CN110368442A - Externally-applied medicine composite and preparation method thereof - Google Patents
Externally-applied medicine composite and preparation method thereof Download PDFInfo
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- CN110368442A CN110368442A CN201910592904.0A CN201910592904A CN110368442A CN 110368442 A CN110368442 A CN 110368442A CN 201910592904 A CN201910592904 A CN 201910592904A CN 110368442 A CN110368442 A CN 110368442A
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- 239000003814 drug Substances 0.000 title claims abstract description 84
- 239000002131 composite material Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 44
- 210000004185 liver Anatomy 0.000 claims abstract description 42
- 241001627955 Tetraodon lineatus Species 0.000 claims abstract description 36
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 13
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940116229 borneol Drugs 0.000 claims abstract description 13
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 13
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 12
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- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 9
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 9
- 239000009136 dragon's blood Substances 0.000 claims abstract description 9
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- 239000011718 vitamin C Substances 0.000 claims abstract description 9
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- 238000003756 stirring Methods 0.000 claims description 21
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- 238000001816 cooling Methods 0.000 claims description 4
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- 239000000443 aerosol Substances 0.000 claims description 3
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- 241001441722 Takifugu rubripes Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
The embodiment of the invention discloses a kind of externally-applied medicine composites and preparation method thereof.Wherein, the raw material components of the externally-applied medicine composite include: globe fish liver oil, calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, dragon's blood, myrrh, olibanum, Radix Glycyrrhizae, borneol and vitamin C.The externally-applied medicine composite will contain the globe fish liver oil of tetraodotoxin as the matrix for carrying medicine, and collocation " monarch drug in a prescription ", " ministerial drug ", " adjutant ", " making medicine " etc. are mixed and made into the externally applied drug of compound prescription.The externally applied drug injures trauma infection contamination to various chronic dermatosis, outside, cureless dermatosis chronic disease is attained by preferable therapeutic effect, has a good application prospect.
Description
Technical field
The present invention relates to the technical fields of Chinese medicine preparation more particularly to a kind of externally-applied medicine composite and preparation method thereof.
Background technique
With being constantly progressive for social and economic activities, all kinds of aquatic products or new food variety have also started quick development
And progress.At on September 5th, 2016, general office, the Ministry of Agriculture, state food pharmaceuticals administration general bureau combined and have issued " about having
The notice that condition decontrols cultivation Fugu rubripes and rearing of fugu obscurus processing is managed ".This makes Fugu rubripes and dark line
These filefish kinds of Fugu can be held the dining table of upper consumer, be eaten as food.
Along with the opening in filefish market, propagates globe fish industry artificially and have quick development.These globe fish industries
Development, can greatly increase filefish fish guts waste.How effectively using the beneficiating ingredient in these wastes, realize
Circular economy and multi-level industry are using being very important industry development target now.For example, ocellated puffer liver accounts for entire fish
As many as 1/6th of body weight, liver oil content reach 60% -65%.These filefish fish guts wastes will be brought very
Sufficient ocellated puffer liver supply.
Vitamin and microelement rich in, topical application can add from the globe fish liver oil extracted in ocellated puffer liver
The formation of fast defect of skin position epithelium, oily matter, which can form protective film in skin surface, prevents bacterial invasion from infecting.
Moreover, being enriched tetraodotoxin in ocellated puffer liver, prove that low dose of use can obtain by a large amount of clinical cases
Good analgesic effect.For example, just had been mentioned in early " China's book on Chinese herbal medicine " in ancient times globe fish liver oil externally used coating have subdhing swelling and detoxicating,
Dissipating bind analgesic function.
And China most just has filefish fish oil to be applied to clinical treatment osteomyelitis, the chronic sinus of Tuberculous early in the eighties
The record in road, the ulcer wound surface not recovered for a long time, burn wound surface, thus it is speculated that it promotes the effect of local blood circulation with inhibiting bacteria and diminishing inflammation.
But inventor finds during realizing the application the prior art has the following problems: globe fish liver oil
It is usually all individually to take orally or outside to probe into its effect, do not provide one kind and other although being had been reported that using even
The technical solution of various ingredients compatible use, it is difficult to really effective the effect of playing globe fish liver oil and bioactivity, it is comprehensive
It is lower using level.
Summary of the invention
In view of the above technical problems, the embodiment of the invention provides a kind of externally-applied medicine composites and preparation method thereof, with solution
Certainly existing tetraodotoxin or globe fish liver oil Land use systems are more single, are unable to give full play its bioactivity, comprehensive utilization
Inefficient problem.
The first aspect of the embodiment of the present invention provides a kind of externally-applied medicine composite.Wherein, the original of the externally-applied medicine composite
Material component include: globe fish liver oil, calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, dragon's blood, myrrh, olibanum, Radix Glycyrrhizae, borneol with
And vitamin C.
Optionally, the dosage form of the externally-applied medicine composite includes suppository, ointment, emulsion, paste, patch and aerosol
Agent.
Optionally, the tetraodotoxin and its derivative in the globe fish liver oil containing 4-12ppm.
Optionally, it calculates by weight, the raw material components of the externally-applied medicine composite include:
Optionally, it calculates by weight, the raw material components of the externally-applied medicine composite include:
The second aspect of the embodiment of the present invention additionally provides a kind of compound globe fish liver oil ointment formulation as described above
Preparation method.Wherein, the preparation method includes the following steps:
Comminuted solids drug forms drug powder, and the solid drugs include calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, Cape jasmine
Son, dragon's blood, myrrh, olibanum and Radix Glycyrrhizae；
Matching addition oily matter in container and be warming up to preset first temperature, to melt the oily matter, institute
Stating oily matter includes vaseline and lanolin；
Under agitation, the drug powder is added to the oily matter after the fusing；
After stirring to preset mixing time, it is cooled to preset second temperature and globe fish is added to the dispensing containers
Liver oil simultaneously stirs the fusing globe fish liver oil；
Borneol and vitamin C are added after being cooled to preset third temperature, in Xiang Suoshu dispensing containers and stirs evenly；
After filtering while hot, the mixture in the cooling dispensing containers is to prepare the compound globe fish liver oil ointment
Preparation.
Optionally, in the comminuted solids drug, after the step of forming drug powder, the method also includes: by institute
Drug powder sieving is stated, the aperture of sieve is 100 mesh.
Optionally, preset first temperature is 80 to 90 degrees Celsius；The preset second temperature is taken the photograph for 75 to 80
Family name's degree；The preset third temperature is 30 to 40 degrees Celsius.
Optionally, the preset mixing time is 4 hours.
Optionally, it calculates by weight, the raw material components of the externally-applied medicine composite include:
Technical solution provided in an embodiment of the present invention provides a kind of composition of globe fish liver oil, will contain tetraodotoxin
Globe fish liver oil as the matrix for carrying medicine, collocation " monarch drug in a prescription ", " ministerial drug ", " adjutant ", " making medicine " etc. are mixed and made into compound prescription
Externally applied drug.The externally applied drug injures trauma infection contamination to various chronic dermatosis, outside, cureless dermatosis chronic disease be attained by compared with
Good therapeutic effect, has a good application prospect.
Detailed description of the invention
Fig. 1 is that one embodiment of the preparation method of compound globe fish liver oil ointment formulation provided in an embodiment of the present invention is shown
It is intended to.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those skilled in the art's every other implementation obtained without creative efforts
Example, shall fall within the protection scope of the present invention.
It should be noted that be expressed " being fixed on " another element when element, it can directly on the other element,
Or there may be one or more elements placed in the middle therebetween.When an element is expressed " connection " another element, it can be with
It is directly to another element or there may be one or more elements placed in the middle therebetween.Used in this specification
The orientation or position of the instructions such as term "vertical", "horizontal", "left" and "right", "upper", "lower", "inner", "outside", " bottom "
Relationship is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, without referring to
Show or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot manage
Solution is limitation of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, and should not be understood as instruction or
Imply relative importance.
Unless otherwise defined, technical and scientific term all used in this specification is led with technology of the invention is belonged to
The normally understood meaning of the technical staff in domain is identical.Used term is only in the description of the invention in this specification
The purpose of description specific embodiment is not intended to the limitation present invention.Term "and/or" used in this specification includes
Any and all combinations of one or more related listed items.In addition, invention described below difference is implemented
Technical characteristic involved in mode can be combined with each other as long as they do not conflict with each other.
The numerical value disclosed in the embodiment of the present invention is approximation, and and non-determined value.Allow in error or experiment condition
In the case where, it may include all values in error range and be not limited to specific value disclosed in the embodiment of the present invention.
The numberical range disclosed in the embodiment of the present invention is for indicating the relative quantity of component in the mixture and its other party
The range of the temperature or other parameters enumerated in method embodiment.One or more numerical point in the numberical range is appropriate
Under conditions of obtain.
The embodiment of the invention provides a kind of externally-applied medicine composites, and globe fish liver oil and other traditional Chinese medicine ingredients is mutual
Compatibility has good bioactivity, can be used for treating various chronic dermatosis, wound and wound infection etc..
The raw material components of the externally-applied medicine composite include: globe fish liver oil, calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine,
Dragon's blood, myrrh, olibanum, Radix Glycyrrhizae, borneol and vitamin C.
Specifically, being enriched tetraodotoxin and its derivative, content 4-12ppm in the globe fish liver oil selected.
Tetraodotoxin is a kind of strong antipsychotic drugs, the channel specific inhibition Na+.It, can be with when it is located on the outside of film
It is combined with sodium-ion channel receptor site I, prevents sodium ion from entering intracellular, so that blocking voltage dependence sodium channel, influences
The generation and conduction of cell membrane action potential, block action potentials, to play the role of analgesic.Modern times medical research hair
Existing, tetraodotoxin also has the function of interfering the release of inflammatory mediator.
In the present embodiment, calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri and cape jasmine are " monarch drug in a prescription ".It primarily serves clearing heat and detoxicating
Effect.Dragon's blood, myrrh and olibanum are " ministerial drug ", primarily serve the effect of eliminating stasis to subdue swelling, anti-inflammatory protection.Containing tetraodotoxin and
The globe fish liver oil of its derivative is " adjutant ", can play the role of antipruritic analgesic, anti-inflammatory protection." making medicine " is to play reconciliation
The Radix Glycyrrhizae of effect and borneol as the side of drawing.
Above-mentioned each formula combines, and lining reconciles irritability, subdhing swelling and detoxicating, and outer inner analgesic antiphlogistic, blood activating and promoting tissue regeneration, internal and external application can
To reach reduction pain, accelerate rehabilitation, reduce neuralgia sequelae and other effects.
By taking herpes zoster as an example, traditional western medical treatment is acted on to be carried out using antiviral and trophic nerve drug
Symptomatic treatment.Although can mitigate illness to a certain extent, there is also bigger side effect, the hairs of post herpetic neuralgia
Raw rate is higher, and there are bigger limitations.
And above-mentioned " monarch " mutual compatibility is used, the externally-applied medicine composite prepared is combined outer by nerve block
Applying treatment can play significant curative effect to patients with post herpetic neuralgia.Furthermore it is also possible to externally injure trauma infection contamination, long
Dermatosis chronic disease not more is controlled, the various serious case of furuncles cured, pain, subcutaneous ulcer, purulence, blister, sore, scabies, tinea, inflammation, the dermatopathies such as itch is difficult to and generates
Certain effect.
In the preferred embodiment, it calculates by weight, the externally-applied medicine composite may include the following raw material component:
It is amazing to be, optimal therapeutic effect, energy can be obtained using the externally-applied medicine composite of such composition proportion
It is enough adequately to be acted on using the nerve block of globe fish liver oil.
In some embodiments, according to actual using needing or the market demand, the externally-applied medicine composite specifically can be with
Using any suitable dosage form, including but not limited to suppository, ointment, emulsion, paste, patch and aerosol etc..
Specifically, the externally-applied medicine composite can also be added further according to the difference of the dosage form for the production of being prepared
There are other suitable auxiliary materials to obtain corresponding dosage form.For example, can additionally add vaseline and sheep when preparing ointment formulation
Hair rouge.
Fig. 1 is the method flow diagram of the preparation method of compound globe fish liver oil ointment formulation provided in an embodiment of the present invention.
As shown in Figure 1, the preparation method includes the following steps:
110, comminuted solids drug forms drug powder.The solid drugs include calculus bovis factitius, radix scutellariae, the coptis, Huang
Cypress, cape jasmine, dragon's blood, myrrh, olibanum and Radix Glycyrrhizae.
Preferably, can also carry out sieving operation after solid drugs crushing and separate the powder of thickness unevenness, thus
The uniform drug powder of granular size is filtered out, the mesh size for selection of being sieved is 100 mesh.
120, matching addition oily matter in container and be warming up to preset first temperature, to melt the oiliness object
Matter.The oily matter includes vaseline and lanolin.
It is described specifically to select the drug of any suitable volume or material with container with container.It can set
It is equipped with heating and stirring device, for executing corresponding function.Vaseline and lanolin are soft solid before addition, can be with
It is melted by way of heating heating, forms sticky pasty masses.
130, the drug powder under agitation, is added to the oily matter after the fusing.
Keep the stirring to pasty masses so that drug powder can adequately be divided while drug powder is added
It is scattered in the mixture of vaseline and lanolin.
140, it after stirring to preset mixing time, is cooled to preset second temperature and river is added to the dispensing containers
Filefish liver oil simultaneously stirs the fusing globe fish liver oil.
The mixing time is an empirical numerical value, can by those skilled in the art according to the needs of actual conditions or
It is verified and is obtained by many experiments.In some embodiments, which is 4 hours.
150, borneol and vitamin C are added after being cooled to preset third temperature, in Xiang Suoshu dispensing containers and stirs equal
It is even.
Similar, first temperature, second temperature and third temperature are also empirical numerical value, can be according to reality
Situation and adjust or determine.Specifically, preset first temperature is 80 to 90 degrees Celsius；Preset second temperature
Degree is 75 to 80 degrees Celsius；The preset third temperature is 30 to 40 degrees Celsius.
160, after filtering while hot, the mixture in the cooling dispensing containers is to prepare the compound globe fish liver oil
Ointment formulation.
After borneol dissolution finishes, the mixture in container of filtering while hot.Then it is dispensed into suitable appearance
It is cooling in device, to prepare the compound globe fish liver oil ointment formulation.
Preparation method based on the embodiment of the present invention and preparation system provide following specific embodiment to be described in detail
The preparation process of the externally-applied medicine composite.
Embodiment 1:
1) it is formulated 1 by shown in following table, weighing needs raw material to be used.
2) Chinese medicine solid drugs are crushed.
3) drug powder is obtained after crushing to sieve with 100 mesh sieve before use.
4) load weighted vaseline and lanolin are put into the stainless steel proportion container with heating and stirring device, are added
Temperature is to 80 DEG C until oily matter dissolves completely.
5) in the case of stirring, by calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, dragon's blood, myrrh, olibanum, Radix Glycyrrhizae
Drug powder is added.
6) it after drug powder addition, keeps at 80 DEG C, stirs 4 hours.
7) after being cooled to 75 DEG C, globe fish liver oil is added and continues stirring to dissolving.
8) continue after being cooled to 30 DEG C, borneol and vitamin C is added, and stir evenly at this temperature.
9) it after borneol is completely dissolved, filters while hot and is cooled to room temperature to obtain compound ocellated puffer liver ointment.
Embodiment 2:
1) 1) 2 are formulated by following table shown in, weighing needs raw material to be used.
2) Chinese medicine solid drugs are crushed.
3) drug powder is obtained after crushing to sieve with 100 mesh sieve before use.
4) load weighted vaseline and lanolin are put into the stainless steel proportion container with heating and stirring device, are added
Temperature is to 90 DEG C until oily matter dissolves completely.
5) in the case of stirring, by calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, dragon's blood, myrrh, olibanum, Radix Glycyrrhizae
Drug powder is added.
6) it after drug powder addition, keeps at 90 DEG C, stirs 4 hours.
7) after being cooled to 80 DEG C, globe fish liver oil is added and continues stirring to dissolving.
8) continue after being cooled to 40 DEG C, borneol and vitamin C is added, and stir evenly at this temperature.
9) it after borneol is completely dissolved, filters while hot and is cooled to room temperature to obtain compound ocellated puffer liver ointment.
In conclusion globe fish liver oil containing quantitative tetraodotoxin in Recipe of external-use medicine provided in an embodiment of the present invention with
Traditional Chinese medicine fine powder.It is made after various exterior-applied formulations, clearing heat and detoxicating, eliminating stasis to subdue swelling, promoting blood circulation can be reached by Drug Percutaneous Absorption
The effect of myogenic, analgesic antiphlogistic, to various chronic dermatosis, outside injure trauma infection contamination, cureless dermatosis chronic disease can reach
To preferable therapeutic effect.
It, can according to the technique and scheme of the present invention and this hair it is understood that for those of ordinary skills
Bright design is subject to equivalent substitution or change, and all these changes or replacement all should belong to the guarantor of appended claims of the invention
Protect range.
Claims (10)
1. a kind of externally-applied medicine composite, which is characterized in that the raw material components of the externally-applied medicine composite include: globe fish liver oil,
Calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, dragon's blood, myrrh, olibanum, Radix Glycyrrhizae, borneol and vitamin C.
2. externally-applied medicine composite according to claim 1, which is characterized in that the dosage form of the externally-applied medicine composite includes bolt
Agent, ointment, emulsion, paste, patch and aerosol.
3. externally-applied medicine composite according to claim 1, which is characterized in that contain 4-12ppm in the globe fish liver oil
Tetraodotoxin and its derivative.
4. externally-applied medicine composite according to claim 1, which is characterized in that calculate by weight, the externally applied drug combination
The raw material components of object include:
5. externally-applied medicine composite according to claim 4, which is characterized in that calculate by weight, the externally applied drug combination
The raw material components of object include:
6. a kind of preparation method of compound globe fish liver oil ointment formulation characterized by comprising
Comminuted solids drug forms drug powder, and the solid drugs include calculus bovis factitius, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, blood
It exhausts, myrrh, olibanum and Radix Glycyrrhizae；
Matching addition oily matter in container and be warming up to preset first temperature, to melt the oily matter, the oil
Property substance includes vaseline and lanolin；
Under agitation, the drug powder is added to the oily matter after the fusing；
After stirring to preset mixing time, it is cooled to preset second temperature and globe fish liver oil is added to the dispensing containers
And stir the fusing globe fish liver oil；
Borneol and vitamin C are added after being cooled to preset third temperature, in Xiang Suoshu dispensing containers and stirs evenly；
After filtering while hot, the mixture in the cooling dispensing containers is to prepare the compound globe fish liver oil ointment system
Agent.
7. preparation method according to claim 6, which is characterized in that in the comminuted solids drug, form drug powder
The step of after, the method also includes:
The drug powder is sieved, the aperture of sieve is 100 mesh.
8. preparation method according to claim 6, which is characterized in that preset first temperature is 80 to 90 Celsius
Degree；The preset second temperature is 75 to 80 degrees Celsius；The preset third temperature is 30 to 40 degrees Celsius.
9. preparation method according to claim 6, which is characterized in that the preset mixing time is 4 hours.
10. according to any preparation method of claim 6-9, which is characterized in that calculate by weight, the externally applied drug group
Close object raw material components include:
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| CN110339389A (en) * | 2019-07-08 | 2019-10-18 | 生升美高科技(武汉)有限责任公司 | A kind of oiliness surface of a wound application and preparation method thereof |
| WO2021000950A1 (en) * | 2019-07-03 | 2021-01-07 | 深圳瑞达生物股份有限公司 | Pharmaceutical composition for external use and preparation method therefor |
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| CN101066340A (en) * | 2007-05-16 | 2007-11-07 | 苏振芳 | Compound externally applied tetrodotoxin ointment and its prepn |
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| CN103610920B (en) * | 2013-11-01 | 2016-04-27 | 刘斌田 | Quick-acting hydrojet of burn and scald and preparation method thereof |
| CN107198689A (en) * | 2017-07-11 | 2017-09-26 | 东新皓特（北京）生化科技有限公司 | Tetraodotoxin pharmaceutical composition and externally applied drug for treating antalgesic |
| CN110368442A (en) * | 2019-07-03 | 2019-10-25 | 深圳瑞达生物股份有限公司 | Externally-applied medicine composite and preparation method thereof |
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| WO2021000950A1 (en) * | 2019-07-03 | 2021-01-07 | 深圳瑞达生物股份有限公司 | Pharmaceutical composition for external use and preparation method therefor |
| CN110339389A (en) * | 2019-07-08 | 2019-10-18 | 生升美高科技(武汉)有限责任公司 | A kind of oiliness surface of a wound application and preparation method thereof |
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