CN110354171A - A kind of pet externally-applied ointment of the leaf extract containing hemp and preparation method thereof - Google Patents
A kind of pet externally-applied ointment of the leaf extract containing hemp and preparation method thereof Download PDFInfo
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- CN110354171A CN110354171A CN201910787428.8A CN201910787428A CN110354171A CN 110354171 A CN110354171 A CN 110354171A CN 201910787428 A CN201910787428 A CN 201910787428A CN 110354171 A CN110354171 A CN 110354171A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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Abstract
The invention discloses pet externally-applied ointments of a kind of leaf extract containing hemp and preparation method thereof, belong to pet external-applied ointment field.It is made of the raw material of following parts by weight: 50~80 parts of matrix；15~25 parts of water；1~10 part of hemp leaf extract；1~10 part of emulsifier；0.1~1 part of preservative；0.01~0.08 part of calcium hydroxide.The sterilization with super strength of effective active components hemp leaf extract, anti-inflammatory, antipruritic and analgesic ability in the ointment, can effectively treat pet various skin symptoms because of caused by bacterium, fungi.The pet ointment is safe, green, without side-effects, and simple process is suitable for industrialized production.
Description
Technical field
The invention belongs to pet external-applied ointment field more particularly to a kind of pet externally-applied ointments of leaf extract containing hemp
And preparation method thereof.
Background technique
With the economic development and improvement of people's living standards, all kinds of pets such as cat, dog have stepped into huge numbers of families.
Raising pet has become the leisure lifestyle of younger generation, while being also the sustenance of unmarried family's emotion and spirit.So
The health of pet is increasingly by the attention of pet lovers.But due to the hirsutism of pet, and unhygienic diet, in addition itself
The foreign matter of secretion makes a variety of helminths have good growth condition, can also carry various germs sometimes.These viruses will lead to
The health problem of pet skin.
Pet skin disease refers to the system that can cause pet skin itch, the disease of depilation, incrustation and skin abnormality variation
Claim.The pathogenic factor of pet skin disease is more and complicated, related with age, dietary structure, living environment, stress factor etc..In recent years
Come, the disease incidence of pet skin disease is still very high, accounts for about 20% of clinical case or so.Although it is dead that skin disease not will lead to pet
It dies, but pet is long-term and people contacts, and then may threaten the health of people.Meanwhile skin disease also can be to the health of pet itself
Generate puzzlement.
Hemp leaf extract is extracted from industrial hemp, one kind cannboid obtained from being separated, being purified and
The general name of terpene substances.Main active ingredient cannabidiol (CBD) in hemp leaf extract is in sterilization, anti-inflammatory, antipruritic, analgesic
It is upper that there is good effect, there is the sterilizing ability of wide spectrum for all kinds of bacteriums, fungi.
Summary of the invention
The purpose of the present invention is to provide pet externally-applied ointments of a kind of leaf extract containing hemp and preparation method thereof.This is soft
The sterilization with super strength of effective active components hemp leaf extract, anti-inflammatory, antipruritic and analgesic ability in cream, can effectively treat and dote on
Object various skin symptoms because of caused by bacterium, fungi.The pet ointment is safe, green, without side-effects.
In order to achieve the above-mentioned object of the invention, the present invention, which mentions, adopts the following technical solutions:
A kind of pet externally-applied ointment of the leaf extract containing hemp, it is prepared by the raw material of following parts by weight:
50~80 parts of matrix；
15~25 parts of water；
1~10 part of hemp leaf extract；
1~10 part of emulsifier；
0.1~1 part of preservative；
0.01~0.08 part of calcium hydroxide.
The matrix is dimethicone, in atoleine, glycerin gelatine, albolene, beeswax, paraffin, lanolin
It is one or more of.
The hemp leaf extract includes that pure cannabidiol crystal or the industrial hemp containing cannabidiol compose oil entirely.
The emulsifier be glycerin monostearate, double stearic acid aluminium, lauryl sodium sulfate, Tween-20, Tween-80,
One or more of Arlacel-20, Arlacel-80, triethanolamine stearate, potassium stearate.
The preservative is ethylparaben, sodium benzoate, benzalkonium chloride, acyl in DMDMH(dihydroxymethyl dimethyl second
Urea), one or more of diazonium imidazolidinyl urea.
A kind of preparation method of the pet externally-applied ointment of the leaf extract containing hemp, it the following steps are included:
(1) matrix is proportionally placed in a beaker, in heating and melting in water-bath.It is added in matrix after thawing a certain amount of big
Sesame slices extract stirring and dissolving.
(2) emulsifier is added to the water under room temperature, after dissolution, sequentially adds calcium hydroxide, preservative, stir evenly.
(3) water phase in (2) is slowly added in (1) oily phase, side edged constantly stirs clockwise, until solution is creamy white partly
Solid-like to get.
In the step (1), heating water bath melts, and 60~80 DEG C of bath temperature.
Using foregoing invention the utility model has the advantages that
1) the effective active components hemp leaf extract sterilization with super strength in the ointment, anti-inflammatory, antipruritic and analgesic ability, energy
Effectively treatment pet various skin symptoms because of caused by bacterium, fungi.
2) the pet ointment skin easily absorbs, safe, green, without side-effects, avoids due to pet licks wound because licking and causes
Eat intoxication conditions by mistake.
3) present invention is simple, and usage is simple, curative for effect, at low cost, is suitable for being mass produced, and is a kind of
There is very much the product of application value.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.
Embodiment 1
A kind of pet externally-applied ointment of the leaf extract containing hemp, required composition of raw materials are as follows:
77.8 parts of matrix；
20 parts of water；
1.55 parts of hemp leaf extract；
0.5 part of emulsifier；
0.1 part of preservative；
0.05 part of calcium hydroxide.
The matrix is the mixture of atoleine, albolene, beeswax, paraffin.
The hemp leaf extract is the cannabidiol crystal of purity 99.6%.
The emulsifier is double stearic acid aluminium.
The preservative is ethylparaben.
Preparation method the following steps are included:
(1) 50.2g beeswax, 20.5g atoleine, 3.35g albolene, 3.75g paraffin are mixed and is placed in beaker, 70 DEG C
Heating and melting in water-bath.The cannabidiol powder of addition 1.55g purity 99.6% after thawing, is sufficiently stirred dissolution, is formed organic
Phase.
(2) 0.5g double stearic acid aluminium is added in 20g pure water under room temperature, after dissolution, sequentially adds 0.05g hydroxide
Calcium, 0.1g ethylparaben, stir evenly, and form water phase.
At (3) 70 DEG C, water phase made from step (2) is slowly added in oil phase made from step (1), side edged is constantly suitable
Hour hands stirring.Continue to stir after adding, the semi-solid until solution is creamy white, up to ointment after natural cooling.
Embodiment 2
A kind of pet externally-applied ointment of the leaf extract containing hemp, required composition of raw materials are as follows:
70.8 parts of matrix；
20 parts of water；
8.55 parts of hemp leaf extract；
0.5 part of emulsifier；
0.1 part of preservative；
0.05 part of calcium hydroxide.
The matrix is the mixture of 18.5g atoleine, 3.35g albolene, 45.2g beeswax, 3.75g paraffin.
The hemp leaf extract is that the industrial hemp of 8.55g cannabidiol content 60% composes oil entirely.
The emulsifier is 0.5g double stearic acid aluminium.
The preservative is 0.1g ethylparaben.
The preparation method is the same as that of Example 1 for a kind of pet externally-applied ointment of the leaf extract containing hemp.
Embodiment 3
A kind of pet externally-applied ointment of the leaf extract containing hemp, required composition of raw materials are as follows:
77.8 parts of matrix；
20 parts of water；
1.55 parts of hemp leaf extract；
0.5 part of emulsifier；
0.1 part of preservative；
0.05 part of calcium hydroxide.
The matrix is the mixture of 18.5g atoleine, 3.35g albolene, 48.95g lanolin.
The hemp leaf extract is that the industrial hemp of 8.55g cannabidiol content 60% composes oil entirely.
The emulsifier is 0.5g glycerin monostearate.
The preservative is 0.1g sodium benzoate.
The preparation method is the same as that of Example 1 for a kind of pet externally-applied ointment of the leaf extract containing hemp.
Ointment study on the stability
Centrefuge experiment: respectively taking 10g to be packed into centrifuge tube with a scale emulsifiable paste made from embodiment 1, embodiment 2, embodiment 3,
30min is centrifuged on the centrifuge of revolving speed 2500r/min, as a result the results show that three ointment are without lamination.
Heat-resisting cold-resistant experiment: it respectively takes 10g to be fitted into 3 emulsifiable paste boxes ointment made from embodiment 1, is respectively placed in baking oven
30 days in (39 ± 1 DEG C), room temperature (25 ± 3 DEG C), refrigerator (5 ± 2 DEG C), observe respectively its consistency, dehydration, color, uniformity with
And whether has and mould lose phenomenon.The results show that the obtained ointment consistency is substantially unchanged under high temperature, room temperature, low temperature environment,
Be not hardened phenomenon of losing water；Bright in color, no discoloration；It has good uniformity, no mildew.
The experimental results showed that ointment produced by the present invention has good stability.
Zoopery 1
100 are selected in pet clinic with dermopathic pet dog, illness dog face, neck back, skin of abdomen flush, play
Itch, occur different degrees of depilation at infection, there is a warts in affected part, pachyderma, and it is ruddy and in cerise to remove skin after crust.
Illness pet dog is randomly divided into 2 groups, experimental group 80, control group 20.
The illness pet dog of experimental group is treated respectively with externally-applied ointment made from embodiment 1.It is carried out in site of disease
It smears, each every place 0.5g dosage, 3 times a day, continuous treatment 15 days.Control group illness pet dog only smears ointment base in affected part
Matter.
Curative effect evaluation is carried out to each group pet dog after 15 days, the chlosma in every dog affected part is detected using methylene blue decoration method
Quantity, and treatment results are judged according to following standard:
Cure: chlosma quantity is within control group par 10%；
Effective: chlosma quantity is control group par 10~50%；
Effective: chlosma quantity is control group par 50~90%；
Invalid: chlosma quantity is 90% or more control group par；
It is efficient: (curing number+significant figure+effective number)/sum × 100%.
The therapeutic effect situation with statistical experiment group dog is calculated separately, as a result as follows:
By above-mentioned experimental result it is found that pet externally-applied ointment produced by the present invention has good healing to the skin infection of pet dog
Effect.For cure rate up to 62%, effective percentage is up to 100%.
Zoopery 2
100 are selected in pet clinic with dermopathic pet cat, illness cat face, neck back, skin of abdomen flush, play
Itch, sick dog have sharp ears and root of the tail etc. cover a large amount of crusts and the scales of skin that peel off, and break hair for Head And Face and other positions of body surface, round hair removal section skin
It considers to be worth doing more；Illness pet dog is randomly divided into 2 groups, experimental group 80, control group 20.
The illness pet cat of experimental group is treated respectively with externally-applied ointment made from embodiment 1.It is carried out in site of disease
It smears, each every place 0.1g dosage, 3 times a day, continuous treatment 15 days.Control group illness pet cat only smears ointment base in affected part
Matter.
Curative effect evaluation is carried out to each group pet cat after 15 days, the chlosma in every cat affected part is detected using methylene blue decoration method
Quantity, and treatment results are judged according to following standard:
Cure: chlosma quantity is within control group par 10%；
Effective: chlosma quantity is control group par 10~50%；
Effective: chlosma quantity is control group par 50~90%；
Invalid: chlosma quantity is 90% or more control group par；
It is efficient: (curing number+significant figure+effective number)/sum × 100%.
The therapeutic effect situation with statistical experiment group cat is calculated separately, as a result as follows:
By above-mentioned experimental result it is found that pet externally-applied ointment produced by the present invention equally has well the skin infection of pet cat
Curative effect.For cure rate up to 69%, effective percentage is up to 100%.
Above embodiments are only the explanations that makes an explanation to the present invention, do not carry out any limit to protection scope of the present invention
System.To those skilled in the art, all same embodiments done without departing from the technology of the present invention spirit or change exist
Within protection scope of the present invention.
Claims (7)
1. pet externally-applied ointment of a kind of leaf extract containing hemp and preparation method thereof, which is characterized in that it is by following parts by weight
Raw material preparation:
50~80 parts of matrix；
15~25 parts of water；
1~10 part of hemp leaf extract；
1~10 part of emulsifier；
0.1~1 part of preservative；
0.01~0.08 part of calcium hydroxide.
2. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 1, feature exists
In, the matrix be one of dimethicone, atoleine, glycerin gelatine, albolene, beeswax, paraffin, lanolin or
It is several.
3. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 1, feature exists
In the hemp leaf extract includes that pure cannabidiol crystal or the industrial hemp containing cannabidiol compose oil entirely.
4. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 1, feature exists
In the emulsifier is glycerin monostearate, double stearic acid aluminium, lauryl sodium sulfate, Tween-20, Tween-80, sapn-
20, one or more of Arlacel-80, triethanolamine stearate, potassium stearate.
5. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 1, feature exists
In, the preservative be ethylparaben, sodium benzoate, benzalkonium chloride, DMDMH(dimethyloldimethylhydantoin), again
One or more of nitrogen imidazolidinyl urea.
6. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 1, feature exists
In, comprising the following steps:
(1) matrix is proportionally placed in a beaker, in heating and melting in water-bath, is added in the matrix after thawing a certain amount of big
Sesame slices extract stirring and dissolving；
(2) emulsifier is added to the water under room temperature, after dissolution, sequentially adds calcium hydroxide, preservative, stir evenly；
(3) water phase in (2) is slowly added in (1) oily phase, side edged constantly stirs clockwise, the semisolid until solution is creamy white
Shape to get.
7. the pet externally-applied ointment and preparation method thereof of a kind of leaf extract containing hemp according to claim 6, feature exists
In, in the step (1), heating water bath melts, and 60~80 DEG C of bath temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910787428.8A CN110354171A (en) | 2019-08-26 | 2019-08-26 | A kind of pet externally-applied ointment of the leaf extract containing hemp and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910787428.8A CN110354171A (en) | 2019-08-26 | 2019-08-26 | A kind of pet externally-applied ointment of the leaf extract containing hemp and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110354171A true CN110354171A (en) | 2019-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910787428.8A Withdrawn CN110354171A (en) | 2019-08-26 | 2019-08-26 | A kind of pet externally-applied ointment of the leaf extract containing hemp and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135121A (en) * | 2020-01-16 | 2020-05-12 | 云南西草资源开发有限公司 | Pet massage oil and preparation method thereof |
| CN111920848A (en) * | 2020-08-24 | 2020-11-13 | 内蒙古科技大学包头医学院 | Antibacterial and antioxidant external ointment and preparation method thereof |
| CN112370478A (en) * | 2020-10-23 | 2021-02-19 | 广州新济薇娜生物科技有限公司 | Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method thereof |
-
2019
- 2019-08-26 CN CN201910787428.8A patent/CN110354171A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135121A (en) * | 2020-01-16 | 2020-05-12 | 云南西草资源开发有限公司 | Pet massage oil and preparation method thereof |
| CN111920848A (en) * | 2020-08-24 | 2020-11-13 | 内蒙古科技大学包头医学院 | Antibacterial and antioxidant external ointment and preparation method thereof |
| CN112370478A (en) * | 2020-10-23 | 2021-02-19 | 广州新济薇娜生物科技有限公司 | Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method thereof |
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Application publication date: 20191022 |
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