CN106038588A - Natural sea salt nasal irrigation agent - Google Patents
Natural sea salt nasal irrigation agent Download PDFInfo
- Publication number
- CN106038588A CN106038588A CN201610541577.2A CN201610541577A CN106038588A CN 106038588 A CN106038588 A CN 106038588A CN 201610541577 A CN201610541577 A CN 201610541577A CN 106038588 A CN106038588 A CN 106038588A
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- CN
- China
- Prior art keywords
- nasal
- sea salt
- natural sea
- rhinitis
- irrigation agent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
The invention discloses a natural sea salt nasal irrigation agent which is prepared through normal-temperature dissolution with purified water and glycerinum as solvent, natural sea salt as solute and domiphen bromide as pathogenic bacteria inhibitor. Every 100 L of nasal irrigation agent contains 0.85-0.95 kg of natural sea salt, 0.5-1.5 L of glycerinum and 0.01-0.05 kg of domiphen bromide. The natural sea salt nasal irrigation agent has the sodium chloride content of 0.85-0.95% (mg/ml), the total heavy metal quantity smaller than or equal to 2 micrograms per milliliter (according to Pb), the pH value of 5.0-7.0 and the cytotoxicity not larger than the second level, causes no sensitization response or vaginal stimulation reaction, has the total bacterial colony number smaller than or equal to 100 cfu/ml and the total fungal colony number smaller than or equal to 100 cfu/ml, can not detect coliform, pseudomonas aeruginosa, staphylococcus aureus and hemolytic streptococcus, can be used for acute and chronic rhinitis, allergic rhinitis, seasonal rhinitis, exercise-induced rhinitis, atrophic rhinitis, nasal polyp, nasal obstruction caused by cold and the like, epistaxis caused by after-nasal-surgery cleaning and dry climatic nasal blood capillary rupture, and the like.
Description
Technical field
The present invention relates to a kind of nasal wash.
Background technology
Rhinitis is that nasal mucosa or sub-mucosal tissues are because virus infection, courses of infection, stimulus object stimulation etc. cause nasal mucosa
Or the impaired caused acute or chronic inflammation of sub-mucosal tissues.Rhinitis results in too much mucus, generally causes watery nasal discharge, nasal obstruction
Etc. symptom.
The medicine of current all for the treatment of nasal obstruction all contains vasoconstrictor composition, and Chinese medicine, chemical drugs all mark " must not
The most long-time use (can not use more than continuously a week) ".
CN1883508A discloses a kind of anti-dust nasal cleanser, and this anti-dust nasal cleanser system moistens thick liquid, main
If having one's ideas straightened out by wind dispelling, restraining blood capillary and reach to alleviate nasal obstruction effect, only dust granules is had part blocks effect, shortcoming
Following points: 1, this anti-dust nasal cleanser consumption is difficult to grasp, consumption is few inoperative, and the big user of consumption has " nose
Tears " sense.2, protein sugar plays the effect of culture medium under thickness moist environment, and pathogenic bacterium can be made at this to cultivate increasing bacterium, and increase is exhaled
Inhale road or even the chance of respiratory system infection.3, EDTA-2Na is a kind of chelating agent, is used herein to thickening, but " eats harmful, sting
Swash eyes, respiratory system and skin ", and in the case of user is without this Professional knowledge, usage amount is uncontrollable, causes the secondary work of poison
Danger can hardly be avoided.4, citric acid have quickening cutin update, promote blood capillary astriction, due to nasal mucosa than
Much, it is the most inappropriate for therefore using at this to skin keratin fragility.
Summary of the invention
It is an object of the invention to provide a kind of natural sea salt nasal irrigation agent, without blood vessel contractile element in this product, to having a stuffy nose, in
The alleviation of the prevention of otitis, treatment and symptom has effect or assosting effect；Simultaneously because be that microbial limit condition provides, also
Can use as nasal cavity postoperative irrigation agent, and safety testing checking, can use the most for a long time.
It is an object of the invention to be achieved through the following technical solutions:
A kind of natural sea salt nasal irrigation agent, with purified water, glycerol as solvent, natural sea salt is solute, and domiphen bromide is pathogenic
Bacteria inhibitor, makes through normal-temperature dissolution, containing natural sea salt 0.85～0.95kg, glycerol 0.5～1.5L, domiphen bromide in every 100L
0.01～0.05kg.
The natural sea salt nasal irrigation agent of the present invention is generally colourless or light color liquid, and without insoluble foreign body, microorganism limits
Condition provides, and has stronger to pathogenic entero becteria, pyococcus, saccharomytes, bacillus pyocyaneus and Hemolytic streptococcus
Inhibitory action, is medical apparatus and instruments 6864 medical material and dressing.
The natural sea salt nasal irrigation agent sodium chloride-containing 0.85～0.95% (g/ml) of the present invention, total metals (in terms of Pb)
≤ 2 μ g/ml, pH value is 5.0～7.0, and cytotoxicity is not more than 2 grades, without sensitivity response, absence of vagina irritant reaction, bacterial clump
Sum≤100cfu/ml, fungus colony sum≤100cfu/ml, coliform, bacillus pyocyaneus, staphylococcus aureus and molten
Courageous and upright streptococcus must not detect；Pathogenic entero becteria, suppurative ball saccharomytes, bacillus pyocyaneus and Hemolytic streptococcus are had
Stronger inhibitory action, can be used for acute or chronic rhinitis, allergic rhinitis, seasonal rhinitis, mobility's rhinitis, atrophic rhinitis,
The epistaxis that nasal polyp and flu etc. clean cleaning after causing nasal obstruction and nasal operation, dry nose capillary rupture causes
Deng.
The natural sea salt nasal irrigation agent of the present invention has the advantage that
1, liquid preparation, formula is the most rigorous, meets medical device product definition, accepts through two class Medical treatment device products
With safety, validation verification.
2, the present invention is defined on physical method effect, is not by compensatory, the product of metabolism acquisition effect.
3, easy to use, without sense of discomfort.
4, there is cleaning bacteriostasis and the most do not affect filtration,nasal function.
5, can use the most for a long time and not produce dependency, dangerous without secondary harm.
Detailed description of the invention
Below technical scheme is further described, but is not limited thereto, every to the technology of the present invention
Scheme is modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention, all should contain in the present invention
Protection domain in.
Embodiment 1:
In the present embodiment, the formula of natural sea salt nasal irrigation agent is as follows: natural sea salt: 0.9kg (is scaled to scale), sweet
Oil: 1.0L, domiphen bromide: 0.03kg, purified water adds to 100L.
Preparation method is as follows:
Weigh purified water and medical glycerol mixing, be heated to 45 DEG C ± 2 DEG C；Add quantitative sea salt magnetic agitation 10 minutes
After, No. 1 sand core funnel filters and get final product.
Embodiment 2:
The present embodiment is as different from Example 1: the formula of natural sea salt nasal irrigation agent is as follows: natural sea salt: 0.85kg
(being scaled to scale), glycerol: 0.8L, domiphen bromide: 0.04kg, purified water adds to 100L.
Embodiment 3:
The present embodiment is as different from Example 1: the formula of natural sea salt nasal irrigation agent is as follows: natural sea salt: 0.95kg
(being scaled to scale), glycerol: 1.4L, domiphen bromide: 0.02kg, purified water adds to 100L.
Embodiment 4:
With the nasal irrigation agent of embodiment 1～3 as experimental group, with 0.9% normal saline as matched group, for 144 example rhinitis
Patient tests: the maleest 69 people, female 75 people, and the age, between 18～55 years old, is randomly divided into two groups, and experimental group 72 people is right
According to organizing 72 people；Experimental group is assigned randomly to each 24 people of embodiment 1～3, and matched group is assigned randomly to each 24 people of embodiment 1～3, and 6
Group is not statistically significant (P > 0.05) on age, sex, the state of an illness and the course of disease are distributed.
1, diagnostic method:
(1) clinical manifestation: nasal obstruction, nasal mucus many (viscous purulence, purulence), headache, hyposmia, hypomnesis.
(2) check: nasal decongestion, swelling or plumpness, middle nasal meatus is narrow, inside has secretions.
(3) nasal sinuses district tenderness.
(4) pharyngorhinoscopy: nasal cavity rear end or nasopharynx part have pus.
2, Therapeutic Method:
Experimental group: give the nasal irrigation agent of embodiment 1～3 respectively.
Matched group: give 250mL, the normal saline of 0.9%.
The course for the treatment of: 7 days.
3, curative effect determinate standard
Recovery from illness: the symptoms such as nasal obstruction, many, the headache of nasal mucus all disappear, nasal cavity nasal meatus cleans.
Effective: symptom disappears substantially, nasal airflow is good, nasal meatus a little mucus tears；
Effective: pus tears significantly reduce, and nasal obstruction alleviates, intranasal pus reduces；
Invalid: symptom and sign are without changing.
4, result
Experimental group total effective rate is 100%, the results are shown in Table 1.
Table 1
Claims (4)
1. a natural sea salt nasal irrigation agent, it is characterised in that described natural sea salt nasal irrigation agent with purified water, glycerol as solvent,
Natural sea salt is solute, and domiphen bromide is pathogenic bacterium inhibitor, makes through normal-temperature dissolution, in every 100L containing natural sea salt 0.85～
0.95kg, glycerol 0.5～1.5L, domiphen bromide 0.01～0.05kg.
Natural sea salt nasal irrigation agent the most according to claim 1, it is characterised in that containing natural sea salt in every 100L
0.9kg, glycerol 1.0L, domiphen bromide 0.03kg.
Natural sea salt nasal irrigation agent the most according to claim 1, it is characterised in that containing natural sea salt in every 100L
0.85g, glycerol 0.8L, domiphen bromide 0.04kg.
Natural sea salt nasal irrigation agent the most according to claim 1, it is characterised in that containing natural sea salt in every 100L
0.95kg, glycerol 1.4L, domiphen bromide 0.02kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610541577.2A CN106038588A (en) | 2016-07-11 | 2016-07-11 | Natural sea salt nasal irrigation agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610541577.2A CN106038588A (en) | 2016-07-11 | 2016-07-11 | Natural sea salt nasal irrigation agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038588A true CN106038588A (en) | 2016-10-26 |
Family
ID=57185230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610541577.2A Pending CN106038588A (en) | 2016-07-11 | 2016-07-11 | Natural sea salt nasal irrigation agent |
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| Country | Link |
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| CN (1) | CN106038588A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066401A (en) * | 2018-01-04 | 2018-05-25 | 蓝栋林 | A kind of drug for being used to treat rhinitis |
| CN109394837A (en) * | 2018-10-22 | 2019-03-01 | 吉林省七维生物科技有限公司 | A kind of nasal mist and preparation method thereof |
| CN110384722A (en) * | 2019-08-27 | 2019-10-29 | 吉林省禹王生物医药有限公司 | A kind of antiviral nasal douche agent of releiving |
| WO2020021483A1 (en) * | 2018-07-27 | 2020-01-30 | Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii | Composition for the treatment of oral cavity inflammations |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183272A (en) * | 1997-12-23 | 1998-06-03 | 齐陶 | Nasal cavity cleaning liquid |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| CN102552316A (en) * | 2012-02-03 | 2012-07-11 | 程旻烈 | Nose washing agent and preparation method thereof |
| CN103386076A (en) * | 2012-05-07 | 2013-11-13 | 四川九峰天然药业股份有限公司 | Mucosa nursing antibacterial gel composition and application thereof |
-
2016
- 2016-07-11 CN CN201610541577.2A patent/CN106038588A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183272A (en) * | 1997-12-23 | 1998-06-03 | 齐陶 | Nasal cavity cleaning liquid |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| CN102552316A (en) * | 2012-02-03 | 2012-07-11 | 程旻烈 | Nose washing agent and preparation method thereof |
| CN103386076A (en) * | 2012-05-07 | 2013-11-13 | 四川九峰天然药业股份有限公司 | Mucosa nursing antibacterial gel composition and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨华明: "《现代医学消毒学 第3版》", 28 February 2013, 人民军医出版社 * |
| 林淋: "《你身边的特种部队 谈真菌与人类》", 31 January 2012, 上海科学普及出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066401A (en) * | 2018-01-04 | 2018-05-25 | 蓝栋林 | A kind of drug for being used to treat rhinitis |
| WO2020021483A1 (en) * | 2018-07-27 | 2020-01-30 | Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii | Composition for the treatment of oral cavity inflammations |
| CN109394837A (en) * | 2018-10-22 | 2019-03-01 | 吉林省七维生物科技有限公司 | A kind of nasal mist and preparation method thereof |
| CN110384722A (en) * | 2019-08-27 | 2019-10-29 | 吉林省禹王生物医药有限公司 | A kind of antiviral nasal douche agent of releiving |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |