CN110381830A - Measuring device, measurement method and program - Google Patents
Measuring device, measurement method and program Download PDFInfo
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- CN110381830A CN110381830A CN201880016217.8A CN201880016217A CN110381830A CN 110381830 A CN110381830 A CN 110381830A CN 201880016217 A CN201880016217 A CN 201880016217A CN 110381830 A CN110381830 A CN 110381830A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4412—Scattering spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0271—Thermal or temperature sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
- A61B5/02233—Occluders specially adapted therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0285—Measuring or recording phase velocity of blood waves
Abstract
A kind of measuring device, it include: first laser source, for emitting the laser of first wave length, second laser source, for emitting the laser of the second wave length different from the first wave length, fluorescence detector, for receiving the scattering laser from tested position, and controller, be configured as based on the fluorescence detector using the scattering laser of received first wave length calculate the first value as the output of foundation, based on the fluorescence detector using the scattering laser of received second wave length as the output of foundation calculate second value, and blood oxygen saturation is measured based on the ratio of first value and the second value.
Description
Cross reference to related applications
The Japanese patent application No.2017-044077 submitted this application claims on March 8th, 2017 and on August 24th, 2017
The priority and right of the Japanese patent application No.2017-161545 of submission, entire contents are incorporated in this as reference.
Technical field
This disclosure relates to measuring device, measurement method and program.
Background technique
It is commonly known for the pulse oximetry of measurement arterial oxygen saturation (for example, see PTL1).It is commonly known to swash
Light emitting measures the bloodstream measurement device (example of blood flow to finger tip and based on the scattering light of the blood flow in fingerstick capillary
Such as referring to PTL 2).
Reference document list
[patent document]
PTL 1:JP H06-66633 U
PTL 2:JP H03-21208 Y
Summary of the invention
Measuring device according to the embodiment includes first laser source, second laser source, fluorescence detector and controller.Institute
State the laser of first laser source transmitting first wave length.The second laser source emits swashing for the second wave length different from first wave length
Light.The fluorescence detector receives the scattering laser from tested position.The controller is configured as examining based on the optics
That surveys device calculates the first value as the output of foundation using the scattering laser of the received first wave length of institute, based on the fluorescence detector
Using the scattering laser of received second wave length calculate second value as the output of foundation, and be based on first value and institute
The ratio of second value is stated to measure blood oxygen saturation.
Measurement method according to the embodiment is the measurement method of measuring device.The measurement method includes sending out to tested position
The step of penetrating the laser of first wave length emits the laser of the second wave length different from the first wave length to the tested position
The step of step and reception are from the scattering laser at the tested position.The measurement method further include based on institute it is received
The scattering laser of first wave length come the step of calculating the first value, based on the scattering laser of received second wave length calculate second
The step of value and based on the ratio of first value and the second value come the step of measuring blood oxygen saturation.
Program according to the embodiment makes computer execute the step of emitting the laser of first wave length to tested position, Xiang Suoshu
The step of tested position emits the laser of the second wave length different from the first wave length and reception come from the tested position
Scattering laser the step of.Program according to the embodiment also make computer execute based on received first wave length scattering laser
Come the step of calculating the first value, based on received second wave length scattering laser come the step of calculating second value and be based on institute
The step of stating ratio measurement blood oxygen saturation of first value with the second value.
Detailed description of the invention
In the accompanying drawings:
Fig. 1 is to show the functional block diagram of the illustrative configurations of measuring device according to first embodiment；
Fig. 2 is the exemplary schematic diagram of the use state for the measuring device for showing Fig. 1；
Fig. 3 is to show the exemplary flow chart of the operation by the controller execution of Fig. 1；
Fig. 4 is to show the functional block diagram of the illustrative configurations of measuring device according to the second embodiment；
Fig. 5 is the exemplary schematic diagram of the use state for the measuring device for showing Fig. 4；
Fig. 6 is to show the functional block diagram of the illustrative configurations of measuring system according to the third embodiment；
Fig. 7 is to show the exemplary precedence diagram of the control process of measuring system 300 of Fig. 6；
Fig. 8 is to show the exemplary schematic diagram of brain blood flow meter；
Fig. 9 is to show the exemplary schematic diagram of sphygmomanometer；
Figure 10 is to show the exemplary schematic diagram of clinical thermometer；
Figure 11 is to show the exemplary schematic diagram of the wearing state of the measuring appliance equipped with measuring device, the measurement
Device at the temple as tested position for measuring；And
Figure 12 is to show the sectional view of a part of the measuring appliance shown in Figure 11.
Specific embodiment
Hereinafter, embodiment of the disclosure will be described in detail with reference to the attached drawings.
(first embodiment)
Fig. 1 is to show the functional block diagram of the illustrative configurations of measuring device 100 according to first embodiment.According to this implementation
The measuring device 100 of example includes biosensor 110, controller 140, notification interface 150 and memory 160.
Measuring device 100 obtains the measured's (user) contacted with measuring device 100 by using biosensor 110
Bio-measurement output, and exported based on the bio-measurement to measure biological information.According to the measuring device 100 of the present embodiment
The blood oxygen saturation and blood flow of measured can be measured by using biosensor 110.According to the measurement of the present embodiment
Device 100 can measure for example percutaneous arterial oxygen saturation (SpO2S: saturation degree (Saturation), P: percutaneous or pulse blood
Oxygen measures (Percutaneous or Pulse Oximetry), O2: oxygen (Oxygen)) as the blood oxygen saturation for indicating measured
The value of degree.However, being not limited to SpO by the biological information that measuring device 100 measures2And blood flow.Measuring device 100, which can measure, appoints
The biological information what can be measured by biosensor 110.Hereinafter, SpO2Also blood oxygen saturation will be called for short.As finger
Show the value of blood oxygen saturation, there are also SaO2(S: saturation degree (Saturation), a: artery (artery), O2: oxygen (Oxygen)),
It indicates the measured value of the blood oxygen saturation of arterial blood.SpO2It is for measuring SaO indirectly2Method, and in the measurement of preparation
Under the conditions of, both take approximation.
Biosensor 110 obtains the bio-measurement output at the tested position of the measured contacted with measuring device 100.Quilt
Surveying position is any position that can obtain bio-measurement output.According to the present embodiment, assume that tested position is in the following description
Finger.Replace finger or other than finger, tested position can be wrist, arm, ear, forehead, neck, back, foot,
Other positions or any combination thereof.Biosensor 110 includes optical launcher and fluorescence detector.It is raw according to the present embodiment
The optical launcher of object sensor 110 includes first laser source 121 and second laser source 122.According to the present embodiment, bio-sensing
The fluorescence detector of device 110 includes the first fluorescence detector 131 and the second fluorescence detector 132.
Each of first laser source 121 and second laser source 122 emit the wave for being able to detect predetermined ingredient in blood
Long laser.Each of first laser source 121 and second laser source 122 are configured as such as LD (laser diode).?
In the present embodiment, VCSEL (vertical cavity surface-emitting laser) diode is used as laser source.However, laser source can be it is another swash
Optical diode, such as DFB (distributed feed-back) laser diode or FP (Fabry-Perot) laser diode.
First laser source 121 and second laser source 122 emit the laser of different wave length.The transmitting of first laser source 121 first
The laser (hereinafter, also referred to as " first laser ") of wavelength.First wave length is such wavelength, is shown in conjunction with oxygen
Hemoglobin (hereinafter, referred to as " oxyhemoglobin ") in absorptance with or not in conjunction with oxygen hemoglobin (
Hereinafter, referred to as " reduced hemoglobin " larger difference between absorptance in).First wave length be such as 600nm extremely
700nm, and first laser is so-called feux rouges.In the present embodiment, it will assume that first wave length is in the following description
660nm.The laser (hereinafter, also referred to as " second laser ") of the transmitting of first laser source 122 second wave length.Second wave length with
First wave length is different.Second wave length is such wavelength, and the extinction in oxyhemoglobin is shown compared to first wave length
Smaller difference between absorptance in rate and reduced hemoglobin.Second wave length is such as 800nm to 1000nm, and first
Laser is so-called near infrared light.In the present embodiment, it will assume that second wave length is 850nm in the following description.
First fluorescence detector 131 and the second fluorescence detector 132 receive the scattering light (detection light) of measurement light, the survey
Amount light is launched into tested position and exports from the scattering of tested position as bio-measurement.First fluorescence detector 131 and second
Each of fluorescence detector 132 is configured as such as PD (photodiode).Biosensor 110 will be examined by the first optics
The photoelectric conversion signal for surveying device 131 and the received scattering light of the second fluorescence detector 132 is sent to controller 140.
Fig. 2 is to show the exemplary schematic diagram of the use state of measuring device 100；As schematically illustrated in Fig. 2, survey
Amount device 100 measures tested position in the state of contact with the specific position (measurement portion) in measuring device 100 in measured
Biological information.Measuring device 100 can not be such that tested position and the specific position (measurement portion) of measuring device 100 connects in measured
Biological information is measured in the state of touching.
As schematically illustrated in Fig. 2, the first fluorescence detector 131 is received from tested position and is sent out by first laser source 121
The scattering light for the first laser penetrated.First fluorescence detector 131 can be configured as be able to detect with scattering first laser it is (red
Light) corresponding wavelength light PD.Second fluorescence detector 132 can be configured as the second laser being able to detect with scattering
The PD of the light of (near infrared light) corresponding wavelength.In measuring device 100, the first fluorescence detector 131 and the second optics are examined
It surveys device 132 and is disposed in the scattering light that can receive the laser emitted by first laser source 121 and second laser source 122 respectively
Position.
Here, first laser, second laser and the pass between first laser and the light of second laser scattering will be described
System.For reduced hemoglobin, the feux rouges of first laser is easy to absorb, and the near infrared light of second laser is difficult to absorb.It is another
Aspect, for oxyhemoglobin, the feux rouges of first laser and the near infrared light of second laser are all difficult to absorb.That is,
The feux rouges of first laser is easy to be reduced hemoglobin absorption and is difficult to be absorbed by oxyhemoglobin.The near-infrared of second laser
Light is difficult to be reduced hemoglobin and oxyhemoglobin absorbs.
So first laser is mainly reduced hemoglobin absorption and is scattered by oxyhemoglobin.Therefore, by the first light
Detector 131 is exported as bio-measurement and the intensity of received scattered first laser is derived from oxyhemoglobin
Amount.On the other hand, second laser is scattered by both reduced hemoglobin and oxyhemoglobin.Therefore, by the second optical detection
Device 132 is exported as bio-measurement and the intensity of received scattered second laser is derived from reduced hemoglobin and oxygenated blood
The total amount of Lactoferrin.
Referring back to Fig. 1, controller 140 includes at least one processor 141, at least one described processor 141 is matched
It is set to and controls and manage measuring device 100, including each of which functional block on the whole.Controller 140 includes at least one processor
141, CPU (central processing units) etc., at least one described processor 141 are configured as executing the journey for defining control process
Sequence, to realize its function.It deposits the outside that such program is stored in such as memory 160 or is connected to measuring device 100
In storage media.
According to various embodiments, at least one described processor 141 can be configured to single integrated circuit (IC) or more
A coupling integration IC circuit communicated and/or discrete circuit.Described in being implemented according to various known technologies at least one
Manage device 141.
In one embodiment, processor 141 includes for example one or more circuits or unit, one or more of electricity
Road or unit be configured as by execute the instruction execution one or more data calculation process that is stored in relational storage or
Processing.In other embodiments, processor 141 can be arranged to execute consolidating for one or more data calculation process or processing
Part (such as discrete logic module).
According to various embodiments, processor 141 may include one or more processors, controller, microprocessor, micro-control
Device processed, ASIC (specific integrated circuit), data signal processor, programmable logic device, field programmable gate array, it is any
Any combination of combination or its configuration, and execute the function of following controllers 140.
Controller 140 is based respectively on output from the first fluorescence detector 131 and from the second fluorescence detector 132
Output (scattering the photoelectric conversion signal of light) calculates value relevant to blood flow.Based on from the first fluorescence detector 131
The value of output is referred to as the first value, and the value based on the output from the second fluorescence detector 132 is referred to as second value.Control
Device 140 can calculate the first value and second value using Doppler frequency shift.
Here, the measurement method used by controller 140 using the first value of Doppler frequency shift and second value will be described.
In order to measure the first value and second value.Controller 140 make optical transmitting set (i.e. first laser source 121 and second laser source 122) to
The tissue emissions laser of living body, and make fluorescence detector (i.e. the first fluorescence detector 131 and the second fluorescence detector 132) from
The tissue of living body receives scattering light.Then, controller 140 calculates the first value and second based on the measurement result of received laser
Value.
In the tissue of living body, frequency displacement (Doppler frequency shift) is undergone by the scattering light of mobile blood cell scattering, due to more
General Le effect, it is proportional to the movement speed of haemocyte in blood.Controller 140 detects Beat Signal, the Beat Signal
It is generated by the interference of light between the scattering light from stationary and the scattering light from mobile haemocyte.Beat Signal indicates to make
For the intensity of the function of time.Beat Signal is converted to power spectrum, letter of the power spectral representation as frequency by controller 140
Several power.In the power spectrum of Beat Signal, Doppler frequency shift frequency is proportional to the movement speed of haemocyte, and power
Amount corresponding to haemocyte.Then controller 140 to multiplied result by quadraturing the power spectrum of Beat Signal multiplied by frequency
To obtain blood flow.
Controller 140 can calculate the first value P1 [ml/min] according to such as P1=K ∫ fP (f) df/ (I × I),
Wherein K indicates that proportionality constant, I × I indicate the square of institute's intensity of received optical signal, and f indicates that frequency and P (f) expression are poor
Clap the power spectrum of signal.Controller 140 can according to such as P1=∫ fP (f) df/ (I × I) or P1=∫ fP (f) df come
Calculate the first value P1.That is, controller 140 can be by using P1=K ∫ fP (f) df/ (I × I), P1=∫ fP
(f) any one in df/ (I × I) and P1=∫ fP (f) df calculates the first value P1.This is equally applicable to second value
P2.That is, controller 140 can according to P2=K ∫ fP (f) df/ (I × I), P2=∫ fP (f) df/ (I × I) with
And any one in P2=∫ fP (f) df calculates second value P2.
As described above, because of the amount of oxyhemoglobin of the output in blood from the first fluorescence detector 131,
So the first value indicates the value of the flow based on oxyhemoglobin.As described above, because coming from the second fluorescence detector 132
Hemoglobin of the output in the blood total amount, the second value indicates the stream based on all hemoglobins in blood
The value of amount.Because the value of the flow rate calculation based on all hemoglobins in blood corresponds to the blood flow of measured,
Second value indicates the blood flow of measured.Therefore, controller 140 can calculate the blood flow of measured by calculating second value
Amount.So measuring device 100 can measure the blood flow of measured.
Controller 140 calculates the SpO of measured based on the first value and second value2.Controller 140 can based on the first value with
The ratio of second value calculates SpO2。
Here it will be described in used by controller 140 for SpO2Calculation method.It calculates according to the following formula
SpO2: { HbO2/(Hb+HbO2) × 100, wherein HbO2The amount and Hb for indicating oxyhemoglobin indicate reduced hemoglobin
Amount (for example, see PTL 1).In the formula, HbO2Indicate the amount of oxyhemoglobin, and (Hb+HbO2) indicate that oxygen closes
The total amount of hemoglobin and reduced hemoglobin.So in the present embodiment, HbO2It can correspond to based on oxyhemoglobin
Flow and the first value for calculating, and (Hb+HbO2) can correspond to by the flow of hemoglobins all in blood and based on
The second value of calculation.Therefore, when in the equation above with the first value replacement HbO2And (Hb+HbO is replaced with second value2), Ke Yigen
It calculates according to such as (the first value/second value) × 100 by SpO2The index of instruction.In the present embodiment, controller 140 by with
Lower formula indicates SpO to calculate2Index: (the first value/second value) × 100.Refer to because controller 140 calculates as described above
Show SpO2Index, so measuring device 100 can measure the SpO of measured2.Here, formula (the first value/second value) × 100
SpO is indicated for calculating2Index.Therefore, it is possible to use being used as SpO below2: formula (the first value/second value) × 100 is logical
Cross the value obtained and execution to predetermined weighting (such as by multiplied by coefficient) of the value of (the first value/second value) or by using
For value (the first value/second value) to be converted to SpO2Table and the value that obtains.
In addition, controller 140 can blood flow and SpO based on measured2Estimation measured suffers from altitude sickness (also known as plateau
Damage) a possibility that.Work as SpO2When reduction or when dehydration when altitude sickness a possibility that it is bigger.When measured's dehydration, in blood
Water deficient causes blood flow bad (blood flow reduction).Therefore, controller 140 can be based on blood flow and SpO2Change
To estimate a possibility that measured suffers from altitude sickness.Controller 140 can be by using pre-defined algorithm to blood flow and SpO2
A possibility that being weighted to estimate altitude sickness.SpO can be measured according to the measuring device 100 of the present embodiment2With blood flow two
Person, and therefore can be based on SpO2With blood flow the two indexs come a possibility that estimating altitude sickness.Therefore, compared to independent base
In SpO2Estimate the device of altitude sickness possibility, plateau can more accurately be estimated according to the measuring device 100 of the present embodiment
A possibility that sick.
Notification interface 150 uses the notification informations such as sound, vibration, image.Notification interface 150 may include loudspeaker, vibration
Device and display.It is (inorganic that display can be such as LCD (liquid crystal display), OELD (display of organic electroluminescence), IELD
Electroluminescent display) etc..Notification interface 150 can notify such as SpO2And/or the measurement result of blood flow.Notification interface
150 can notify the information for example about altitude sickness possibility.
Memory 160 can be configured to semiconductor memory, magnetic memory etc..The storage of memory 160 is for operating measurement
The various information and program of device 100.Memory 160 is also used as working storage.Memory 160 can will be for example by controlling
The SpO for the measured that device 140 processed calculates2Historical information is stored as with blood flow.
Next, the operation that will be executed with reference to flow chart shown in Fig. 3 come the controller 140 described by measuring device 100
Example.When measuring device 100 is activated, or when there is the predetermined input operation for starting measurement operation, controller
140 can repeat process shown in Fig. 3.There is the function for being able to detect tested position and whether contacting with measuring appliance in controller 140
In the case where energy, when determining that tested position and measurement portion contact, controller 140 can execute process shown in Fig. 3.
Controller 140 makes first laser source 121 emit first laser (step S101).
Controller 140 makes 122 transmitting second laser (step S102) of second laser member.
When emitting first laser in step s101, the first fluorescence detector 131 receives scattering light from tested position.When
When emitting second laser in step s 102, the second fluorescence detector 132 receives scattering light from tested position.First optical detection
The photoelectric conversion signal of corresponding scattering light is sent to controller 140 by device 131 and the second fluorescence detector 132.
Controller 140 obtains output (step S103) from the first fluorescence detector 131 and the second fluorescence detector 132.
Controller 140 is calculated the first value based on the output obtained from the first fluorescence detector 131 and is based on from the second light
The output that detector 132 obtains is learned to calculate second value (step S104).
Controller 140 calculates instruction SpO based on the first value and second value that calculate in step S1042Index, and
And according to corresponding to SpO2Index calculate SpO2(step S105).
Controller 140 is based on blood flow (i.e. second value) and SpO2To estimate a possibility that measured suffers from altitude sickness (step
S106)。
Controller 140 makes notification interface 150 notify blood flow and SpO2And information (the step about altitude sickness possibility
107)。
As described above, according to the measuring device 100 of the present embodiment by Laser emission to tested position and based on from tested
The intensity of the scattering laser at position calculates the first value and second value.Measuring device 100 is based on the first value and second value calculates
SpO2.As described above, measuring device 100 obtains bio-measurement output using laser.Because laser have high directivity and
Wavelength and phase alignment, so measuring device 100 can be more accurate the case where compared to laser is replaced with the light of wide wave-length coverage
Ground measures SpO2.Therefore, according to measuring device 100, availability is improved.
Measuring device 100 can measure blood flow and SpO2The two, therefore blood flow need not be measured using individual device
Amount and SpO2.So measuring device 100 improves the convenience and availability for measured.
(second embodiment)
Fig. 4 is to show the functional block diagram of the illustrative configurations of measuring device according to the second embodiment.According to the present embodiment
Measuring device 200 include biosensor 210, controller 240, notification interface 250 and memory 260.
Measuring device according to the second embodiment 200 with measuring device 100 according to first embodiment the difference is that,
Biosensor 210 only include a fluorescence detector 230, and biosensor 110 include two fluorescence detectors, i.e., first
Fluorescence detector 131 and the second fluorescence detector 132.
According to this city embodiment, that is to say, that biosensor 210 includes two light sources (i.e. first laser source 221 and the
Two laser sources 222) and fluorescence detector 230.The function in first laser source 221 and second laser source 222 is real with first respectively
The first laser source 121 for applying example is similar with the function in second laser source 122.That is, the transmitting of first laser source 221 first swashs
Light, and second laser source 222 emits second laser.With different timings, first laser source 221 emits first laser, and second
Laser source 222 emits second laser.For example, first laser source 221 and second laser source 222 alternately emit laser.Namely
Say, in through the measurement of measuring device 200 operation, such as with predetermined time interval by first laser and second laser alternately
It is emitted to tested position.
Fluorescence detector 230 is configured as example so-called multifrequency response PD, and the multifrequency response PD is able to detect and the
The scattering light of the corresponding wavelength of both one laser (feux rouges) and second laser (near infrared light).So the second fluorescence detector 232
The first laser of detection scattering when first laser is emitted to tested position, and the inspection when second laser is emitted to tested position
Survey the second laser of scattering.Biosensor 210 will be sent by the photoelectric conversion signal of the received scattering light of fluorescence detector 230
To controller 240.
Fig. 5 is to show the exemplary schematic diagram of the use state of measuring device 200.As schematically illustrated in Fig. 5, light
Learn the scattering light for the first laser that detector 230 is emitted from the reception of tested position by first laser source 221 and by second laser source
The scattering light of the second laser of 222 transmittings.As mentioned above alternately emit first laser and second laser, so optics
Detector 230 alternately receives the first laser of scattering and the second laser of scattering.Although Fig. 5 shows first laser, second
The second laser of laser, the first laser of scattering and scattering, however actually first laser or second laser are in some time
Point is launched into tested position, and fluorescence detector 230 receives the scattering light of the laser emitted.Fluorescence detector 230
It is disposed in the scattering light that can receive the laser emitted by first laser source 221 of measuring device 200 and by second laser source
The position of the scattering light of the laser of 222 transmittings.
Referring back to Fig. 4, controller 240 includes at least one processor 241, at least one described processor 241 is matched
It is set to and controls and manage measuring device 200, including each of which functional block on the whole.The function of controller 240 and processor 241 point
It is not similar to the function of the controller of first embodiment 140 and processor 141.Therefore, thereof will be omitted detailed descriptions.In addition,
The function of the notification interface 250 and memory 260 function phase with the notification interface 150 of first embodiment and memory 160 respectively
Seemingly.Therefore, thereof will be omitted detailed descriptions.
In the measuring device 200 according to the present embodiment, controller 240 by execute with referring to operation phase described in Fig. 3
As operation to measure blood flow and SpO2, and estimate a possibility that measured suffers from altitude sickness.In the present embodiment, controller
240 obtain output from fluorescence detector 230 in step s 103.Controller 240 is in step S104 according to from fluorescence detector
230 outputs obtained correspond to the second laser that still scatters of first laser scattered to calculate the first value or second value.
As described above, Laser emission to tested position and is measured SpO according to the measuring device 200 of this city embodiment2.Institute
With compared to the device for the light for using for example wide wave-length coverage, measuring device 200 can more accurately measure SpO2.In this way, root
According to measuring device 200, availability is improved.It can be multiple by using corresponding to according to the measuring device 100 of the present embodiment
The fluorescence detector 230 of frequency receives the first laser of scattering and the second laser of scattering.Therefore, compared to including two lists
Only fluorescence detector receives the device of the first laser of scattering and the second laser of scattering, 210 He of biosensor respectively
Measuring device 200 can be reduced the size more.
(3rd embodiment)
Fig. 6 is the functional block diagram for showing measuring system 300 according to the third embodiment and configuring.Measuring system 300 includes
Measuring device 400, information processing unit 500 and terminal installation 600.Information processing unit 500 is via wire communication, channel radio
Letter or combinations thereof is communicatively connected to measuring device 400 and terminal installation 600.Measuring device 400 and terminal installation 600 can be with
It directly communicates with each other.The network that measuring device 400, information processing unit 500 and terminal installation 600 are connected together can be with
It is internet, Wireless LAN etc..
Measuring device 400 is configured as measuring the dress that bio-measurement exports by that will measure light emitting to tested position
It sets.Measuring device 400 can send information processing unit 500 for the information exported about bio-measurement.
Information processing unit 500 can be configured to the service unit such as such as calculating.Information processing unit 500 can be with
The blood flow and SpO of measured are calculated based on the information about bio-measurement output obtained from measuring device 4002.Information
Processing unit 500 can estimate a possibility that measured suffers from altitude sickness.Information processing unit 500 can store blood flow and SpO2
Calculated result and information about altitude sickness possibility.Information processing unit 500 can be by blood flow and SpO2Calculating
As a result and the information about altitude sickness possibility is sent to terminal installation 600.
Terminal installation 600 can be configured as such as personal computer, smart phone, tablet computer.Terminal installation 600
Can be owned by measured.Terminal installation 600 can be based on the blood flow and SpO obtained from information processing unit 5002Calculating knot
Fruit and notice is executed about the information of altitude sickness possibility.
Measuring device 400 includes biosensor 410, controller 440, notification interface 450 and memory 460.Biology
Sensor 410 includes first laser source 421, second laser source 422, the first fluorescence detector 431 of inspection and the second optical detection
Device 432.First laser source 421, second laser source 422, the first fluorescence detector 431 and the second fluorescence detector 432 function
Can respectively with first laser source 121, second laser source 122, the first fluorescence detector 131 and the second light in first embodiment
The function of learning detector 132 is similar.The measurement similar to first embodiment can be passed through according to the measuring device 400 of the present embodiment
The mode of device 100 exports to obtain bio-measurement.
Controller 440 includes at least one processor 441, at least one described processor 441 is configured as controlling on the whole
Tubulation manages measuring device 400, including each of which functional block.Controller 440 includes at least one processor 441, CPU etc.
, at least one processor 441 is configured as executing the program for defining control process, and realizes its function.By such journey
Sequence is stored in such as memory 460 or is connected in the exterior storage medium of measuring device 400.Processor 441 have with for example
The configuration of the processor 141 of first embodiment being similarly configured.Therefore, thereof will be omitted detailed descriptions.Controller 440 to give birth to
Object sensor 410 obtains bio-measurement and exports and send letter for the information exported about bio-measurement via communication interface 470
Cease processing unit 500.
Memory 460 can be configured as semiconductor memory, magnetic memory etc..The storage of memory 460 is surveyed for operating
Measure the various information and/or program of device 400.Memory 460 is also used as working storage.Memory 460 can store
Such as the data acquired in biosensor 410 about the information of bio-measurement output (scattering the intensity of light).
Communication interface 470 by with information processing unit 500 carry out wire communication, wireless communication or combinations thereof sending and
Receive various information.For example, communication interface 570 sends the information about bio-measurement output measured by measuring device 400
To information processing unit 500.
Information processing unit 500 includes controller 540, memory 560 and communication interface 570.
Controller 540 includes at least one processor 541, at least one described processor 541 is configured as controlling on the whole
System and management information handle device 500, including each of which functional block.Controller 540 includes at least one processor 541, such as
CPU, at least one described processor 541 is configured as executing the program for defining control process, to realize its function.By this
The program of sample is stored in such as memory 560 or is connected in the exterior storage medium of information processing unit 500.Processor 541
The configuration being similarly configured with the processor 141 with such as first embodiment.Therefore, thereof will be omitted detailed descriptions.Control
Device 540 can be calculated based on the information obtained from measuring device 400 about bio-measurement output measured blood flow and
SpO2.Controller 540 can estimate a possibility that measured suffers from altitude sickness.Blood flow and SpO2Calculation method and altitude sickness can
The estimation method of energy property is similar to calculation method described in first embodiment and estimation method.Therefore, it will omit and be described in detail.
Memory 560 can be configured as semiconductor memory, magnetic memory etc..The storage of memory 560 is for operating letter
Cease the various information and/or program of processing unit 500.Memory 560 is also used as working storage.Memory 560 can be with
Deposit the information exported about bio-measurement that numerical example is such as obtained from measuring device 400.Memory 160 can store for example by controlling
The blood flow and SpO that device 540 calculates2And the various information for estimating altitude sickness possibility.
Communication interface 570 is by carrying out wire communication, wireless communication or its group with measuring device 400 and terminal installation 600
It closes to send and receive various information.For example, communication interface 570 receives the letter exported about bio-measurement from measuring device 400
Breath.For example, blood flow and SpO that communication interface 570 will be calculated by information processing unit 5002And about altitude sickness possibility
Information be sent to terminal installation 600.
Terminal installation 600 includes that controller 640, notification interface 650, memory 660, communication interface 670 and input connect
Mouth 680.
Controller 640 includes at least one processor 641, at least one described processor 641 is configured as controlling on the whole
System and management terminal device 600, including each of which functional block.Controller 640 includes at least one processor 641, such as CPU,
At least one described processor 641 is configured as executing the program for defining control process, to realize its function.It will be such
Program is stored in such as memory 660 or is connected in the exterior storage medium of terminal installation 600.Processor 641 has and example
Such as the configuration of the processor 141 of first embodiment being similarly configured.Therefore, thereof will be omitted detailed descriptions.Controller 640 can be with
The blood flow and SpO for obtaining notification interface 650 will from information processing unit 5002With the information one about altitude sickness possibility
Play notice.
Notification interface 650 carrys out notification information using sound, vibration, image etc..The function and configuration of notification interface 650 and the
The function of one notification interface 150 as described in the examples be similarly configured.Therefore, thereof will be omitted detailed descriptions.
Memory 660 can be configured as semiconductor memory, magnetic memory etc..Memory 660 is stored for operating end
The various information and/or program of end device 600.Memory 660 is also used as working storage.Memory 660 can store
Such as the blood flow and SpO obtained from information processing unit 5002And the information about altitude sickness possibility.
Communication interface 670 by with information processing unit 500 carry out wire communication, wireless communication or combinations thereof sending and
Receive various information.For example, communication interface 670 receives the blood flow obtained from information processing unit 500 and SpO2And it comes from
The information about altitude sickness possibility of information processing unit 500.
Input interface 680 is configured as receiving the input operation of the user (such as examinee) from terminal installation 600 simultaneously
It is configured as such as operation button (operation key).Input interface 680 can be configured as touch panel, and the touch panel is matched
It is set to operation key of the display for operating from user's reception input in a part of display equipment, and can receive by user
The touch input operation made.
Fig. 7 is to show the exemplary precedence diagram of the control process executed by measuring system 300；When such as activation measurement dress
When setting 400 or executing the predetermined input operation for starting measurement operation, process shown in Fig. 7 is executed.In measuring device 400
In the case that controller 440 has the function of whether be able to detect tested position contacts with measurement portion, when determine tested position with
When measurement portion contacts, step shown in fig. 7 can be executed.
Measuring device 400 makes first laser source 421 emit first laser (step S201).
Measuring device 400 makes second laser source 422 emit second laser (step S202).
Measuring device 400 obtains bio-measurement output (step from the first fluorescence detector 431 and the second fluorescence detector 432
Rapid S203).
Measuring device 400 sends information processing unit for the information exported about bio-measurement via communication interface 470
500 (step S204).
When receiving the information about bio-measurement output from measuring device 400, information processing unit 500 is based on biology
Measurement output calculates the first value and second value (step S205).
Information processing unit 500 calculates SpO based on the first value and second value that calculate in step S2052(step
S206)。
Information processing unit 500 is based on blood flow (i.e. second value) and SpO2To estimate a possibility that measured suffers from altitude sickness
(step S207).
Information processing unit 500 is via communication interface 570 by blood flow, SpO2And the information about altitude sickness possibility
It is sent to terminal installation 600 (step S208).
When receiving blood flow, SpO from information processing unit 5002And about altitude sickness possibility information when, terminal
Device 600 makes notification interface 650 notify blood flow, SpO2And the information (step S209) of a possibility that about altitude sickness.
According to the present embodiment, the biosensor 410 of measuring device 400 has been described as having the life with first embodiment
The configuration of object sensor 110 being similarly configured.However, biosensor 410 can have the bio-sensing with second embodiment
The configuration of device 210 being similarly configured.
In the present embodiment, information processing unit 500 has been described as calculating blood flow and SpO2And estimate altitude sickness
Possibility.However, for example measuring device 200 can execute blood flow and SpO2Calculating and altitude sickness possibility estimation.
In this case, measuring device 400 can be by blood flow and SpO2Calculated result and altitude sickness possibility estimated result
It is sent to information processing unit 500.Measuring system 300 does not need to include information processing unit 500.In this case, it measures
Device 400 can be by blood flow and SpO2Calculated result and the estimated result of altitude sickness possibility be sent to terminal installation 600.
As described above, the measuring system 300 according to the present embodiment calculates SpO based on the laser for being emitted to tested position2,
Therefore compared to the device for the light for using for example wide wave-length coverage, SpO can more accurately be measured2.Therefore, according to measuring system
300, availability is improved.
It is complete and clearly open in order to provide the disclosure, describe several embodiments.However, appended claims are unlimited
In above embodiments, and should be construed as including those skilled in the art can in the range on basis shown in this specification
The all modifications made and replacement configuration.Each element of embodiment can combine reality by any mode appropriate.
It may be mounted in various equipment with measuring device described in embodiment (measuring device 100,200 and 400).
For example, measuring device 100,200 or 400 can be being installed in based on the brain blood flow of brain blood flow by measuring.Brain blood flow
Meter is the equipment by the way that Laser emission to brain to be measured to brain blood flow.For example, as shown in Figure 8, measured will be by that will have
The measuring part winding head of belt like shape is come using brain blood flow meter 700.Can be installed in measuring part measuring device 100,
200 or 400.When measuring device 100,200 or 400 is mounted in brain blood flow meter 700, measured can be in brain blood flow meter 700
Measuring part winding head in the state of activate brain blood flow meter 700 and measuring device 100,200 or 400.Therefore, measured can
Brain blood flow, blood flow and SpO are measured simultaneously2.In this case, brain blood flow meter 700 can based on brain blood flow, blood flow with
And SpO2To estimate a possibility that measured suffers from altitude sickness.Therefore, estimation accuracy is better than exclusive use SpO2To estimate altitude sickness
The case where possibility.
For example, measuring device 100,200 or 400 can be installed in the sphygmomanometer for measuring blood pressure.Sphygmomanometer can be with
It is the known upper arm sphygmomanometer that blood pressure in upper arm is for example measured by using cuff (armband).For example, as shown in Figure 9,
Measured uses sphygmomanometer 800 by the way that cuff is wound upper arm.Measuring device 100,200 or 400 can be installed in cuff.When
When measuring device 100,200 or 400 is mounted in sphygmomanometer 800, measured can activate in the state that cuff winds upper arm
Sphygmomanometer 800 and measuring device 100,200 or 400.Therefore, measured can measure blood pressure, blood flow and SpO simultaneously2.?
In this case, sphygmomanometer 800 can be based on blood pressure, blood flow and SpO2To estimate a possibility that measured suffers from altitude sickness.
Therefore, estimation accuracy is better than exclusive use SpO2Come the case where estimating altitude sickness possibility.
For example, measuring device 100,200 or 400 can be installed in the clinical thermometer for measuring body temperature.For example, as in Figure 10
It is shown, contact clinical thermometer 900 with human skin to measure skin temperature.When measuring device 100,200 or 400 is mounted on body
When in temperature meter 900, measured can activate measuring device 100,200 when making clinical thermometer 900 and skin contact to measure body temperature
Or 400.Therefore, measured can measure body temperature, blood flow and SpO simultaneously2.In this case, clinical thermometer 900 can base
In body temperature, blood flow and SpO2To estimate a possibility that measured suffers from altitude sickness.Therefore, estimation accuracy is better than exclusive use
SpO2Come the case where estimating altitude sickness possibility.
It can be in can measure about living body other than brain blood flow meter 700, sphygmomanometer 800 and clinical thermometer 900
Measuring device 100,200 or 400 is installed in the device of information.
The controller of each embodiment has been described as based on blood flow and SpO2To estimate that measured suffers from altitude sickness
Possibility.However, the controller of each embodiment can be based on blood flow and SpO2At least one come detect blood pressure, dehydration
The other symptoms of state, relaxation state, the state of autonomic nerve or heart disease etc..
Although tested position is described as finger in above embodiments, being tested position is necessarily finger.Tested portion
Position can be wrist for example as described above, arm, ear, forehead, neck, back, foot, other positions or any combination thereof.
Here, it will be discussed in detail the configuration of measuring device when tested position is temple.Figure 11 is measuring appliance 1000
The exemplary schematic diagram of wearing state, measuring appliance 1000 include the measuring device for measuring temple as tested position.
Measuring appliance 1000 includes two maintaining parts 1001 and the headband 1002 for being joined together two maintaining parts 1001.
In the wearing state of measuring appliance 1000, two maintaining parts 1001 and measured obtain left temple and right temple
It contacts and keeps wearing state.Maintaining part 1001 can be shaped as avoiding the ear of covering measured.For example, maintaining part 1001
It can be configured as in ear's overlying contact temple.In this case, it is tested under the wearing state of measuring appliance 1000
The ear of person is uncovered, so that measured be allowed to hear the sound of surrounding.Therefore, with covering measured ear situation phase
Than the safety that can easily guarantee measured.
Headband 1002 can have bowed shape for example as shown in Figure 11.Measured is located at head with such as headband 1002
Mode on top dresses measured device 1000.It can be with measured by the length that headband 1002 is designed such as such as headband 1002
Controllable nose section.Headband 1002 can have the component of rigidity to be made by stainless steel or carbon fiber etc..Headband 1002
The wearing state of measurement device 1000 can be kept by the way that maintaining part 1001 to be pressed on measured's body.
At least one of maintaining part 1001 includes measuring device.The measuring device for including in maintaining part 1001 can be
Such as any measuring device of the above-mentioned first embodiment into the measuring device of 3rd embodiment.In the following description, it keeps
Portion 1001 will be described as including the measuring device 200 described in a second embodiment.
Figure 12 is the cross-sectional view of a part of measuring appliance 1000 shown in Figure 11, and schematically illustrates to have and survey
Measure the maintaining part 1001 of device 200.As shown in Figure 12, each maintaining part 1001 is equipped with measuring device 200, measuring device
200 include first laser source 221 as described in the second embodiment, second laser source 222 and fluorescence detector 230.It is surveying
In the wearing state of measuring device tool 1000, laser (measurement light) the irradiation temporo emitted by first laser source 221 and second laser 222 is shallow
Artery.Fluorescence detector 230 receives the measurement light of scattering from superficial temporal artery.That is, measuring appliance 1000 is by using next
Blood flow and SpO are calculated from the scattering light of superficial temporal artery2.Blood vessel in the blood vessel ratio such as finger tip of superficial temporal artery is big, thus
Promote the acquisition of biological information.Because the blood vessel in the blood vessel ratio such as finger tip of superficial temporal artery is big, blood volume tends towards stability.Cause
This can more accurately measure blood flow and SpO2 by that will measure light emitting to superficial temporal artery and obtain biological information.
As shown in Figure 12, measuring device 200 can be connect via interconnecting piece 1003 with headband 1002.Interconnecting piece 1003 rises
To the effect of buffering, for reducing the vibration for being transferred to measuring device 200 from headband 1002.Interconnecting piece 1003, which is used as, for example to be damped
Device.Interconnecting piece 1003 can be made of the elastic material that can reduce vibration.Interconnecting piece 1003 can be by spring, rubber, silicon tree
Rouge, gel, fabric, sponge, paper, other component or any combination thereof are made.Interconnecting piece 1003 can be for example comprising fluid (i.e.
Liquid or gas) fluid fill damper.Fluid can be viscous liquid.The reduction of interconnecting piece 1003 is transferred to measuring device
The vibration of 200 headband 1002.Therefore, measuring device 200 hardly changes its position relative to tested position.Therefore, it surveys
Amount device 200 can more accurately measure blood flow and SpO2。
In measuring appliance 1000, it is not limited to described in second embodiment including the measuring device in maintaining part 1001
Measuring device 200, and can be measuring device 100 described in such as first embodiment.One of maintaining part 1001 may include
First laser source 121 described in first embodiment and the first fluorescence detector 131, and another in maintaining part 1001 can
To include second laser source 122 described in first embodiment and the second fluorescence detector 132.
In the embodiment above, first laser source and the second laser source transmitting laser of biosensor have been described.However,
A light source that can be configured as other than laser source in first laser source and second laser source, such as LED (luminous two
Pole pipe).When replacing first laser source using LED light source, LED light source emits feux rouges.When use LED light source replaces second laser
When source, LED light source emits near infrared light.When replacing laser source using LED light source, controller is based on for example sending out with LED light source
The amount for the light the penetrated corresponding intensity by the received light of fluorescence detector calculates the first value P1 and second value P2.For example, when making
When replacing first laser source with LED light source, amount of the controller based on the light emitted with LED light source is corresponding by the first optical detection
The intensity of the received light of device calculates the first value P1.It can be by the ratio and the first value P1 of luminous intensity corresponding with the transmitting amount of light
Relationship stored in memory in the form of such as table.Controller can calculate the first value P1 by reference to the table.
Reference signs list
100,200,400 measuring device
110,210,410 biosensor
121,221,421 first laser source
122,222,422 second laser source
131,431 first fluorescence detector
132,432 second fluorescence detector
140,240,440,540,640 controller
141,241,441,541,641 processor
150,250,450,650 notification interface
160,260,460,560,660 memory
230 fluorescence detectors
300 measuring systems
470,570,670 communication interface
500 information processing units
600 terminal installations
680 input interfaces
700 brain blood flow meters
800 sphygmomanometers
900 clinical thermometers
1000 measuring appliances
1001 maintaining parts
1002 headbands
1003 interconnecting pieces.
Claims (18)
1. a kind of measuring device, comprising:
First laser source, for emitting the laser of first wave length；
Second laser source, for emitting the laser of the second wave length different from the first wave length；
Fluorescence detector, for receiving the scattering laser from tested position；With
Controller, be configured as based on the fluorescence detector using received first wave length scattering laser as the defeated of foundation
Calculate the first value out, based on the fluorescence detector using received second wave length scattering laser as the output of foundation come
Second value is calculated, and blood oxygen saturation is measured based on the ratio of first value and the second value.
2. measuring device according to claim 1,
It is near infrared light that wherein the laser of the first wave length, which is the laser of feux rouges and the second wave length,.
3. measuring device according to claim 1,
Wherein the blood oxygen saturation is percutaneous arterial oxygen saturation SpO2。
4. measuring device according to claim 1,
Wherein in the difference under the first wave length between the absorptance of oxyhemoglobin and the absorptance of reduced hemoglobin
Greater than in the difference under the second wave length between the absorptance of oxyhemoglobin and the absorptance of reduced hemoglobin.
5. measuring device according to claim 1,
Wherein the scattering laser of the first wave length is the laser and second wave by the first wave length of Doppler frequency shift
Long scattering laser is the laser by the second wave length of Doppler frequency shift.
6. measuring device according to claim 1,
Wherein the second value indicates blood flow.
7. measuring device according to claim 5,
Wherein the controller estimates a possibility that measured suffers from altitude sickness based on the blood oxygen saturation and the blood flow.
8. measuring device according to claim 1,
Wherein the fluorescence detector includes: the first fluorescence detector, is able to detect the scattering laser of the first wave length；And
Second fluorescence detector is able to detect the scattering laser of the second wave length.
9. measuring device according to claim 1,
Wherein the fluorescence detector is able to detect the scattering laser of the first wave length and the scattering laser of the second wave length,
And
The first laser source and the second laser source are emitted respectively with different timings.
10. measuring device according to claim 1, including at least any of following item: brain blood flow can be measured
Brain blood flow meter, the sphygmomanometer that blood pressure can be measured and the clinical thermometer that body temperature can be measured.
11. measuring device according to claim 1,
The first value P1 is wherein calculated one of according to the following formula
P1=K ∫ fP (f) df/ (I × I),
P1=∫ fP (f) df/ (I × I), and
P1=∫ fP (f) df,
Wherein K indicates that proportionality constant, I × I indicate the square of institute's intensity of received optical signal, f expression frequency and P (f) table
Show the power spectrum of Beat Signal.
12. measuring device according to claim 1,
Second value P2 is wherein calculated one of according to the following formula
P2=K ∫ fP (f) df/ (I × I),
P2=∫ fP (f) df/ (I × I), and
P2=∫ fP (f) df,
Wherein K indicates that proportionality constant, I × I indicate the square of institute's intensity of received optical signal, f expression frequency and P (f) table
Show the power spectrum of Beat Signal.
13. measuring device according to claim 1,
Wherein the controller calculates the blood oxygen saturation according to (the first value/second value) × 100.
14. measuring device according to claim 1,
Wherein the controller calculates the blood oxygen saturation by the predetermined weighting of the value of execution (the first value/second value).
15. measuring device according to claim 1,
Wherein the controller is come by using the table for the value of (the first value/second value) to be converted to the blood oxygen saturation
Calculate the blood oxygen saturation.
16. measuring device according to claim 1,
Superficial temporal artery is wherein launched by the laser that the first laser source and the second laser source emit.
17. a kind of measurement method of measuring device, comprising:
The step of emitting the laser of first wave length to tested position；
The step of emitting the laser of the second wave length different from the first wave length to the tested position；
The step of receiving from the scattering laser at the tested position；
Based on received first wave length scattering laser come the step of calculating the first value；
Based on received second wave length scattering laser come the step of calculating second value；And
Based on the ratio of first value and the second value come the step of measuring blood oxygen saturation.
18. a kind of program, for making computer execute following steps:
The step of emitting the laser of first wave length to tested position；
The step of emitting the laser of the second wave length different from the first wave length to the tested position；
The step of receiving from the scattering laser at the tested position；
Based on received first wave length scattering laser come the step of calculating the first value；
Based on received second wave length scattering laser come the step of calculating second value；And
Based on the ratio of first value and the second value come the step of measuring blood oxygen saturation.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017044077 | 2017-03-08 | ||
| JP2017-044077 | 2017-03-08 | ||
| JP2017-161545 | 2017-08-24 | ||
| JP2017161545A JP6847789B2 (en) | 2017-03-08 | 2017-08-24 | Measuring device, measuring method and program |
| PCT/JP2018/005805 WO2018163784A1 (en) | 2017-03-08 | 2018-02-19 | Measurement device, measurement method, and program |
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| CN110381830A true CN110381830A (en) | 2019-10-25 |
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| CN201880016217.8A Pending CN110381830A (en) | 2017-03-08 | 2018-02-19 | Measuring device, measurement method and program |
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| Country | Link |
|---|---|
| US (1) | US11666228B2 (en) |
| EP (1) | EP3593719A4 (en) |
| JP (2) | JP6847789B2 (en) |
| CN (1) | CN110381830A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113576474A (en) * | 2020-04-30 | 2021-11-02 | Oppo广东移动通信有限公司 | Electronic equipment and blood oxygen detection method thereof |
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| JP7124525B2 (en) | 2018-07-31 | 2022-08-24 | 住友ゴム工業株式会社 | Golf ball |
| WO2021214775A1 (en) * | 2020-04-22 | 2021-10-28 | Bar-Ilan University | Optical system and method for detecting light scattered from tissue |
| CN116940280A (en) * | 2020-11-30 | 2023-10-24 | 光谱公司 | Alternative energy modes for measuring blood and tissue oxygenation |
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| EP3593719A4 (en) | 2020-12-16 |
| JP2018143747A (en) | 2018-09-20 |
| EP3593719A1 (en) | 2020-01-15 |
| JP2021090833A (en) | 2021-06-17 |
| JP6847789B2 (en) | 2021-03-24 |
| US20200297221A1 (en) | 2020-09-24 |
| US11666228B2 (en) | 2023-06-06 |
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