CN110433260A

CN110433260A - A kind of pharmaceutical composition and preparation method thereof for treating psoriasis

Info

Publication number: CN110433260A
Application number: CN201910785604.4A
Authority: CN
Inventors: 李萍; 底婷婷; 王燕; 付京; 郭肖瑶; 翟春艳
Original assignee: BEIJING INSTITUTE OF TRADITIONAL CHINESE MEDICINE
Current assignee: BEIJING INSTITUTE OF TRADITIONAL CHINESE MEDICINE
Priority date: 2019-08-23
Filing date: 2019-08-23
Publication date: 2019-11-12
Anticipated expiration: 2039-08-23
Also published as: CN110433260B

Abstract

The present invention relates to technical field of traditional Chinese medicine preparation, in particular to a kind of pharmaceutical composition and preparation method thereof for treating psoriasis.The pharmaceutical composition for being used to treat psoriasis, raw material includes the active component of following parts by weight: 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax and 20-40 parts of fructus polygoni orientalis.The active component has the function of that excellent clearing heat and detoxicating, clearing damp dissipate the stasis of blood, can preferably treat psoriasis.

Description

A kind of pharmaceutical composition and preparation method thereof for treating psoriasis

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, in particular to a kind of for treating the pharmaceutical composition of psoriasis Object and preparation method thereof.

Background technique

Psoriasis is the common chronic auto-immune disease of dermatology, using erythema, the scales of skin that peel off as typical clinical skin lesion.Silver bits The pathogenesis of disease is still not clear at present, and genetic predisposition and environmental factor are its main risk factors.It is carried on the back in multiple-factor inheritance It under scape, interacts between immunocyte and its relevant cell factor, chemotactic factor (CF) and then mediates a series of inflammatory reaction, formed Epidermal proliferation, parakeratosis, acanthosis etc. change.

Psoriasis there is no the drug and method for effectively curing psoriasis at present, and clinically used remedy measures can be divided into physics Therapy, topical medications and systemic drug treatment.Physical therapy and topical medications are suitable for the lighter patient that falls ill, moderate Then systemic drug is needed to treat with severe patient.Legacy system therapeutic agent, such as methotrexate (MTX), vitamin D derivative, Tretinoin Class, hydroxycarbamide etc., it is main to improve psoriasis symptom by inhibiting epidermal hyperplasia and anti-inflammatory effect, prolonged application exist to liver, The toxic hazard of kidney and marrow.The drug of biological agent and targeted inhibition agent, the listing that such as gone through at present includes Yi Naxi General, Ying Fulixi, A Damu etc. regulate and control inflammatory reaction and then inhibiting cytokine receptor and its access to target spot, but There is a problem of being discontinued easy to recur.Curing psoriasis drug continue explore and R&D process be still the disease primary study side To.

In view of this, the present invention is specifically proposed.

Summary of the invention

The present invention relates to a kind of for treating the pharmaceutical composition of psoriasis, and raw material includes the activity of following parts by weight Component: 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax and 20-40 parts of fructus polygoni orientalis.

The active component has effects that clearing heat and detoxicating, clearing damp dissipates the stasis of blood, has preferable effect to the treatment of psoriasis.

According to another aspect of the present invention, the invention further relates to a kind of for treating the system of the pharmaceutical composition of psoriasis Preparation Method, comprising the following steps:

Each drug component and water Hybrid Heating are extracted；

The heating extraction includes being cooked by slow fire after decocting with high heat, obtains extraction medical fluid.

The preparation method of the pharmaceutical composition for the treatment of psoriasis of the invention is simple to operation, the use obtained by this method There is good therapeutic effect to psoriasis in the pharmaceutical composition for the treatment of psoriasis.

Compared with prior art, the invention has the benefit that

(1) oldenlandia diffusa in the present invention, smilax and fructus polygoni orientalis cooperate, and have clearing heat and detoxicating clearing damp function Effect is more conducive to treatment psoriasis.

(2) preparation method of the pharmaceutical composition for the treatment of psoriasis of the invention is simple to operation, is obtained by this method The pharmaceutical composition for treating psoriasis have good therapeutic effect to psoriasis.

Detailed description of the invention

Fig. 1 is that each group mouse of the present invention skin lesion in 7th day shows situation；

Fig. 2 is 7th day skin lesion Histological change situation of each group mouse of the present invention；

Fig. 3 is CD3 expression in each group mouse of the present invention skin lesion in 7th day.

Specific embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is It can be with conventional products that are commercially available.

It is a kind of for treating the pharmaceutical composition of psoriasis, raw material includes the active component of following parts by weight: white flower 20-40 parts of HERBA HEDYOTIS DIFFUSAE, 20-40 parts of smilax and 20-40 parts of fructus polygoni orientalis.

Oldenlandia diffusa has effects that clearing heat and detoxicating and dampness removing is treating stranguria, cures mainly carbuncle sore tumefacting virus, venomous snake bite, abscess of throat and Puckery pain of heat gonorrhea.

Smilax has removing toxic substances, dehumidifying, and easing joint movement effect cures mainly red bayberry carbuncle, eczema itch, limbs muscular constricture.

Fructus polygoni orientalis has the effect of invigorating spleen to remove dampness, promoting blood circulation to remove stagnation, clearing heat and detoxicating and improving eyesight, cures mainly epigastric pain, deficiency of food Abdominal distension, ascites, acute conjunctivitis, sore swells and scrofula.

It is acted on by the mutual cooperation of oldenlandia diffusa, smilax and fructus polygoni orientalis, can get has excellent heat-clearing solution Poison, clearing damp dissipate the pharmaceutical composition of the treatment psoriasis of stasis of blood effect.

In one embodiment, the oldenlandia diffusa is 20-40 parts, it is also an option that 21 parts, 22 parts, 23 parts, 24 Part, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts or 39 Part.

In one embodiment, the smilax is 20-40 parts, it is also an option that 21 parts, 22 parts, 23 parts, 24 parts, 25 Part, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts or 39 parts.

In one embodiment, the fructus polygoni orientalis is 20-40 parts, it is also an option that 21 parts, 22 parts, 23 parts, 24 Part, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts or 39 Part.

Preferably, the raw material further include 5-15 parts of Asian puccoon, 2-6 parts of radix gentianae, 5-15 parts of radix scutellariae, 10-20 parts of cornu bubali, Raw sophora flower 10-30 parts and cortex dictamni 5-15 parts.

Asian puccoon has the effect of cooling and activating blood clearing heat and detoxicating promoting eruption, can treat warm macula, neonatal jaundice caused by dampness-heat, maggot blood, bloody flux, The diseases such as stranguria with turbid discharge, haematemesis, burn, eczema, constipation with heat retention.

Radix gentianae bitter, cold in nature, the special heat-clearing and damp-drying drug of function, the effect of purging the liver of pathogenic fire gallbladder excess fire is stronger, and can Inflammation Zhijing analgesic.

It is radix scutellariae bitter, cold in nature, there are heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm heat disease, the upper respiratory tract The diseases such as infection, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, threatened abortion, hypertension, carbuncle swells furuncle sore.The clinic of radix scutellariae Antibiotic property is better than the coptis, and does not develop drug resistance.

The effect of cornu bubali is calmed the frightened with heat-clearing, cool blood, removing toxic substances, can cure the wound cold warm epidemic disease, shy mad, agitation, and macula is turned to be yellow, Delirium, bleeding from five sense organs or subcutaneous tissue, lower blood are spitted blood, swollen ulcer drug.

Raw sophora flower bitter, cold nature, return liver；Enter blood and hold back drop, body slightly dissipates；With cooling blood and hemostasis, the effect of clearing liver-fire； Curing mainly hematochezia, hematuria, hemorrhoid blood, blood strangury, bloody flux, metrorrhagia and metrostaxis spit blood, bleeding from five sense organs or subcutaneous tissue, red eye, swell pain, sore throat, irascibility headache, aphonia, Ulcer sores.

Cortex dictamni has the function of immunosupress, anti-inflammatory, antiallergy, antibacterial, antipruritic.

In one embodiment, the Asian puccoon is 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 Part, 12 parts, 13 parts or 14 parts.

In one embodiment, described radix gentianae 2-6 parts, it is also an option that 3 parts, 4 parts or 5 parts.

In one embodiment, described radix scutellariae 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described cornu bubali 10-20 parts, it is also an option that 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts or 19 parts.

In one embodiment, described raw sophora flower 10-30 parts, it is also an option that 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts.

In one embodiment, described cortex dictamni 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 Part, 12 parts, 13 parts or 14 parts.

Pass through oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and cortex dictamni Compatibility effect, have effects that enhance clearing heat and cooling blood, the illness of blood-heat type psoriatic can be effectively treated.

Preferably, the raw material further includes 5-15 parts of Radix Angelicae Sinensis, 20-40 parts of Radix Astragali, 10-20 parts of Radix Paeoniae Alba, 20-40 parts of Caulis Spatholobi With 6-12 parts of tribulus terrestris.

Radix Angelicae Sinensis has blood-supplementing blood-nourishing, logical intestines defaecation, regulating menstruation and activating blood, anticancer, anti-ageing prevents old, anti-treating chilblain and immune function Effect.

Radix Paeoniae Alba acrid flavour, hardship, it is warm-natured；It is slightly poisonous；The positive clearing damp of tool temperature, complement void, strengthening the spleen and stomach and other effects.

Caulis Spatholobi has effects that expelling wind and activating blood flow, relaxing tendons and activating collaterals.Cure mainly soreness of waist and knee joint, irregular menstruation.

Tribulus terrestris can calming the liver and dispelling melancholy, dispelling pathogenic wind for improving eyesight.Liver-depressed hypochondrium pain can be treated, dizziness due to hyperactivity of liver-YANG is had a headache, headache due to pathogenic wind-heat, and hot eyes is swollen Bitterly, pruitus.

In one embodiment, described Radix Angelicae Sinensis 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described Radix Astragali 20-40 parts, it is also an option that 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts or 39 parts.

In one embodiment, described Radix Paeoniae Alba 10-20 parts, it is also an option that 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts or 19 parts.

In one embodiment, described Caulis Spatholobi 20-40 parts, it is also an option that 21 parts, 22 parts, 23 parts, 24 parts, 25 Part, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts or 39 parts.

In one embodiment, described tribulus terrestris 6-12 parts, it is also an option that 7 parts, 8 parts, 9 parts, 10 parts or 11 parts.

Made by the compatibility of oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris With, have effects that promoted enriching the blood to restore normal menstruation, to blood-dryness type psoriatic have good therapeutic effect.

Preferably, the raw material further include 5-15 parts of ramulus cinnamomi, 5-15 parts of Poria cocos, 5-15 parts of Radix Paeoniae Alba, 10-30 parts of Caulis Spatholobi, 5-15 parts and peach kernel 5-15 parts of the root bark of tree peony.

The pungent sweet, warm of ramulus cinnamomi；Enter the heart, lung, bladder meridian；With sweating expelling pathogenic factors from muscles and skin, the effect of warming meridians and promoting circulation of qi.

Poria cocos has the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart, is used for loose stool diarrhea, edema and little urine, spleen eating less, the mind Uneasiness, phlegm retention anti-dazzle nervous, insomnia of palpitating with fear.

The root bark of tree peony has effects that anti-inflammatory, anticoagulant, enhancing is immune.

In one embodiment, described ramulus cinnamomi 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described Poria cocos 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described Radix Paeoniae Alba 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described Caulis Spatholobi 10-30 parts, it is also an option that 11 parts, 12 parts, 13 parts, 14 parts, 15 Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts.

In one embodiment, described root bark of tree peony 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

In one embodiment, described peach kernel 5-15 parts, it is also an option that 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

Pass through the compatibility of oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel The effect of acting on, activating microcirculation and removing stasis medicinal can be improved has excellent therapeutic effect to blood stasis type psoriatic.

The preparation method of the pharmaceutical composition as described above for being used to treat psoriasis, comprising the following steps:

Each drug component and water Hybrid Heating are extracted；

The present invention heats extraction after mixing drug component with water, decocts with high heat, and temperature rises fastly, and moisture evaporation is fast； With being cooked by slow fire, medicine gas rapid evaporation can be prevented；By the cooperation of mild fire and intense fire, the effective component in each medicinal material can be made more preferable Be added in water.

Preferably, the weight ratio of the drug component and the water is 1:(5~8).

Preferably drug can be decocted using the water of appropriate amount.

In one embodiment, the weight ratio of the drug component and the water is 1:(5~8), it is also an option that 1: 5.5,1:6,1:6.5,1:7 or 1:7.5.

Preferably, the time of the high heat decoction is 4-8min, and the time being cooked by slow fire is 20-40min.

In one embodiment, the time of the high heat decoction be 4-8min, it is also an option that 5min, 6min or 7min。

In one embodiment, the time being cooked by slow fire is 20-40min, it is also an option that 22min, 25min, 27min, 30min, 33min, 35min or 37min.

Preferably, described be cooked by slow fire at least is repeated twice, and the medical fluid that merging obtains after being cooked by slow fire every time obtains described Extract medical fluid；

Preferably, only with being cooked by slow fire from for the second time, the additive amount of the water be medicine material constituent mass 2.5~ 4 times.

By the way that the dregs of a decoction are repeatedly cooked by slow fire, it is ensured that effective ingredient can effectively be precipitated.

In one embodiment, the additive amount of the water is 2.5~4 times of medicine material constituent mass, can also be selected Select 3 times or 4 times.

In one embodiment, the time being cooked by slow fire be 25-40min, it is also an option that 27 min, 30min, 32min, 35min or 37min.

It preferably, further include the operation that the extraction medical fluid is concentrated；

Preferably, it is 0.37~0.46g/mL that the extraction medical fluid, which is concentrated into crude drug concentration,；

In one embodiment, it is 0.37~0.46g/mL that the extraction medical fluid, which is concentrated into crude drug concentration, can also be selected Select 0.38g/mL, 0.39/mL, 0.40g/mL, 0.41g/mL, 0.42g/mL, 0.43g/mL, 0.44g/mL or 0.45g/mL.

It preferably, further include the operation impregnated before the heating extraction to drug；

Preferably, the time of the immersion is 20-40min.

By the way that medicinal material to be soaked for a period of time, medicinal material softens, and cell expansion is more advantageous to effective component in decoction process Dissolution.

In one embodiment, the soaking time be 20-40min, it is also an option that 25min, 30min or 35min。

It is preferably carried out in mode in one kind, the preparation method of the pharmaceutical composition for being used to treat psoriasis, including Following steps:

(a) by 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax, 20-40 parts of fructus polygoni orientalis, 5-15 parts of Asian puccoon, rough gentian 2-6 parts careless, 5-15 parts of radix scutellariae, 10-20 parts of cornu bubali, raw sophora flower 10-30 parts and 5-15 parts of cortex dictamni mixing, are added water and impregnate 20-40min first decocts 4-8min with high heat, then with 20-40min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:(5~8)；

(b) water is added in the dregs of a decoction in step (a), with 20-40min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

The additive amount of the water is 2.5~4 times of medicine material constituent mass.

The obtained medical fluid that decocts is concentrated into crude drug concentration as 0.37~0.46g/mL.

(a) by 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax, 20-40 parts of fructus polygoni orientalis, 5-15 parts of Radix Angelicae Sinensis, Radix Astragali 20-40 parts, 10-20 parts of Radix Paeoniae Alba, 20-40 parts of Caulis Spatholobi and 6-12 parts of tribulus terrestris mixing, are added water and impregnate 20-40min, first use High heat decoction 4-8min, then with 20-40min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:(5~8)；

(a) by 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax, 20-40 parts of fructus polygoni orientalis, 5-15 parts of ramulus cinnamomi, Poria cocos 5-15 parts, 5-15 parts of Radix Paeoniae Alba, 10-30 parts of Caulis Spatholobi, 5-15 parts of the root bark of tree peony and 5-15 parts of peach kernel mixing, are added water and impregnate 20- 40min first decocts 4-8min with high heat, then with 20-40min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:(5~8)；

The additive amount of the water is 2.5~4 times of medicine material constituent mass；

Below in conjunction with specific embodiments, control group and attached drawing the present invention will be further explained explanation.

Embodiment 1

It is a kind of for treating the pharmaceutical composition of psoriasis, raw material components are as follows:

Oldenlandia diffusa 30g, smilax 30g, fructus polygoni orientalis 30g, Asian puccoon 10g, radix gentianae 3g, radix scutellariae 10g, cornu bubali 15g, raw sophora flower 10g and cortex dictamni 10g；

The preparation method of the pharmaceutical composition for being used to treat psoriasis, comprising the following steps:

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and shaggy-fruited dittany Skin mixing is added water and impregnates 30min, first decocts 5min with high heat, then with 25min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

(b) water is added in the dregs of a decoction in step (a), with 30min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

The additive amount of the water is 3 times of medicine material constituent mass；

The obtained medical fluid that decocts is concentrated into crude drug concentration as 0.37g/mL.

Embodiment 2

Oldenlandia diffusa 20g, smilax 40g, 20g parts of fructus polygoni orientalis, Asian puccoon 15g, radix gentianae 6g, radix scutellariae 5g, cornu bubali 20g, raw sophora flower 10g and cortex dictamni 15g；

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and shaggy-fruited dittany Skin mixing is added water and impregnates 20min, first decocts 8min with high heat, then with 35min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

(b) water is added in the dregs of a decoction in step (a), with 20min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

The additive amount of the water is 2.5 times of medicine material constituent mass；

Embodiment 3

Oldenlandia diffusa 40g, smilax 20g, fructus polygoni orientalis 40g, Asian puccoon 5g, radix gentianae 6g, radix scutellariae 5g, cornu bubali 20g, Raw sophora flower 10g and cortex dictamni 15g；

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and shaggy-fruited dittany Skin mixing is added water and impregnates 40min, first decocts 4min with high heat, then with 35min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:7；

The additive amount of the water is 4 times of medicine material constituent mass；

Embodiment 4

Oldenlandia diffusa 25g, smilax 25g, fructus polygoni orientalis 30g, Asian puccoon 8g, radix gentianae 3g, radix scutellariae 6g, cornu bubali 15g, Raw sophora flower 12g and cortex dictamni 8g；

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and shaggy-fruited dittany Skin mixing is added water and impregnates 25min, first decocts 6min with high heat, then with 30min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

(b) water is added in the dregs of a decoction in step (a), with 25min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

Embodiment 5

Oldenlandia diffusa 35g, smilax 25g, fructus polygoni orientalis 35g, Asian puccoon 6g, radix gentianae 5.5g, radix scutellariae 6g, cornu bubali 12g, raw sophora flower 28g and cortex dictamni 7g；

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Asian puccoon, radix gentianae, radix scutellariae, cornu bubali, raw sophora flower and shaggy-fruited dittany Skin mixing is added water and impregnates 30min, first decocts 8min with high heat, then with 35min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:5.5；

(b) water is added in the dregs of a decoction in step (a), with 40min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

Embodiment 6

Oldenlandia diffusa 28g, smilax 28g, fructus polygoni orientalis 28g, Asian puccoon 12g, radix gentianae 5g, radix scutellariae 13g, cornu bubali 18g, raw sophora flower 11g and cortex dictamni 8g；

The preparation method is the same as that of Example 1 for the pharmaceutical composition for treating psoriasis.

Embodiment 7

Oldenlandia diffusa 30g, smilax 30g, fructus polygoni orientalis 30g, Radix Angelicae Sinensis 10g, Radix Astragali 300g, Radix Paeoniae Alba 15g, Caulis Spatholobi 30g and tribulus terrestris 9g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris are mixed, is added Enter water and impregnate 30min, first decocts 5min with high heat, then with 30min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

The obtained medical fluid that decocts is concentrated into crude drug concentration as 0.46g/mL.

Embodiment 8

Oldenlandia diffusa 20g, smilax 40g, fructus polygoni orientalis 20g, Radix Angelicae Sinensis 15g, Radix Astragali 20g, Radix Paeoniae Alba 20g, Caulis Spatholobi 20g With tribulus terrestris 12g；

(a) by oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, 10-20 parts of Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris Water is added and impregnates 20min, first decocts 8min with high heat, then with being cooked by slow fire 20, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6.5；

The additive amount of the water is 3.5 times of medicine material constituent mass；

Embodiment 9

Oldenlandia diffusa 40g, smilax 20g, fructus polygoni orientalis 40g, Radix Angelicae Sinensis 5g, Radix Astragali 40g, Radix Paeoniae Alba 10g, Caulis Spatholobi 40g With tribulus terrestris 6g；

(a) water logging is added in oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris 25min is steeped, first decocts 6min with high heat, then with 30min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

(b) water is added in the dregs of a decoction in step (a), with 35min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

Embodiment 10

Oldenlandia diffusa 22g, smilax 36g, fructus polygoni orientalis 23g, Radix Angelicae Sinensis 13g, Radix Astragali 22g, Radix Paeoniae Alba 18g, Caulis Spatholobi 22g With tribulus terrestris 10g；

(a) water logging is added in oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris 35min is steeped, first decocts 6min with high heat, then with 35min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:8；

The additive amount of the water is 3.8 times of medicine material constituent mass；

Embodiment 11

Oldenlandia diffusa 38g, smilax 23g, fructus polygoni orientalis 28g, Radix Angelicae Sinensis 7g, Radix Astragali 37g, Radix Paeoniae Alba 12g, Caulis Spatholobi 38g With tribulus terrestris 8g；

(a) water logging is added in oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris 25min is steeped, first decocts 7min with high heat, then with 20min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:7；

Embodiment 12

Oldenlandia diffusa 28g, smilax 28g, fructus polygoni orientalis 28g, Radix Angelicae Sinensis 9g, Radix Astragali 28g, Radix Paeoniae Alba 15g, Caulis Spatholobi 30g With tribulus terrestris 10g；

(a) water logging is added in oldenlandia diffusa, smilax, fructus polygoni orientalis, Radix Angelicae Sinensis, Radix Astragali, Radix Paeoniae Alba, Caulis Spatholobi and tribulus terrestris 20min is steeped, first decocts 8min with high heat, then with 24min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6.5；

(b) water is added in the dregs of a decoction in step (a), with 32min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

The weight ratio of the dregs of a decoction and the water is 1:3.2；

Embodiment 13

Oldenlandia diffusa 30g, smilax 30g, fructus polygoni orientalis 30g, ramulus cinnamomi 10g, Poria cocos 10g, Radix Paeoniae Alba 10g, Caulis Spatholobi 10g, root bark of tree peony 10g and peach kernel 10g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 30min, first decocts 5min with high heat, then with 30min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6；

The obtained medical fluid that decocts is concentrated into crude drug concentration as 0.375g/mL.

Embodiment 14

Oldenlandia diffusa 20g, smilax 40g, fructus polygoni orientalis 20g, ramulus cinnamomi 15g, Poria cocos 5g, Radix Paeoniae Alba 15g, Caulis Spatholobi 10g, Root bark of tree peony 15g and peach kernel 5g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 40min, first decocts 4min with high heat, then with 35min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:5；

Embodiment 15

Oldenlandia diffusa 40g, smilax 20g, fructus polygoni orientalis 40g, ramulus cinnamomi 5g, Poria cocos 15g, Radix Paeoniae Alba 5g, Caulis Spatholobi 30g, Root bark of tree peony 5g and peach kernel 15g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 40min, first decocts 4min with high heat, then with 20-min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:8)；

Embodiment 16

Oldenlandia diffusa 22g, smilax 38g, fructus polygoni orientalis 22g, ramulus cinnamomi 12g, Poria cocos 7g, Radix Paeoniae Alba 12g, Caulis Spatholobi 12g, Root bark of tree peony 12g and peach kernel 6g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 25min, first decocts 7min with high heat, then with 23min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:7.5；

Embodiment 17

Oldenlandia diffusa 38g, smilax 22g, fructus polygoni orientalis 37g, ramulus cinnamomi 7g, Poria cocos 14g, Radix Paeoniae Alba 7g, Caulis Spatholobi 28g, Root bark of tree peony 7g and peach kernel 14g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 28min, first decocts 6min with high heat, then with 28min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:5.5；

(b) water is added in the dregs of a decoction in step (a), with 34min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

The additive amount of the water is 3.6 times of medicine material constituent mass；

Embodiment 18

Oldenlandia diffusa 28g, smilax 28g, fructus polygoni orientalis 28g, ramulus cinnamomi 11g, Poria cocos 9g, 11 parts of Radix Paeoniae Alba, Caulis Spatholobi 20g, root bark of tree peony 12g and peach kernel 13g；

(a) oldenlandia diffusa, smilax, fructus polygoni orientalis, ramulus cinnamomi, Poria cocos, Radix Paeoniae Alba, Caulis Spatholobi, the root bark of tree peony and peach kernel are mixed, Water is added and impregnates 40min, first decocts 8min with high heat, then with 27min is cooked by slow fire, medical fluid is obtained by filtration；

The weight ratio of the drug component and the water is 1:6.5；

(b) water is added in the dregs of a decoction in step (a), with 26min is cooked by slow fire, collects medical fluid twice and be concentrated jointly；

Experimental example 1

The psoriasiform mouse skin lesion model induced using imiquimod.It BALB/c male mice 50, is given birth to by magnificent Fukang Object Science and Technology Co., Ltd. provides, 18~20g of weight.Experimental animal uses credit number: SYXK (capital) 2013-0002. Mouse is anaesthetized by the way that yellow Jackets (80mg/kg) is injected intraperitoneally, and by its back about 2 × 2cm²Hair cutting；

Using digits table, at random by mouse be divided into control group (Ctrl), model group (IMQ), silver-colored (ZF1) group of bits side 1, Silver-colored bits side 2 (ZF2) group, silver-colored bits side 3 (ZF3) group, single cage is raised in independent ventilation cage tool (IVC)；

Vaseline 42mg is smeared at control group mice back daily, remaining each group smears 5% imiquimod cream (1- of 42mg (2- methyl-propyl) -1H- imidazo [4,5-C] quinolin-4-amines, IMQ；0.25g:12.5mg)；Control group and model group mouse are every 1 0.2mL distilled water stomach-filling of day, silver-colored bits side each group mouse give silver-colored bits side Chinese herbs decoction, and dosage is rolled over by adult human dose (60kg) It calculates and measures mouse dose for half, daily 0.2ml continues to apply outside back and stomach-filling is handled 7 days.Silver-colored bits side 1 (ZF1) group: it gives respectively It gives embodiment 1-6 and obtains pharmaceutical composition, following tests is for giving the pharmaceutical composition of embodiment 1；Silver-colored bits side 2 (ZF2) group: giving the obtained pharmaceutical composition of embodiment 7-12 respectively, and following tests is to give the pharmaceutical composition of embodiment 7 For；Silver-colored bits side 3 (ZF3) group: embodiment 13-18 is given respectively and obtains pharmaceutical composition, following tests is to give embodiment For 13 pharmaceutical composition.

1. Psoriasis-like Model mouse skin lesion situation

As shown in Figure 1, mouse Pigs with Psoriasis is significantly eased, and shows themselves in that after three prescriptions gavage administration 7 days Erythema lighter switchs to pale pink by red, and part has been subsided；Scales of skin that peel off area is reduced, and the scales of skin that peel off is thinning, becomes clast from sheet Shape, only close to the easy friction of neck, a small amount of scales of skin that peel off of easy plication region remaining, easy to fall off, the blutpunkte under the scales of skin that peel off is reduced；Skin lesion It infiltrates thickness to mitigate, the lower visible different degrees of normal skin form in region in back of mice.

It can thus be appreciated that: the Psoriasis-like Model mouse skin lesion that silver bits Fang Jun can be relieved imiquimod induction changes.It compares The intervention effect of 3 prescriptions in silver-colored bits side, wherein silver-colored bits side 1 is the most significant in terms of improving mouse skin lesion erythema, silver-colored bits side 2 Reducing, mouse skin lesion scales of skin that peel off degree is the most significant, and silver-colored bits side 3 intervenes the infiltration plumpness for alleviating mouse skin lesion the most significant.

2. psoriasis area and severity index (PASI scoring)

Score according to PASI standards of grading, the results are shown in Table 1, as shown in Table 1, control group mice infiltration, erythema, The scales of skin that peel off and overall score remain at 0 or so, and remaining each group mouse score value persistently increases in various degree, reach high in the 7th day Peak；Statistics discovery compared with model group, the scales of skin that peel off, infiltration, erythema and the TOP SCORES of silver-colored bits side's each group decrease (P < 0.05)。

1 psoriatic lesion degree of table scoring situation

3. the Psoriasis-like Model mouse skin lesion histomorphological changes that silver medal bits side improves imiquimod induction

It is dyed through HE, the 7th day each group mouse skin slice is compared under light microscopic, compared with model mice skin lesion, silver-colored bits side is each Group significantly reduces the thickness of skin epidermis, reduces the generation of microabscess, parakeratosis is improved, stratum spinosum epidermidis core Mitotic figure is reduced, basal layer cell arranged regular, and proliferation degree reduces, and skin corium lymphocytic infiltration is reduced, wherein silver-colored bits side 3 Number effect it is the most significant.In addition, the group skin lesion blood vessel outgrowth expansion phenomenon of silver-colored bits side No. 1, No. 2 significantly reduces, silver The visible new life of No. 3 tiny capillary in bits side, as shown in Figure 2.

The vertical thickness of epidermis is measured by IPP, test result is as shown in table 2；

The vertical thickness test result of 2 epidermis of table

Each group	The vertical thickness (μm) of epidermis
		Control group (Ctrl)	21.130±0.600
Model group (IMQ)	98.891±2.769
		Silver-colored bits side 1 (ZF1)	65.181±4.200
Silver-colored bits side 2 (ZF2)	66.471±3.309
		Silver-colored bits side 3 (ZF3)	57.181±4.412

As shown in Table 2, model group skin layer thickness thickens about 5 times compared with control group, and silver-colored bits side each group skin layer thickness is compared with mould Type group significantly reduces (P < 0.001), wherein the degree of the silver-colored No. 3 skin layer thickness reductions in bits side becomes apparent.

In conclusion the silver-colored prescription of bits side 3 all show as the proliferation of inhibition epidermal layer cells, promotion prickle cell differentiation, The infiltration of skin corium inflammatory cell is reduced, wherein inhibited proliferation of the silver-colored bits side 3 to horn cell is most strong, skin layer thickness It is minimum, while the new life of the visible tiny capillary of high dermis.

4. the Infiltrating that silver medal bits side inhibits inflammatory cell in the Psoriasis-like Model mouse skin lesion of imiquimod induction

As shown in figure 3, Immunohistochemical study each group mouse skin corium CD3 positive T cell can be found: silver-colored bits side each group CD3 in mouse skin lesion tissue⁺The number of T cell is below model group.

5. the Psoriasis-like Model mouse systemic inflammatory conditions state status that silver medal bits side inhibits imiquimod induction

Each group mouse spleen and thymic tissue are weighed, computation organization's hyperplasia index compared with own body weight, as shown in table 3；

3 mouse spleen of table and thymic tissue hyperplasia exponential case

As shown in Table 3, silver-colored bits side each group mouse spleen index is below model group, and hyperblastosis trend reduces, scorching Disease state of activation is inhibited；Silver-colored bits side 1 makes thymic tissue atrophy trend obtain a degree of alleviation, silver-colored bits side 2 with No. 3 Number thymus index is not improved.

6. the measurement of Psoriasis-like Model mouse skin water content；

Using the daily epidermis water content of skin epidermis moisture detector detection each group mouse skin, as shown in table 4；

4 each group mouse of table, 7 days skin lesion epidermis water content testing results

Each group	7 days skin lesion epidermis water content (%) of mouse
		Control group (Ctrl)	13.972±1.927
Model group (IMQ)	8.815±1.319
		Silver-colored bits side 1 (ZF1)	8.055±0.242
Silver-colored bits side 2 (ZF2)	12.534±1.026
		Silver-colored bits side 3 (ZF3)	8.693±1.394

As can be seen from Table 4, model was substantially reduced at the 7th day compared with normal control, and silver-colored bits side 2 group mouse skin Epidermis water content be apparently higher than model group, the skin with Normal group mouse is without statistical discrepancy.

In conclusion each prescription in silver-colored bits side can obviously improve erythema, the scales of skin that peel off and infiltration in the skin lesion of Psoriasis-like Model The inflammatory reaction of skin lesion is alleviated in the change thickened.Silver-colored bits side 1 is the most significant in terms of the erythema for improving Pigs with Psoriasis, After the 5th day, erythema integral is substantially less than same period model group, is better than other two prescription groups, the results showed that silver-colored bits side 1 Effect in terms of inhibiting psoriatic lesion inflammatory reaction or endothelial injuries is the most prominent, reaches the function of clearing heat and cooling blood；Silver-colored bits side 2 There is significant advantage, the prescription has been shown when testing the 3rd day number in terms of improving Pigs with Psoriasis water content of stratum corneum The trend for improving water content of stratum corneum, water content of stratum corneum of the silver bits side 2 compared with other treatment group significantly increases at the 6th day, knot Fruit shows the benefits of silver-colored bits side 2 plays a significant role in restoring psoriasis stratum corneum barrier function, plays enriching the blood to restore normal menstruation；Silver bits Side 3 is the most prominent in the infiltration plumpness effect for alleviating Pigs with Psoriasis, and the skin lesion scales of skin that peel off cell that the party intervenes is easy to fall off, skin The colour of skin it is red but it is plump infiltration it is light compared with other treatment group, epidermis vertical thickness is most thin, keratinocyte nuclear fission picture and angling Incomplete minimum, inflammatory cell expression is minimum in skin corium, and the effect of silver-colored bits side 3 is as a result prompted to concentrate on that cutin is inhibited to be formed carefully In born of the same parents' proliferation, the link for promoting apoptosis and immune response to adjust, while the tiny blood capillary of skin corium superficial of silver-colored No. 3 interventions in bits side Pipe is obvious, this may be related with the blood circulation-promoting functions of drug, promotes the power of activating microcirculation and removing stasis medicinal.The present invention is in same core side's detoxifying, removing dampness Effect on, for psoriasis different syndrome type feature have excellent therapeutic effect.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Present invention has been described in detail with reference to the aforementioned embodiments for pipe, but those skilled in the art should understand that: its It is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features It is equivalently replaced；And these are modified or replaceed, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution The range of art scheme.

Claims

1. a kind of for treating the pharmaceutical composition of psoriasis, which is characterized in that its raw material includes the activity of following parts by weight Component: 20-40 parts of oldenlandia diffusa, 20-40 parts of smilax and 20-40 parts of fructus polygoni orientalis.

2. according to claim 1 for treating the pharmaceutical composition of psoriasis, which is characterized in that the raw material further includes 5-15 parts of Asian puccoon, 2-6 parts of radix gentianae, 5-15 parts of radix scutellariae, 10-20 parts of cornu bubali, sophora flower 10-30 parts and 5-15 parts of cortex dictamni of life.

3. according to claim 1 for treating the pharmaceutical composition of psoriasis, which is characterized in that the raw material further includes 5-15 parts of Radix Angelicae Sinensis, 20-40 parts of Radix Astragali, 10-20 parts of Radix Paeoniae Alba, 20-40 parts of Caulis Spatholobi and 6-12 parts of tribulus terrestris.

4. according to claim 1 for treating the pharmaceutical composition of psoriasis, which is characterized in that the raw material further includes 5-15 parts of ramulus cinnamomi, 5-15 parts of Poria cocos, 5-15 parts of Radix Paeoniae Alba, 10-30 parts of Caulis Spatholobi, 5-15 parts of the root bark of tree peony and 5-15 parts of peach kernel.

5. special according to claim 1 for treating the preparation method of the pharmaceutical composition of psoriasis described in any one of -4 Sign is, comprising the following steps:

Each drug component and water Hybrid Heating are extracted；

6. according to claim 5 for treating the preparation method of the pharmaceutical composition of psoriasis, which is characterized in that described The weight ratio of drug component and the water is 1:(5~8).

7. according to claim 5 for treating the preparation method of the pharmaceutical composition of psoriasis, which is characterized in that described The time of high heat decoction is 4-8min, and the time being cooked by slow fire is 20-40min.

8. according to claim 5 for treating the preparation method of the pharmaceutical composition of psoriasis, which is characterized in that described It is cooked by slow fire and is at least repeated twice, merge the medical fluid obtained after being cooked by slow fire every time and obtain the extraction medical fluid；

Preferably, only with being cooked by slow fire from for the second time, the additive amount of the water is 2.5~4 times of medicine material constituent mass.

9. special for treating the preparation method of the pharmaceutical composition of psoriasis according to any one of claim 5-8 Sign is, further includes the operation that the extraction medical fluid is concentrated；

Preferably, it is 0.37~0.46g/mL that the extraction medical fluid, which is concentrated into crude drug concentration,.

10. special for treating the preparation method of the pharmaceutical composition of psoriasis according to any one of claim 5-8 Sign is, further includes the operation impregnated before the heating extraction to drug；

Preferably, the time of the immersion is 20-40min.