CN110381951A - 用于治疗肺性高血压和其他肺病症的方法及组合物 - Google Patents

用于治疗肺性高血压和其他肺病症的方法及组合物 Download PDF

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Publication number
CN110381951A
CN110381951A CN201780086527.2A CN201780086527A CN110381951A CN 110381951 A CN110381951 A CN 110381951A CN 201780086527 A CN201780086527 A CN 201780086527A CN 110381951 A CN110381951 A CN 110381951A
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China
Prior art keywords
carrier
vasodilator
drug
composition
pharmaceutical composition
Prior art date
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Pending
Application number
CN201780086527.2A
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English (en)
Chinese (zh)
Inventor
杰夫瑞·威尔斯
阿兰·罗梅罗
休·史密斯
罗伯特·柯蒂斯
阿达阿尼·弗罗斯特
徐震
雷瓦蒂·施里尼瓦斯
马丁·多诺万
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Rebecch Corp
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Rebecch Corp
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Publication of CN110381951A publication Critical patent/CN110381951A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780086527.2A 2016-12-14 2017-12-14 用于治疗肺性高血压和其他肺病症的方法及组合物 Pending CN110381951A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434185P 2016-12-14 2016-12-14
US62/434,185 2016-12-14
PCT/US2017/066519 WO2018112258A1 (en) 2016-12-14 2017-12-14 Methods and compositions for treatment of pulmonary hypertension and other lung disorders

Publications (1)

Publication Number Publication Date
CN110381951A true CN110381951A (zh) 2019-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780086527.2A Pending CN110381951A (zh) 2016-12-14 2017-12-14 用于治疗肺性高血压和其他肺病症的方法及组合物

Country Status (10)

Country Link
US (5) US10912778B2 (https=)
EP (2) EP4620525A3 (https=)
JP (3) JP2020502121A (https=)
CN (1) CN110381951A (https=)
AU (3) AU2017378409A1 (https=)
BR (1) BR112019012251A2 (https=)
CA (1) CA3046025A1 (https=)
MX (1) MX2019006938A (https=)
RU (1) RU2019121646A (https=)
WO (1) WO2018112258A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021093376A1 (zh) * 2019-11-11 2021-05-20 广州华真医药科技有限公司 磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用
CN116687888A (zh) * 2023-06-02 2023-09-05 苏州易合医药有限公司 伐地那非和达泊西汀复方干粉吸入制剂及其制备方法
WO2026061535A1 (zh) * 2024-09-23 2026-03-26 上海欣药智能科技有限公司 一种可吸入的含可溶性鸟苷酸环化酶受体激动剂的药物组合物及其用途以及肺动脉高压的治疗方法

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CN110946826B (zh) * 2019-12-12 2022-02-22 烟台大学 一种利奥西呱口服制剂及其制备方法
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US11013688B1 (en) * 2020-05-28 2021-05-25 Softhale Nv Methods of treatment of viral diseases
WO2022094100A1 (en) * 2020-10-28 2022-05-05 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
US20250000873A1 (en) * 2021-09-10 2025-01-02 Justus-Liebig-Universitaet Giessen Inhaled iloprost for rescue treatment and treatment as needed in pulmonary hypertension
WO2024249775A2 (en) * 2023-05-31 2024-12-05 Respira Therapeutics, Inc. Methods for treatment of pulmonary hypertension

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021093376A1 (zh) * 2019-11-11 2021-05-20 广州华真医药科技有限公司 磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用
US12569484B2 (en) 2019-11-11 2026-03-10 Shenzhen Hanhui Pharmaceutical Technology Co., Ltd.. Use of phosphodiesterase 5 inhibitor in preparation of medicament for resisting fibrotic diseases
CN116687888A (zh) * 2023-06-02 2023-09-05 苏州易合医药有限公司 伐地那非和达泊西汀复方干粉吸入制剂及其制备方法
WO2026061535A1 (zh) * 2024-09-23 2026-03-26 上海欣药智能科技有限公司 一种可吸入的含可溶性鸟苷酸环化酶受体激动剂的药物组合物及其用途以及肺动脉高压的治疗方法

Also Published As

Publication number Publication date
RU2019121646A3 (https=) 2021-03-17
WO2018112258A1 (en) 2018-06-21
EP4620525A3 (en) 2025-12-03
US20210205318A1 (en) 2021-07-08
JP2025065408A (ja) 2025-04-17
US11491160B2 (en) 2022-11-08
US20250195531A1 (en) 2025-06-19
MX2019006938A (es) 2019-09-06
US20220347183A1 (en) 2022-11-03
BR112019012251A2 (pt) 2019-11-05
AU2025260006A1 (en) 2025-11-20
JP2023036678A (ja) 2023-03-14
US11491161B2 (en) 2022-11-08
CA3046025A1 (en) 2018-06-21
EP4620525A2 (en) 2025-09-24
US12263174B2 (en) 2025-04-01
AU2022256085A1 (en) 2022-11-17
AU2017378409A1 (en) 2019-07-04
EP3554507A1 (en) 2019-10-23
US20200093830A1 (en) 2020-03-26
US10912778B2 (en) 2021-02-09
RU2019121646A (ru) 2021-01-15
JP2020502121A (ja) 2020-01-23
US20220079949A1 (en) 2022-03-17

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Application publication date: 20191025