CN110448574A - Composition and preparation method thereof for treating tympanitis - Google Patents
Composition and preparation method thereof for treating tympanitis Download PDFInfo
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- CN110448574A CN110448574A CN201910872112.9A CN201910872112A CN110448574A CN 110448574 A CN110448574 A CN 110448574A CN 201910872112 A CN201910872112 A CN 201910872112A CN 110448574 A CN110448574 A CN 110448574A
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- borneol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/345—Nitrofurans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention discloses a kind of compositions and preparation method thereof for treating tympanitis.The composition is made of the raw material of following parts by weight: 30~45 parts of alum, 25~35 parts of borneol, 8~15 parts of nitrofurazone and 95~105 parts of cuttlebone.The composition can kill the bacterium of ear channel skin as a result, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Have the function of clearing heat and detoxicating, erosion prevention and muscle growing simultaneously, is beneficial to that the surface of a wound is promoted to grow new skin, so that patient be helped to restore.Preparation method takes cuttlebone and pounce is made the following steps are included: according to the material rate in composition described above；According to the material rate in composition described above, alum, borneol and the nitrofurazone in the composition for the treatment of tympanitis is taken, and pulverize, obtain mixed powder；Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.The preparation method step is simple, easy to operate, beneficial to promoting.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of composition and its preparation side for treating tympanitis
Method.
Background technique
Tympanitis is to involve the inflammatory lesion of middle ear all or part structure, be mainly shown as otalgia, suppurate, eardrum is worn
Hole, Hearing etc., serious person can cause the outer complication of encephalic, cranium, such as purulent meningitis, brain abscess, labyrinthitis, facial nerve
Paralysis, or even can threat to life.
Tympanitis is mainly infected by course of eustachian tube.For example, pharyngeal after flu, nose inflammation is spread to Eustachian tube,
There is congested, swelling in pharyngeal opening of auditory tube and lumen mucous membrane, and ciliary movement occurs obstacle, causes tympanitis.Otitis media acuta it is normal
See that pathogenic bacteria are mainly pneumococcus, haemophilus influenzae etc..Due to containing a large amount of virus and bacterium in nasal mucus, if two sides
Nostril all pinches and firmly blows, then pressure forces nasal mucus to squeeze out to choana, reaches Eustachian tube, causes tympanitis.In addition, when swimming
Water may also induce tympanitis by the infection of the tympanic membrane perforation caused by pharynx nasalis, wound.In some cases, some baby
Young children.Its pathogenesis, frequently with supine position, since the Eustachian tube of child is more straight, and is managed when infant sucks the breast
Chamber is shorter, and internal diameter is wider, and milk can choke into middle ear through Eustachian tube and cause tympanitis.In addition, listening big decibel with earphone for a long time
Music also easily cause chronic otitis media.
However tympanitis is in clinical treatment, it usually needs for oral administration and outer parallel processing in two ways.Due to drug kind
Class is various and needs often to carry out coating to ear, and some patientss are easy to forget thus to lead to illness using drug because of some reasons
It cannot control in time, so that illness cannot be treated effectively.
There are problems that more than type and need frequent medication the drug for treating tympanitis in the prior art, propose it is a kind of more
For reasonable technical solution, with solve the problems, such as there is currently.
Summary of the invention
It is an object of that present invention to provide a kind of for treating the composition of tympanitis, to solve the problems, such as that medication is frequent.
It is another object of the present invention to provide a kind of for treating the preparation method of the composition of tympanitis, with simplification
Preparation step.
To achieve the goals above, present disclose provides a kind of for treating the composition of tympanitis, the composition by with
The raw material of lower parts by weight forms: 30~45 parts of alum, 25~35 parts of borneol, 8~15 parts of nitrofurazone and cuttlebone 95~105
Part.
Further, the composition is made of the raw material of following parts by weight: 32~43 parts of alum, 27~33 parts of borneol, furan
It mutters 8~13 parts of XiLin and 97~104 parts of cuttlebone.
Further, the composition is made of the raw material of following parts by weight: 35~40 parts of alum, 28~32 parts of borneol, furan
It mutters 9~11 parts of XiLin and 98~102 parts of cuttlebone.
Specifically, the composition is made of the raw material of following parts by weight: 30 parts of alum, 25 parts of borneol, 8 parts of nitrofurazone and
95 parts of cuttlebone.
Specifically, the composition is made of the raw material of following parts by weight: 35 parts of alum, 27 parts of borneol, 9 parts of nitrofurazone and
97 parts of cuttlebone.
Specifically, the composition is made of the raw material of following parts by weight: 38 parts of alum, 30 parts of borneol, 10 parts of nitrofurazone
With 100 parts of cuttlebone.
Specifically, the composition is made of the raw material of following parts by weight: 42 parts of alum, 33 parts of borneol, 11 parts of nitrofurazone
With 102 parts of cuttlebone.
Specifically, the composition is made of the raw material of following parts by weight: 45 parts of alum, 35 parts of borneol, 12 parts of nitrofurazone
With 105 parts of cuttlebone.
Optionally, the nitrofurazone is pulvis.
It is a kind of for treating the preparation method of the composition of tympanitis, comprising the following steps:
It takes cuttlebone and pounce is made, cross 120~150 meshes；
Alum, borneol and the nitrofurazone in the composition for the treatment of tympanitis are taken, and is pulverized, crosses 150~200
Mesh obtains mixed powder；
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
Optionally, pounce is crossed into 120 meshes；Mixed powder is crossed into 150 meshes.
Optionally, pounce is crossed into 130 meshes；Mixed powder is crossed into 170 meshes.
Optionally, pounce is crossed into 140 meshes；Mixed powder is crossed into 180 meshes.
Optionally, pounce is crossed into 150 meshes；Mixed powder is crossed into 200 meshes.
Further, the mass ratio of mixed powder and pounce is between 33/50~9/10.
Optionally, the mass ratio of mixed powder and pounce is 33:50.
Optionally, the mass ratio of mixed powder and pounce is 39:50.
Optionally, the mass ratio of mixed powder and pounce is 9:10.
The characteristic of part material is as follows in the present invention:
Alum is to crystallize made of the processed refinement of mineral alunite.Main chemical compositions are 12 hydrazine aluminum sulfate potassium.
Minerals Chinese medicine, external application can detoxify desinsection, and eliminating dampness is antipruritic；Interior hemostasis, antidiarrheal, resolving sputum.Cure mainly scald, aphthae,
The diseases such as belepharitis ciliaris eye and Ting discharging ear have antibacterial action, convergent effect.Alum nature and flavor are sour and astringent, tremble with fear, there is micro- poison, can be a small amount of
It is edible.
Borneol is the native crystal compound that is precipitated in the resin of Dipterocarpaceae plant borneo camphor tree, artificial synthesized machine
Make ice the processed goods of piece and Blumea balsamifera distillation crystallization.Kapur aiphyllium, is born in tropical rain forest, with being distributed in Southeast Asia
Area.Borneol is Chinese medicine, has the function of inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison and improving eyesight.It swells in addition, borneol can also treat hot eyes
Bitterly, eyes are red, throat throat has the heat symptom-complexs such as aphtha, and borneol has good therapeutic effect.Further for some sores, i.e. wound
Always fester disunion, by borneol external application, can clearing heat and detoxicating, erosion prevention and muscle growing, restrain ulcer surface rapidly, there is certain effect
Fruit.
Nitrofurazone is lemon yellow grain powder；It is odorless, bitter.Clinic is used only as Cidex-7, external application
In treatment wound, burn, suppurative dermatitis, tympanitis, dacryocystitis, vaginitis, bladder irrigation, bedsore etc..
Cuttlebone is called cuttle bone, and property is salty, puckery, temperature.Returns spleen, kidney channel.Main effect is astringing to arrest bleeding, and controlling nocturnal emission with astringent drugs stops
Band, hyperacidity and pain relief, hygroscopic sore.It is usually used in hematemesis and epistaxis, metrorrhagia and metrostaxis hematochezia, emission and spermatorrhea, leukorrhea with reddish discharge；Bleeding due to trauma is controlled outside,
Purulence ulcer swelling and pain.Modern pharmacological research cuttle bone is rich in there is calcium carbonate, so gastric acid can be neutralized, alleviates sour regurgitation or the symptoms such as heartburn,
It can promote the absorption of ulcer surface inflammation again, prevent bleeding, mitigate local pain, therefore antiacid can be made.
In conclusion above-mentioned technical proposal is used, the invention has the benefit that
Provided by the present invention for treat tympanitis composition in have alum, borneol, nitrofurazone and cuttlebone this
Several raw materials, can kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Simultaneously
Have the function of clearing heat and detoxicating, erosion prevention and muscle growing, is beneficial to that the surface of a wound is promoted to grow new skin, so that patient be helped to restore.
When in use, need using profession ear tool of adopting the smelly cerumen in ear-drum bottom is dug out, with hydrogen peroxide (or its
Its disinfectant) cleaning ear-drum, then blots the moisture on ear-drum using villus brush.Appropriate ointment (example is picked with clean hairbrush
Such as PIKANGWANG) and the bottoming on ear-drum, bottoming thickness multiple is introduced into ear for medicinal powder is a small amount of in 0.01mm or so, then
In film.In order to enable the composition for being used to treat tympanitis can be uniformly distributed on ear-drum, the composition can be blown to
In ear-drum.In addition when in use, total amount can be between 0.3 gram to 0.5 gram, and is divided into three to five times and blows to ear for composition
In film.By this small amount of multiple mode of operation, it can make the surface of a wound in ear-drum that can be uniformly adhered to combine in this way
Object, thus wound healing.Composition can be fused together after entering ear canal ten minutes or so with ointment, and about half
Starting to play drug effect after hour, composition can constantly be absorbed by ear channel skin, and ear canal superficial skin is constantly repaired, and seven to ten days
It can restore normal muscle energy, 20 to 30 days ear canals start normal secretions cerumen no longer skinning after medicine-feeding.It should be noted that herein
Process middle ear canal need to keep intaking for 7 to 10 days.
In addition, in the case where mould group is more, for wound healing, when adding medicine to or so latter week for the first time,
Can dip ointment by original with hairbrush without the drug that has absorbed and clean out, then upper one layer of ointment again, and equally with
A small amount of multiple mode is blown into 3 to 5 grams of compositions into ear canal.After one month, observe patient ear canal whether normal secretions ear
Dung or whether skinning, if so, continue to operate according to above-mentioned coating mode, until ear channel skin restores normal function.
In addition, filling the ear heart is excessively to corrode skin by mould to generate pus, it is viscous the generally visual nasal mucus as purulence
Liquid, in the case where having confirmed that ear-drum does not rupture wound, uses same apply in adopting after ear tool cleans out with profession
The composition is introduced ear canal by prescription formula.It should be noted that the interval time of coating is 1 week/time.
Especially it should be noted that, the composition for being used to treat tympanitis is significant only for having in tympanitis and tympanitis
Curative effect, and can only external application, cannot take orally.Furthermore it should be noted that child in medication, the use for reducing drug can be taken the circumstances into consideration
Amount.In addition, the composition is when stored, the composition need to be placed at shady and cool ventilation.
The preparation method step for the composition for treating tympanitis that the disclosure provides is simple, easy to operate, beneficial to pushing away
Extensively.
Specific embodiment
Embodiment will be enumerated below the specific embodiment of the disclosure is described in detail.It should be understood that herein
Described specific embodiment is only used for describing and explaining the disclosure, is not limited to the disclosure.
It is a kind of for treating the composition of tympanitis, the composition is made of the raw material of following parts by weight: alum 30~45
Part, 25~35 parts of borneol, 8~15 parts of nitrofurazone and 95~105 parts of cuttlebone.
The invention has the benefit that
Provided by the present invention for treat tympanitis composition in have alum, borneol, nitrofurazone and cuttlebone this
Several raw materials, can kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Simultaneously
Have the function of clearing heat and detoxicating, erosion prevention and muscle growing, is beneficial to that the surface of a wound is promoted to grow new skin, so that patient be helped to restore.
Embodiment one
The composition for being used to treat tympanitis is made of the raw material of following weight: alum 30g, borneol 25g, nitrofurazone
8g and cuttlebone 95g.
In the present embodiment, the concrete content of the composition each component is specified, composition made from the proportion can have
Effect kills the bacterium of ear channel skin, and promotes the absorption of ulcer surface inflammation, prevents Skin exudate body.There is heat-clearing solution simultaneously
The effect of poison, erosion prevention and muscle growing is beneficial to that the surface of a wound is promoted to grow new skin, so that patient be helped to restore.
Embodiment two
The composition for being used to treat tympanitis is made of the raw material of following weight: alum 35g, borneol 27g, nitrofurazone
9g and cuttlebone 97g.
In the present embodiment, the concrete content of the composition each component is changed relative to embodiment one, which is made
Composition can effectively kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Together
When have the function of clearing heat and detoxicating, erosion prevention and muscle growing, be beneficial to promote the surface of a wound grow new skin, so that patient be helped to restore.
Embodiment three
The composition for being used to treat tympanitis is made of the raw material of following weight: alum 38g, borneol 30g, nitrofurazone
10g and cuttlebone 100g.
In the present embodiment, the concrete content of the composition each component is changed relative to embodiment one, which is made
Composition can effectively kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Together
When have the function of clearing heat and detoxicating, erosion prevention and muscle growing, be beneficial to promote the surface of a wound grow new skin, so that patient be helped to restore.
Example IV
The composition for being used to treat tympanitis is made of the raw material of following weight: alum 42g, borneol 33g, nitrofurazone
11g and cuttlebone 102g.
In the present embodiment, the concrete content of the composition each component is changed relative to embodiment one, which is made
Composition can effectively kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Together
When have the function of clearing heat and detoxicating, erosion prevention and muscle growing, be beneficial to promote the surface of a wound grow new skin, so that patient be helped to restore.
Embodiment five
The composition for being used to treat tympanitis is made of the raw material of following weight: alum 45g, borneol 35g, nitrofurazone
12g and cuttlebone 105g.
In the present embodiment, the concrete content of the composition each component is changed relative to embodiment one, which is made
Composition can effectively kill the bacterium of ear channel skin, and promote the absorption of ulcer surface inflammation, prevent Skin exudate body.Together
When have the function of clearing heat and detoxicating, erosion prevention and muscle growing, be beneficial to promote the surface of a wound grow new skin, so that patient be helped to restore.
Embodiment six
For treating the preparation method of the composition of tympanitis, comprising the following steps: S1, press raw material described in embodiment one
Ratio, take cuttlebone and pounce be made, cross 120 meshes；S2, in the ratio of raw material described in embodiment one, take in
Alum, borneol and the nitrofurazone in the composition of tympanitis are treated, and is pulverized, 150 meshes is crossed, obtains mixed powder；S3,
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
In step s3, the mass ratio of mixed powder and pounce is 33:50.
In the present embodiment, specify the design parameter in each step so that it is obtained treatment tympanitis composition at
Product can absorb convenient for skin.And step is simple, easy to operate, beneficial to promoting.
Embodiment seven
For treating the preparation method of the composition of tympanitis, comprising the following steps: S1, press raw material described in embodiment two
Ratio, take cuttlebone and pounce be made, cross 130 meshes；S2, in the ratio of raw material described in embodiment two, take in
Alum, borneol and the nitrofurazone in the composition of tympanitis are treated, and is pulverized, 170 meshes is crossed, obtains mixed powder；S3,
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
In step s3, the mass ratio of mixed powder and pounce is 36:50.
In the present embodiment, the design parameter in each step is changed on the basis of embodiment six, so that obtained control
The composition finished product for treating tympanitis can absorb convenient for skin.And step is simple, easy to operate, beneficial to promoting.
Embodiment eight
For treating the preparation method of the composition of tympanitis, comprising the following steps: S1, press raw material described in embodiment three
Ratio, take cuttlebone and pounce be made, cross 140 meshes；S2, in the ratio of raw material described in embodiment three, take in
Alum, borneol and the nitrofurazone in the composition of tympanitis are treated, and is pulverized, 180 meshes is crossed, obtains mixed powder；S3,
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
In step s3, the mass ratio of mixed powder and pounce is 39:50.
In the present embodiment, the design parameter in each step is changed on the basis of embodiment six, so that obtained control
The composition finished product for treating tympanitis can absorb convenient for skin.And step is simple, easy to operate, beneficial to promoting.
Embodiment nine
For treating the preparation method of the composition of tympanitis, comprising the following steps: S1, press raw material described in example IV
Ratio, take cuttlebone and pounce be made, cross 140 meshes；S2, in the ratio of raw material described in example IV, take in
Alum, borneol and the nitrofurazone in the composition of tympanitis are treated, and is pulverized, 180 meshes is crossed, obtains mixed powder；S3,
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
In step s3, the mass ratio of mixed powder and pounce is 42:50.
In the present embodiment, the design parameter in each step is changed on the basis of embodiment six, so that obtained control
The composition finished product for treating tympanitis can absorb convenient for skin.And step is simple, easy to operate, beneficial to promoting.
Embodiment ten
For treating the preparation method of the composition of tympanitis, comprising the following steps: S1, press raw material described in embodiment five
Ratio, take cuttlebone and pounce be made, cross 150 meshes；S2, in the ratio of raw material described in embodiment five, take in
Alum, borneol and the nitrofurazone in the composition of tympanitis are treated, and is pulverized, 200 meshes is crossed, obtains mixed powder；S3,
Mixed powder is mixed in proportion with pounce by the method for physics, encapsulation is got product.
In step s3, the mass ratio of mixed powder and pounce is 9:10.
In the present embodiment, the design parameter in each step is changed on the basis of embodiment six, so that obtained control
The composition finished product for treating tympanitis can absorb convenient for skin.And step is simple, easy to operate, beneficial to promoting.
It is the treatment case for the composition for treating tympanitis that the disclosure provides below
There are a small amount of hydrops in No. 1 patient, tympanitis early stage, i.e. obstruction of eustachian tube phase in ear canal.Show as lassitude, food
It is intended to decline, tinnitus occurs and Er Nei is uncomfortable.According to 1 times/week of medicine frequency, after coating 3 times, the hydrops in ear canal all disappears
It loses, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.Be discontinued March after further consultation again, ear canal function
Normally, patient is not recurred.
No. 2 patients, tympanitis early stage, i.e. obstruction of eustachian tube phase, hydrops is slightly more compared with No.1 patient in ear canal.Show as spirit
, there is tinnitus in depressed, appetite stimulator and Er Nei is uncomfortable.According to 1 times/week of medicine frequency, after coating 4 times, the hydrops in ear canal
It all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.Be discontinued March after further consultation again, ear
Road function is normal, and patient is not recurred.
No. 3 patients, tympanitis early stage, i.e. obstruction of eustachian tube phase, hydrops is slightly more compared with No. 2 patients in ear canal.Show as spirit
, there is tinnitus in depressed, appetite stimulator and Er Nei is uncomfortable.According to 1 times/week of medicine frequency, after coating 4 times, the hydrops in ear canal
It all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.Be discontinued March after further consultation again, ear
Road function is normal, and patient is not recurred.
, there are useless fellow in No. 4 patients, tympanitis progressive stage in ear canal.Patient shows as having a high fever, Hearing and otalgia, together
When with symptoms of digestive tract such as nausea, diarrhea.According to 1 times/week of medicine frequency, after coating 6 times, the hydrops in ear canal all disappears
It loses, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.Be discontinued March after further consultation again, ear canal function
Normally, patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not recurred.
, there are useless fellow in No. 5 patients, tympanitis progressive stage in ear canal, have a small amount of fester to overflow.Patient shows as having a high fever, and listens
Power decline and otalgia, while with symptoms of digestive tract such as nausea, diarrhea.According to 1 times/week of medicine frequency, after coating 6 times, ear
Hydrops in road all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.It is discontinued after March
Further consultation again, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not recurred.
, there are fester spilling in No. 6 patients, tympanitis progressive stage in ear canal, and fester is more compared with No. 5 patients.Patient shows as sending out
High fever, Hearing and otalgia, while with symptoms of digestive tract such as nausea, diarrhea.According to 1 times/week of medicine frequency, coating 7
After secondary, the hydrops in ear canal all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.Stop
Further consultation again after medicine March, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, Huan Zhewei
Recurrence.
No. 7 patients, mycotic tympanitis, patient shows as ear itching, uncomfortable in ear, and has stream watery secretion in ear canal.
There is white membranoid substance when inspection in visible ear canal.Flowing water sample point according to 1 times/week of medicine frequency, after coating 4 times, in ear canal
Secretion all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.It is discontinued multiple again after March
It examines, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not recurred.
No. 8 patients, mycotic tympanitis, patient shows as ear itching, uncomfortable in ear, and has a small amount of flowing water sample to secrete in ear canal
Object.There is yellow membranoid substance when inspection in visible ear canal.According to 1 times/week of medicine frequency, after coating 4 times, the flowing water sample in ear canal
Secretion all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.It is discontinued after March again
Further consultation, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not recurred.
No. 9 patients, mycotic tympanitis, patient show as ear itching, uncomfortable in ear, and the stream watery secretion in ear canal compared with
No. 8 patients are slightly more.There is yellow membranoid substance when inspection in visible ear canal.According to 1 times/week of medicine frequency, after coating 5 times, ear canal
Interior stream watery secretion all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.It is discontinued
Further consultation again after March, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not multiple
Hair.
No. 10 patients, mycotic tympanitis, patient show as ear itching, uncomfortable in ear, and the stream watery secretion in ear canal
It is more compared with No. 8 patients.There is black membranoid substance when inspection in visible ear canal.According to 1 times/week of medicine frequency, after coating 6 times, ear canal
Interior stream watery secretion all disappears, and ear canal normal secretions cerumen.It is discontinued further consultation after January, ear canal function is normal.It is discontinued
Further consultation again after March, ear canal function is normal, and patient is not recurred.Drug withdrawal continues further consultation after June, and ear canal function is normal, and patient is not multiple
Hair.
By above-mentioned clinical case, illustrate this for treating the composition of tympanitis for tympanitis and mycotic tympanitis
With significant curative effect.
It is further to note that the physical admixture can be mixed by machine mechanical in the disclosure, it can also
To be manually to mix, also with no restrictions to this disclosure.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are each under the inspiration of the present invention
The product of kind form.Above-mentioned specific embodiment should not be understood the limitation of pairs of protection scope of the present invention, protection of the invention
Range should be subject to be defined in claims, and specification can be used for interpreting the claims.
Claims (9)
1. a kind of for treating the composition of tympanitis, which is characterized in that the composition is made of the raw material of following parts by weight: white
30~45 parts of alum, 25~35 parts of borneol, 8~15 parts of nitrofurazone and 95~105 parts of cuttlebone.
2. according to claim 1 for treating the composition of tympanitis, which is characterized in that the composition is by following weight
The raw material composition of part: 32~43 parts of alum, 27~33 parts of borneol, 8~13 parts of nitrofurazone and 97~104 parts of cuttlebone.
3. according to claim 1 for treating the composition of tympanitis, which is characterized in that the composition is by following weight
The raw material composition of part: 35~40 parts of alum, 28~32 parts of borneol, 9~11 parts of nitrofurazone and 98~102 parts of cuttlebone.
4. according to claim 1 for treating the composition of tympanitis, which is characterized in that the composition is by following weight
The raw material composition of part: 38 parts of alum, 30 parts of borneol, 10 parts of nitrofurazone and 100 parts of cuttlebone.
5. according to claim 1 for treating the composition of tympanitis, which is characterized in that the nitrofurazone is powder
Agent.
6. a kind of such as according to any one of claims 1 to 5 for treating the preparation method of the composition of tympanitis, feature
It is, comprising the following steps:
According to claim 1, material rate in~any one of 5 take cuttlebone and pounce be made, and crosses 120~150 meshes；
According to claim 1, material rate in~any one of 5 take alum, borneol and nitrofurazone in composition, and grind
Cheng Fen crosses 150~200 meshes, obtains mixed powder；
Mixed powder is uniformly mixed with pounce by the method for physics, encapsulation is got product.
7. according to claim 6 for treating the preparation method of the composition of tympanitis, which is characterized in that by cuttlebone
Powder crosses 130 meshes；Mixed powder is crossed into 170 meshes.
8. it is according to claim 6 for treat tympanitis composition preparation method, which is characterized in that mixed powder with
The mass ratio of pounce is between 33/50~9/10.
9. it is according to claim 8 for treat tympanitis composition preparation method, which is characterized in that mixed powder with
The mass ratio of pounce is 39/50.
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| CN201910872112.9A CN110448574A (en) | 2019-09-16 | 2019-09-16 | Composition and preparation method thereof for treating tympanitis |
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| CN201910872112.9A CN110448574A (en) | 2019-09-16 | 2019-09-16 | Composition and preparation method thereof for treating tympanitis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429562A (en) * | 2001-12-31 | 2003-07-16 | 李莉 | Chinese medicine for treating tympanitis |
| WO2009042270A2 (en) * | 2007-07-05 | 2009-04-02 | Trustees Of Boston University | Reca inhibitors and their uses as microbial inhibitors or potentiators of antibiotic activity |
| CN101537019A (en) * | 2009-04-01 | 2009-09-23 | 牛维德 | Medicine for curing tympanitis |
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2019
- 2019-09-16 CN CN201910872112.9A patent/CN110448574A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429562A (en) * | 2001-12-31 | 2003-07-16 | 李莉 | Chinese medicine for treating tympanitis |
| WO2009042270A2 (en) * | 2007-07-05 | 2009-04-02 | Trustees Of Boston University | Reca inhibitors and their uses as microbial inhibitors or potentiators of antibiotic activity |
| CN101537019A (en) * | 2009-04-01 | 2009-09-23 | 牛维德 | Medicine for curing tympanitis |
Non-Patent Citations (2)
| Title |
|---|
| 东兴明等: "呋冰粉治疗慢性化脓性中耳炎35例", 《中原医刊》 * |
| 陈宝海等: "复方胆矾甘油剂的研制和临床应用", 《中国医院药学杂志》 * |
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Application publication date: 20191115 |