment
Specific embodiment
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
In the present invention, in the absence of explanation to the contrary, the noun of locality used such as " upper and lower, left and right " typically refers to
Upper and lower, left and right in attached drawing.
Recognizable chip provided by the invention, as shown in Figs. 1-2, the chip have multiple reaction tanks, multiple reactions
Pond is arranged in using the center of the recognizable chip to be correspondingly arranged with the reaction tank useful on more than one circumference in the center of circle
In the label for determining detection signal.
Such as above-mentioned, in the present invention recognizable chip, by being correspondingly arranged on reaction tank for determining detection signal
Label, so as to by rotary chip, be detected so that the reaction tank in chip is located in the use process that can recognize chip
The corresponding inspection positions of device, while can determine corresponding detection part.Preferably, it respectively corresponds and sets with each reaction tank
It is equipped with the label for determining detection signal, thus a chip can be completed in a short time the inspection of a variety of different Testing index
It surveys.And detection process is easy to operate, and accuracy is high, and can be suitable for various detection methods.
In the present invention, the label can be the label with specific color or shape, such as can pass through printing
Or the modes such as stickup are formed on the recognizable chip, the groove with specific shape, the notch being also possible on chip
Deng.There is no particular limitation for the shape of the label, achievees the purpose that identify and distinguish between, such as can be triangle, just
Rectangular, regular pentagon, star, naturally it is also possible to for number, letter or various irregular shapes.It can on it can recognize chip
1 above-mentioned label is only arranged, the label is for determining that the detection signal of chip (can be same detection signal, be also possible to
The detection ordering of unlike signal in multiple reaction tanks), thus when carrying out different tests with the recognizable chip of difference convenient for determination
Detection mode；One group of even each corresponding detection signal of reaction tank setting can also be corresponded on it can recognize chip, thus
One chip completes the detection of unlike signal.
In the present invention, there is no particular limitation for the shape of the recognizable chip, can be commonly used in micro-total analysis
The various shape of chip, from the point of view of convenient for rotation, the recognizable chip is preferably circular or regular polygon, more preferably
For circle.When the recognizable chip is round, preferably rotated around its center of circle.
According to the present invention, as long as differential responses pond can be with after the set-up mode of the multiple reaction tank rotates chip
Positioned at the detection zone of detection device.By the multiple reaction tank being arranged in the center of the recognizable chip
On more than one circumference in the center of circle, so as to complete the detection of multiple reaction tanks on chip with single detection part, reach
The purpose of batch detection.
In the present invention, the reaction tank on the recognizable chip can be 2 or more, preferably 5 or more, more preferably
It is 10-50.
A preferred embodiment according to the present invention, as shown in Figure 1, the multiple reaction tank setting with it is described can
The center of identification chip is on the circumference in the center of circle.The distance phase at center of the i.e. the multiple reaction tank apart from the recognizable chip
Deng.
A preferred embodiment according to the present invention, as shown in Fig. 2, the reaction tank is divided into multiple groups, and every group anti-
Ying Chi has multiple reaction tanks, and every group of multiple reaction tanks are separately positioned on using the center of the recognizable chip as the one of the center of circle
In group concentric circles on one circumference.That is center of every group of the multiple reaction tanks apart from the recognizable chip is equidistant.
At this point, there is no particular limitation for the set-up mode of label, from the point of view of makeup of conforming to the principle of simplicity is set, every group of reaction tank setting is preferably corresponded to
Detect the mark of same signal.
In accordance with the present invention it is preferred that being provided with fixation member at the center of the recognizable chip, the fixation member is used
It is fixed on detection means in by the recognizable chip, and the recognizable chip can be revolved in detection device
Turn.Above-mentioned rotation is preferably carried out around the center of the recognizable chip.The fixation member can be for buckle or screw thread etc.
Hollow bore configuration, groove structure, sucker structure or loop fastener structures of structure etc., as long as inspection can be fixed on the recognizable chip
It surveys on device, and the recognizable chip can be rotated in detection device.
According to the present invention, there is no particular limitation for the material of the chip, preferably smaller to the light absorption in test section
Translucency material, such as the chip can be for glass-chip, quartz chip or high molecular material chip etc..Wherein preferred glass
Glass chip, organic glass chip etc..
Water quality many reference amounts detection device provided by the invention, as shown in figure 3, the water quality many reference amounts detection device includes chip
Detection device, and the above-mentioned recognizable chip being fixed on the chip-detecting apparatus, and the recognizable chip can
It is rotated in detection device.
According to the present invention, in order to realize the detection of many kinds of parameters, there is signal identification in the preferably described chip-detecting apparatus
Component and more than one detection part, the signal identification component are used to detect detecting on the recognizable chip for determining
The label of signal, the detection part are used to determine that the detection label of signal to be corresponding on the recognizable chip.In core
In the rotary course of piece, the identification component, which identifies, can recognize the label that each reaction tank setting is corresponded on chip, then true respectively
The detection mode that fixed each reaction tank needs to use, to realize the detection respectively to unlike signal object.
According to the present invention, there is no particular limitation for the rotating manner of the recognizable chip, it is preferable that the recognizable core
Piece can be rotated in detection device by driving either manually or by the driving part in chip-detecting apparatus, preferably around
The center of the recognizable chip rotates.From detection device is simplified, cost is reduced, is convenient for from the point of view of portable operation, institute
Stating recognizable chip and preferably passing through can be manually rotated.And from detection efficiency is improved, realize that the angle detected on a large scale is examined in the short time
Consider, the recognizable chip preferably passes through the driving rotation of the driving part in chip-detecting apparatus.
According to the present invention, there is no particular limitation for the detection part, can be used for the various detection parts of chip detection,
Such as the detection part can be chromaticity sensing section, absorbance detection component, fluorescence signal detection part, Raman signal inspection
Survey one of component and infrared spectroscopy detection part or a variety of.It is wherein preferably absorbance detection component and/or fluorescence detection
Component.
A preferred embodiment according to the present invention, the detection part are set by light source 1, branch optical fiber 2 and spectrum
Standby 3 are constituted.The light source 1 is used for while detecting multiple anti-for generating the light for carrying out testing required wavelength, the branch optical fiber 2
Optical signalling in Ying Chi, the spectroscopy equipment 3 are used to collect optical signal generating or after absorbing.When on recognizable chip
When being provided with the more than two reaction tanks not waited with the centre distance of the recognizable chip, the branch optical fiber 2 can will be examined
The incident light of survey is divided into multichannel, to realize the detection for the reaction tank not waited with the centre distance of the recognizable chip.
According to the present invention, in order to realize that function is integrated, which can also include sample introduction component, letter
One of number acquisition component, data processor, data output component and data communication component are a variety of.It is more as the water quality
A kind of preferred embodiment of Parametric Detection equipment comprising data processor, data output component, data transfer component.
As the data processor, the central processing unit etc. including controller, arithmetic unit and register can be；As the number
It may include that there is display screen, touch screen, voice output of images outputting function etc. according to output block；It is passed as the data
Initial data can be uploaded to remote server and remotely be handled, then result is returned directly to designated terminal by defeated component,
Data processor can also be generated to treated information remote transmitting to cloud and carry out information collection.
The present invention also provides a kind of detection methods, this method comprises: using above-mentioned recognizable chip or above-mentioned water quality
Many reference amounts detection device, by rotating the sample detection in the recognizable chip progress differential responses pond.It is such as above-mentioned, it detected
Cheng Zhong, by the way that recognizable chip to be fixed in detection device, and by the modes rotary chip such as manual, so that differential responses pond
Into the detectable region of detection device, label on the signal identification component identification chip of detection device, detection part is to each
A reaction tank is detected.
The present invention also provides above-mentioned recognizable chip, above-mentioned water quality many reference amounts detection device or above-mentioned detection methods
In the application of environmental pollution analyte detection, in-vitro diagnosis or micro-total analysis chip field.It is above-mentioned recognizable chip of the invention, above-mentioned
Water quality many reference amounts detection device and above-mentioned detection method can be readily achieved the measurement of a large amount of samples in a short time, especially
It is suitble to the application of water quality many reference amounts detection.
In invention, there is no particular limitation for sample detected, as long as can be reacted or be detected in the chips
The fluid sample of operation, such as can be water sample, humoral sample, liquid food etc..
The present invention will be described in detail by way of examples below.In following embodiment, specific detection agents difference
The commercially available product for being WAK for the Japanese physical and chemical company trade mark vertical altogether, sample COD, total nitrogen, sulfide, the mixing of total phosphorus titer are molten
Liquid.
Embodiment 1
Using band, there are four types of the circles of not isolabeling can recognize that chip, all 12 reaction tanks are averaged scattering device away from core
On the circumference of the center of circle equidistance R of piece.Using the hand-held spectrophotometer structure of rotary fixing frame built in as shown in Figure 3
At water quality many reference amounts detection device, which is made of light source 1, branch optical fiber 2 and spectroscopy equipment 3, and is prefixed
Measuring wavelength is optional 410nm (total nitrogen), 620nm (COD), 665nm (sulfide), 880nm (total phosphorus).Hand is used when test
Dynamic formula rotary process, rotates chip around the center of circle.Specific detection agents are prefixed on it can recognize chip, are drawn by sample solution
After entering reaction tank, reacts with preset reaction reagent, absorption values are read after 30min.
1-3 is total nitrogen detection cell in 12 reaction tanks, and 4-6 is COD detection cell, and 7-9 is sulfide detection cell, and 10-12 is
Total phosphorus detection cell corresponds to reaction tank in 4 groups and different labels is respectively set.It can be manually rotated chip and pass through above-mentioned reaction tank one by one,
Water quality many reference amounts detection device determines the corresponding measurement wavelength of index to be detected after detecting above-mentioned label, then changes light source
Wavelength is simultaneously measured.The corresponding concentration measured is respectively such as the following table 1:
Table 1
Embodiment 2
Using band, there are four types of the circles of not isolabeling can recognize that chip, 4 reaction tanks are averaged scattering device away from chip
The distance in the center of circle is the circle that distance of the scattering device in the center of circle away from chip is R2 in addition, 4 reaction tanks are averaged on the circumference of R1
Zhou Shang.Water quality many reference amounts detection device is constituted using the hand-held spectrophotometer of rotary fixing frame built in as shown in Figure 3,
The spectrophotometer is made of light source 1, branch optical fiber 2 and spectroscopy equipment 3, and being prefixed measurement wavelength is optional 410nm
(total nitrogen), 620nm (COD), 665nm (sulfide), 880nm (total phosphorus).Hand rotary process is used when test, makes chip around circle
Heart rotation.Specific detection agents are prefixed on it can recognize chip, it is and preset anti-after sample solution is introduced reaction tank
It answers reagent to react, absorption values is read after 30min.
It 1,2 is total nitrogen detection cell that the distance in the center of circle away from chip, which is on the circumference of R1, in 8 reaction tanks, and 3,4 detect for COD
Pond, it 5,6 is sulfide detection cell that distance, which is on the circumference of R2,7,8 is total phosphorus detection cell.Reaction tank is corresponded in 4 groups to be respectively set
Different labels.It can be manually rotated chip and pass through above-mentioned reaction tank one by one, after water quality many reference amounts detection device detects above-mentioned label
It determines the corresponding measurement wavelength of index to be detected, is then measured.The corresponding concentration measured is respectively such as the following table 2:
Table 2
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (9)
1. a kind of recognizable chip, which is characterized in that the chip has multiple reaction tanks, and multiple reaction tanks are arranged with institute
The center for stating recognizable chip is to be correspondingly arranged on the reaction tank for determining detection letter on more than one circumference in the center of circle
Number label.
2. recognizable chip according to claim 1, wherein respectively correspond and be provided with for determining inspection with each reaction tank
Survey the label of signal.
3. recognizable chip according to claim 1, wherein, the chip is circle.
4. recognizable chip according to claim 1, wherein the reaction tank is arranged in the recognizable chip
The heart is on the circumference in the center of circle.
5. recognizable chip according to claim 1, wherein the reaction tank is divided into multiple groups, and every group of reaction tank has
Multiple reaction tanks, every group of multiple reaction tanks are separately positioned on one group of concentric circles using the center of the recognizable chip as the center of circle
In on one circumference.
6. recognizable chip described in any one of -5 according to claim 1, wherein set at the center of the recognizable chip
It is equipped with fixation member, the fixation member is used for the recognizable chip is fixed on detection means and described recognizable
Chip can be rotated in detection device.
7. recognizable chip described in any one of -5 according to claim 1, wherein the chip is glass-chip, quartz
Chip or high molecular material chip.
8. a kind of detection method, which is characterized in that this method comprises: using knowing described in any one of claim 1-7
Other chip, by rotating the sample detection in the recognizable chip progress differential responses pond.
9. recognizable chip described in any one of claim 1-7 or the detection method in claim 8 are in environment dirt
Contaminate the application of analyte detection, in-vitro diagnosis or micro-total analysis chip field.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810448601.7A CN110470617A (en) | 2018-05-11 | 2018-05-11 | It can recognize chip and detection method and its application |
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| CN201810448601.7A CN110470617A (en) | 2018-05-11 | 2018-05-11 | It can recognize chip and detection method and its application |
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| CN208366834U (en) * | 2018-05-11 | 2019-01-11 | 中国石油化工股份有限公司 | It can recognize chip and water quality many reference amounts detection device |
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| CN103389371A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Disc-type multi-index analysis chip |
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