TWI379662B - Diagnostic measuring device - Google Patents

Description

VI. Description of the Invention: [Technical Field] The present invention relates to a medical measuring instrument, and more particularly to a non-invasive diagnostic measuring instrument. [Prior Art] It is known that oxygen supply to body tissues is the most important function of human life. Therefore, the current diagnostic method of oximetry is very important in medicine; the usual system uses the pulse oximeter; Such a pulse oximetry sensor||unit comprises - an optical measuring unit having two light sources, the light source being in contact with the woven material (four) and/or infrared light. This light is scattered in the body group and partially recorded. The most stored (four) photosensors in the form of photocells (photodiodes) to detect this scattered light. Light Sensing 3 The amount of scattered light that is detected will vary depending on the intensity function of the == and/or oxygen deficiency supplied to the examined body tissue. Therefore, it can be compared by pulse = oxygen. In addition, the conventional pulse domain meter can generate a volumetric pulse wave 亦 'also _ reflected in the pulse 4 system of blood volume changes in the production of π, the cover of the micro-blood in the I-domain (photoplethysmography - Recently, a comprehensive application of different diagnostic methods has been known, such as the treatment of 舆 邮 测量 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Obtaining the Invention [Abstract] 1379662 The present invention relates to a diagnostic measuring instrument for non-invasively recording at least one physiological parameter of body tissue, the diagnostic measuring instrument being an optical having at least one radiation source for illuminating body tissue to be examined The measuring unit and the at least one illuminating sensor for detecting radiation scattered and/or transmitted by the body tissue, wherein the at least one radiation source and the at least one radiation detector are disposed in a general sensing The object of the present invention is to provide a cold cut measuring instrument that non-invasively measures physiological parameters. The diagnostic measuring instrument is technically more functional than the prior art. Specifically, the purpose is to create a low-cost production of food b 10 on the one hand, and to allow users to use it in a comfortable and simple way on the other hand, for example, through self-diagnosis, to continuously monitor existing diseases for early identification. Sensor unit for disease. The present invention accomplishes this task on the basis of a measuring instrument of the kind originally mentioned, the measuring instrument for recording ECG signals comprising two or more ECG electrodes, wherein At least one ECG electrode of the ECG unit is disposed on a surface of the outer casing of the sensor housing, and the bioelectrical impedance measuring unit is disposed in the housing, and at least one feeding electrode or measuring electrode of the impedance measuring unit is disposed on the sensing unit. The surface of the outer casing of the casing is such that the ECG electrode and the feeding electrode or the measuring electrode are in contact with the skin surface of the body part 20 woven portion of the optical measuring unit. By the integration of the optical measuring unit and the ECG unit by the present invention, Create small devices that provide multiple diagnostic measurements. These measurements can be obtained individually or in combination for quick and reliable access to the inspection. Healthy persons

4 information. This small measuring instrument can be pre-fabricated in large quantities at low cost and then combined into the most diverse types of diagnostic equipment. The actual measurement can be made in a very simple and comfortable way. In order to achieve such an effect, contacting the surface of the sensor housing with the skin of the body tissue to be examined can be accomplished, for example, by placing the patient's finger on the outer surface of the sensor unit. The sensor unit is then touched by the skin point while performing optical measurements, ECG derivation, and impedance measurements. The ECG unit of the sensor unit of the present invention is composed of two or more. EC, the electrode to record the ECG signal. Thereby, it is advantageous to make the functional range of the sensor unit of the present invention more expandable than the conventional system. The sensor unit of the present invention can record and estimate the pulse oximetry signal and the brain signal together. The s s is used to estimate the optical pulse signal and the estimate of the change in the timing of the optical signal for this purpose. This estimation unit can be part of the body formed with the instrument in 4]. It can also be equipped with an estimate of 77 and an open estimate, and at the same time, through an appropriate number of measurement signals, it can be transmitted to the estimated manure T system, 笪 笪 ^ & For example, the r-wave in the foot signal is automatically recognized by the appropriate program control. Then automatically: the time point of the second jump. In addition, by appropriate program control, r fresh:, the maximum value in the volume pulse signal is identified. According to the maximum value of the volume 22:, it can be measured around the age of the difficulty unit and the time point at which the pulse of the heart __ is obtained. The most L is it, this is the timing interval between the skin and the pulse signal in the pulse signal. This timing interval is in the range of the so-called pulse rate 20 1379662. In one aspect, blood pressure can be described in terms of pulse rate. The decrease in pulse rate is accompanied by an increase in pressure, and (4) an increase in wave material causes a decrease in =. However, it has only been shown that such a tendency cannot accurately determine the blood pressure from the pulse rate. Furthermore, the pulse wave system depends on the density of the blood, especially the elasticity of the blood vessel wall (e.g., the aorta). Then, it can be inferred from the elasticity of blood vessels that arteriosclerosis may exist. It is also possible to estimate the absolute value of the heart rhythm, the heart rate change, and the corresponding heart and law irregularities. For example, Lu's can automatically measure sinus rhythm too fast, sinus rhythm is too slow, sinus 10 two-hop stop and volitional arrhythmia. The ECG signal can also be subtracted to describe the atrial contraction time, ventricular contraction time, and ventricular diastolic time. In addition, blockage of the irritated electrical stimulation signal channel (atrioventricular blockade, branching beam blockage, etc.), or even blood circulation disorders or infarction. Other irregularities in the pulse material can be detected based on the volume pulse signal. In addition, 'the present invention' is based on the discovery that the possibility of measuring metabolic parameters can be turned on in conjunction with different diagnostic methods in a particular measuring instrument. According to the invention, the conventional (optical) oximetry unit is integrated not only with the ecg unit but also with the bioelectrical impedance measuring unit in a particular measuring instrument. The measurement signal obtained by the bioelectrical impedance measuring unit can measure, for example, the composition of the examined body tissue. On the basis of this, preferably, the microvascular oxygen saturation in the tissue can be determined from the blood oxygen signal by an appropriate program control estimating unit connected to the measuring unit of the measuring instrument of the present invention. The arterial oxygen saturation (1379662 jSa〇2) and venous oxygen saturation (Sv〇2), depending on the type of body tissue being examined, determine the microvascular (arteriovenous) oxygen saturation (St〇2). The applicable formula is as follows: κ * Sv〇2 + (1 _ K) * Sa〇2 = St〇2 5 where K is the tissue-related correction factor, which depends on the volume ratio of the middle artery and vein. This value is on average slightly less than 〇.5. According to the present invention, the value determined by the relevant tissue can be determined by bioelectrical impedance measurement to determine the venous oxygen saturation according to the above formula. The sensor unit of the present invention can be used to determine blood circulation ν, i.e., 10 volume fluctuations of the examined body tissue depending on blood circulation. According to the off-form, the amount is the metabolism at the measurement point V〇2 = V * (Sa〇2-Sv02) Finally, the local oxygen consumption ν〇2 activity metric can be calculated. 15

For bioelectrical impedance measurements, the feed or measurement electrodes are placed on the surface of the housing of the sensor housing to allow bioimpedance measurements to be made with blood oxygen measurement and foot measurement. Therefore, the same part of the body _, that is, the position of the patient touching the surface of the sensor housing, is also covered by the law. $20 According to the invention, at least one ECG electrode and at least a feed electrode or a measurement electrode of the impedance measuring unit are disposed on the surface of the sensor housing. - The ECG electrode and the additional feed electrode of the necessary hybrid anti-measurement unit are designed so that the patient can touch all the electrode ends. 1379662 The hands are respectively touched by one of the electrodes. According to an advantageous configuration, the measuring instrument comprises an integrated temperature and thermal sensor. This configuration can be used to determine local heat production. In the simplest case, a temperature sensor (e.g., an NTC element) is suitably configured to measure the skin surface temperature at 5 points of measurement. Preferably, the thermal sensor is used to determine the position, time and depth of the thermal measurement at the measurement point. Local metabolic activity can be inferred based on heat exchange. In addition, the 'thermal detector is suitable for measuring local blood circulation. For more accurate background information on heat measurements, refer to the publication published by Nitzan et al. (Meir Nitzan, Boris Khanokh,,, Infrared 10 Radiometry of Thermally Insulated Skin for the Assessment of

Skin Blood Flow", Optical Engineering 33, 1994, No. 9 p 2953 to 2956). Overall, thermal sensors provide information that can be used to determine metabolic parameters. One of the unique advantages is the present invention. Combined with the measurement 15 method described above, namely oximetry, ECG measurement, temperature and/or heat measurement, and bioelectrical impedance measurement. All measurement signals can be estimated and combined by appropriate algorithms. By combining different measurement methods, high efficiency, repeatability and reliability can be achieved in the identification of pathological changes. All parameters are conducive to the integration of the user's easy to understand and can provide users with a direct view of their general health status. Overall indicator according to the suggestion. Since the non-invasive indirect measurement of blood glucose concentration can be performed by the measuring instrument of the present invention, the combination of the measuring instrument of the present invention summarized above and the different measuring methods has a greater advantage. The following statement is more detailed 966 966 illustrating and describing the blood glucose level by the device of the present invention; under normal conditions, that is, in a dormant state The state and the so-called thermo-neutral region, the metabolism of the human body is mainly determined by the balance of blood sugar. Therefore, the normal amount and the blood glucose concentration in the tissue cells can be described as only a function of the oxygen consumption of heat production. It is: [Glu] = fj(AT, V02) » 10 [Glu] represents the concentration of sugar. The heat yield ΔΤ can be completely separated by the thermal sensor of the sensor unit of the present invention, for example, by the surface of the secret temperature surface. The difference in temperature of heat is UT = Ts. - T_y), fi (AT, ν secret 罝 and oxygen consumption as a function of blood glucose concentration _. As mentioned above, oxygen consumption is saturated by vein and arterial oxygen The difference between the degree and the money cycle. However, in order to determine the blood glucose concentration during the eating period or the eclipse reading, it is necessary to take into account the correction of the fat metabolism part of the energy balance towel. The following formula is applicable: 15 [ Glu] = fl(AT, V02) + X * f2(AT, V〇2) 〇X is negative (four)@子 after eating. Therefore, χ depends on the composition of the food ingested. In particular, X depends on participation. Metabolic fat to carbohydrate ratio, as described above, based on pulse rate at the time The change in the axis is used to determine the factor X. If only carbohydrates are ingested or glucose 20 is directly ingested, x is zero. The more fat in the food taken, the greater the amount of X. In order to get from pulse rate, blood pressure The amplitude and/or the change in pulse on the time axis to determine the correction factor X usually requires correction to suit the user associated with the device. For fat metabolism, f2 (ΔΤ, V〇2) represents heat production and oxygen consumption. A functional correlation to blood glucose concentration. Thus, the local money concentration can be determined from the localized heat production using the measuring instrument of the present invention. The measuring instrument includes an appropriate measuring method that can achieve this effect. As described above, oxygen consumption can be measured in combination with oximetry and bioelectrical impedance measurement. The aforementioned thermal sensing f is also required to determine the heat yield. Finally, in order to be able to calculate the blood glucose concentration according to the above function, the correction factor should be determined, for example, by the change of the pulse wave velocity in time series. As described above, the above measurement can be performed by combining the k number and the volume pulse. The measurement of the wave signal is done. Therefore, in order to measure the blood glucose concentration, it is preferred to incorporate a pulse oximeter, an ECG single it, a bio-anti-test #, and a thermal sensor in the diagnostic measuring instrument of the present invention. The above methods initially only provide for the determination of intracellular blood glucose concentrations. In the simplified version, there is a correlation of the following blood glucose concentrations: [Glu]ce丨丨=a ten b ”n (c * [Glu]b丨..d) 15 constants a, b, and C depend on The individual's physiology of the patient being examined. These parameters can be determined using appropriate corrections, such as blood glucose values for invasive measurements performed by conventional methods. etc. [Optical measurement unit, ECG unit, impedance measurement sheet in accordance with the present invention.兀 and if a temperature sensor or thermal sensor is present, the system is housed in a general 20 sensor housing. In a preferred embodiment, the at least one ECG electrode and the impedance meter 7G are at least The feed electrode or the measuring electrode is arranged on the upper side of the sensor housing, and the flat box or metal made of a conductive material is thin. Therefore, the gold (four) sheet and/or the gold shot g may include at least a recessed hole. ,Make

10 1379662 At least one light source emits a light shot through the body tissue to be examined, or the body tissue is scattered and/or transmitted through the radiation sensor and transmitted to the radiation sensor. Another recess for the temperature sensor or thermal sensor can be set. The radiation source, radiation sensor, and temperature sensor or thermal sensor can be placed on a general printed circuit board located within the sensor housing. The required measurement methods are then integrated into the sensor housing to form a unit that can be flexibly integrated into any diagnostic instrument without problems. The sensor housing can have a size of less than 1 cm x 1 emx 丨 cm so that it can be used without problems in the concept of the present invention. Therefore, the object is to simultaneously use at least one ecg electrode 10 for a feed electrode or a measuring electrode for bioimpedance measurement. Overall, 5, is: to an ultra-small integrated measuring instrument that contains various measurement methods. All measurement methods may cover the same part of the body tissue being examined (e.g., the fingertip of the patient touching the surface of the sensor housing) to simultaneously detect the patient's metabolism and cardiovascular system as described above. Therefore, the measurement becomes very simple and effective. According to a preferred embodiment of the present invention, the bioelectrical impedance measuring unit is adapted to be configured to transmit at least β-the impedance of the surface of the skin to be measured by the measuring electrode, and the distance of the pair of measuring electrodes is less than - From millimeters to several centimeters' ^, when the measurement is performed, the two (four) poles used for locally recording the impedance measurement signal can simultaneously collide with the same portion (four) of the skin surface of the examined patient. By shortening the electrode distance to less than - mm to a few centimeters, it is impossible to integrate the whole body by bioelectrical impedance measurement, but the bioelectrical impedance can be recorded locally. Root [S3 11 20 1379662 According to this U, all the electric cores are in the same state as the surface touch of the patient's skin to be examined. The 卩 position, that is, all electrode systems are in contact with the same part of the body (such as the hand, palm, foot or toe). In order to measure the game. ΡResistance and Reactance ′ In the present invention, it is preferred to include a pair of electrodes for transducing alternating current through the surface of the surface of the surface of the measuring electrode. The feed electrode distance corresponding to the measuring electrode is preferably from several millimeters to several centimeters. It is proved to be very advantageous to design the measuring electrodes (four) to form the contact electrodes extending parallel to each other. The local impedance of the body tissue can be tolerated without any distortion results, for example due to transfer resistance between the electrode and the skin surface. 15 / In order to generate a frequency conversion parent current, the diagnostic measuring instrument of the present invention preferably comprises an alternating current generator. The impedance measurement signal is converted by the analog/digital conversion and then subjected to Discrete Fourier Transform (DFT). The DFT and 寅 algorithm provide the imaginary part of the impedance, that is, the resistance value and the reactance value. These values can be entered. In a preferred embodiment, the maximum distance between the electrodes is (7) coffee, and in a special aspect of 20, the distance is 50 micrometers to 5 cm. In a better aspect, the distance is from the micron to the micro! Cm, and in a very good aspect, this distance is from i-face to 5 mm. The configuration of the invention can vary the local time of the impedance. In order to achieve such an effect, the measuring instrument preferably comprises an estimating unit connected to the 12 1379662 ( and (4) measuring unit. The lining unit can be estimated by the program (4). Cattle and CT due to changes in blood volume during a pulse period 5 bio-impedance changes, this can be! The local hunter measures the heart rhythm by local bioelectrical impedance. At the same time, the pulse amplitude is measured as an important physiological parameter. Obviously, the pulse amplitude is related to body temperature', which means that it can be assisted by bioimpedance analysis. (4) Determine the body temperature of the examinee. Furthermore, the local bioimpedance also depends on the volume of the liquid 'that is, depending on the amount of local blood in the tissue being examined, thereby measuring the local blood circulation (local volume fluctuations regulated by blood circulation) in the examined tissue. For example, in the form of a volume signal). Finally, the body's crotch bioelectrical impedance changes as a function of food intake' so as is well known, the metabolism defined by blood glucose values can be examined by bioimpedance. Thus, the measuring instrument of the present invention also provides non-invasive blood glucose monitoring by means of an impedance measuring unit, having the effect of being able to check the glucose and/or energy requirements of the in vivo physiological response of Φ initiated by glucose. The blood glucose value and its variation in timing can be described by the recorded impedance measurement signal by estimating the appropriate algorithm performed by the software in the unit. According to another preferred configuration of the diagnostic measuring instrument of the present invention, a sputum-fixing device is provided for fixing a body part of a patient to be examined, such as a finger. In the case of performing impedance measurement and also performing pulse blood sputum measurement, the contact pressure of the body tissue (e.g., a finger) acting on the optical sensor and/or on the measuring electrode and the feeding electrode can significantly affect the measurement signal. Therefore, by [S3 13 5 by the fixed device to mention the material connection _ the fixture can contain - inflatable gas (4), for example, the part pressure in the measurement of mine; ground) will be related to the body in the wife / or feed The electric electrode is on, above, and fixed there. By the movement of the part of the drop-out feeling, it is also prevented from being such a solid; the body has another #== the result of the measurement of the measuring instrument in the present invention. A plurality of feed electrodes are also set and/or the amount I' is in a matrix form. The source and the electricity are _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The data and data obtained from the 11th fiscal rule can be inferred about the pH value, pco2 value, and electrolyte balance (Na+-, κ+ 2+ 2 八 La, Mg2++ concentration, etc.). As described above, the light of the measuring instrument of the present invention illuminates the coffee body of the examined body tissue and at least one of the radiation sensors for the scatter and/or transmission of the == body. The appropriate source is light that emits light, that is, light in the corresponding spectral range, only the light diode or even the laser diode. The meter of the present invention proves to be particularly advantageous for measuring the light absorption of the examined body tissue in at least two or even more preferably three different wavelengths to determine the gray oxygen concentration and blood circulation of the tissue. 20 According to the configuration of the present invention for the purpose of the present invention, the optical pre-measurement unit of the measuring instrument of the present invention is composed of at least two H-radiation sensors for detecting scattering or transmission by body tissues. The radiation sensors are arranged at different distances from the light source. Such a configuration opens the possibility of inferring the distance covered by the body and the ray in the weave. According to this, blood can be checked

14 i3?9662 5 ::, Oxygen concentration in different depth tissue layers. Can be used more: the signal is affected by the mixed blood (four) louder than the ton, and the New (four) near surface ^ ^ in the ejaculation of the suction is affected by the micro-tube system, the blood is relatively large, use - for the side to transmit light Light-emitting sensor = the scattering of the body tissue (return) _ Sense of radiation (4) ^ ^ The measurement signal that is fined during the second transmission process is relatively large by the arterial blood suction, and the scattered radiation mainly comes from Close to the surface _ ^ Therefore, the absorption can be inferred, and thereby the oxygen in the microvasculature is estimated to be 0 0. The advantage of the item is that in the configuration of the measuring instrument of the present invention, the selective irradiation of the second to the π can be different. The range of volume is: - the effect of the body, and the weave. For example, in order to achieve such an effect, it is possible to illuminate a light shot 15 f of the examined body tissue of different volume ranges, whereby different measurements of light absorption can be performed early. Blood can be used to enrich oxygen/excess oxygen. To check the change in the blood circulation of the examined body tissue by the generation = reference: The factor used here is a function of the local oxygen consumption as a function of the metabolic activity. The variable oxygen consumption and oxygen consumption Directly related local energy consumption, in which special = 20 to focus on such a configuration can further infer the blood sugar level. Therefore, the invention of the present invention changes the blood sugar level of non-invasiveness. Oxygen-rich or lack of blood The volumetric shadow of the selective illumination is achieved as two radians with different spatial maneuver characteristics. For example, Lu can use a light-emitting diode with similar wavelengths (eg 630 譲 and 15 IS) 1379662 650 nm) The body and a laser act as a radiation source. However, the radiation sources have different radiation aperture angles. For example, although the light-emitting diode illuminates the body tissue with a large aperture angle, the laser diode is extremely small.The aperture angle enters the body tissue. As a result, the two radiation sources draw body tissues of different volume ranges, because in the case of large aperture angles, the light-emitting diodes extract a larger volume of un-supplied blood than the laser. The epidermal layer. The epidermal layer that is not supplied with blood is not actually affected by the change in hemoglobin concentration. Therefore, the correlation between the radiation intensity of the light-emitting diode scattered and/or transmitted by the body tissue and the change in hemoglobin concentration is lower than that. The intensity of the laser radiation. The first 10 items are the wavelengths of the radiation emitted by the two sources, so that the oxyhemoglobin and/or non-oxyhemoglobin absorb different radiation intensities. Therefore, the wavelength should be 600. Between 700 nm, preferably between 630 and 650 nm. According to the configuration of the diagnostic measuring instrument capable of achieving the object of the present invention, the at least one radiation source is connected to a light guiding element, such as an optical fiber. The element conducts the radiation source and/or the radiation emitted by the radiation sources to the surface of the sensor housing. This may facilitate the bonding of several light source sources, for example, a plurality of light sources on a general substrate. The radiation of the LED wafer is coupled into a particular light guiding element. Different light source sources can be lightly coupled to the light guiding element in different ways. In this way, it is possible to achieve a body group with different light-light characteristics from different sources. Alternatively, the light guiding element can be attached to an optical system that produces directional radiation and/or diffuse radiation into the body tissue. In this manner, tissue layers of different depths can be selectively examined. For example, the light guiding element can be The exit forms an optical fiber like a Y-shaped bifurcation. Connected to 16 1379662: the exit end of the splitter is a concentrating lens that produces an orientation (substantially flat 6, ^ „ ν, D) light into the deep tissue. . The radiation is extracted in the end of the Μ-Μ, and is close to the table _ bit. In a preferred configuration in which the measuring instrument of the present invention can be provided in an extremely small and sturdy manner, it is conceivable to arrange at least a fine source in the 15 20: empty chamber of the diffusion ride. For example, the hollow reflector can be constructed of a so-called Ubnehtsph (10). In the present concept, the hollow reflection (four) geometry is not limited to a sphere. The Ubri ball system represents a hollow body with a diffuse reflective coating inside. The source is reflected from the inside and the (4) radiation is close to the ideal diffusion. It is also said that the directional characteristics of the light source, such as the light-emitting diode, are destroyed. A wire system capable of producing directional jets into the body tissue can be attached to the hollow reflector. Additionally, the hollow reflector can include an exit orifice that allows a diffuse light to pass into the body tissue. The optical measurements described above can be performed on different volume models in such a manner. The hollow reflector does not have to be hollow, but can also be made of an outer, (four) coated turn. The actual source of the shunt (e.g., an LED chip) can be embedded in the material of the hollow reflector and can be supplied with current through the wiring derived from the hollow reflector. In this way, the optical measuring unit can be miniaturized. Hollow reflectors can be prefabricated in large quantities at very low cost into extremely small components. The meter H of the present invention can facilitate the determination of metabolic parameters by radiation of at least one source of radiation that is scattered and/or transmitted by the body domain. If checked

LSI 17 body, woven > Xiao Oxygen', then oxygenated hemoglobin will be converted into non-oxyhemoglobin three by comparing the different volume range of radiation from selective irradiation, can be measured oxyhemoglobin and non-oxygenation The change in hemoglobin concentration ratio. In turn, the local oxygen consumption is derived, and finally the blood glucose value can be derived (indirectly). 5 For practical applications, the measuring instrument of the present invention can be connected to any control device such as a computer, a mobile phone, a handheld device, etc., having a software that can be executed on a private control device for the measurement of the recorded measurement signal. 2 function. Since the size of the sensing H casing is small, it is also possible to integrate any accessory towel such as glasses, a watch or a first material, or integrate it into a clothing (a smart type of clothing) in such a configuration to control the money in any way. The coexisting data processing circuit is used to process the obtained =1 号 ° °. Such processing is expected to be able to memorize and store the diagnostic data determined by the software by configuring the appropriate software. 5 = 3 :: The efficacy of the course and the corresponding therapy. Remote data transmission: The data of the logistics and estimated data is reasonable and feasible. The data network (such as the Internet) can be used to perform data 'for example' if The measuring instrument of the present invention is integrated in line 20 =: two = data can be transmitted by the mobile wireless network. The original = inner w or estimated material transfer can be transmitted to the central station, for example, when the medical examination is held, the exhibition 11 heart-u The document t and monitors the individual value of the private development of the door. Example: Continue to consider the archived patient data (including chronic disease or past estimates). The results can then be sent back via the data network or communication network, for example, 18 5 =本=知裳f user about The user's health status. Selective, > 丨 ^ 之 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器 仪器The results of the data can be automatically transmitted to the physician performing the examination. If the measurement and estimation > month indicates an urgent medical situation, the necessary measures can be activated immediately (for example, a distress alert is automatically issued). One advantage is that the skirt itself does not need to perform the software required to estimate the measurement signal, as long as it is performed at the center of the received data, the software must remain available and be held in good condition. 15 For pulse oximetry In contrast, the contact pressure of the body tissue (such as a finger) acting on the optical sensor can significantly affect the measurement signal. Therefore, it is reasonable to make the measuring instrument of the present invention useful for measuring the contact pressure of body tissue. The device may be a conventional pressure sensor, such as in the form of a piezoresistive element. Optical methods may also be used to determine contact. Since the contact pressure has a special influence on the measurement signal, the contact pressure can also be determined from the (pulse oximetry) signal itself. The measured contact pressure can then be considered for further estimation of the measurement signal to compensate for the contact pressure for example [Embodiment] Referring to the first figure, the measuring instrument 1 of the present invention is integrated into a computer system composed of a computer 2 and a keyboard 3, and the measuring instrument 1 is included in the keyboard 3. Different measurement methods for accessing the user interface 'The computer 19 system j uses the fingertip to touch the keyboard 3 to perform measurement, and is integrated in: the light source 4, 4'', for example, can emit various kinds of In order to achieve this goal, a variety of different light-emitting semiconductors 70 pieces are housed in a general sensor housing (keyboard 3 housing). It is also possible to use a light waveguide to guide the light from different light sources to the user of the keyboard 3, and the measuring instrument 1 includes - or a plurality of light sensors 5, which are respectively in close proximity The light sources 4 and 4' are disposed, and the light sensor 5 receives light scattered from the light source 4 and/or 4'' in the tissue at the fingertip of the user. In addition, the thermal sensor 6 is also adjacent to the light source 4. / or 4, set, , to ensure that the blood supply measurement according to the heat measurement can be completed at the same position as the optical measurement; in addition, four electrodes 7 and/or 7, all of which are disposed on the surface of the sensing n On, to measure bioelectrical impedance. I put the user to touch the two electrodes 7 and/or 7 simultaneously with one hand, and one of the two contact faces is used to apply current to the measurement position, and the other contact surface is used. The amount of electricity (four) is measured. In this way, the result of the side measurement is not affected by the contact resistance of the measuring electrode. The two electrodes 7 are also used as the ECG electrode 7 of the ECG unit, and the ECG unit is also integrated in the measuring instrument 1 Among them, the knife touches the two electrodes 7 with the tip of the pellet to generate a two-point derivative (arm-to-arm measurement). The computer 2 is used to process the measurement signal obtained by the measuring instrument integrated in the keyboard 3, and this way The resulting physiological parameters are displayed on the display screen of the display 9 connected to the computer 2, for example, the display shows no arterial oxygen saturation (Sa〇2), microvascular oxygen saturation (St〇2) and venous oxygen. Saturation (Sv〇2)' further shows the measured heart rhythm 1371662 and tissue fat content (10), and finally shows the blood glucose level (10) so that the physiological parameters of interest can be determined at any time, so that = fine electrode __(4) Press _ 5 15 f to make 2 computers for this purpose After the measurement signal, immediately followed by fast 9 = not show significant parameters, measuring instrument ^ ϋ user 1 actually requires for the measurement of physiological parameters interrupted working on the computer 2. Month> Read the visual inspection instrument II! Set two kinds of examined body tissues _radiation sources 4 and 4 that illuminate different volume ranges, in order to achieve such an effect 'the two _ sources 4 and 4 have different spatial radiation Characteristics, that is, different radiation angles, 'light source 4 is a light-emitting diode, and light source 4 is a laser, such as a so-called VCSEL-laser (vertical cavity surface-emitting laser) 'lighting diode Body 4 and Laser 4, both emit light with very similar wavelengths (eg, coffee (10) and coffee nm), but with different aperture angles (eg, 25 and 55.), which can cause oxygen in the gold liquid caused by metabolism. The content changes are measured differently. In order to achieve such an effect, the two kinds of radiation sources 4 and 4, respectively, must emit light at a wavelength that can absorb different light intensities in the dog's oxygenated and non-oxygenated erythropoietin. In order to be able to measure the oxygen content (oxygen saturation) in the blood, there must be other light source (not shown in Fig. i) whose wavelength is at the oxygen interstitial and non-oxygenated The light absorption is approximately equal (the apparent absorption point) within the spectral range The light can be guided to the corresponding position of the user interface of the keyboard 3 by a suitable optical fiber, in which case the 'light emitting diode 4' or the laser 4 dimming _ end can be used to illuminate the diode 4 and The laser 4' is connected to the appropriate fiber so that they illuminate the body tissue to be examined at different aperture angles desired by 21 I S3 20 1379662, so two light sources can be used to examine different volumes of body tissue because In the case of = angle, the epidermis of the uncharged blood detected by the light-emitting diode 4 is larger than that of the laser 4, and the fine sensor is used to detect the source 4, 4' in the body tissue. Internal scattering and partially absorbed light, radiation sensing fast 5 does not need to be directly set in the measuring instrument ^ is provided by _ _ 1 1 敎 料 light guide = to provide light 'in order to make light source 4 light and radiation The light of source 4 has a difference, and the light sources 4 and 4 can be operated by using different time modules and demodulating the signals detected by the time module 5. Or, 15 20 is based on the same wavelength, so that the light source 4 and 4 have different apjections. The light-intensity of the radiation emitted by the light source 4 and 4' is attenuated with the length of the path through the body tissue, and the intensity decay is also known as the absorption material (oxygen) in the familiar amberbert Beer law. Hemoglobin) [With the light sensor 5, the intensity attenuation of the parameter of interest can be determined, which is represented by the volume ranges of the irradiated sources 4 and 4, respectively, of the body tissue being examined. The parameter intensity attenuation to the different radiation sources 4 and 4 is correlated with each other by an appropriate program-controlled estimating unit to perform the differential measurement in such a manner that, in the simplest case, by the radiation source 4 and 4's radiation parameter intensity decay is used to calculate the quotient, and changes in these quotients can be inferred to change the metabolism. For example, if the blood glucose level rises after eating' then (after a certain time delay) there will be more Glucose enters the cells of the body tissue and switches there, in the process of 22 1379662 will consume more sputum, which will be absorbed by the cells through the blood, so by Blood consumption, oxyhemoglobin will become non-oxyhemoglobin, so the proportion of non-conjugated heme to oxygenated erythropoietin will increase, because the angle of the radiation from the radiation source 4 and 4' is different, so the blood red The change of the concentration of 5 has different effects on the related intensity decay. Therefore, the change of hemoglobin concentration can be detected by the quotient of the parameter intensity attenuation, and the oxygen consumption can be indirectly estimated because the oxygen consumption depends on the blood glucose level. Therefore, the blood glucose level can also be measured by the differential measurement of the radiation absorption as described above, in order to complement this method, the bioimpedance analysis of the optical measurement using the set electrodes 7 and 7' is performed to achieve this. The effect, especially the purpose of bioimpedance measurement, is to measure the local blood supply. This measurement can also be used as a blood glucose value for the blood consumption of Zhejiang, another parameter, or just use appropriate optical components (such as beam splitters, lenses). And the light measuring source 4 is used to generate light of different aperture angles. The diagnostic measuring instrument 1 of the present invention is also advantageous for estimating the measured values in a pulse synchronous manner, because The measuring instrument i of the invention includes a suitable sensor (such as an ECG) that has been pulsed, so it is possible to (4), 20 ί::; dan: when the maximum value of the rf pulse wave is also/minimum, the selectivity is estimated to be Nuclear resistance measurement _ measured value, according to the pulse = detection can be used with the diagnostic measuring instrument of the present invention 1, the respective ratio = and the pulse-related blood volume in the tissue can be useful for pulse-related blood volume Diagnostic data and pulse-independent metabolic data, 23 ί S3 1379662 10 15

Please refer to the second figure, the measuring instrument of the invention! The optical measuring unit 100 is included (the H system is used for optically measuring the oxygen concentration of the body tissue at a known measuring point, and the blood oxygen signal residual pulse signal recorded by the optical hard unit 100 is transmitted to The analysis unit 110, another necessary component of the measuring instrument 1 is a heat measuring unit 120 for determining the local heat yield. The heat measuring unit 120 is a special thermal detector that can isolate the body part to be inspected. It can only be used to absorb heat from the private stream. Therefore, the amount of blood can be measured by the time-quantity of the temperature. In the case of a large amount of growth, the fork can check the body's energy to reach the highest temperature in a very short period of time. In the case of a small amount, it takes a long time. In addition, since the temperature at the measurement position is measured only by the arterial temperature and the hairline, the temperature of the artery can be estimated by extrapolation of the measured temperature. The measurement signal recorded by the heat measuring unit 120 is transmitted to the analysis unit ιι to perform advanced processing. In addition, the measuring instrument 1 includes an impedance measuring unit i30. The impedance measuring unit i3G is used to record the raw The measurement signal of the impedance measurement of the object is also processed by the impedance measurement unit (10). Finally, the ECG unit 132 with the ECG for recording ECG money is also connected to the analysis. Unit 110, for processing the ECG, refer to the first figure, the measurement to the optical measuring unit: the handle 4 of the Yiyi 1 and the photo sensor 5, and the heat measuring unit 12G is connected to the measuring unit II 6, the impedance measuring unit (10) Storage diagnosis _ quantity instrument i electric ^ 7 also / or 7 to record the measurement signal 'analysis unit 1HH system for all the pre-processing of the measurement signal, in order to achieve this effect, the signal is passed through the bandpass 20 1379662 filter, Interference in the region where the net frequencies are 5〇 and 6〇Hz, respectively, and the signal is subjected to noise suppression from the optical measuring unit 1〇〇, the heat measuring unit 120, the impedance measuring unit 130, and the ECG unit. The signal processed by the knife analyzing unit 110 enters the estimating unit 14A, and the estimating unit 5 7G 140 is responsible for calculating the necessary diagnostic parameters from the measurement signal, which is first recorded by the unit 130 in accordance with the time. Measurement signal comes Calculate the composition of the body tissue (water content, fat content, etc.), and calculate the arterial oxygen saturation and microvascular oxygen saturation based on the optical measurement unit 1〇〇-based on the tissue parameters measured by impedance measurement. The measurement signal from the heat measurement unit 120 1 以及 and the volume pulse wave derived from the time-dependent impedance measurement, according to further determination is the blood supply volume and the arterial temperature 'pulse wave rate is the signal and optical measurement by the ecg unit= The signal of unit 1〇〇 is determined. Finally, all the calculation results before the estimation of it 14 〇 (4) are calculated at the measurement point ^ vein such as oxygen saturation and other metabolic parameters, especially local consumption of 15 oxygen and blood sugar The diagnosis unit 150 is used to interpret the calculation result, and the diagnostic unit 15 (also as a software on the computer 2) can be used to estimate the local metabolic parameters calculated by the estimation unit 140, the estimation unit 14 and the diagnosis unit: It is connected to the graphic unit 16A capable of starting the display 9, so as to display the measurement, and the data obtained by the word "can be memorized in the memory material 1? wipes, that is, simultaneously add = recall related test Date and time, in addition, set the interface unit (10) that can connect the computer's 2 disk number to the physiological parameter calculated by (10), and: = 18〇 can put all the data and parameters, especially the memory in the record The parameters are transmitted to the pc that is not exactly shown for the doctor to enter the 25 tSl = instrument, where a more detailed analysis is performed, in particular, the data of the long-term record and the change of parameters can be verified by the kernel == In the second embodiment of the measuring instrument 1 of the invention, it can be understood that the conventional operating key 11 is located in the device 10 and the flat configuration is integrated in the side area of the outer casing of the mobile phone 10. Measuring sensor, mobile phone (4) user touches with a finger to measure 'four electrodes', or; set = phone 1 〇 on the side of the outer casing surface to measure the bio-resistance 15 With the two electrodes 7 also / ^ touch, the two electrodes touched to get the two-point derivative (arm = ::), using the mobile phone 1 〇 microprocessor (not shown) to call 10 different measuring instruments of the measuring instrument 1 recorded = Xia domain, will be used this way The physiological parameters that are displayed are displayed on the mobile power == screen 12, ^ 柯 is called _ its concern, - the user simply puts the finger on the electrodes 7, 7, and drives the operation key U with the finger to achieve this The effect of the system will automatically identify the touch and start the measurement. After processing the measurement signal with the microprocessor of the action 2, then immediately by the camp 12, the fine function can be used as a medical measuring instrument. The method is based on the non-invasive measurement of the city value, the method is to check the effect of glucose and/or energy conversion of the physiological reaction initiated by the grape in vivo, please refer to the first Figure 20 1379662 shows a related description of the example, similar to the keyboard 3, the light sources 4, 4, and the light sensor 5 need not be directly disposed on the outer surface of the mobile phone 10, but instead can be optical fiber Light is also directed from the surface of the outer casing and/or directed to the surface of the outer casing 'and the actual light source and/or the sensor is disposed inside the outer casing 5' can couple several light sources and/or sensors to a particular optical fiber. Referring to the fourth figure, in addition to the embodiment of the measuring instrument of the present invention, various measuring units of the measuring instrument 1 are integrated in the sensor housing 400 having a very small outer shape and disposed on the upper side of the sensor housing 400. The planar ECG electrode 7' is composed of a thin conductive foil. When the measuring instrument 1 is mounted 10 to the computer keyboard 3 or the mobile device, the user can touch the ecg electrode 7 and the other has various ECGs. The end of the electrode (not shown) is used to set the sensor housing 4〇〇, and the ECG electrode 7 is suitable for a thin stainless steel box. The example shows a size of 5 mm (w) X 8 mm (L) X 1.8 The small-sized module of the micro-shell of mm(8) can be used to install the measuring instrument 15 in different housings of various commercially available devices flexibly and at low cost. In order to simultaneously measure arterial oxygen saturation, the optical measuring unit 100, that is, the pulse is used. The oximeter is integrated in a sensor housing 4〇〇, the pulse oximeter comprising one or several optical radiation sensors 'light-lighting through a recess 410 of the Ecg electrode 7, in addition, the pulse oximeter Also includes two optical radiation sensing For example, in the form of a photodiode 20 body, light scattered in body tissue (eg, a finger pressed against the electrode 7) will descend through the two recessed holes 42 and 430 of the electrode 7 to reach the radiation sensor's recessed hole. 420 and 430 are set at different distances from the recess 410. In this measuring instrument 1, two or more 27 IS3 1379662 light source sources from the inside of the housing shed (for example, a light-emitting diode, a suitable guide towel) , nubP, has - tied optical fiber in or: 'and will measure the whole heart of the instrument 1:: in the phase == to the body tissue to be inspected nf" 5 fiber or appropriately shaped light guide, the Knife __ combined with a light r to check the blood of the body _ inner circulation; only the illuminating diode is applicable and other light source, such as = cavity surface type laser (vc: SEL) is also suitable /, sensing , that is, the thermal resistor is integrated in the sensor housing 400 = 1 〇 读 ^ ^ 组织 组织 组织 组织 ^ ^ ^ 咖 咖 咖 咖 咖 咖 咖 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感 感Axis == good thermal contact, the thermal resistor is set in the light source of the light source == hole and the photodiode of the photodiode Between the holes Z, the reader! The impedance measuring unit (10) can be added without the effect of ^=I for the sample 'must be in the sensor housing 400: set to the additional plane electrode (not shown) as the impedance Measuring unit 70 (four) electric _ or measuring electrode, the same measuring electrode can be used to record the bio-impedance signal and the ECG signal, in order to make the measuring instrument (== such as the electronic circuit of the mobile phone) electrically contact Appropriate) wire routing allows the sensor housing shed and all integrated measuring units to be mounted directly on the ribbon cable 450, so that the ribbon cable 45 can be used for gas installation, and the strip electron microscope 45G can have a suitable position. Strengthen the paste to improve its stability. Referring to the fifth figure 'the light guiding element 500 related to the fourth figure and the four LED chips 501, 502, 503, 504 which are all lightly coupled to the bottom surface of the light guiding element 500, the LED chips 501, 502, 503, 504 constitute a measuring instrument. The light source of the optical measuring unit 100, by which the radiation emitted by all the LED chips 501, 502, 503, 504 is guided to the surface of the sensor housing 400 by the specific light guiding element 5? The wafers 501, 502, 503, 504 are bonded together on a substrate (not shown) such as a PCB. Referring to FIG. 6 , an alternative embodiment of the measuring instrument 1 of the present invention, the measuring instrument 1 includes two finger splints 601 and 602 through which a finger of the right and left hands can be respectively fixed in the measurement. On the wheel sensor 5 of the instrument 1, the light source 4 for the ECG measurement and impedance measurement, the ray detector 5, the electrodes 7, 7', and the thermal sensor 6 are integrated in the finger plate 601. In the eighth embodiment, the example is characterized in that the light source generated by the radiation source 4 is in a dual manner by the radiation sensor 5, that is, by the 15 radiation sensor 5 (the radiation sensing The device 5 is disposed in the direction in which the upper half of the finger splint 601 opposite the radiation source 4 is transmitted and additionally by the radiation sensor 5 integrated in the lower half of the finger splint 601 (the radiation sensors detect finger tissue) The internally scattered light is measured in the direction of transmission, and the lenses 6 〇 3, 604 respectively disposed on the radiation source 4 and the opposite radiation minus 20 are provided for the transmission measurement, and the lens 603 is provided to directional radiation of the light. Illuminating into the tissue, lens 604 concentrates the transmitted light and focuses it on the spoke On the sensor '5, there are only two electrodes 7, 7 disposed in the finger splint 602, and the two electrodes 7, 7' are made up of the opposite electro-electrodes 1371662 poles integrated in the electrode of the finger splint. Used for ECG measurement (two-point derivative) and (overall) bioimpedance measurement, finger splints 601 and 602 are connected to the central unit by electric winding 605, coffee, and the central unit _ contains the analysis of measuring instrument i το 11〇 The estimating unit 14A and the diagnostic unit 15A. The measured value obtained by the camp _ 5, as shown in the sixth figure, can be used to measure various optical measurements recorded by the sensor 5, for example, in the form of light intensity, wherein the transmission intensity The intensity that is scattered back by different tissue parts is /. and can be measured on the (artificial) reference material for correction. Then the /re/ value can be obtained. These four measurements constitute a further estimate. 10 The basis of the nose. Please refer to the seventh figure, which is provided with a hollow reflector 701 of one (or several) LEDS 702, which is an SMD-LED capable of emitting light in all spatial directions, and the light of the LED 702 is in the hollow reflector The inner surface of the 701 is diffusely reflected, and the hollow reflector 701 is composed of a Ubrich ball. The connection of the I5 to the hollow reflector 701 is an optical system 7〇3 in the form of a collecting lens, as shown in the seventh figure. The concentrating lens generates directional radiation by the light emitted by the LED 702. In addition, the hollow reflector 701 further includes an exit hole 7〇4 through which the diffuse light ray enters the body tissue, and the vent of the exit hole 704 Appropriate optical system can also be set in the solid In order to obtain the desired radiation angle, different radiation angles can be generated by using 2 lenses with different focal length ranges, and the structure shown in the seventh figure can be advantageously manufactured into a small prefabricated unit at a low cost. The flexible connection leads to a hollow reflector 701, which may be formed, for example, as a solid 1379662 body made of a transparent plastic material and embedding the LED 702 therein' and then externally diffusing a reflective material (such as alumina or The barium sulfate is coated. Referring to the eighth figure, an alternative structure is shown in which the light-emitting diodes 8〇1 are coupled to the Y-shaped bifurcated optical fibers 802, and the collecting lens 803 is connected at the end of the left branch. The directional radiation of the radiation emitted by the radiation source 801 can be obtained, and a light cone is emitted from the exit aperture 804, the aperture angle of which corresponds to the maximum total reflection angle inside the optical fiber 802, in such a manner that different volumes can be inspected. Scope of body tissue. Please refer to the ninth figure, the sensor of the optical measuring unit 100 on the surface of the sensor housing of the measuring instrument 1 of the present invention. The measuring device is placed on the body tissue to be inspected, the optical system 7〇3 and the outlet opening 7〇4 are located on the plane of the measuring surface, and the optical system 703 and the outlet opening 7〇4 are respectively disposed on the left side of the axis 901 and On the right, in addition, the illuminating sensor 5 is placed on the axis 901. Each of the strobe sensors 5 has the same distance from the exit holes 704 of the optical systems 7〇3 and 15, which are two radiation sensors. 5 has a different kind of light source than the light source. This configuration can take into account the distance from the detected radiation in the body tissue. Therefore, the oxygen concentration in the blood and tissue t can be checked in different depth tissue layers. Figure 2 is a perspective view of the diagnostic measuring instrument 1 of the present invention, the sensor housing 400 is provided with 'electrodes 7 and 7, which are arranged to the ecg unit ΐ 32 unit 130, as shown in the twelfth figure, for the 'arm Riding difficulty _ counter electrode configuration, the tenth 31 [S1 == two single: including _ cross _ (see the sixth figure) in the case of the finger position measurement of the patient being examined, the electricity 7' ' _ four will not be distorted Production, the transition resistance between the remaining 7 2 to a few centimeters, such as the tenth, the distance can only There are a few metres of rice 7, as shown in the figure, during the measurement process, all the four electrodes 7, 15 are simultaneously at the same part of the skin surface, for example, the patient's finger touches. It is wrong to supply the variable frequency alternating current to measure the complex impedance (not shown). The electric weight is recorded by the electrode 7, and the measurement signal is digitized by a = digital converter (also not shown), and then the discrete Fu > transform is performed. Then the result is the real part and the virtual of the impedance. '' is the resistance value and the reactance value, which can be digitally processed for estimation'. For example, the tenth, tenth, and the 'electrodes 7, 7' are formed in parallel with each other, column and each other. Strips insulated by intermediate spaces. The xenon light source 4, the radiation sensor 5, and the thermal sensing _6 disposed at the intermediate interval are in contact with the body tissue to be inspected. Referring to FIG. 13, another example of the measuring instrument of the present invention is disposed outside the sensor housing 400 as an ECG electrode 7, which is touched by the finger of one hand with the ECG electrode 7. The finger of one hand is inserted into the tubular hole 13, and the inside of the tubular tie 13 is the electrode 7, 7', the radiation source 4, the radiation sensor 5, and the thermal sensor 6' are additionally disposed inside the tubular hole η It is an inflatable air cushion 14 capable of fixing a finger and gently pressing a finger on the sensor with a limited pressure. For the sake of clarity, the measurement unit 20 is omitted and the measuring eye is read. The fourteenth figure, the present invention, shows the screen. The conversion technique of the element 130, the impedance measurement of the instrument 1 is performed by the digital signal of the single external periodic signal 61. The binary: inclusion-infeed converter 62 converts the digital signal into Class number 60, the error is amplified by digital/analog conversion, in such a way that the frequency conversion 5 2 '=, ^ pole 7 is supplied to the body _, and the connection number 5 ', # is fed by the electric appliance 66 and the _ hopper R7 The downstream of the 65 is variable. · Dahe Wei Houwei is more than two trustworthy?: by the number of Fourier Conversion unit 69 converts the 4 Fu: pure silk = real and imaginary part of the post 71 is present, = ❹ The memory, interface 71 can be _ 72 ⑽. This brief [simplified description of the diagram] 筮一图 The inventor of the inventor disconnected the measuring instrument integrated into the computer keyboard schematic. = Functional block diagram of the diagnostic instrument _ meter H of the present invention. The invention is integrated with a mobile phone schematic diagram. Figure 4 is a schematic view of the sensor housing of the diagnostic measuring instrument of the present invention. Figure 5 is a schematic view of a light guiding element of the diagnostic measuring instrument of the present invention. A further embodiment of the diagnostic measuring instrument of the present invention. Figure 7 is a schematic view of a hollow reflector of the invention having a radiation source. Figure 8 is a schematic view of a γ-shaped bifurcated light guiding member of the present invention. The ninth figure is an example of the configuration of the optical measuring unit of the diagnostic measuring instrument of the present invention. Figure 11 shows an embodiment of a configuration of an outer surface of a sensor housing having electrodes, radiation sources, radiation sensors and thermal sensors. Fig. 12 shows another example of the configuration of the outer surface of the outer casing of the sensor housing of the present invention. Twelfth Figure The present invention is a relative electrode configuration embodiment for ECG measurement and bioimpedance measurement. Thirteenth embodiment Another embodiment of the diagnostic measuring instrument of the present invention. Figure 14 is a block diagram of the impedance measuring unit of the diagnostic measuring instrument of the present invention. [Main component symbol description] 1 Measuring instrument 10 Mobile phone 100 Optical measuring unit 110 Analysis unit 15 120 Thermal measuring unit 130 Impedance measuring unit 132 ECG unit 140 Estimating unit 150 Diagnostic unit 160 Graphic unit 170 Memory unit 180 Interface unit 11 Operation key 12 Screen 20 13 Tubular hole 14 Inflatable gas cylinder 2 Computer 3 Keyboard 4 Light source (radiation source, LED) 4, Light source (radiation source, laser) 400 Sensor housing 410 Recessed hole 1379662 (S3 420 concave 430 concave Hole - 440 Draw 450 Ribbon Cable 460 Reinforcement 5 Light Sensor (radiation sensor) 5 500 Light Guide Element 501 LED Chip 502 LED Chip 503 LED Chip 504 LED Chip 6 Thermal Sensor • 60 Digital Signal Generator 61 Feeding external periodic signal 10 62 Digital/analog converter 63 Amplifier 65 Amplifier 66 Variable attenuator 67 Deep-pass filter, waver 68 Analog/digital device* 69 Digital Fourier transform unit 601 Finger splint 602 Finger splint 15 603 Lens 604 lens • 605 cable 606 cable 607 central unit 60 8 Screen 7 electrode (ECG electrode, feed electrode) 7, electrode 70 register. 20 71 register 72 interface 701 hollow reflector 702 LEDs 703 optical system 704 outlet hole 705 electrical connection 801 LED 35 1379662 802 optical fiber 803 condenser lens 804 exit hole 9 display 901 axis

36

Claims (1)

1379662 - May 101 | Next day revised replacement page VII. Patent application scope: 1. A non-invasive diagnostic measuring instrument for recording at least one physiological parameter of body tissue, the diagnostic measuring instrument having at least one for irradiation An optical measurement unit for examining a radiation source of body tissue and at least one radiation sensor for detecting radiation scattered and/or transmitted by body tissue, wherein the at least one radiation source and the at least one radiation sensor The device is disposed in a general sensor housing and is characterized by an ECG unit for recording ECG signals by two or more ECG electrodes, wherein the ECG unit is set to the sensing of less than one ECG electrode system a surface of the outer casing of the casing, and a bioelectrical impedance measuring unit, wherein at least one feeding electrode or measuring electrode of the impedance measuring unit is disposed on a surface of the outer casing of the sensor housing, so that the ECG electrode and the feeding electrode or The measuring electrode is in contact with the skin surface of the body tissue portion taken by the optical measuring unit, and the at least one radiation source is disposed in a diffuse reflection hollow inverse Vessel. 2. The diagnostic measuring instrument of claim 1, wherein a temperature sensor or a thermal sensor is disposed in the sensor housing or on the sensing 11 housing. 3. The diagnostic measuring instrument of claim 1, wherein the at least one ECG electrode and the at least one feeding electrode or measuring electrode are designed as planar foils or foils made of a conductive material. 4. The diagnostic measuring instrument of claim 3, wherein the ECG electrode or the feeding electrode or the measuring electrode has at least one recessed hole, so that at least one radiation source emits radiation and enters the to be inspected. Body tissue 37 1379662 May 2011 p modified within the replacement page *, or the body tissue scattered and / or transmitted radiation through, transmission / radiation sensor. A diagnostic measuring instrument according to claim 4, characterized in that it has at least one other recess for a temperature sensor or a thermal sensor. 6. The diagnostic measuring instrument according to claim 1, wherein at least one of the ECG electrodes is simultaneously a feeding electrode or a measuring electrode of the bioelectrical impedance measuring unit. The diagnostic measuring instrument of claim 1, wherein the bioelectrical impedance measuring unit is provided with an impedance measuring signal for recording a skin surface by at least one pair of measuring electrodes, the pair of measuring electrodes The electrode distance is less than - 亳 to a few centimeters' so that during the measurement, the two electrodes of the pair of measuring electrodes can simultaneously touch the same portion of the skin surface to locally measure the impedance measurement signal. M8. The diagnostic measuring instrument according to claim 7, characterized in that: the electric electrode is applied to the body tissue through the skin surface, that is, a variable frequency alternating current is applied to the skin surface portion of the electrode to be touched. A diagnostic measuring instrument according to claim 7 of the patent application, characterized in that the measuring electrode and the feeding electrode are designed as contact strips extending parallel to each other. 10 II. For the diagnostic measuring instrument of claim 1 of the patent scope, the characteristic and estimating unit is connected to the bioelectrical impedance measuring unit for measuring the time variation of the local impedance measuring signal. For example, the diagnostic measuring instrument of claim 1 has the features, and the mouth and mouth device for fixing the body part of the patient to be inspected to the minus 38 1379662. . 12. A diagnostic measuring instrument according to claim 11 of the patent scope, characterized in that the fixing device is designed as a finger splint. 13. The diagnostic measuring instrument of claim 11, wherein the fixing device comprises an inflatable air cushion capable of pressing a body part against the measuring electrode and/or the feeding electrode. 14. A diagnostic measuring instrument as claimed in claim 1 which is characterized in that it is connected to an entertainment device or communication technology device or to another portable device or accessory. 15. A diagnostic measuring instrument according to claim 14 which is characterized in that the device is a mobile device, in particular a notebook computer, a laptop computer, a mobile phone, a palmtop computer or a handheld device. 16. The diagnostic measuring instrument of claim 1, wherein the optical measuring unit comprises at least two conditioned sensors for detecting scatter and/or transmission by body tissue, such The radiation sensor is arranged at a different distance from the radiation source. 17. A diagnostic measuring instrument according to claim 1 wherein the optical radiation of at least one of the radiation sources has the effect of illuminating different volumetric locations of the body tissue being examined. 18. A diagnostic measuring instrument according to clause 17 of the patent application, characterized in that two radiation sources having different spatial radiation characteristics are provided. 19. The diagnostic measuring instrument according to claim 1, wherein the at least one radiation source is connected to a light guiding element, and the light guiding element is modified by a replacement page of the source of the light. Radiation is conducted to the surface of the sensor housing. 20. A decimating measuring instrument according to claim 19, characterized in that an optical system capable of producing directional radiation and/or diffuse radiation into the body tissue is connected to the optical guiding element. 2 Bu as the scope of patent application! The diagnostic measuring instrument of the present invention is characterized in that the hollow reflector is composed of a Ubrich ball. 22. A diagnostic apparatus according to the present invention, characterized in that an optical system capable of generating directional radiation entering the body tissue is coupled to the hollow reflector. 23. The diagnostic measuring instrument of claim 3, wherein the hollow reflector comprises at least one exit aperture for passage of diffuse radiation into the body tissue. 24. The diagnostic measuring instrument of claim i, wherein the at least one physiological parameter is a blood glucose level. 25. A diagnostic measuring instrument for non-invasively recording at least one physiological parameter of body tissue, the diagnostic measuring instrument comprising an optical measuring unit having at least one radiation enthalpy for illuminating body tissue to be examined and at least one for detecting A radiation sensor that measures radiation scattered and/or transmitted by body tissue is characterized in that the at least radiation source is disposed in a diffusely reflecting hollow reflector. 26. The diagnostic measuring instrument of claim 25, wherein the hollow reflector is comprised of a Ubrich ball. 27. A diagnostic measuring instrument as claimed in claim 25, characterized in that it is attached to the hollow reflector in an optical system capable of generating directional radiation entering the body tissue. . 28. The diagnostic measuring instrument of claim 25, wherein the hollow reflector comprises an exit orifice that passes through the diffused radiation into the body tissue to less than 0 t. 41