CN110464775A - A kind of honeysuckle takes orally slimming drugs and preparation method thereof - Google Patents
A kind of honeysuckle takes orally slimming drugs and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Slimming drugs and preparation method thereof are taken orally the present invention relates to a kind of honeysuckle, and each component includes: 30~50 parts of agaricus bisporus water extract, 30~50 parts of navy bean water extract, 2~10 parts of Siraitia grosvenorii water extract, 10~20 parts of honeysuckle slag zymolyte, 10~15 parts of folium isatidis and 5~10 parts of glycosidase inhibitor according to parts by weight.Honeysuckle slag zymolyte uses the honeysuckle dregs of a decoction for raw material, is obtained by snail enzyme hydrolysis.Preparation method of the present invention is simple, step is easily operated, honeysuckle slag is digested using glusulase, obtained honeysuckle the zymolyte cellulose being decomposed, starch and albumen rich in, so that the effective component in honeysuckle slag sufficiently releases, it is easier to be absorbed by the body, collocation agaricus bisporus, navy bean water extract and be aided with Siraitia grosvenorii water extract correction taste, avoid the use of artificial synthesized food additives, the product being prepared improves mouthfeel, has the effect of that certain prevention and treatment are fat for doing to use for canteen.
Description
Technical field
The present invention relates to a kind of honeysuckles to take orally slimming drugs and preparation method thereof, belongs to natural product extraction and application technology
Field.
Background technique
With the continuous social and economic development, people's lives level is continuously improved, and obesity person increases therewith, fat
Inconvenience not only is brought to the work and life of people, also easily induces hypertension, diabetes, heart disease, fatty liver, cancer etc.
A variety of difficult and complicated cases reduce quality of life, improve the death rate, at present the common concern by medical circles or even society.Obesity belongs to
In lifestyle disease, occurrence and development process is very long, treatment obesity generally using oral fat-reducing medicament, liposuction, combustion rouge,
The gimmicks such as operation, side effect is big, risk is high, and treatment method is undesirable.Traditional Chinese medicine theory thinks, fat Etiological with
The factors such as eating and drinking without temperance, taste imbalance, phlegm dampness obstruction pattern are related, and human righteousness's virtual loss, inability of food and drink to be digested and transported is precise and tiny, leads to wet hot phlegm
The stasis of blood is jammed.In conjunction with theory of traditional Chinese medical science, for obese people, research and develop Traditional Chinese medicine health-preserving product, be the research and development of food and medicine industry hot spot it
One.
Honeysuckle is traditional Chinese medicine, is clearing heat and detoxicating top grade, it is not only clearing heat and detoxicating to record honeysuckle, and have help
Effect can correct human body its " healthy tendency virtual loss ".In industrialized production, honeysuckle waste residue is abandoned generally as waste, both unrestrained
Take resource, and pollute environment, be the waste resource for being worth research and development, honeysuckle waste residue is recycled, improves comprehensive benefit
With rate, have important practical significance and practical application value.
Agaricus bisporus is a kind of fungi based food, produces the busy season, and there are product overloading and inferior mushroom wasting phenomenon, navy bean is made
It is constantly in the status that awareness is low, utilization rate is low for the miscellaneous beans of coarse cereals, the two raw materials are all the fields for being worth development and utilization.Energy
It is enough to find effective formula, the processing technology of science is developed, is industry urgent problem to be solved.
Summary of the invention
The purpose of the present invention is to solve the above problems, develop a kind of using honeysuckle waste residue as the oral weight-reducing of raw material
Medicine improves the utility value of honeysuckle waste residue.
The present invention adopts the following technical scheme: a kind of honeysuckle takes orally slimming drugs, each component includes: according to parts by weight
30~50 parts of agaricus bisporus water extract, 30~50 parts of navy bean water extract, 2~10 parts of Siraitia grosvenorii water extract, gold
10~20 parts of honeysuckle flower slag zymolyte, 10-15 parts of folium isatidis and 5-10 parts of glycosidase inhibitor.
Further, the honeysuckle slag zymolyte uses the honeysuckle dregs of a decoction for raw material, is obtained by snail enzyme hydrolysis.
A kind of honeysuckle takes orally the preparation method of slimming drugs, includes the following steps:
(1) preparation of honeysuckle slag zymolyte: extracting honeysuckle waste residue is raw material, and solution water is added by solid-liquid ratio 1:10kg/L
And be sufficiently stirred, be added glusulase into honeysuckle waste residue, the additive amount of glusulase be honeysuckle waste residue weight 0.05~
0.2%, enzyme digestion reaction is carried out, extracting solution is filtered to obtain after reaction, honeysuckle slag zymolyte is obtained after concentrate drying；
(2) agaricus bisporus, navy bean, Siraitia grosvenorii the preparation of raw material water extract: are added to 10 times of volumes in extractor respectively
Deionized water using heat reflux by the way of extract, is extracted 1.5-2 hours under slight boiling condition, extracting solution is obtained by filtration, divide
Agaricus bisporus water extract, navy bean water extract and Siraitia grosvenorii water extract are obtained after not being concentrated under reduced pressure.
(3) it mixes: taking 30~50 parts of agaricus bisporus water extract, 30~50 parts of navy bean water extract, Siraitia grosvenorii water extract 2
~10 parts, 10~20 parts of honeysuckle slag zymolyte are uniformly mixed, and are added folium isatidis 10-15 parts, are eventually adding glycosidase inhibitor
5-10 parts obtain honeysuckle and take orally slimming drugs.
Further, in the step (1) hydrolysis temperature be 30 DEG C~40 DEG C, pH5~7, enzymolysis time for 24 hours~72h.
Preparation method of the present invention is simple, and step is easily operated, is digested using glusulase to honeysuckle slag, obtained gold
Honeysuckle flower the zymolyte cellulose being decomposed, starch and albumen rich in, so that the effective component in honeysuckle slag is abundant
Release, be easier to be absorbed by the body, collocation agaricus bisporus, navy bean water extract and be aided with Siraitia grosvenorii water extract correction mouth
Taste avoids the use of artificial synthesized food additives, and preparing product improves mouthfeel, has centainly for doing to use for canteen
Prevent and treat fat effect.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
The honeysuckle zymolyte being prepared in the present invention is that industrial honeysuckle slag digests to obtain by glusulase
, the content and performance and use amylase+protease water of the dietary fiber for the honeysuckle zymolyte that snail enzymatic treatment is obtained
Solution gained dietary fiber compares.
Honeysuckle zymolyte (A group): using honeysuckle slag for raw material, 35 DEG C of glusulase hydrolysis temperature, pH value 5.5, material
Liquor ratio 1:10 (kg/L), glusulase additive amount are honeysuckle slag dosage 0.1%, enzymolysis time 1.5h, honeysuckle dregs diet fibre
Average yield is 13.49%.
Common zymolyte (B group): using honeysuckle slag for raw material, pH 6.5, and 55 DEG C of temperature, solid-liquid ratio 1:10 (kg/L),
ɑ-amylase additive amount is the 0.4% of honeysuckle slag dosage, neutral proteinase additive amount 0.4%, hydrolysis time 90min；It is solvable
Property dietary fiber yield be 10.90%.
Its retention ability, expansive force hold oily power and see Tables 1 and 2 to the adsorption capacity to sodium taurocholate and cholesterol.
1 retention ability of table, expansive force and hold oily power measurement result
Adsorption capacity of the table 2 to sodium taurocholate and cholesterol
By Tables 1 and 2 it is found that A group passes through the retention ability of the honeysuckle slag of snail enzymatic treatment, expansive force, saturated fatty acid
It holds oily power and unsaturated fatty acid holds oily power and is above common zymolyte group, the gold and silver for the snail enzymatic treatment that pH is 2 and pH is 7
The sodium taurocholate and cholesterol level of flower zymolyte are above the content in common zymolyte.
Embodiment one: a kind of oral slimming drugs of honeysuckle, each component are calculated by weight as: 30 parts of agaricus bisporus water extract,
50 parts of navy bean water extract, 10 parts of Siraitia grosvenorii water extract, 10 parts of honeysuckle slag zymolyte, 15 parts of folium isatidis and glycosidase
5 parts of inhibitor.
Preparation method includes the following steps:
(1) preparation of honeysuckle slag zymolyte: extracting honeysuckle waste residue is raw material, and solution water is added by solid-liquid ratio 1:10kg/L
And be sufficiently stirred, glusulase is added into honeysuckle waste residue, the additive amount of glusulase is the 0.05% of honeysuckle waste residue weight, into
Row enzyme digestion reaction, hydrolysis temperature are 30 DEG C, pH5, and enzymolysis time for 24 hours, filters to obtain extracting solution after reaction, after concentrate drying
To honeysuckle slag zymolyte；
(2) agaricus bisporus, navy bean, Siraitia grosvenorii the preparation of raw material water extract: are added to 10 times of volumes in extractor respectively
Deionized water using heat reflux by the way of extract, is extracted 1.5 hours under slight boiling condition, extracting solution is obtained by filtration, distinguish
Agaricus bisporus water extract, navy bean water extract and Siraitia grosvenorii water extract are obtained after being concentrated under reduced pressure.
(3) it mixes: taking 30 parts of agaricus bisporus water extract, 50 parts of navy bean water extract, 10 parts of Siraitia grosvenorii water extract, gold and silver
10 parts of slag zymolyte of flower is uniformly mixed, and is added 15 parts of folium isatidis, is eventually adding 5 parts of glycosidase inhibitor and is obtained that honeysuckle is oral to be subtracted
Fertile medicine.
Embodiment two:
A kind of oral slimming drugs of honeysuckle, each component are calculated by weight as: 48 parts of agaricus bisporus water extract, navy bean water mention
Take 35 parts of object, 8 parts of Siraitia grosvenorii water extract, 15 parts of honeysuckle slag zymolyte, 12 parts of folium isatidis and 8 parts of glycosidase inhibitor.
Preparation method includes the following steps:
(1) preparation of honeysuckle slag zymolyte: extracting honeysuckle waste residue is raw material, and solution water is added by solid-liquid ratio 1:10kg/L
And be sufficiently stirred, glusulase is added into honeysuckle waste residue, the additive amount of glusulase is the 0.1% of honeysuckle waste residue weight, into
Row enzyme digestion reaction, hydrolysis temperature is 35 DEG C, pH6, enzymolysis time 36h and filters to obtain extracting solution after reaction, obtains after concentrate drying
To honeysuckle slag zymolyte；
(2) agaricus bisporus, navy bean, Siraitia grosvenorii the preparation of raw material water extract: are added to 10 times of volumes in extractor respectively
Deionized water using heat reflux by the way of extract, is extracted 1.5 hours under slight boiling condition, extracting solution is obtained by filtration, distinguish
Agaricus bisporus water extract, navy bean water extract and Siraitia grosvenorii water extract are obtained after being concentrated under reduced pressure.
(3) it mixes: taking 48 parts of agaricus bisporus water extract, 35 parts of navy bean water extract, 8 parts of Siraitia grosvenorii water extract, gold and silver
15 parts of slag zymolyte of flower is uniformly mixed, and is added 12 parts of folium isatidis, is eventually adding 8 parts of glycosidase inhibitor and is obtained that honeysuckle is oral to be subtracted
Fertile medicine.
Embodiment three:
A kind of oral slimming drugs of honeysuckle, each component are calculated by weight as: 50 parts of agaricus bisporus water extract, navy bean water mention
Take 30 parts of object, 2 parts of Siraitia grosvenorii water extract, 20 parts of honeysuckle slag zymolyte, 10 parts of folium isatidis and 10 parts of glycosidase inhibitor.
Preparation method includes the following steps:
(1) preparation of honeysuckle slag zymolyte: extracting honeysuckle waste residue is raw material, and solution water is added by solid-liquid ratio 1:10kg/L
And be sufficiently stirred, glusulase is added into honeysuckle waste residue, the additive amount of glusulase is the 0.2% of honeysuckle waste residue weight, into
Row enzyme digestion reaction, hydrolysis temperature is 40 DEG C, pH7, enzymolysis time 72h and filters to obtain extracting solution after reaction, obtains after concentrate drying
To honeysuckle slag zymolyte；
(2) agaricus bisporus, navy bean, Siraitia grosvenorii the preparation of raw material water extract: are added to 10 times of volumes in extractor respectively
Deionized water using heat reflux by the way of extract, extracted 2 hours under slight boiling condition, extracting solution be obtained by filtration, respectively into
Row obtains agaricus bisporus water extract, navy bean water extract and Siraitia grosvenorii water extract after being concentrated under reduced pressure.
(3) it mixes: taking 50 parts of agaricus bisporus water extract, 30 parts of navy bean water extract, 2 parts of Siraitia grosvenorii water extract, gold and silver
20 parts of slag zymolyte of flower is uniformly mixed, and is added 10 parts of folium isatidis, and being eventually adding 10 parts of glycosidase inhibitor, to obtain honeysuckle oral
Slimming drugs.
The honeysuckle being prepared in Example two takes orally slimming drugs, verifies to its fat-reducing effect.
Experimental program: taking healthy ICR mouse, male, 20 ± 2g of weight, be randomly divided into normal group, model group, honeysuckle it is thin
Powder group, agaricus bisporus group, navy bean group and product group of the invention.Normal group gives normal diet, and model group gives high lipid food,
Remaining several groups of mouse is in addition to feeding high lipid food daily, and the Honegsukle flower P.E of stomach-filling 100mg/ (kgd), agaricus bisporus are extracted respectively
The product that object, navy bean extract and the embodiment of the present invention two obtain.Successive administration 15 days.The weight for investigating each group mouse becomes
Change, fat changes, serum total cholesterol (TC) and triglycerides (TG) are horizontal.Different dosing group mouse weight result of variations such as table
Shown in 3.
3 different dosing group mouse weight Changeement result of table (N=10)
Compared with model group: * P < 0.05.
As seen from the results in Table 3, have the tendency that mitigation, and Lee' compared with before perfusion using the mouse weight of this product stomach-filling
S index is lower than independent stomach-filling honeysuckle group, agaricus bisporus group and navy bean group, and is far below model group, this shows using the present invention
Honeysuckle take orally slimming drugs to weight-reducing have certain effect.
The results are shown in Table 4 for the fatty weight in wet base and fat coefficient of each group mouse.
4 different dosing group mouse adipose weight in wet base of table and fat coefficient comparison
As seen from the results in Table 4, the mouse of slimming drugs stomach-filling is taken orally using the honeysuckle that the embodiment of the present invention two is prepared
Fatty weight in wet base and fat coefficient be significantly lower than model group, this shows the oral weight-reducing medical instrument of the honeysuckle that is prepared of the present invention
There is certain reduction fat, and effect is better than independent component honeysuckle, agaricus bisporus and navy bean group.
To in mouse blood serum total cholesterol and triglycerides test and analyze, the results are shown in Table 5.
The analysis of table 5 different dosing group mice serum total cholesterol and triglycerides
As seen from the results in Table 5, the mouse of slimming drugs stomach-filling is taken orally using the honeysuckle that the embodiment of the present invention two is prepared
Serum in TG and TC content apparent decline has been obtained compared with model group, and in serum TG and TC content be lower than independent stomach-filling
Component honeysuckle, agaricus bisporus and navy bean group.
Claims (4)
1. a kind of honeysuckle takes orally slimming drugs, it is characterised in that: each component include: according to parts by weight agaricus bisporus water extract 30~
50 parts, 30~50 parts of navy bean water extract, 2~10 parts of Siraitia grosvenorii water extract, 10~20 parts of honeysuckle slag zymolyte, smalt
10~15 parts of leaf and 5~10 parts of glycosidase inhibitor.
2. honeysuckle as described in claim 1 takes orally slimming drugs, it is characterised in that: the honeysuckle slag zymolyte uses gold and silver
Anther slag is raw material, is obtained by snail enzyme hydrolysis.
3. the preparation method that a kind of honeysuckle described in claim 1 takes orally slimming drugs, characterized by the following steps:
(1) preparation of honeysuckle slag zymolyte: extracting honeysuckle waste residue is raw material, and solution water is added by solid-liquid ratio 1:10~15kg/L
And be sufficiently stirred, be added glusulase into honeysuckle waste residue, the additive amount of glusulase be honeysuckle waste residue weight 0.05~
0.2%, sufficiently progress enzyme digestion reaction, filter to obtain extracting solution after reaction, honeysuckle slag zymolyte are obtained after concentrate drying；
(2) agaricus bisporus, navy bean, Siraitia grosvenorii the preparation of raw material water extract: are added to 10~15 times of volumes in extractor respectively
Deionized water using heat reflux by the way of extract, is extracted 1.5-2 hours under slight boiling condition, extracting solution is obtained by filtration, divide
Agaricus bisporus water extract, navy bean water extract and Siraitia grosvenorii water extract are obtained after not being concentrated under reduced pressure.
(3) it mixes: taking 30~50 parts of agaricus bisporus water extract, 30~50 parts of navy bean water extract, Siraitia grosvenorii water extract 2~10
Part, 10~20 parts of honeysuckle slag zymolyte be uniformly mixed, be added 10~15 parts of folium isatidis, be eventually adding glycosidase inhibitor 5~
10 parts obtain honeysuckle and take orally slimming drugs.
4. the preparation method that honeysuckle as claimed in claim 3 takes orally slimming drugs, it is characterised in that: enzyme in the step (1)
Solve temperature be 30 DEG C~40 DEG C, pH5~7, enzymolysis time for 24 hours~72h.
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| CN114457131A (en) * | 2021-12-22 | 2022-05-10 | 哈尔滨理工大学 | Degradable bacterial cellulose nano material and production method thereof |
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