CN101869642A - Chinese medicinal composition - Google Patents
Chinese medicinal composition Download PDFInfo
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- CN101869642A CN101869642A CN201010209769A CN201010209769A CN101869642A CN 101869642 A CN101869642 A CN 101869642A CN 201010209769 A CN201010209769 A CN 201010209769A CN 201010209769 A CN201010209769 A CN 201010209769A CN 101869642 A CN101869642 A CN 101869642A
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- chinese medicine
- hydrargyrum
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Abstract
The invention relates to the field of medicinal preparations, in particular to a Chinese medicinal preparation for treating psoriasis and a preparation method thereof. The Chinese medicinal composition of the invention is prepared by processing the following raw materials: potassium nitrate, calamine, mercury, arsenolite, borax, table salt, dried alum, borneol, unprocessed rhizoma pinelliae and musk.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, be specifically related to a kind of Chinese medicine composition for the treatment of tinea and preparation method thereof.
Background technology
Itch is by the microbial a kind of infectious dermatosis of dermatophyte.Tinea is divided into tinea capitis, the tinea manuum, tinea pedis, tinea cruris, tinea unguium, tinea corporis etc. according to the disease sites difference.Mainly be by public article and individual unhygienic custom and infectious mutually, confidential relation arranged with the health of public places such as hotel, bathing pool, swimming pool, haircut.The Clinical symptoms of itch is: occur the silvery white dry squama of multilamellar on the erythema repeatedly, squama is easily struck off, and exposes the pale red semitransparent thin film below, gently scrapes it again, as seen sieve the hemorrhage of shape such as dewdrops sample, be called " thin film phenomenon " and " reveal and drip phenomenon ".
Itch pathogenic factor more complicated, the cause of disease are not clear and definite as yet.Most in recent years scholars think, and are relevant with heredity, infection, dysbolismus, immune dysfunction, endocrine disturbance.It is more and more general to have become now, the city of particularly having developed.Psoriasis is not a kind of infectious disease, but because psoriatic's skin problem often brings great body and mind misery and financial burden to the patient.
The medicine of the treatment itch of Xiao Shouing is varied in the market, and reacting therapeutic effect according to the patient is not clearly, and treatment cycle is long, even there is side effect in some medicines after taking or smearing.
The inventor has invented a kind of Chinese medicine composition for the treatment of tinea according to continuous research and summary, and its curative effect is fast, few side effects.
Chinese medicine composition of the present invention comprises following raw material: Sal Nitri, Calamina, hydrargyrum, arsenicum sablimatum, Borax, Sal, dried Alumen, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus.
Raw material described in the prescription of the present invention all can buy in market.
Wherein, Sal Nitri is Nitrates sodium potassium stone family mineral K Sal Nitri.Be Sal Nitri again.Chemical molecular formula KNO3 or NaNO3, the main potassium nitrate (KNO3) that contains.
Calamina is carbonate mineral calcite family smithsonite, the main zinc carbonate that contains.After excavating, clean, dry, remove roguing stone.
Arsenicum sablimatum is the product of being processed into of Ores such as natural product arsenic-containing ores arsenic bloom, mispickel or Realgar.
Borax also is tincal, is a kind of not only soft but also light colourless crystallization material.
Dried Alumen has another name called calcined Alumen, and is for irregular crystalline solid, not of uniform size.Colourless, transparent or semitransparent, the surface is slightly level and smooth or uneven, and the fine and closely woven vertical rib of tool has hyaloid gloss.Matter is hard and crisp, easily smashes.Feeble QI, it is little sweet and puckery to distinguish the flavor of.
Hydrargyrum, a kind of metallic element, normally silvery white liquid is commonly called as hydrargyrum.
Summary of the invention
The objective of the invention is to solve the tinea problem, a kind of Chinese medicine composition is provided.
Chinese medicine composition curative effect of the present invention is fast, and the cycle is short, good stability, and few side effects, with low cost, preparation technology is simple, is subjected to patient's favorable comment deeply.
The present composition is processed into by following raw material process:
Sal Nitri 23-90g Calamina 75-300g hydrargyrum 8-30g arsenicum sablimatum 3-10g
Borax 50-200g Sal 25-100g dried Alumen 5-20g Borneolum Syntheticum 5-20g
Rhizoma Pinelliae 5-20g Moschus 0.5-2g
Preferably, Chinese medicine composition of the present invention is processed into by following raw material process:
Sal Nitri 45g Calamina 150g hydrargyrum 15g arsenicum sablimatum 5g
Borax 100g Sal 50g dried Alumen 10g Borneolum Syntheticum 10g
Rhizoma Pinelliae 10g Moschus 1g
Other preferably fill a prescription the present invention in an embodiment.
In more than forming, the weight of each medicine of distinguishing the flavor of is calculated with crude drug.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Raw material of Chinese medicine, especially adjuvant drug in more than forming can be replaced with the suitable Chinese medicine with identical property of medicine with messenger drug, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutical composition of the present invention, its pharmaceutically active substance makes through extracting processing, and processing can be adopted any combination in the said method.
Preferably, the preparation method of active constituents of medicine of the present invention may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is poured in the marmite, and heat-setting covers pot cover, seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder.
Preferably, preparation of drug combination method of the present invention may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is poured in the marmite, and heat-setting covers pot cover, seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder;
Get adjuvant and mix and be heated to 35 degrees centigrade of dissolvings, add medicated powder then, get it filled after the emulsifying and pour blender into and mix tinning sealing after finishing thoroughly.
Further preferred, preparation of drug combination method of the present invention may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, be ground into earlier thin art separately, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is gone in the fire-resistant marmite, heat-setting, the fireproof china bowl of loam cake covers seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder;
Get adjuvant and mix and be heated to 35 degrees centigrade of dissolvings, add medicated powder then, get it filled after the emulsifying and pour blender into and mix tinning sealing after finishing thoroughly.
Wherein, the described raw material that is used for sealing is: fine sand, and loess, straw ash and Jia Shui mix well.
Other preferred manufacturing procedure of the present invention in an embodiment.
Compositions of the present invention optionally adds suitable medicine acceptable carrier when being prepared into medicament, medicine acceptable carrier of the present invention is selected from: propylene glycol, monoglyceride, disodiumedetate, Mentholum, triethanolamine and benzoic acid.
Its consumption is: propylene glycol 125-500ml, monoglyceride 18-70g, disodiumedetate 8-30g, Mentholum 5-20g, triethanolamine 13-50ml, benzoic acid 0.5-2g.
Be preferably: propylene glycol 250ml, monoglyceride 35g, disodiumedetate 15g, Mentholum 10g, triethanolamine 25ml, benzoic acid 1g.
Compositions of the present invention active component wherein, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.
Compositions of the present invention obtains by above-mentioned active component and medicine acceptable carrier are mixed with.
Compositions of the present invention, its pharmaceutical dosage forms can be any pharmaceutically useful dosage forms, and composition medicine preparation of the present invention is unguentum preferably.
Described unguentum of the present invention is an externally used paste, determines usage and dosage according to patient's situation in use, as every day 1 time, is applied to the affected part, and 7 days is 1 course of treatment.
Below further specify beneficial effect of the present invention by test data.
1, clinical data
1.1, ordinary circumstance
200 routine patients, wherein male 150 examples, women 50 examples, age 20-50 year, psoriasis 50 examples wherein, tinea manus and pedis 60 examples, tinea corporis 30 examples, tinea cruris 20 examples, neurotic dermatitis 20 examples, beriberi 20 examples.
1.2, Therapeutic Method
Experimental group: select the unguentum of the embodiment of the invention 1 for use, be applied to the affected part every day 1 time, 7 days is 1 course of treatment.
Matched group: tinea enemy unguentum (Guangdong Taicheng Pharmaceutical Co., Ltd's production), every day each 1 time sooner or later, 2～4 weeks of the course of treatment.
2, criterion of therapeutical effect
Cure: skin lesion all disappears, and blister disappears, no scratchiness, and illing skin is smooth normal;
Produce effects: skin lesion disappears 70%, and blister disappears substantially, and the gargalesthesia symptom obviously alleviates;
Effectively: skin lesion disappears 50%, and blister partly disappears, and scratchiness alleviates;
Invalid: no change before and after the treatment.
3, therapeutic outcome
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Cure rate | Total effective rate |
| Experimental group | ??120 | ??115 | ??2 | ??1 | ??2 | ??96％ | ??98％ |
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Cure rate | Total effective rate |
| Matched group | ??80 | ??14 | ??25 | ??26 | ??15 | ??17％ | ??81％ |
Result of the test shows: unguentum of the present invention is being treated psoriasis, tinea manus and pedis, and tinea corporis, tinea cruris, impetigo, aspects such as neurotic dermatitis and beriberi have good therapeutic effect, and pharmaceutical composition of the present invention has removes the rotten and lets fresh grow, functions such as parasite killing counteracting toxic substances.In addition, according to patient's reflection, unguentum of the present invention is rapid-action, and the cycle is short, does not have other side effect, has won the favorable comment of extensive patients.
The specific embodiment
The invention will be further described by following specific embodiment, but not as limitation of the present invention.
Embodiment 1, unguentum
Sal Nitri 45g Calamina 150g hydrargyrum 15g arsenicum sablimatum 5g
Borax 100g Sal 50g dried Alumen 10g Borneolum Syntheticum 10g
Rhizoma Pinelliae 10g Moschus 1g
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is gone in the fire-resistant marmite, heat-setting, the fireproof china bowl of loam cake covers seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder;
Adjuvant:
Propylene glycol 250ml monoglyceride 35g disodiumedetate 15g Mentholum 10g
Triethanolamine 25ml benzoic acid 1g
Above-mentioned adjuvant mixes to heat to 35 degrees centigrade and makes its dissolving, puts into 6g medicated powder after the dissolving, gets it filled after the emulsifying to pour blender into and mix thoroughly.Tinning sealing after finishing.
Embodiment 2, unguentum
Sal Nitri 45g Calamina 150g hydrargyrum 15g arsenicum sablimatum 5g
Borax 100g Sal 50g dried Alumen 10g Borneolum Syntheticum 10g
Rhizoma Pinelliae 10g Moschus 1g
Embodiment 3, unguentum
Sal Nitri 23g Calamina 75g hydrargyrum 8g arsenicum sablimatum 3g
Borax 50g Sal 25g dried Alumen 5g Borneolum Syntheticum 5g
Rhizoma Pinelliae 5g Moschus 0.5g
Embodiment 4, unguentum
Sal Nitri 90g Calamina 300g hydrargyrum 30g arsenicum sablimatum 10g
Borax 200g Sal 100g dried Alumen 20g Borneolum Syntheticum 20g
Rhizoma Pinelliae 20g Moschus 2g
Embodiment 5, unguentum
Sal Nitri 50g Calamina 180g hydrargyrum 20g arsenicum sablimatum 8g
Borax 100g Sal 70g dried Alumen 15g Borneolum Syntheticum 12g
Rhizoma Pinelliae 15g Moschus 1.5g
Embodiment 6, unguentum
Sal Nitri 45g Calamina 150g hydrargyrum 15g arsenicum sablimatum 5g
Borax 100g Sal 50g dried Alumen 10g Borneolum Syntheticum 10g
Rhizoma Pinelliae 10g Moschus 1g
Adjuvant:
Propylene glycol 125ml, monoglyceride 18g, disodiumedetate 8g, Mentholum 5g,
Triethanolamine 13ml, benzoic acid 0.5g.
Embodiment 7, unguentum
Sal Nitri 45g Calamina 150g hydrargyrum 15g arsenicum sablimatum 5g
Borax 100g Sal 50g dried Alumen 10g Borneolum Syntheticum 10g
Rhizoma Pinelliae 10g Moschus 1g
Adjuvant:
Propylene glycol 500ml, monoglyceride 70g, disodiumedetate 30g, Mentholum 20g,
Triethanolamine 50ml, benzoic acid 2g.
The function of embodiment 8, unguentum of the present invention and consumption
Function: remove the rotten and let fresh grow the parasite killing counteracting toxic substances.
Cure mainly: psoriasis, tinea manus and pedis, tinea corporis, tinea cruris, neurotic dermatitis, beriberi.
Curative effect: short treating period, instant effect.
Usage: whenever use a little, be applied to the affected part, once a day.
Points for attention: to the careful usefulness of hydrargyrum allergy sufferers, the medicated powder symptoms of allergic is that skin is itched, and uses antiallergic agent and alleviates allergy soon.Be used externally only, unsuitable oral, the causalgia sense is arranged when putting the affected part on the skin,, please place away from the place at child place and preserve.
Claims (10)
1. a Chinese medicine composition is characterized in that, comprises that following raw material is through being processed into
Sal Nitri 23-90g Calamina 75-300g hydrargyrum 8-30g
Arsenicum sablimatum 3-10g Borax 50-200g Sal 25-100g
Dried Alumen 5-20g Borneolum Syntheticum 5-20g Rhizoma Pinelliae 5-20g
Moschus 0.5-2g.
2. compositions according to claim 1 is characterized in that, comprises that following raw material is through being processed into
Sal Nitri 45g Calamina 150g hydrargyrum 15g
Arsenicum sablimatum 5g Borax 100g Sal 50g
Dried Alumen 10g Borneolum Syntheticum 10g Rhizoma Pinelliae 10g
Moschus 1g.
3. Chinese medicine composition according to claim 1 and 2 wherein contains the medicine acceptable carrier.
4. Chinese medicine composition according to claim 1, it is characterized in that, described medicine acceptable carrier is selected from: propylene glycol, monoglyceride, disodiumedetate, Mentholum, triethanolamine and benzoic acid, its consumption is: propylene glycol 125-500ml, monoglyceride 18-70g, disodiumedetate 8-30g, Mentholum 5-20g, triethanolamine 13-50ml, benzoic acid 0.5-2g.
5. Chinese medicine composition according to claim 4 is characterized in that, described medicine acceptable carrier is selected from: propylene glycol 250ml, monoglyceride 35g, disodiumedetate 15g, Mentholum 10g, triethanolamine 25ml, benzoic acid 1g.
6. a method for preparing claim 1 or 2 described Chinese medicine compositions is characterized in that, may further comprise the steps:
The raw material of Chinese medicine that above-mentioned prescription is formed being processed through extraction or other modes, made pharmaceutically active substance, subsequently, is raw material with this material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.
7. a method for preparing claim 1 or 2 described Chinese medicine compositions is characterized in that, may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is poured in the marmite, and heat-setting covers pot cover, seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder.
8. a method for preparing the described Chinese medicine composition of claim 3 is characterized in that, may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is poured in the marmite, and heat-setting covers pot cover, seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder;
Get adjuvant and mix and be heated to 35 degrees centigrade of dissolvings, add medicated powder then, get it filled after the emulsifying and pour blender into and mix tinning sealing after finishing thoroughly.
9. a method for preparing the described Chinese medicine composition of claim 3 is characterized in that, may further comprise the steps:
The nitre of getting fire, Calamina, arsenicum sablimatum, Borax, Sal, Borneolum Syntheticum, Rhizoma Pinelliae, Moschus and dried Alumen, first separately pulverization, after lump together grinding, add hydrargyrum again, be ground to hydrargyrum and lose brightness, ground medicated powder is gone in the fire-resistant marmite, heat-setting, the fireproof china bowl of loam cake covers seal, must not lose heart, treat the moisture evaporate to dryness after, put on the stove refining three hours, stop heating then, getting bowl after cooling and scrape medicine, adhering to one deck bloom on the bowl, promptly is medicated powder;
Get adjuvant and mix and be heated to 35 degrees centigrade of dissolvings, add medicated powder then, get it filled after the emulsifying and pour blender into and mix tinning sealing after finishing thoroughly.
10. claim 1 or 2 described Chinese medicine compositions are in treatment psoriasis, tinea manus and pedis, tinea corporis, tinea cruris, impetigo, the application in neurotic dermatitis and the beriberi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102097696A CN101869642B (en) | 2010-06-25 | 2010-06-25 | Chinese medicinal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102097696A CN101869642B (en) | 2010-06-25 | 2010-06-25 | Chinese medicinal composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101869642A true CN101869642A (en) | 2010-10-27 |
| CN101869642B CN101869642B (en) | 2012-08-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2010102097696A Expired - Fee Related CN101869642B (en) | 2010-06-25 | 2010-06-25 | Chinese medicinal composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872341A (en) * | 2012-10-13 | 2013-01-16 | 张伟 | Traditional Chinese medicine ointment for treating tinea corporis |
| CN113350377A (en) * | 2021-07-16 | 2021-09-07 | 高庆德 | Composition for removing necrotic tissue and promoting tissue regeneration, preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171266A (en) * | 1997-06-17 | 1998-01-28 | 董立本 | Fuyanyu (exterior-use capsule) |
| CN1062147C (en) * | 1995-11-27 | 2001-02-21 | 寇志强 | Cuochuangjing-external use medicine for treating acne |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
-
2010
- 2010-06-25 CN CN2010102097696A patent/CN101869642B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062147C (en) * | 1995-11-27 | 2001-02-21 | 寇志强 | Cuochuangjing-external use medicine for treating acne |
| CN1171266A (en) * | 1997-06-17 | 1998-01-28 | 董立本 | Fuyanyu (exterior-use capsule) |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872341A (en) * | 2012-10-13 | 2013-01-16 | 张伟 | Traditional Chinese medicine ointment for treating tinea corporis |
| CN102872341B (en) * | 2012-10-13 | 2014-07-23 | 山东大学齐鲁医院 | Traditional Chinese medicine ointment for treating tinea corporis |
| CN113350377A (en) * | 2021-07-16 | 2021-09-07 | 高庆德 | Composition for removing necrotic tissue and promoting tissue regeneration, preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN101869642B (en) | 2012-08-08 |
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