CN110384722A - A kind of antiviral nasal douche agent of releiving - Google Patents
A kind of antiviral nasal douche agent of releiving Download PDFInfo
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- CN110384722A CN110384722A CN201910794386.0A CN201910794386A CN110384722A CN 110384722 A CN110384722 A CN 110384722A CN 201910794386 A CN201910794386 A CN 201910794386A CN 110384722 A CN110384722 A CN 110384722A
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- nasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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Abstract
The present invention relates to a kind of antiviral nasal douche agent of releiving, and belong to technical field of medicine.To solve the problems, such as that existing nasal spray causes stimulation to cause patient uncomfortable nasal membrane, the present invention provides a kind of antiviral nasal douche agent of releiving, the nasal douche agent active drug ingredient includes: 1~10mg/mL of algal polysaccharides, 5~12mg/mL of natural sea salt, 5~15mg/mL of Angelica Dahurica extract, 0.1~1mg/mL of moisturizer, and solvent is sterile water for injection.The algal polysaccharides that the present invention adds can be cross-linked to form reticular structure, form one layer of moisturizing mucous membrane, can provide barrier while alleviating mycteroxerosis and resist external poisonous and harmful substance, prevent the propagation and breeding of common cold virus.Natural sea salt has no stimulation to nasal cavity, can maintain cleaning and wet, the symptom of alleviation nasal obstruction nasal cavity dryness in nasal cavity.Angelica Dahurica extract has the effectiveness of sensible analgesic, can improve the symptom of nasal obstruction.
Description
Technical field
The invention belongs to technical field of medicine, more particularly to a kind of antiviral nasal douche agent of releiving.
Background technique
Rhinitis refers to the inflammation of nasal membrane and submucous tissue, and showing as congested or oedema, patient often will appear
It has a stuffy nose, stay the symptoms such as clear water tears, rhiocnesmus, the uncomfortable, cough of throat.Rhinovirus is the principal causative microorganism for causing rhinitis, and
The primary causative agents of common cold.The current therapies form of rhinovirus infection includes using western medicine antibiotics, Histamine agents object
It is treated, but is easy to produce drug resistance using Western medicine, toxic side effect is big；And oral western medicine, active drug ingredient is because of stomach and intestine
Part drug effect is had lost to first pass effect, therefore it is relatively slow to take effect, and cannot quickly treat Rhinitis Symptoms.
Spray is the novel nasal cavity regional administration dosage form to grow up in recent years, refer to drug containing solution-type, emulsion type or
Suspension type liquid is encapsulated in the pressure vessel with special valving, by the pressure or other modes of manual pump when use
The preparation that content is sprayed in the form of mist etc..Nasal spray is easy to use, has the function of quick-acting and positioning, and can be with
Dosage is accurately controlled with quantitative valve.But since nasal membrane is more fragile, it is viscous that common antibiotic etc sprays application to nasal cavity
Stimulation is easily caused after film, causes the dry symptom itched of nasal cavity and causes the discomfort of patient.
Summary of the invention
To solve the problems, such as that existing nasal spray causes stimulation to cause patient uncomfortable nasal membrane, the present invention provides one
The antiviral nasal douche agent of releiving of kind.
Technical solution of the present invention:
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: 1~10mg/mL of algal polysaccharides, natural sea salt 5
~12mg/mL, 5~15mg/mL of Angelica Dahurica extract, 0.1~1mg/mL of moisturizer, solvent are sterile water for injection.
Further, active drug ingredient includes: that 2~8mg/mL of algal polysaccharides, 6~10mg/mL of natural sea salt, the root of Dahurain angelica mention
6~12mg/mL of object, 0.3~0.8mg/mL of moisturizer are taken, solvent is sterile water for injection.
Further, active drug ingredient includes: that 3~5mg/mL of algal polysaccharides, 7~9mg/mL of natural sea salt, the root of Dahurain angelica mention
7~10mg/mL of object, 0.4~0.6mg/mL of moisturizer are taken, solvent is sterile water for injection.
Further, active drug ingredient includes: algal polysaccharides 4mg/mL, natural sea salt 8mg/mL, Angelica Dahurica extract
8mg/mL, moisturizer 0.5mg/mL, solvent are sterile water for injection.
Further, the moisturizer is the combination of one or more of glycerol, propylene glycol or sorbierite.
Further, also containing the preservative of 1~5mg/mL.
Further, the preservative is one of ethyl-para-hydroxybenzoate, benzyl alcohol or benzyl carbinol.
Beneficial effects of the present invention:
The algal polysaccharides added in antiviral nasal douche agent of releiving provided by the invention contain great amount of hydroxy group, carboxyl isopolarity
Group can form hydrogen bond with hydrone to which crosslinking becomes reticular structure, which has preferable viscosity and film forming
Can, one layer of moisturizing mucous membrane is formed, barrier can be provided while alleviating mycteroxerosis and resist external poisonous and harmful substance and nasal cavity
Inner recipient combines, and can adhere to the soakage that harmful substance is reduced into the harmful substance in nasal cavity, thus adjuvant treatment and
Preventing cold, this layer film have physical protection effect, prevent the propagation and breeding of general common cold virus.Natural sea salt is to nasal cavity
It has no stimulation, there is stronger inhibiting effect to invasive organism, while cleaning in nasal cavity and wet can also be maintained, delay
The symptom of solution nasal obstruction nasal cavity dryness.Angelica Dahurica extract has the effectiveness of sensible analgesic, can improve the symptom of nasal obstruction.
Antiviral nasal douche agent of releiving provided by the invention can use acute or chronic rhinitis, allergic rhinitis, seasonal nose
Inflammation, motility rhinitis, atrophic rhinitis and flu etc. cause cleaning cleaning, dry nose capillary after nasal obstruction and nasal operation
Nosebleed caused by rupturing etc..
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: 1~10mg/mL of algal polysaccharides, natural sea salt 5
~12mg/mL, 5~15mg/mL of Angelica Dahurica extract, 0.1~1mg/mL of moisturizer, solvent are sterile water for injection.
Embodiment 2
A kind of antiviral nasal douche agent of releiving, active drug ingredient include: 2~8mg/mL of algal polysaccharides, natural sea salt 6~
10mg/mL, 6~12mg/mL of Angelica Dahurica extract, 0.3~0.8mg/mL of moisturizer, 1~5mg/mL of preservative, solvent are sterile note
It penetrates and uses water.
Embodiment 3
A kind of antiviral nasal douche agent of releiving, active drug ingredient include: 3~5mg/mL of algal polysaccharides, natural sea salt 7~
9mg/mL, 7~10mg/mL of Angelica Dahurica extract, 0.4~0.6mg/mL of moisturizer, solvent are sterile water for injection.
Embodiment 4
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 4mg/mL, natural sea salt 8mg/
ML, Angelica Dahurica extract 8mg/mL, moisturizer 0.5mg/mL, solvent are sterile water for injection.
Embodiment 5
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 1mg/mL, natural sea salt 5mg/
ML, Angelica Dahurica extract 5mg/mL, glycerol 0.1mg/mL, solvent are sterile water for injection.
Embodiment 6
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 2mg/mL, natural sea salt 6mg/
ML, Angelica Dahurica extract 6mg/mL, glycerol 0.2mg/mL, solvent are sterile water for injection.
Embodiment 7
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 3mg/mL, natural sea salt 7mg/
ML, Angelica Dahurica extract 8mg/mL, propylene glycol 0.3mg/mL, solvent are sterile water for injection.
Embodiment 8
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 4mg/mL, natural sea salt 8mg/
ML, Angelica Dahurica extract 9mg/mL, propylene glycol 0.4mg/mL, solvent are sterile water for injection.
Embodiment 9
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 5mg/mL, natural sea salt 10mg/
ML, Angelica Dahurica extract 10mg/mL, sorbierite 0.5mg/mL, solvent are sterile water for injection.
Embodiment 10
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 6mg/mL, natural sea salt 11mg/
ML, Angelica Dahurica extract 11mg/mL, sorbierite 0.6mg/mL, ethyl-para-hydroxybenzoate 1mg/mL, solvent are aseptic injection use
Water.
Embodiment 11
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 8mg/mL, natural sea salt 12mg/
ML, Angelica Dahurica extract 12mg/mL, sorbierite 0.8mg/mL, benzyl alcohol 3mg/mL, solvent are sterile water for injection.
Embodiment 12
A kind of antiviral nasal douche agent of releiving, active drug ingredient includes: algal polysaccharides 10mg/mL, natural sea salt 12mg/
ML, Angelica Dahurica extract 12mg/mL, sorbierite 1.0mg/mL, benzyl carbinol 3mg/mL, solvent are sterile water for injection.
Claims (7)
1. a kind of antiviral nasal douche agent of releiving, which is characterized in that active drug ingredient include: 1~10mg/mL of algal polysaccharides,
5~12mg/mL of natural sea salt, 5~15mg/mL of Angelica Dahurica extract, 0.1~1mg/mL of moisturizer, solvent are sterile water for injection.
2. a kind of antiviral nasal douche agent of releiving according to claim 1, which is characterized in that active drug ingredient includes: sea
2~8mg/mL of polysaccharides, 6~10mg/mL of natural sea salt, 6~12mg/mL of Angelica Dahurica extract, 0.3~0.8mg/mL of moisturizer,
Solvent is sterile water for injection.
3. a kind of antiviral nasal douche agent of releiving according to claim 1, which is characterized in that active drug ingredient includes: sea
3~5mg/mL of polysaccharides, 7~9mg/mL of natural sea salt, 7~10mg/mL of Angelica Dahurica extract, moisturizer 0.4~0.6mg/mL, it is molten
Agent is sterile water for injection.
4. a kind of antiviral nasal douche agent of releiving according to claim 1, which is characterized in that active drug ingredient includes: sea
Polysaccharides 4mg/mL, natural sea salt 8mg/mL, Angelica Dahurica extract 8mg/mL, moisturizer 0.5mg/mL, solvent are aseptic injection use
Water.
5. -4 any antiviral nasal douche agent of releiving of described one kind according to claim 1, which is characterized in that the moisturizer is sweet
The combination of one or more of oil, propylene glycol or sorbierite.
6. a kind of antiviral nasal douche agent of releiving according to claim 5, which is characterized in that also anti-containing 1~5mg/mL
Rotten agent.
7. a kind of antiviral nasal douche agent of releiving according to claim 6, which is characterized in that the preservative is para hydroxybenzene
One of Ethyl formate, benzyl alcohol or benzyl carbinol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910794386.0A CN110384722A (en) | 2019-08-27 | 2019-08-27 | A kind of antiviral nasal douche agent of releiving |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910794386.0A CN110384722A (en) | 2019-08-27 | 2019-08-27 | A kind of antiviral nasal douche agent of releiving |
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| Publication Number | Publication Date |
|---|---|
| CN110384722A true CN110384722A (en) | 2019-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910794386.0A Pending CN110384722A (en) | 2019-08-27 | 2019-08-27 | A kind of antiviral nasal douche agent of releiving |
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| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111658664A (en) * | 2020-06-18 | 2020-09-15 | 大连工业大学 | Application of sea cucumber polysaccharide in resisting novel coronavirus |
| CN116211884A (en) * | 2023-02-16 | 2023-06-06 | 海孵(海南自贸区)医疗科技有限责任公司 | Nasal cavity spray and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042640A (en) * | 2013-06-27 | 2014-09-17 | 辽宁亿灵科创生物医药科技有限公司 | Nasal spray of seaweed extract and preparation method thereof |
| CN106038588A (en) * | 2016-07-11 | 2016-10-26 | 长春呈实健康实业有限公司 | Natural sea salt nasal irrigation agent |
| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
-
2019
- 2019-08-27 CN CN201910794386.0A patent/CN110384722A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042640A (en) * | 2013-06-27 | 2014-09-17 | 辽宁亿灵科创生物医药科技有限公司 | Nasal spray of seaweed extract and preparation method thereof |
| CN106038588A (en) * | 2016-07-11 | 2016-10-26 | 长春呈实健康实业有限公司 | Natural sea salt nasal irrigation agent |
| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111658664A (en) * | 2020-06-18 | 2020-09-15 | 大连工业大学 | Application of sea cucumber polysaccharide in resisting novel coronavirus |
| CN116211884A (en) * | 2023-02-16 | 2023-06-06 | 海孵(海南自贸区)医疗科技有限责任公司 | Nasal cavity spray and preparation method thereof |
| CN116211884B (en) * | 2023-02-16 | 2024-05-17 | 海孵(海南自贸区)医疗科技有限责任公司 | Nasal cavity spray and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20191029 |
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