CN110404597A - A kind of Multi-function self-cleaning liquid-transfering device and its application method - Google Patents

A kind of Multi-function self-cleaning liquid-transfering device and its application method Download PDF

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Publication number
CN110404597A
CN110404597A CN201910728165.3A CN201910728165A CN110404597A CN 110404597 A CN110404597 A CN 110404597A CN 201910728165 A CN201910728165 A CN 201910728165A CN 110404597 A CN110404597 A CN 110404597A
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CN
China
Prior art keywords
liquid
liquid chamber
containing liquid
cleaning
pipette
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Pending
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CN201910728165.3A
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Chinese (zh)
Inventor
石永博
王玉龙
马仁芹
赵福明
赵慧琴
王慧春
王俊锋
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Wuxi Apptec Tianjin Co Ltd
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Wuxi Apptec Tianjin Co Ltd
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Priority to CN201910728165.3A priority Critical patent/CN110404597A/en
Publication of CN110404597A publication Critical patent/CN110404597A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56Labware specially adapted for transferring fluids
    • B01L3/561Tubes; Conduits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08Cleaning containers, e.g. tanks
    • B08B9/093Cleaning containers, e.g. tanks by the force of jets or sprays

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Cleaning By Liquid Or Steam (AREA)

Abstract

The invention discloses a kind of Multi-function self-cleaning liquid-transfering devices, wherein, including inlet pipe, containing liquid chamber, pipette, crossover sub, peristaltic pump, pump line, the bottom of the containing liquid chamber is connect with the pipette, the top of the containing liquid chamber is connect with the bottom of the crossover sub, the inside of the containing liquid chamber is equipped with spray shower head, the inlet pipe is connected to the top of the spray shower head after the crossover sub, the both ends of the pump line be connected to the crossover sub top and the peristaltic pump, one end of the closely described containing liquid chamber of the pipette is inserted with Fastener.In addition, the invention also discloses the application methods of the Multi-function self-cleaning liquid-transfering device.The present invention can effectively prevent peristaltic pump blocking, realize that the liquid including suspension, viscous fluid, clarified solution is shifted, stored, discharged;It is able to achieve automatic cleaning, increases service life, reduces cost;Single treatment amount is big, can shift 150 milliliters of liquid, and structure is simple, is easy to use.

Description

A kind of Multi-function self-cleaning liquid-transfering device and its application method
Technical field
The present invention relates to automatic fluid transfer and related cleaning devices, and in particular to a kind of Multi-function self-cleaning liquid relief dress It sets.Moreover, it relates to the application method of the Multi-function self-cleaning liquid-transfering device.
Background technique
A kind of liquid-transfering device and liquid relief are disclosed in the patent that Chinese invention patent application number is CN201811593141.3 Method, fluid path mechanism described in the patent of invention is used to draw by disposable fluid suction head and filling liquid sample, and the invention is in institute During stating probe decline, by the gas supply mechanism to the gas supply of the gas circuit pipe, the gas circuit intraductal atmospheric pressure can be promoted Stationarity so that when the fluid suction head contact the body fluid sample liquid level when, the gas circuit intraductal atmospheric pressure relative to contact body fluid sample Air pressure change before the liquid level is significant, so that staff is easy accurately to conclude detection according to air pressure change in the gas circuit pipe The liquid level being somebody's turn to do to body fluid sample mainly solves detecting liquid level precision and asks to promote the accuracy of the body fluid sample detecting liquid level Topic;
It is flat that a kind of biologic medical liquid relief work is disclosed in the patent that Chinese invention patent application number is CN201910058715.5 Platform, the invention provide it is a kind of with the biologic medical liquid relief workbench for automatically extracting cell function, will be in experimental implementation process High-throughput sample handling processes realize automatic operating;
A kind of liquid transcription device is disclosed in the patent that Chinese invention patent application number is CN201910058734.8, the invention Can be used in multiple holes that reagent, sample etc. are transported on porous plate, can unrestricted choice carry out multichannel liquid feeding or Single channel liquid feeding, and the fluid means for drawing liquid and liquid-transfering device are provided separately, guarantee that there is sufficiently long stroke, It avoids generating pollution;
But at present in the industries such as medicine, chemical industry, three above invention is transferable small in size every time, and maximum is no more than 2 millis Rise, and supernatant liquid can only be shifted, pipette tips be it is disposable, replaced after needing servicing fluids, can not automatically cleaning regenerate;
A kind of liquid transfer gun head, which is disclosed, in the patent that Chinese invention patent application number is CN201710260855.1 cleans dress automatically It sets, which can control the automatic control system that the liquid transfer gun head automatic flushing device executes default cleaning procedure in cleaning case System, can effectively solve the problems, such as the cleaning of liquid transfer gun head, but the patent is only applicable to the cleaning of liquid-transfering gun pipette tips, the rifle cleaned The problem of head liquid storage volume maximum is no more than 5 milliliters, and furthermore the invention is a cleaning device, not can solve liquid transfer,
In order to cooperate the usage scenario of automation, unattended 24 hours continuous operations are realized, while realizing all types liquid Carrying, transfer, storage, discharge reaction solution as needed, the cleaning of each automatic on-line, without being opened manually, it is existing on the market Product, be all unable to satisfy application demand, transferable suspension after the reaction was completed, 100 milliliters of single transfer amount or more, because This, needs to design and develop a kind of liquid relief cleaning device suitable for automation application scene.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Multi-function self-cleaning liquid-transfering device, can effectively prevent wriggling Pump blocking realizes that the liquid including suspension, viscous fluid, clarified solution is shifted, stored, discharged;The inlet tube added Road and spray shower head can be realized automatic cleaning, increase inlet pipe, the service life of containing liquid chamber, pipette, crossover sub, Reduce cost;Single treatment amount is big, can shift 150 milliliters of liquid, and structure is simple, is easy to use, to solve existing skill Defect caused by art.The present invention also provides the application methods of the Multi-function self-cleaning liquid-transfering device thus.
The present invention provides technical solution below to solve above-mentioned technical problem:
A kind of Multi-function self-cleaning liquid-transfering device, wherein including inlet pipe, containing liquid chamber, pipette, crossover sub, peristaltic pump, Pump line, the bottom of the containing liquid chamber are connect with the pipette, and the bottom of the top of the containing liquid chamber and the crossover sub connects It connects, the inside of the containing liquid chamber is equipped with spray shower head, and the inlet pipe is connected to the spray after running through the crossover sub The top of shower, the both ends of the pump line be connected to the crossover sub top and the peristaltic pump, the pipette One end of the nearly containing liquid chamber is inserted with Fastener.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the top of the containing liquid chamber, which is equipped with, is connected to described turn The inlet tube of changing-over head, the bottom of the crossover sub offer the first port being connected to the inlet tube, and the conversion connects The top of head offers the second port being connected to the pump line.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the bottom of the containing liquid chamber is equipped with and the pipette The outlet tube of connection.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the containing liquid chamber includes successively fixed from top to bottom connects The cylindrical tube and back taper tube body connect.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the inlet tube is inverted trapezoidal inlet tube.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the crossover sub is glass frosted crossover sub.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the Fastener is to be fixed by inserting block and knob block The T-type Fastener of connection, the pipette are equipped with the through-hole for inserting block insertion.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the spray shower head is cylindrical body spray shower head, described The periphery of cylindrical body spray shower head is uniformly provided with the plurality of openings being connected to the inlet pipe.
Above-mentioned a kind of Multi-function self-cleaning liquid-transfering device, wherein the aperture offers 50, each aperture Diameter is 0.7 millimeter.
In addition, the present invention also provides a kind of application methods of Multi-function self-cleaning liquid-transfering device, wherein including reaction mother liquor Application method, containing liquid chamber and the cleaning of related liquid flow path that application method, containing liquid chamber and the related liquid flow path of transfer rinse Application method;
The application method of reaction mother liquor transfer the following steps are included:
Step A1: pipette is put into reacted reaction flask, and starting peristaltic pump rotates forward, the complete mother liquor of abstraction reaction to liquid storage In storehouse, Fastener clamping pipette is prevented into water clock;
Step A2: pipette is put into receiving bottle, Fastener is unclamped pipette, starting peristaltic pump reversion will be in containing liquid chamber Liquid discharge;
Application method that the containing liquid chamber and related liquid flow path rinse the following steps are included:
Step B1: inlet pipe, which is pumped into, rinses liquid, rinses liquid A and is sprayed to containing liquid chamber, automatic rinsing storage from spray shower head for the first time Liquid storehouse and related liquid flow path, and liquid will be rinsed and be discharged into receiving bottle;
Step B2: rinsing second of liquid A and be sprayed to containing liquid chamber, automatic rinsing containing liquid chamber and related liquid flow path from spray shower head, And liquid will be rinsed and be discharged into receiving bottle;
The containing liquid chamber and related liquid flow path cleaning application method the following steps are included:
Step C1: pipette is put into waste liquid tank, inlet pipe is pumped into cleaning solution A, and cleaning solution A is sprayed to liquid storage from spray shower head Storehouse, automatic rinsing containing liquid chamber and related liquid flow path, and cleaning solution is discharged into waste liquid tank;
Step C2: inlet pipe is pumped into cleaning solution B, and cleaning solution B is sprayed to containing liquid chamber, automatic rinsing containing liquid chamber 1 from spray shower head With related liquid flow path, and cleaning solution is discharged into waste liquid tank.
The technical solution provided according to a kind of Multi-function self-cleaning liquid-transfering device of aforementioned present invention has following technical effect that
Peristaltic pump can be effectively prevent to block, realize that the liquid including suspension, viscous fluid, clarified solution is shifted, deposited It puts, discharge;
The inlet pipe and spray shower head added can be realized automatic cleaning, increase inlet pipe, containing liquid chamber, pipette, conversion The service life of connector, reduces cost;
Single treatment amount is big, can shift 150 milliliters of liquid, and structure is simple, is easy to use.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of Multi-function self-cleaning liquid-transfering device of the present invention;
Fig. 2 is the forward sight structural schematic diagram of spray shower head in a kind of Multi-function self-cleaning liquid-transfering device of the present invention;
Fig. 3 is the overlooking structure diagram of spray shower head in a kind of Multi-function self-cleaning liquid-transfering device of the present invention.
Wherein, appended drawing reference is as follows:
Inlet pipe 101, containing liquid chamber 102, pipette 103, crossover sub 104, peristaltic pump 105, pump line 106, spray shower head 107, Fastener 108, aperture 201.
Specific embodiment
In order to realize invention technological means, create feature, reach purpose and effect is easy to understand, lower combination tool Body diagram, the present invention is further explained.
It should be clear that this specification structure depicted in this specification institute accompanying drawings, ratio, size etc., only to cooperate specification to be taken off The content shown is not intended to limit the invention enforceable qualifications so that those skilled in the art understands and reads, therefore Do not have technical essential meaning, the modification of any structure, the change of proportionate relationship or the adjustment of size are not influencing the present invention Under the effect of can be generated and the purpose that can reach, it should all still fall in disclosed technology contents and obtain the model that can cover In enclosing.
Meanwhile cited such as "upper" in this specification, "lower", "left", "right", " centre " and " one " term, also Only being illustrated convenient for narration, rather than to limit the scope of the invention, relativeness is altered or modified, in nothing Under essence change technology contents, when being also considered as the enforceable scope of the present invention.
A preferred embodiment of the invention is to provide a kind of Multi-function self-cleaning liquid-transfering device, it is therefore an objective to can effectively prevent Peristaltic pump blocking realizes that the liquid including suspension, viscous fluid, clarified solution is shifted, stored, discharged;Add into Liquid pipeline and spray shower head can be realized automatic cleaning, increase the use longevity of inlet pipe, containing liquid chamber, pipette, crossover sub Life, reduces cost;Single treatment amount is big, can shift 150 milliliters of liquid, and structure is simple, is easy to use.
As shown in Figure 1, a kind of Multi-function self-cleaning liquid-transfering device, wherein including inlet pipe 101, containing liquid chamber 102, move The bottom of liquid pipe 103, crossover sub 104, peristaltic pump 105, pump line 106, containing liquid chamber 102 is connect with pipette 103, containing liquid chamber 102 top is connect with the bottom of crossover sub 104, and the inside of containing liquid chamber 102 is equipped with spray shower head 107, and inlet pipe 101 is passed through The top that spray shower head 107 is connected to after crossover sub 104 is worn, the both ends of pump line 106 are connected to the top of crossover sub 104 Portion and peristaltic pump 105, one end of the nearly containing liquid chamber 102 of pipette 103 is inserted with Fastener 108.
The top of a kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the containing liquid chamber 102 of use is equipped with connection In the inlet tube of crossover sub 104, the bottom of crossover sub 104 offers the first port being connected to inlet tube, crossover sub 104 top offers the second port being connected to pump line 106.
The bottom of a kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the containing liquid chamber 102 of use is equipped with and shifting The outlet tube that liquid pipe 103 connects.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the containing liquid chamber 102 of use include from top to bottom according to The secondary cylindrical tube being fixedly connected and back taper tube body.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the inlet tube used is inverted trapezoidal inlet tube.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the crossover sub 104 used turn for glass frosted Changing-over head 104.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the Fastener 108 used is by inserting block and rotation The T-type Fastener 108 that button block is fixedly connected, pipette 103 are equipped with the through-hole being inserted into for inserting block, and rotation knob block can be just Make containing liquid chamber 102 be connected to pipette 103 and separate in extracting inserting block, liquid can be prevented in transfer liquid due to weighing Liquid leakage when power effect or operation error.
As Figure 2-3, a kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the spray shower head 107 of use For cylindrical body spray shower head 107, the periphery of cylindrical body spray shower head 107 is uniformly provided with the plural number being connected to inlet pipe 101 A aperture 201, when in use, cleaning solution is delivered to spray shower head 107 by inlet pipe 101 can be in containing liquid chamber 102 Portion is cleaned, it is only necessary to which less amount of cleaning solution just can clean up, because of traditional transfer mode, liquid is from containing liquid chamber The pipette 103 of 102 bottoms enters, and is stored in containing liquid chamber 102, after device is moved to receiving bottle, liquid is again from pipette 103 release, and this mode will shift 150 milliliters of reaction solutions, at least need 150 milliliters of cleaning solutions, guarantee cleaning liquid level and last time Liquid level is shifted with height, can just be cleaned up, very waste of resource, this structure can save cleaning agent dosage to the greatest extent, section About cost reduces waste while protecting environment.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment, the aperture 201 of use offer 50, Mei Gekai The diameter in hole 201 is 0.7 millimeter.
A kind of Multi-function self-cleaning liquid-transfering device provided in this embodiment has following several situations when specifically used:
1. reaction mother liquor shifts:
Purpose is that reaction solution is transferred in receiving bottle;
Pipette 103 is put into reacted reaction flask first, starting peristaltic pump 105 rotates forward, and the complete mother liquor of abstraction reaction is extremely In containing liquid chamber 102,108 clamping pipette 103 of Fastener is prevented into water clock, pipette 103 is put into receiving bottle, Fastener 108 unclamp pipette 103, and starting peristaltic pump 105 inverts, liquid in containing liquid chamber 102 is discharged;
2. containing liquid chamber 102 and related liquid flow path rinse
Purpose: containing liquid chamber 102 and the remaining reaction solution of fluid path are rinsed into receiving bottle, are guaranteed " Every grain should be sent to the granary ", and liquid is improved The rate of transform;
Inlet pipe 101, which is pumped into, rinses liquid, rinses liquid A and is sprayed to containing liquid chamber 102, automatic rinsing from spray shower head 107 for the first time Containing liquid chamber 102 and related liquid flow path, and liquid will be rinsed and be discharged into receiving bottle, it rinses second of liquid A and is sprayed from spray shower head 107 To containing liquid chamber 102, automatic rinsing containing liquid chamber 102 and related liquid flow path, and liquid will be rinsed and be discharged into receiving bottle;
3. the cleaning of containing liquid chamber 102 and related liquid flow path
Purpose: by containing liquid chamber 102 and fluid path cleaning and regeneration;
Pipette 103 is put into waste liquid tank, inlet pipe 101 is pumped into cleaning solution A, and cleaning solution A is sprayed to storage from spray shower head 107 Liquid storehouse 102, automatic rinsing containing liquid chamber 102 and related liquid flow path, and cleaning solution is discharged into waste liquid tank, inlet pipe 101 is pumped into Cleaning solution B, cleaning solution B are sprayed to containing liquid chamber 102, automatic rinsing containing liquid chamber 102 and related liquid flow path from spray shower head 107, And cleaning solution is discharged into waste liquid tank.
To sum up, a kind of Multi-function self-cleaning liquid-transfering device of the invention, can effectively prevent peristaltic pump to block, realization includes Liquid including suspension, viscous fluid, clarified solution is shifted, is stored, is discharged;The inlet pipe and spray shower head added, energy It is enough to realize automatic cleaning, increase inlet pipe, the service life of containing liquid chamber, pipette, crossover sub, reduces cost;At single Reason amount is big, can shift 150 milliliters of liquid, and structure is simple, is easy to use.
The specific embodiment of invention is described above.It is to be appreciated that invention be not limited to it is above-mentioned specific Embodiment, devices and structures not described in detail herein should be understood as is practiced with the common mode in this field; Those skilled in the art can make within the scope of the claims various deformations or amendments make it is several it is simple deduce, deformation or Replacement, this has no effect on the substantive content of invention.

Claims (10)

1. a kind of Multi-function self-cleaning liquid-transfering device, which is characterized in that connect including inlet pipe, containing liquid chamber, pipette, conversion Head, peristaltic pump, pump line, the bottom of the containing liquid chamber are connect with the pipette, and the top of the containing liquid chamber connects with the conversion The bottom connection of head, the inside of the containing liquid chamber are equipped with spray shower head, and the inlet pipe connects after running through the crossover sub In the top of the spray shower head, the both ends of the pump line be connected to the crossover sub top and the peristaltic pump, One end of the closely described containing liquid chamber of the pipette is inserted with Fastener.
2. a kind of Multi-function self-cleaning liquid-transfering device as described in claim 1, which is characterized in that set at the top of the containing liquid chamber There is the inlet tube for being connected to the crossover sub, it is logical that the bottom of the crossover sub offers first be connected to the inlet tube Mouthful, the second port being connected to the pump line is offered at the top of the crossover sub.
3. a kind of Multi-function self-cleaning liquid-transfering device as claimed in claim 2, which is characterized in that the bottom of the containing liquid chamber is set There is the outlet tube connecting with the pipette.
4. a kind of Multi-function self-cleaning liquid-transfering device as claimed in claim 3, which is characterized in that the containing liquid chamber includes by upper The cylindrical tube and back taper tube body being fixedly connected sequentially under.
5. a kind of Multi-function self-cleaning liquid-transfering device as claimed in claim 4, which is characterized in that the inlet tube is inverted trapezoidal Inlet tube.
6. a kind of Multi-function self-cleaning liquid-transfering device as claimed in claim 5, which is characterized in that the crossover sub is glass Frosted crossover sub.
7. a kind of Multi-function self-cleaning liquid-transfering device as described in claim 1, which is characterized in that the Fastener is by being inserted into The T-type Fastener that block is fixedly connected with knob block, the pipette are equipped with the through-hole for inserting block insertion.
8. a kind of Multi-function self-cleaning liquid-transfering device as described in claim 1, which is characterized in that the spray shower head is cylinder The periphery of body spray shower head, the cylindrical body spray shower head is uniformly provided with the plurality of openings being connected to the inlet pipe.
9. a kind of Multi-function self-cleaning liquid-transfering device as claimed in claim 8, which is characterized in that the aperture offers 50 A, the diameter of each aperture is 0.7 millimeter.
10. a kind of application method of Multi-function self-cleaning liquid-transfering device, which is characterized in that the user including reaction mother liquor transfer The application method of application method, containing liquid chamber and the cleaning of related liquid flow path that method, containing liquid chamber and related liquid flow path rinse;
The application method of reaction mother liquor transfer the following steps are included:
Step A1: pipette is put into reacted reaction flask, and starting peristaltic pump rotates forward, the complete mother liquor of abstraction reaction to liquid storage In storehouse, Fastener clamping pipette is prevented into water clock;
Step A2: pipette is put into receiving bottle, Fastener is unclamped pipette, starting peristaltic pump reversion will be in containing liquid chamber Liquid discharge;
Application method that the containing liquid chamber and related liquid flow path rinse the following steps are included:
Step B1: inlet pipe, which is pumped into, rinses liquid, rinses liquid A and is sprayed to containing liquid chamber, automatic rinsing storage from spray shower head for the first time Liquid storehouse and related liquid flow path, and liquid will be rinsed and be discharged into receiving bottle;
Step B2: rinsing second of liquid A and be sprayed to containing liquid chamber, automatic rinsing containing liquid chamber and related liquid flow path from spray shower head, And liquid will be rinsed and be discharged into receiving bottle;
The containing liquid chamber and related liquid flow path cleaning application method the following steps are included:
Step C1: pipette is put into waste liquid tank, inlet pipe is pumped into cleaning solution A, and cleaning solution A is sprayed to liquid storage from spray shower head Storehouse, automatic rinsing containing liquid chamber and related liquid flow path, and cleaning solution is discharged into waste liquid tank;
Step C2: inlet pipe is pumped into cleaning solution B, and cleaning solution B is sprayed to containing liquid chamber, automatic rinsing containing liquid chamber 1 from spray shower head With related liquid flow path, and cleaning solution is discharged into waste liquid tank.
CN201910728165.3A 2019-08-08 2019-08-08 A kind of Multi-function self-cleaning liquid-transfering device and its application method Pending CN110404597A (en)

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