CN110338411A - A kind of food compositions and preparation method thereof for tumor disease - Google Patents
A kind of food compositions and preparation method thereof for tumor disease Download PDFInfo
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- CN110338411A CN110338411A CN201910780693.3A CN201910780693A CN110338411A CN 110338411 A CN110338411 A CN 110338411A CN 201910780693 A CN201910780693 A CN 201910780693A CN 110338411 A CN110338411 A CN 110338411A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to the food compositions of tumor disease and preparation methods, based on raw-food material, exempt and solve the food product industrialized production and listing product qualified as specification there are risk and safety；The problems such as tumor disease people is able to solve because of vitamin and minerals insufficiency of intake, lacks nutrition；Each ingredient uniformly meets state's laws regulation in the food compositions, being capable of industrialized production and listing；By being improved to preparation process, sufficiently solves the problems, such as that nutriment mixing is non-uniform, can be realized industrialized production；The dosage of strict control carbohydrate in the food compositions is significantly reduced because the problem of Hi CHO stimulates tumor tissue growth occurs.
Description
Technical field
The invention belongs to special medicine formula food fields, and in particular to a kind of food compositions for tumor disease and
Preparation method.
Background technique
Tumour is body under the effect of various tumorigenesis factors, and the cell of local organization loses at the genetic level grows it
Normal regulation cause paraplasm and differentiation and formed neoformation.Tumour lacks the enzyme for the acid that reduces fat, cannot be sharp very well
With free fatty acid, for host using fat as main energy sources, appropriate high fat diet can maintain weight and cell quality.Carbon water
Compound may potential stimulus tumor tissue growth, can also cause patient's water-sodium retention, aggravate peritonaeum and internal organs oedema, because
This, high-fat low-carb is the basic of formula.
Show that Incidence in 2015 is about according to the Nattonal Cancer statistical data of publication in National Cancer Center 2019
392.9 ten thousand people, dead about 233.8 ten thousand people.It is average to be diagnosed as cancer more than 10,000 people daily, there are 7.5 people to be diagnosed per minute
For cancer.And the product of food of existing production tumour patient and few, existing several prods majority does not meet national solid
Beverage standard and the national standard of nutrition fortifier addition, criteria of right and wrong helping digestion product do not meet listing.
For the foodstuff product of existing tumour patient, the problem of being primarily present the following aspects:
1, most of tumour patient food is added to plurality of raw materials, and the raw material integration of drinking and medicinal herbs of most of product, some are even
It is Chinese medicine, but does not consider raw material risk that may be present, safety and side effect.It cannot be excessive or a large amount of long-term
It is edible, and the laws and regulations of food are not accounted for, as listing product, do not meet state's laws regulation；
2, although most of tumour patient food is added to vitamin or minerals, because research staff grasps nutrient knowledge
Degree is inadequate, does not know about to state food policy and regulation.It is not comprehensive enough so as to cause the product nutrition developed, add one kind
Or several vitamins or minerals, it is far from satisfying demand of the tumour patient to nutrition.Such as many products do not add
Vitamin or minerals, or it is only added to vitamin C, without enhanced vitamin A, vitamin B1, vitamin B2, vitamin
B6 etc.；Vitamin and minerals additive amount do not meet the national standard of nutrition fortifier simultaneously, and product nutritive index does not meet state
Family's laws and regulations, cannot cannot function as regular food listing in plant produced；
3, technique is incomplete.One side dry production, mixing time are random, do not set mixing time and parameter.Albumen
Matter, the mixing of the nutrients such as fat, vitamin and minerals are uneven；On the other hand it is not premixed, such as mixing 500kg
Ingredient, wherein the low monomer vitamin of additive amount or minerals only have several grams, in this way if being difficult will in this way without premix
The low element of additive amount is uniformly mixed；
4, product energy-structure ratio is not accounted for.Tumour lacks the enzyme for the acid that reduces fat, and cannot utilize free-fat very well
Acid, for host using fat as main energy sources, appropriate high fat diet can maintain weight and cell quality.Carbohydrate may
Meeting potential stimulus tumor tissue growth, can also cause patient's water-sodium retention, aggravate peritonaeum and internal organs oedema, therefore, high-fat low
Carbohydrate is the basic of formula.
Summary of the invention
The characteristics of present invention is generally directed to tumour patients improves the prior art and its production technology, is with food
Raw material, adjustment proportion, realizes the scientific matching of protein, fat and carbohydrate, swells in the prior art to significantly improve
The generally existing safety issue of tumor disease food, while the nutritional supplementation effect to tumour patient is significantly improved, it is swollen to meet
The demand to three big magnanimity nutrition and vitamin and minerals to nutrition of tumor patient, and meet the rule of national relevant laws and regulations
It is fixed.By the improvement to technique, setting premix solves product nutritive element content uniformity.It is adjusted by the ratio to formula,
With low-carb, high fat content is more advantageous to the health of tumour patient, alleviates the flourish of tumour cell.
The present invention mainly has the technical scheme that
The present invention provides a kind of food compositions for tumor disease, comprising plant fat powder, medium chain triglyceride,
Protein composition, dextrin, oligosaccharide, vitamin combination and mineral composition；
Preferably, the parts by weight of each component are as follows in the food compositions: 5-30 parts of plant fat powder, medium chain triglyceride
Three 3-30 parts of esters, 10-40 parts of protein composition, 3-40 parts of dextrin, 1-15 parts of oligosaccharide, 0.1-5 parts of vitamin combination, mineral
0.1-5 parts of matter composition；
Preferably, the protein composition is selected from one or both of whey protein concentrate and soybean protein isolate；
Preferably, the dextrin is selected from one or both of maltodextrin and resistant dextrin；
Preferably, the oligosaccharide is selected from one or both of oligoisomaltose and oligofructose；
Preferably, the vitamin combination be selected from vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2,
One of vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, maltodextrin are a variety of；
Preferably, the mineral composition is selected from one of phosphorus agent, calcium agent, chalybeate, zinc agent, magnesia mixture, maltodextrin
Or it is a variety of, wherein the phosphorus agent is selected from one of calcium monohydrogen phosphate or ferric pyrophosphate or a variety of, calcium agent is selected from calcium monohydrogen phosphate, chalybeate
Selected from ferric pyrophosphate, zinc agent is selected from zinc oxide, and magnesia mixture is selected from magnesia；
Preferably, the food compositions also include compound amino acid, linseed oil powder, high oleic sunflower oil powder, DHA
One of algae oil powder, yeast dextran, taurine, L-carnitine are a variety of；
Invention further provides a kind of preparation method for preparing the food compositions for tumor disease, including it is as follows
Step:
(1) dextrin, vitamin combination, mineral composition and oligosaccharide are mixed in batch mixer, premix is made；
(2) premix is poured into batch mixer, remaining ingredient is added and is uniformly mixed；
(3) each component that step (2) are uniformly mixed is packed to get finished product；
Preferably, incorporation time is 10-30 minutes in the step (1), and batch mixer revolving speed is 15-50 revs/min；It is described
Incorporation time is 10-30 minutes in step (3).
For the present invention mainly with raw-food material, adjustment proportion realizes the proportion of protein, fat and carbohydrate, with
Realize the demand to three big magnanimity nutrition and vitamin and minerals to nutrition of tumour patient.
The present invention has the effect that compared with the existing technology
1, the food that product of the invention is configured to raw-food material exempts existing risk, significantly improves safety；
2, product nutritive index of the invention meets the laws and regulations of country, solves the method as food because not meeting country
Laws & Regulations, the problem of being unable to industrialized production and listing；
3, product of the invention meets the needs of tumour patient is to nutrition, solves product because vitamin and mineral etc. is sought
It supports insufficient, causes tumour patient nutritional deficiency；
4, present invention process process implements preparatory mixing, makes protein, fat, carbohydrate, vitamin and minerals
It is more uniform Deng mixing, product is solved because nutriment does not meet national legislation unevenly, is unable to industrialized production and listing stream
The problems such as logical.
Specific embodiment
To make the purpose of the present invention, technical solution and effect clearer, clear and definite, referring to specific embodiment to this hair
It is bright to be described in further detail.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not used to limit
The fixed present invention.
Embodiment 1
A kind of food compositions for tumor disease, including following component: whey protein concentrate 10kg, soybean separation protein
White 12kg, compound amino acid 8kg, plant fat powder 5kg, medium chain triglyceride MCT 20kg, linseed oil powder 10kg, high oleic acid
Sunflower seeds oil powder 15kg, maltodextrin 5.5kg, resistant dextrin 3kg, oligoisomaltose 5kg, oligofructose 1kg, DHA algal oil
Powder 1kg, yeast dextran 1kg, vitamin combination 0.5kg, mineral composition 3kg；
Wherein, the vitamin combination includes following ingredient: 1360 μ gRE of vitamin A, 1.60 μ g of vitamin D, dimension
Raw element E, 14.39mg α-TE, vitamin B1 1.76mg, vitamin B2 1.70mg, vitamin B6 1.2mg, vitamin B12
5.00 μ g, vitamin C 195.62mg, niacin 20mg, 360 μ g of folic acid, pantothenic acid 6mg, surplus is maltodextrin；
The mineral composition includes following ingredient: phosphorus (calcium monohydrogen phosphate) 325.15mg, calcium (calcium monohydrogen phosphate) 400mg,
Iron (ferric pyrophosphate) 19.11mg, zinc (zinc sulfate) 15.6mg, magnesium (magnesia) 180.01mg, surplus is maltodextrin；
The food compositions are prepared as follows:
(1) by maltodextrin, resistant dextrin, vitamin combination, mineral composition, oligoisomaltose and oligomeric fruit
Sugar is mixed in batch mixer, and three batch mixer revolving speeds are 15 revs/min, and incorporation time is 30 minutes, and premix is made；
(2) premix is poured into batch mixer, remaining ingredient is added and is uniformly mixed；
(3) each component that step (2) are uniformly mixed is packed to get finished product.
Embodiment 2
A kind of food compositions for tumor disease, including following component: whey protein concentrate 25kg, compound amino acid
8kg, plant fat powder 7kg, medium chain triglyceride MCT 20kg, linseed oil powder 10kg, high oleic sunflower oil powder 13kg, wheat
Bud dextrin 2.5kg, resistant dextrin 3.5kg, oligoisomaltose 4.3kg, oligofructose 1.2kg, DHA algal oil powder 1kg, yeast
Glucan 1kg, vitamin combination 0.5kg, mineral composition 3kg, taurine 125mg；
Wherein, the vitamin combination includes following ingredient: 1350 μ gRE of vitamin A, 1.50 μ g of vitamin D, dimension
Raw element E, 14.8mg α-TE, vitamin B1 1.5mg, vitamin B2 1.60mg, vitamin B6 1.3mg, vitamin B12 5.10
μ g, vitamin C 185.62mg, niacin 22mg, 367 μ g of folic acid, pantothenic acid 6mg, surplus is maltodextrin；
The mineral composition includes following ingredient: phosphorus (calcium monohydrogen phosphate) 329.15mg, calcium (calcium monohydrogen phosphate) 450mg,
Iron (ferric pyrophosphate) 19.81mg, zinc (zinc sulfate) 15.8mg, magnesium (magnesia) 185.01mg, surplus is maltodextrin.
The food compositions are prepared as follows:
(1) maltodextrin, vitamin combination, mineral composition and oligofructose are mixed in batch mixer, mixing
Machine revolving speed is 15 revs/min, and incorporation time is 30 minutes, and premix is made；
(2) premix is poured into batch mixer, remaining ingredient is added and is uniformly mixed；
(3) each component that step (2) are uniformly mixed is packed to get finished product.
Comparative example 1
A kind of food compositions, including following component: soybean protein isolate 25kg, pueraria lobata 8kg, plant fat powder 7kg, pupa
Cordyceps sinensis 20kg, konjaku 10kg, Poria cocos 13kg, kudzu-vine root powder 2.5kg, wolfberry fruit powder 4.5kg, oligoisomaltose 4.3kg, oligofructose
1.2kg, sea-buckthorn 1kg, vitamin C 160mg, calcium (calcium monohydrogen phosphate) 530mg；
Preparation process is the same as embodiment 1.
Comparative example 2
A kind of food compositions for tumor disease, including following component: whey protein concentrate 10kg, soybean separation protein
White 12kg, compound amino acid 8kg, plant fat powder 5kg, medium chain triglyceride MCT 20kg, linseed oil powder 10kg, high oleic acid
Sunflower seeds oil powder 15kg, maltodextrin 5.5kg, resistant dextrin 3kg, oligoisomaltose 5kg, oligofructose 1kg, DHA algal oil
Powder 1kg, yeast dextran 1kg, vitamin combination 0.5kg (1360 μ gRE of vitamin A, 1.60 μ g of vitamin D, dimension life
Plain E, 14.39mg α-TE, vitamin B1 1.76mg, vitamin B2 1.70mg, vitamin B6 1.2mg, vitamin B12 5.00
μ g, vitamin C 195.62mg, niacin 20mg, 360 μ g of folic acid, pantothenic acid 6mg, surplus is maltodextrin), mineral composition
3kg (phosphorus (calcium monohydrogen phosphate) 325.15mg, calcium (calcium monohydrogen phosphate) 400mg, iron (ferric pyrophosphate) 19.11mg, zinc (zinc sulfate)
15.6mg, magnesium (magnesia) 180.01mg, surplus is maltodextrin)；
The food compositions are prepared as follows:
(1) composition material mixes 30 minutes in batch mixer；
(2) each component that step (1) is uniformly mixed is packed to get finished product.
Verify example 1
The food compositions for tumor disease that the embodiment of the present invention 1 and embodiment 2 are prepared, all using food
Raw material all meets food production tolerance band, and nutrition fortifier meets national regulation, safer, more standardizes, by country
Nutrition fortifier meets national safety standard using regulation addition, protein therein, fat, carbohydrate etc..I.e. originally
It invents the food compositions nutritive index for tumor disease being prepared and meets state food regulation, it can be with listing.
Verify example 2
20 lung cancer chemotherapy patients are chosen, are randomly divided into 4 groups, successively labeled as group 1, group 2, group 3 and group 4, every group of 5 trouble
Person.The food compositions that embodiment 1, embodiment 2, comparative example 1 and comparative example 2 are prepared are given respectively to group 4 patient of 1- group,
It is primary for each person every day, altogether to 30 days.
After 30 days respectively to biochemical indicator, adverse reaction, the state of mind etc. before and after four groups of edible for patients carry out observation and
Detection, to carry out Nutrition Evaluation.As a result as shown in table 1 below, wherein weight is calculated as practical, the state of mind with it is very poor, poor, one
As, it is preferable, fabulous assessed, the synthesis product average that seralbumin increases or decreases be evaluation of estimate.
Table 1
| Changes of weight | The state of mind | Seralbumin variation | |
| Before edible | 0% | It is poor | 0% |
| Group 1 | 2.12% | Preferably | 0.92% |
| Group 2 | 2.02% | Preferably | 0.82% |
| Group 3 | 0.92% | Generally | 0.26% |
| Group 4 | 1.96% | Preferably | 0.88% |
The results show that group 1 and 2 patient's weight of group dramatically increase, and the state of mind is more preferable, and haemocyanin increases relative to group 3
Degree is added to become apparent.Prove that the present composition is significantly higher than the composition of comparison example 1 to tumour patient nutrition improvement.
Through embodiment 1 and 2 composition of embodiment compared with comparative example 1, protein in embodiment 1 and embodiment 2, rouge
Fat, carbohydrate, vitamin, mineral matter and other components are clear, and index is stablized, and product index, which is clearly eaten, more safety.It is right
It include pueraria lobata, Cordyceps militaris 20kg, konjaku 10kg, Poria cocos, kudzu-vine root powder, the raw material of the integration of drinking and medicinal herbs such as wolfberry fruit powder, containing many than example 1
Traditional Chinese medicine ingredients can not detect, there are biggish risks completely at being grouped as and the composition of chemical combination is indefinite.And this
Invention all meets food production tolerance band, and nutrition fortifier meets national regulation, more pacifies all using raw-food material
Entirely, it more standardizes.
Verify example 3
The food compositions that Example 1 and comparative example 2 are prepared respectively, to protein therein, fat, carbon aquation
Conjunction object, sodium, vitamin C, calcium component are detected, and testing result is as shown in table 2 below:
Table 2
By the above results it can be seen that, the food for tumor disease being prepared by using preparation method of the present invention
Composition, protein therein is fatty, the ingredients such as carbohydrate regulation that meet national standards, testing result in example 1
1 and 2 deviation of testing result it is little, and 2 testing result deviations are larger in comparison example 2, illustrate the premix after the present invention
Technique is more preferable than the composition uniformity for not doing premixing process.
In compared with the existing technology using non-food stuff even medicinal material as the product of raw material, product of the present invention use raw-food material
Based on, safety is more preferable.Product of the present invention nutrition is comprehensive, adds multivitamin and minerals, meets tumour patient to battalion
Feeding demand.Existing product nutrients are single, are not able to satisfy tumour patient to the nutritional need of vitamin and minerals.
Whole vitamin and minerals added by the present invention, all meet the national standard of nutrition fortifier, and finished product refers to
Reference symbol closes state's laws regulation, and the legal industrialized production of energy can listing.Even if portioned product is added to dimension in the prior art
Raw element and minerals, but state's laws regulation is not met, the industrialized production of alimentary codex cannot be met, be unable to listing.
Present invention process process implements preparatory mixing, make nutrient mixing it is more uniform, solve product because of nutriment not
Not the problems such as uniformly not meeting national legislation, be unable to industrialized production and listing.
The above specific embodiment part has carried out specific introduction to analysis method according to the present invention.It should be noted that
, only to assist in those skilled in the art, methods of this invention will be better understood and thinking for above-mentioned introduction, rather than right
The limitation of related content.Without departing from the principles of the present invention, those skilled in the art can also fit the present invention
When adjustment or modification, above-mentioned adjustment and modification should also be as belonging to the scope of protection of the present invention.
Claims (10)
1. a kind of food compositions for tumor disease include plant fat powder, medium chain triglyceride, protein composition, paste
Essence, oligosaccharide, vitamin combination and mineral composition.
2. food compositions according to claim 1, which is characterized in that the parts by weight of each component in the food compositions
Number is as follows: 5-30 parts of plant fat powder, 3-30 parts of medium chain triglyceride, 10-40 parts of protein composition, 3-40 parts of dextrin, oligomeric
It is 1-15 parts sugared, 0.1-5 parts of vitamin combination, 0.1-5 parts of mineral composition.
3. food compositions according to claim 1, which is characterized in that the protein composition is selected from whey protein concentrate
One or both of with soybean protein isolate.
4. food compositions according to claim 1, which is characterized in that the dextrin is selected from maltodextrin and resistant dextrin
One or both of.
5. food compositions according to claim 1, which is characterized in that the oligosaccharide is selected from oligoisomaltose and low
One or both of Fructooligosaccharides.
6. food compositions according to claim 1, which is characterized in that the vitamin combination is selected from vitamin A, dimension
Raw element D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, wheat
One of bud dextrin is a variety of.
7. food compositions according to claim 1, which is characterized in that the mineral composition be selected from phosphorus agent, calcium agent,
One of chalybeate, zinc agent, magnesia mixture, maltodextrin are a variety of, wherein the phosphorus agent is in calcium monohydrogen phosphate or ferric pyrophosphate
One or more, calcium agent is selected from calcium monohydrogen phosphate, and chalybeate is selected from ferric pyrophosphate, and zinc agent is selected from zinc oxide, and magnesia mixture is selected from magnesia.
8. food compositions according to claim 1, which is characterized in that the food compositions also include compounded amino
Acid, linseed oil powder, high oleic sunflower oil powder, DHA algal oil powder, yeast dextran, taurine, L-carnitine, beta-hydroxy-
Beta-methyl butyrate, one of or it is a variety of.
9. the preparation method of any one of -8 food compositions according to claim 1, which is characterized in that the preparation method packet
Include following steps:
(1) dextrin, vitamin combination, mineral composition and oligosaccharide are mixed in three-dimensional material mixer, premix is made；
(2) premix is poured into batch mixer, remaining ingredient is added and is uniformly mixed；
(3) each component that step (2) are uniformly mixed is packed to get finished product.
10. preparation method according to claim 9, which is characterized in that incorporation time is 10-30 points in the step (1)
Clock, batch mixer revolving speed are 15-50 revs/min；Incorporation time is 10-30 minutes in the step (3).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529715A (en) * | 2020-04-22 | 2020-08-14 | 山东大学 | Dextran-docosahexaenoic acid coupling polymer and synthesis method and application thereof |
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| CN103330215A (en) * | 2013-07-11 | 2013-10-02 | 西安力邦临床营养有限公司 | Nutrition formula food applicable to tumor patient |
| CN105533696A (en) * | 2015-12-17 | 2016-05-04 | 北京振东光明药物研究院有限公司 | Powder type total-nutrient formula food for patients suffering from tumors |
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