CN110393675A - A kind of chlorophyll freeze-dried powder and preparation method thereof - Google Patents
A kind of chlorophyll freeze-dried powder and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The present invention relates to beautification product field, a kind of chlorophyll freeze-dried powder and preparation method thereof is provided, for improving the quality of chlorophyll freeze-dried powder.A kind of chlorophyll freeze-dried powder provided by the invention, the formula of the freeze-dried powder include: chlorophyll 0.05 ~ 0.15%, excipient 8 ~ 9.25%, water phase 90.75 ~ 91.85%.It is carried out preferably by the content to chlorophyll, excipient, available surfacing, uniform color, viscosity is smaller, the freeze-dried powder of greater homogeneity.
Description
Technical field
The present invention relates to beautification product fields, and in particular to a kind of chlorophyll freeze-dried powder and preparation method thereof.
Background technique
Beauty industry has increased a new varieties newly again in recent years, that is, freeze-dried powder.Due to much having good beauty
The product of effect such as polypeptide, polysaccharide, nucleic acid, protein isoreactivity ingredient are easy to inactivate, and are difficult to protect in common beauty product
Their bioactivity is held, so, a part U.S. industry personage has devised this dose of freeze-dried powder using the freeze drying technology on drug
The product of type.Freeze-dried powder can keep the activity of functional component well, since drying carries out under vacuum conditions, for some easy
The substance of oxidation plays a very good protection.Product water content after freeze-drying is very low, improves the stability of product,
Contaminated chance reduces, and facilitates the pot-life that transport also extends product.But freeze-dried powder quality in the market is irregular not
Together, it is the product structure ratio using polypeptide, polysaccharide, nucleic acid, protein isoreactivity ingredient as effect additive that the product to do very well is also mostly
It is more single.
Scientists had found the effect and effect of chlorophyll, SOD, P4-D1 and 2-O-GL that chlorophyll contains in recent years
Equal anticancer components, have good antitumaous effect.SOD is a kind of powerful antioxidants, is discharged in the metabolic process of human body
Harmful superoxide radical, they can not only destroy cell, even more aging and cause the arch-criminal of tumour, and SOD energy
Protect body from the infringement of oxygen radical, antiradical activities are thousands of times of VA and VE, and P4-D1, then can repair
The cell of damage resists the toxicity of carcinogen.Medical research shows that chlorophyll has significant liver protecting, hematopoiesis, solution
Poison anticancer, delays senescence, prevents gene mutation, promote wound healing, deodorization, improve constipation, analgesic, reduce the function such as cholesterol
Effect can also provide vitamin, maintain the effects of activity of enzyme.The product that many health products Co., Ltd all have developed chlorophyll supplies
People take.The beauty product of chlorophyll class also continues to bring out, but shows all general.
Currently, the effect of freeze-drying beauty product in the market ingredient is usually the ingredients such as polypeptide, polysaccharide, nucleic acid, protein,
Product structure is relatively simple.The freeze-dried powder that chlorophyll how is obtained using freeze drying technology is a technical problem to be solved urgently.
Summary of the invention
Present invention solves the technical problem that improve the quality of chlorophyll freeze-dried powder, provide a kind of chlorophyll freeze-dried powder and its
Preparation method.
In order to solve the above technical problem, the present invention provides technical solution are as follows:
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.05 ~ 0.15%, excipient 8 ~ 9.25%, water phase
90.75~91.85%。
It is soluble in the aqueous phase after chlorophyll is mixed with excipient, uniformly mixed freeze-drying can obtain the preferable freeze-dried powder of condition.
It being carried out preferably by the content to chlorophyll, excipient, available surfacing, uniform color, viscosity is smaller,
The freeze-dried powder of greater homogeneity.
Preferably, the formula of the freeze-dried powder includes: chlorophyll 0.1%, excipient 9.15%, water phase 90.75%.
Preferably, the excipient includes mannitol, sucrose, trehalose, glucose, sodium chloride, lactose, histidine, essence
Propylhomoserin, glycine, hyaluronic acid, polyglutamic acid are one such or several.The quality of excipient effects freeze-dried powder, by tax
The content of shape agent carries out preferably, the freeze-dried powder of available high-quality.
Preferably, the water phase include water, PEG-400, TW-20 it is one of or several.
Preferably, the chlorophyll 0.05 ~ 0.15%, mannitol 3 ~ 5%, trehalose 3 ~ 5%, polyglutamic acid 0.4 ~ 0.5%, thoroughly
Bright matter acid 0.1 ~ 0.2%, lysine 0.1 ~ 0.3%, arginine 0.2 ~ 0.3%, histidine 0.1 ~ 0.2%, water 90.8 ~ 91.85%.It is right
The excipient of chlorophyll carries out preferably, the freeze-dried powder of available higher quality.
A kind of preparation method of chlorophyll freeze-dried powder, including
S11. excipient is added in water phase, 200 ~ 500 turns/min stirring and dissolving is complete, obtains mixed liquor；
S12. it sterilizes after mixed liquor being filtered, chlorophyll is added, obtains mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.
Preferably, the excipient in the S11 step includes mannitol, trehalose, polyglutamic acid, hyaluronic acid, relies ammonia
Acid, arginine, histidine, it is described to include: by excipient addition water phase
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added.
Preferably, the water phase is water.
Preferably, the filtering are as follows: with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；The sterilizing are as follows: will filter
Liquid is under 110 ~ 130 degrees Celsius, 10 ~ 30min of high-temp steam sterilizing；Temperature≤45 degree Celsius when the addition chlorophyll.
Preferably, the freeze-drying are as follows: -35 ~ -30 DEG C of plate layer temperature of setting, 5 ~ 6h of pre-freeze time；After pre-freeze,
When rear cabinet temperature reaches -50 ~ -40 DEG C, start to vacuumize, be started to warm up after vacuum degree drops to 0.6 ~ 0.8mbar；Once
Drying stage first sets -20 ~ -10 DEG C, 8 ~ 12h of plate layer temperature, then resets -5 ~ 5 DEG C of plate layer temperature, continue 1 ~ 3h；Parsing
Drying stage sets 8 ~ 15 DEG C, 1 ~ 3h of duration of plate layer temperature, resets 20 ~ 40 DEG C of plate layer temperature, continue 5 ~ 8h.
Compared with prior art, the device have the advantages that are as follows: carried out by content to chlorophyll, excipient excellent
Choosing, available surfacing, uniform color, viscosity is smaller, the freeze-dried powder of greater homogeneity；The pH value of freeze-dried powder is the same as skin
It is close, it is more mild to skin, easily by percutaneous absorption.
Specific embodiment
Following implementation column is to further explanation of the invention, is not limitation of the present invention.
Embodiment 1
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.1%, mannitol 3%, trehalose 5%, poly- paddy
Propylhomoserin 0.5%, hyaluronic acid 0.2%, lysine 0.05%, arginine 0.3%, histidine 0.1%, water 90.75%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 7h.
It is soluble in the aqueous phase after chlorophyll is mixed with excipient, uniformly mixed freeze-drying can obtain the preferable freeze-dried powder of condition.Pass through
The content of chlorophyll, excipient is carried out preferably, available surfacing, uniform color, viscosity is smaller, the jelly of greater homogeneity
Dry powder.The quality of excipient effects freeze-dried powder carries out the preferably freeze-drying of available high-quality by the content to excipient
Powder.The excipient of chlorophyll is carried out preferably, the freeze-dried powder of available higher quality.
Embodiment 2
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.15%, mannitol 4%, trehalose 3%, poly- paddy
Propylhomoserin 0.4%, hyaluronic acid 0.2%, lysine 0.1%, arginine 0.2%, histidine 0.1%, water 91.85%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 6h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 6h.
Embodiment 3
A kind of chlorophyll freeze-dried powder, a kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.05%, sweet dew
Alcohol 5%, trehalose 3%, polyglutamic acid 0.4%, hyaluronic acid 0.1%, lysine 0.1%, arginine 0.2%, histidine 0.1%, water
91.05%。
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -30 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 9h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 5h.
Embodiment 4
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.15%, mannitol 5%, trehalose 3%, poly- paddy
Propylhomoserin 0.4%, hyaluronic acid 0.2%, lysine 0.1%, arginine 0.2%, histidine 0.2%, water 90.75%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 7h.
Embodiment 5
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.1%, mannitol 3%, sucrose 2%, lactose 2%,
Glucose 1%, polyglutamic acid 0.5%, hyaluronic acid 0.2%, lysine 0.05%, arginine 0.3%, histidine 0.1%, water
90.75%。
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, sucrose, lactose, glucose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/
Min stirring and dissolving is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 7h.
Embodiment 6
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.1%, mannitol 3%, sodium chloride 5%, poly- paddy
Propylhomoserin 0.5%, hyaluronic acid 0.2%, lysine 0.05%, arginine 0.3%, histidine 0.1%, water 90.75%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, sodium chloride, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 7h.
Embodiment 7
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.1%, mannitol 3%, trehalose 5%, poly- paddy
Propylhomoserin 0.5%, hyaluronic acid 0.2%, lysine 0.05%, arginine 0.3%, glycine 0.1%, water 90.75%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, glycine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -45 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 30 DEG C of plate layer temperature, continues 7h.
Embodiment 8
A kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder include: chlorophyll 0.1%, mannitol 3%, trehalose 5%, poly- paddy
Propylhomoserin 0.5%, hyaluronic acid 0.2%, lysine 0.05%, arginine 0.3%, histidine 0.1%, water 90.75%.
A kind of preparation method of chlorophyll freeze-dried powder, comprising:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added；
S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor；
S12. mixed liquor is stirred evenly, with 0.22 μm of membrane filtration at -0.09 ~ 0.1MPa；Filtrate is taken, filtrate is existed
Under 120 degrees Celsius, high-temp steam sterilizing 20min after cooling when system temperature≤45 degree Celsius, is added chlorophyll, stirs evenly,
Obtain mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.The freeze-drying are as follows: -35 DEG C of temperature of plate layer of setting, pre-freeze time 5h；
After pre-freeze, when rear cabinet temperature reaches -35 DEG C, starts to vacuumize, be started to warm up after vacuum degree drops to 0.8mbar；
The primary drying stage first sets -15 DEG C of temperature of plate layer, then 10h resets 0 DEG C of plate layer temperature, continues 2h；Parsing-desiccation rank
Section sets 10 DEG C, duration 1.5h of plate layer temperature, resets 20 DEG C of plate layer temperature, continues 7h.
Comparative example 1
Comparative example 1 with embodiment 1 the difference is that, a kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder includes: that leaf is green
Element 0.1%, mannitol 9.15%, water 90.75%.A kind of preparation method of chlorophyll freeze-dried powder, comprising: mannitol is added S111.
In water phase, stirring and dissolving is complete；S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor.Remaining is the same as embodiment 1.
Comparative example 2
Comparative example 2 with embodiment 1 the difference is that, a kind of chlorophyll freeze-dried powder, the formula of the freeze-dried powder includes: that leaf is green
Element 0.1%, trehalose 9.15%, water 90.75%.A kind of preparation method of chlorophyll freeze-dried powder, comprising: trehalose is added S111.
In water phase, stirring and dissolving is complete；S11.200 ~ 500 turn/min stirring and dissolving is complete, obtains mixed liquor.Remaining is the same as embodiment 1.
Comparative example 3
Comparative example 3 with embodiment 1 the difference is that, the formula of the freeze-dried powder includes: chlorophyll 0.1%, arginine 3.3%,
Lysine 3.15%, histidine 3%, water 90.75%.A kind of preparation method of chlorophyll freeze-dried powder, comprising: S111. by arginine,
Lysine, histidine are added in water phase, and stirring and dissolving is complete；S11.200 ~ 500 turn/min stirring and dissolving is complete, is mixed
Liquid.Remaining is the same as embodiment 1
Experimental example 1
The performance of testing example 1 ~ 8 and comparative example 1 ~ 3, as shown in table 1.
1 freeze-dried powder performance of table
As known from Table 1, the appearance of embodiment and comparative example, dissolubility are substantially qualification, show the figuration using the application
The quality of product, but the friability > 1% of the freeze-dried powder in comparative example 1 ~ 3, freeze-dried powder can be effectively ensured with chlorophyll compounding for agent
It is frangible, influence product appearance.The formula and preparation method of embodiment 1 easily absorb skin, and product appearance is more exquisite.
Experimental example 2
Freeze-dried powder in embodiment 1 ~ 7 and comparative example 1 ~ 3 is measured to the removal rate of free radical using spectrophotometry.Such as 2 institute of table
Show.
2 free radical removal rate of table
From table 2 it can be seen that the freeze-dried powder in embodiment 1 ~ 4 has preferable elimination effect to hydroxyl radical free radical.In comparative example
Excipient has biggish difference with the excipient in embodiment, and content also has difference, and the effect for removing free radical is relatively poor.
Above-listed detailed description is illustrating for possible embodiments of the present invention, and above embodiments are not to limit this
The scope of the patents of invention, all equivalence enforcements or change without departing from carried out by the present invention, is intended to be limited solely by the scope of the patents of this case.
Claims (10)
1. a kind of chlorophyll freeze-dried powder, which is characterized in that the formula of the freeze-dried powder includes: chlorophyll 0.05 ~ 0.15%, figuration
Agent 8 ~ 9.25%, water phase 90.75 ~ 91.85%.
2. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the formula of the freeze-dried powder includes: leaf
Green plain 0.1%, excipient 9.15%, water phase 90.75%.
3. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the excipient includes mannitol, sugarcane
Sugar, trehalose, glucose, sodium chloride, lactose, histidine, arginine, glycine, hyaluronic acid, polyglutamic acid are one such
Or it is several.
4. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the water phase include water, PEG-400,
TW-20's is one of or several.
5. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the chlorophyll 0.05 ~ 0.15%, it is sweet
Reveal alcohol 3 ~ 5%, trehalose 3 ~ 5%, polyglutamic acid 0.4 ~ 0.5%, hyaluronic acid 0.1 ~ 0.2%, lysine 0.1 ~ 0.3%, arginine
0.2 ~ 0.3%, histidine 0.1 ~ 0.2%, water 90.8 ~ 91.85%.
6. a kind of preparation method of chlorophyll freeze-dried powder, which is characterized in that including
S11. excipient is added in water phase, 200 ~ 500 turns/min stirring and dissolving is complete, obtains mixed liquor；
S12. it sterilizes after mixed liquor being filtered, chlorophyll is added, obtains mother liquor；
S13. mother liquor is freeze-dried to obtain freeze-dried powder.
7. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the excipient packet in the S11 step
Mannitol, trehalose, polyglutamic acid, hyaluronic acid, lysine, arginine, histidine are included, it is described that water phase packet is added in excipient
It includes:
S111. mannitol, trehalose, polyglutamic acid, hyaluronic acid are sequentially added in water phase, 200 ~ 500 turns/min stirring is molten
Solution is complete；
S112. arginine, histidine, lysine are added.
8. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the water phase is water.
9. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the filtering are as follows: -0.09 ~
With 0.22 μm of membrane filtration under 0.1MPa；The sterilizing are as follows: by filtrate 110 ~ 130 degrees Celsius of lower high-temp steam sterilizings 10 ~
30min；Temperature≤45 degree Celsius when the addition chlorophyll.
10. a kind of chlorophyll freeze-dried powder according to claim 1, which is characterized in that the freeze-drying are as follows: setting plate layer
Temperature -35 ~ -30 DEG C, 5 ~ 6h of pre-freeze time；After pre-freeze, when rear cabinet temperature reaches -50 ~ -40 DEG C, start to vacuumize, when
Vacuum degree starts to warm up after dropping to 0.6 ~ 0.8mbar；The primary drying stage first sets -20 ~ -10 DEG C, 8 ~ 12h of plate layer temperature,
Then -5 ~ 5 DEG C of plate layer temperature is reset, 1 ~ 3h is continued；The parsing-desiccation stage, 8 ~ 15 DEG C of plate layer temperature of setting, the duration 1 ~
3h resets 20 ~ 40 DEG C of plate layer temperature, continues 5 ~ 8h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533570A (en) * | 2020-11-27 | 2022-05-27 | 广州美蔻生物科技有限公司 | Fullerene freeze-dried powder with repairing and anti-aging effects |
| CN114557919A (en) * | 2020-11-27 | 2022-05-31 | 广州美蔻生物科技有限公司 | Bluecapeptide freeze-dried powder with repairing and anti-aging effects |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263380A (en) * | 2013-05-30 | 2013-08-28 | 成都大学 | Horseradish facial mask and preparation method thereof |
| US20140301959A1 (en) * | 2013-03-14 | 2014-10-09 | Elias Chavando | Composition for deodorizing breath |
| CN104726336A (en) * | 2015-02-27 | 2015-06-24 | 河南城建学院 | Method for optimizing bacterial powder protective agent of freeze-dried algicidal bacteria NP23 |
| CN106699767A (en) * | 2015-11-15 | 2017-05-24 | 重庆都好生物科技有限公司 | Method for extracting chlorophylls from watermelon peel |
-
2019
- 2019-08-14 CN CN201910750984.8A patent/CN110393675A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140301959A1 (en) * | 2013-03-14 | 2014-10-09 | Elias Chavando | Composition for deodorizing breath |
| CN103263380A (en) * | 2013-05-30 | 2013-08-28 | 成都大学 | Horseradish facial mask and preparation method thereof |
| CN104726336A (en) * | 2015-02-27 | 2015-06-24 | 河南城建学院 | Method for optimizing bacterial powder protective agent of freeze-dried algicidal bacteria NP23 |
| CN106699767A (en) * | 2015-11-15 | 2017-05-24 | 重庆都好生物科技有限公司 | Method for extracting chlorophylls from watermelon peel |
Non-Patent Citations (3)
| Title |
|---|
| 姚静等: "《药物冻干制剂技术的设计及应用》", 30 June 2007, 中国医药科技出版社 * |
| 玉鑫化妆品OEM: "《黑科技|缤纷原色冻干粉，get护肤新技能》", 19 July 2019 * |
| 胡英等: "《药物制剂》", 28 February 2013, 中国医药科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533570A (en) * | 2020-11-27 | 2022-05-27 | 广州美蔻生物科技有限公司 | Fullerene freeze-dried powder with repairing and anti-aging effects |
| CN114557919A (en) * | 2020-11-27 | 2022-05-31 | 广州美蔻生物科技有限公司 | Bluecapeptide freeze-dried powder with repairing and anti-aging effects |
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