CN110448579A - A kind of quick anti-trioxypurine formula - Google Patents
A kind of quick anti-trioxypurine formula Download PDFInfo
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- CN110448579A CN110448579A CN201910853787.9A CN201910853787A CN110448579A CN 110448579 A CN110448579 A CN 110448579A CN 201910853787 A CN201910853787 A CN 201910853787A CN 110448579 A CN110448579 A CN 110448579A
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- Prior art keywords
- cordyceps militaris
- trioxypurine
- maltodextrin
- maltitol
- oligofructose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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Abstract
The present invention provides a kind of quick anti-trioxypurine formula, and the raw material of the recipe ingredient include Cordyceps militaris extract, oligofructose, maltitol, maltodextrin；The raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract 1-2g, oligofructose 1-3g, maltitol 0.8-2g, maltodextrin 0.5-3g.The present invention can play the role of quickly reducing uric acid level, repair damaging cells, promote metabolism, prevent gout.
Description
Technical field
The present invention relates to pharmaceutical technology field, in particular to a kind of quick anti-trioxypurine formula.
Background technique
As economic level improves the change with people life style and diet structure, the hair of gout and hyperuricemia
Sick rate is worldwide presented ascendant trend, and China's Patients with Hyperuricemia number is up to 1.7 hundred million, and wherein patient with gout is more than
80000000 people, and just increased sharply with annual 9.7% growth rate.It is expected that the year two thousand twenty, gout number is up to 100,000,000.Height urine
Acidaemia usually with hyperlipidemia, high blood pressure, do by the diseases such as diabetes B, obesity, atherosclerosis, coronary heart disease
Method, and and blood vessel, heart, kidney is bad closely related, seriously threatens human health.
High lithemia symptom can cause gout, and sudden arthritis often occurs at night in patient with gout, and morbidity is anxious,
There is serious pain, oedema, redness and inflammation in joint part, and big toe is burnt equally, felt bad extremely, people with high uric acid is opened
Begin frightened complication, and many patient with gout cannot be alleviated and treat, eventually dead because of kidney failure.
There are mainly two types of the drug markets of existing treatment hyperuricemia, and one kind is alkalinity, neutralizes intracorporal acidity, and another
One kind is diuretics, promotes the excretion of kidney, uric acid is excluded in vitro, therefore general to current high lithemia symptom effect, and
It can not prevent the generation of gout.The effect of data and existing drug and health care product for the people with high uric acid of rising, I
Strive to find a kind of food that can intervene people with high uric acid, effect through diet helps people with high uric acid to improve body,
Prevent gout, and alleviates the pain sensation for having broken out gout patient.
Summary of the invention
The purpose of the present invention is to provide a kind of quick anti-trioxypurine formula, the present invention, which can play, quickly reduces uric acid level
Effect repairs damaging cells, promotes metabolism, prevents gout.
The purpose of the present invention is be achieved by following technical proposals: a kind of quick anti-trioxypurine formula, the formula group
The raw material divided include Cordyceps militaris extract, oligofructose, maltitol, maltodextrin；The raw material weight of the recipe ingredient
It is as follows to measure component: Cordyceps militaris extract 1-2g, oligofructose 1-3g, maltitol 0.8-2g, maltodextrin 0.5-3g.
As a kind of perferred technical scheme: the raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract
1-1.5g, oligofructose 1-2g, maltitol 1-1.5g, maltodextrin 0.5-2g.
As a kind of perferred technical scheme: the raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract
1.25mg, oligofructose 1.5g, maltitol 1.25g, maltodextrin 1g.
A kind of quick anti-trioxypurine formula, the preparation method is that:
S1: carrying out low temperature drying for the Cordyceps militaris of harvesting, rear to crush --- to impregnate --- enzymatic hydrolysis --- homogeneous --- secondary water
Mentioning -- spray drying obtains the Cordyceps militaris extract rich in cordycepin and selenium；
S2: mixing after oligofructose, maltitol, maltodextrin, Cordyceps militaris extract are sieved respectively, spare；
S3: the mixture in step 2 is sieved again, is then put into blender and is mixed；
S4: the mixture in step 2 is put into one-step-granulating method, carries out granulating process；
S5: mixture is cooling, and sterile workshop completes canned molding.
As a kind of perferred technical scheme: 80 mesh of grit number was mixed in the S2.
As a kind of perferred technical scheme: mixture crosses grit number 150-200 mesh in the S3.
As a kind of perferred technical scheme: by purple before oligofructose, maltitol, maltodextrin mixing in the S4
Outside line irradiation, irradiation time 2 hours.
Compared with prior art, the winning feature that the present invention has the prior art and can not reach is:
The present invention is safe, without side-effects, can quickly reduce uric acid level and reduce uric acid synthesis, from root reduction uric acid, clearly
Except inflammatory reaction, increase discharge capacity, promote kidney and intestine beneficial bacteria colony growth promote excretion increase high osmosis, repair by
Cell is damaged, eubolism is restored.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments, based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
A kind of quick anti-trioxypurine formula, which is characterized in that the raw material of the recipe ingredient include Cordyceps militaris extract, low
Fructooligosaccharides, maltitol, maltodextrin；The raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract 1-2g, low
Fructooligosaccharides 1-3g, maltitol 0.8-2g, maltodextrin 0.5-3g.
Specific embodiment one
The raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract 1-1.5g, oligofructose 1-2g, malt
Sugar alcohol 1-1.5g, maltodextrin 0.5-2g.
It is described the preparation method is as follows:
S1: carrying out low temperature drying for the Cordyceps militaris of harvesting, rear to crush --- to impregnate --- enzymatic hydrolysis --- homogeneous --- secondary water
Mentioning -- spray drying obtains the Cordyceps militaris extract rich in cordycepin and selenium；
S2: mixing after oligofructose, maltitol, maltodextrin, Cordyceps militaris extract are sieved respectively, spare；
S3: the mixture in step 2 is sieved again, is then put into blender and is mixed；
S4: the mixture in step 2 is put into one-step-granulating method, carries out granulating process；
S5: mixture is cooling, and sterile workshop completes canned molding.
Specific embodiment two
The raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract 1.25g, oligofructose 1.5g, malt
Sugar alcohol 1.25g, maltodextrin 1g.
It is described the preparation method is as follows:
S1: carrying out low temperature drying for the Cordyceps militaris of harvesting, rear to crush --- to impregnate --- enzymatic hydrolysis --- homogeneous --- secondary water
Mentioning -- spray drying obtains the Cordyceps militaris extract rich in cordycepin and selenium；
S2: mixing after oligofructose, maltitol, maltodextrin, Cordyceps militaris extract are sieved respectively, spare；
S3: the mixture in step 2 is sieved again, is then put into blender and is mixed；
S4: the mixture in step 2 is put into one-step-granulating method, carries out granulating process；
S5: mixture is cooling, and sterile workshop completes canned molding.
80 mesh of grit number was mixed in the S2.
Mixture crosses grit number 150-200 mesh in the S3.
It is irradiated before oligofructose, maltitol, maltodextrin mixing by ultraviolet light in the S4, irradiation time 2 hours.
The sugar alcohol it is low in calories, low G I, metabolic process without insulin participate in and not by oral microorganism decompose utilize
Etc. all having good value medical health care, therefore the patient that sugar alcohol needs to control diet heat to diabetes, obesity etc. has
Benefit, while also playing the role of pre- anti-caries, improving function of intestinal canal.In addition, maltitol, lactitol, sorbierite, mannitol is quiet
Arteries and veins infusion preparation is also clinically common dehydrated pharmaceutical, and other sugar alcohols that hesitate in maltitol relax bowel and defecation after tested, can
Favorably uric acid to be excluded.
It can inhibit xanthine oxidase rich in beneficiating ingredients such as cordycepin, selenium, Cordyceps sinensis polysaccharides in Cordyceps militaris extract in the present invention
Change enzymatic activity, inhibits uric acid synthesis.Creatinine, the uric acid level in hyperuricemia serum are reduced, is prevented and treated from the source of generation
Hyperuricemia is broken out.
The uric acid is the excretion pathway by kidney.The main excretion pathway of Uric Acid is exactly the renal tubule filtering through kidney
Metabolism.The vigor of kidney antioxidase can be enhanced in Cordyceps militaris, improves glomerular filtration, promotes the Regeneration and Repair of renal tubule.
Delay renal hypofunction, inhibits the remaining glomerulosclerosis of nephridial tissue and the development of renal tubular-interstitial injury, improve renal tubule pair
The metabolism of uric acid.Uric acid is also by large intestine excretion pathway simultaneously.Normal person daily about 1/3 uric acid in enteron aisle, warp
Some intestinal beneficial bacterium degradation treatments are crossed, prebiotics (oligofructose) contained in formula can promote intestinal beneficial bacterium all living creatures
It is long, accelerate the metabolism to uric acid.
The cordycepin is natural anti-inflammatory factors, and adjustable inflammatory reaction, and intervening rapidly reduces pain, in addition
Cordycepin is nucleoside derivate again, can rapidly enter cell, repairs damaged cell, is metabolized back to human body and reforms often.
Efficient combination of the present invention can quickly reduce uric acid content according to the formula after appropriate compatibility as with Cordyceps militaris,
The activity and molecular structure of cordycepin are not changed in extraction Cordyceps militaris process simultaneously, the pharmacological property of drug is with more steady upon mixing
It is qualitative.
According to clinical statistics analysis shows that, investigation is sampled to the patient for taking this product, verifies clinical effectiveness, especially taken out
25 hyperuricemia patients are taken, wherein male patient 20, female patient 5, oldest 50 years old, minimus 25 years old,
Without important organ diseases such as serious angiocarpy, kidney, lungs.
The inventive formulation of 1 month dosage is provided for 25 patients, it is early to take after the meal, first day, uric acid number was measured on an empty stomach
Value, after take product 1 and as a child measure uric acid numerical value again, and record data, be measured as in the 7th day morning, surveying on an empty stomach for the third time
Uric acid level is measured, measures on an empty stomach the 4th morning for being measured as the 28th day, records data, and compare.
Measuring instrument: three promise uric acid measurement instrument.
Correlation data result record is as follows:
Data comparison is shown, takes product for a period of time, and reducing occurs in uric acid numerical value, and the ratio that reduces the moon is 12%.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (7)
1. a kind of quick anti-trioxypurine formula, which is characterized in that the raw material of the recipe ingredient include Cordyceps militaris extract, oligomeric
Fructose, maltitol, maltodextrin；The raw-material weight component of the recipe ingredient is as follows: Cordyceps militaris extract 1-2g, oligomeric
Fructose 1-3g, maltitol 0.8-2g, maltodextrin 0.5-3g.
2. a kind of quick anti-trioxypurine formula according to claim 1, it is characterised in that: the raw material weight of the recipe ingredient
It is as follows to measure component: Cordyceps militaris extract 1-1.5mg, oligofructose 1-2g, maltitol 1-1.5g, maltodextrin 0.5-2g.
3. a kind of quick anti-trioxypurine formula according to claim 1, it is characterised in that: the raw material weight of the recipe ingredient
It is as follows to measure component: Cordyceps militaris extract 1.25g, oligofructose 1.5g, maltitol 1.25g, maltodextrin 1g.
4. a kind of quick anti-trioxypurine formula according to claim 1, which is characterized in that the preparation method is that:
S1: carrying out low temperature drying for the Cordyceps militaris of harvesting, rear to crush --- to impregnate --- enzymatic hydrolysis --- homogeneous --- secondary water proposes -- spray
Mist is dry, obtains the Cordyceps militaris extract rich in cordycepin and selenium；
S2: mixing after oligofructose, maltitol, maltodextrin, Cordyceps militaris extract are sieved respectively, spare；
S3: the mixture in step 2 is sieved again, is then put into blender and is mixed；
S4: the mixture in step 2 is put into one-step-granulating method, carries out granulating process；
S5: mixture is cooling, and sterile workshop completes canned molding.
5. a kind of quick anti-trioxypurine formula according to claim 4, which is characterized in that mixed grit number 80 in the S2
Mesh.
6. a kind of quick anti-trioxypurine formula according to claim 4, which is characterized in that mixture crosses grit number in the S3
150-200 mesh.
7. a kind of quick anti-trioxypurine formula according to claim 4, which is characterized in that oligofructose, malt in the S4
It is irradiated before sugar alcohol, maltodextrin mixing by ultraviolet light, irradiation time 2 hours.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910853787.9A CN110448579A (en) | 2019-09-10 | 2019-09-10 | A kind of quick anti-trioxypurine formula |
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| CN201910853787.9A CN110448579A (en) | 2019-09-10 | 2019-09-10 | A kind of quick anti-trioxypurine formula |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112189849A (en) * | 2020-10-28 | 2021-01-08 | 无锡市世纪生物工程有限公司 | Uric acid reducing composition and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473977A (en) * | 2014-11-18 | 2015-04-01 | 广东省微生物研究所 | Cordyceps militaris water extract as well as preparation method and application thereof |
| CN107788315A (en) * | 2017-11-27 | 2018-03-13 | 威海养经堂医药科技有限公司 | A kind of Cordyceps militaris LBP-X solid beverage |
-
2019
- 2019-09-10 CN CN201910853787.9A patent/CN110448579A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473977A (en) * | 2014-11-18 | 2015-04-01 | 广东省微生物研究所 | Cordyceps militaris water extract as well as preparation method and application thereof |
| CN107788315A (en) * | 2017-11-27 | 2018-03-13 | 威海养经堂医药科技有限公司 | A kind of Cordyceps militaris LBP-X solid beverage |
Non-Patent Citations (4)
| Title |
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| 王飞生等主编: "《食品营养卫生与健康》", 29 February 2016, 中国质检出版社、中国标准出版社 * |
| 谢红旗等: "酶法提取蛹虫草中虫草素的研究", 《时珍国医国药》 * |
| 邹琳等: "食品中降尿酸活性物质及其作用机理研究进展", 《食品工业科技》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112189849A (en) * | 2020-10-28 | 2021-01-08 | 无锡市世纪生物工程有限公司 | Uric acid reducing composition and preparation method thereof |
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Application publication date: 20191115 |