CN110314094A - A kind of Ni Lapani electuary and preparation method thereof efficiently utilized - Google Patents
A kind of Ni Lapani electuary and preparation method thereof efficiently utilized Download PDFInfo
- Publication number
- CN110314094A CN110314094A CN201910614587.8A CN201910614587A CN110314094A CN 110314094 A CN110314094 A CN 110314094A CN 201910614587 A CN201910614587 A CN 201910614587A CN 110314094 A CN110314094 A CN 110314094A
- Authority
- CN
- China
- Prior art keywords
- electuary
- lapani
- discharge pipe
- turntable
- top discharge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 43
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 36
- 238000012856 packing Methods 0.000 claims abstract description 24
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 18
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 18
- 239000011718 vitamin C Substances 0.000 claims abstract description 18
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 17
- 239000008103 glucose Substances 0.000 claims abstract description 17
- 229940122274 Carboxylesterase inhibitor Drugs 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 238000004806 packaging method and process Methods 0.000 claims description 18
- 239000000945 filler Substances 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 16
- 235000013339 cereals Nutrition 0.000 claims description 15
- 238000009826 distribution Methods 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 238000010276 construction Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011122 softwood Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000012043 crude product Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000020985 whole grains Nutrition 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 4
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 3
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 abstract description 33
- 239000003814 drug Substances 0.000 abstract description 28
- 229940079593 drug Drugs 0.000 abstract description 23
- 230000009471 action Effects 0.000 abstract description 10
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 6
- 230000029142 excretion Effects 0.000 abstract description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- 239000006052 feed supplement Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 5
- 229910052742 iron Inorganic materials 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 229920000881 Modified starch Polymers 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- 102000013392 Carboxylesterase Human genes 0.000 description 3
- 108010051152 Carboxylesterase Proteins 0.000 description 3
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 3
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 3
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- 230000005778 DNA damage Effects 0.000 description 2
- 231100000277 DNA damage Toxicity 0.000 description 2
- 206010064571 Gene mutation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 108091007743 BRCA1/2 Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000004611 cancer cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 description 1
- 229950011068 niraparib Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B1/06—Methods of, or means for, filling the material into the containers or receptacles by gravity flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
- B65B1/36—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by volumetric devices or methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/42—Heating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/70—Device provided with specific sensor or indicating means
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Quality & Reliability (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Basic Packing Technique (AREA)
Abstract
The invention discloses the Ni Lapani electuaries and preparation method thereof that one kind efficiently utilizes, and belong to technical field of medicament, the component of Ni Lapani electuary includes Ni Lapani, glucose, vitamin C and carboxylesterase inhibitor；The electuary packing machine used in preparation method includes material storing box and the transparent top discharge pipe through material storing box, and the two sides of top discharge pipe are respectively equipped with liftable infrared transmitter and infrared remote receiver；The turntable for offering arc port is equipped with below top discharge pipe, turntable side is equipped with the telescopic scotch with close switch, offers arc groove on turntable.Granule provided by the invention can reduce the amount of the Ni Lapani drug with excretion, and the drug action of Ni Lapani can be made to be maintained；The service life of the valve associated components of the electuary packing machine used in the granule preparation process is longer, it is ensured that each blanking is enough, and the electuary clout for making surplus be less than setting value stays in top discharge pipe, and application is more convenient.
Description
Technical field
The present invention relates to technical field of medicament, it is specifically related to the Ni Lapani electuary and its system that one kind efficiently utilizes
Preparation Method.
Background technique
Ni Lapani (Niraparib) is a kind of oral Poly ADP-ribose polymerase (PARP) inhibitor, mainly for
It is the cancer of BRCA1/2 gene mutation, exploitation is used for oophoroma and breast cancer.Ni Lapani inhibits cell to repair DNA damage
It is multiple, for the cancer cell with BRCA gene mutation, if PARP activity is further suppressed, when these cell divisions
A large amount of DNA damages will be generated, cancer cell death is caused.The chemical name of Ni Lapa is 2- [4- ((3S) -3- piperidyl) benzene
Base] -2H- indazole -7- formamide, it is developed by MSD Corp., after transfer biotech company, U.S. Tesaro, the public affairs
Department announces the three phase clinical datas that Ni Lapani is directed to advanced ovarian cancer, presents extremely good curative effect.
Studies show that, recycling mean value is from urine after single oral radiolabeled Ni Lapani 300mg, 21d
47.5% (33.4%~60.2%) recycles the radioactivity of 38.8% (28.3%~47.0%) in stool.Collect 6d collection
Sample, unchanged prototype medicine account for medication dose 11% and 19% respectively in urine and stool.This indicates that some drugs not
It plays a role, causes the waste of Ni Lapani.
Electuary refers to that the extract of medicinal material adds appropriate excipient or part fine medicinal material powder that dry particle shape or block-like is made
Oral medicine need to increase mixing in water for oral taking when taking.Electuary is more rapid compared with pill, tablet effect, small in size compared with decoction, syrup,
It is light-weight, it is readily transported carrying.Electuary usually requires to carry out bag distribution packaging with electuary packing machine in the preparation, and existing impact
Packing machine usually in discharge outlet using the frequent opening and closing realization Quantitative dosing of electric control valve, the service life of the electric control valve compared with
It is short；Existing electuary packing machine closes electric control valve when detecting that electuary surplus is less than preset value immediately, if automatically controlled at this time
Valve is just at opening in the period, then containing quantity needed for the amount of last time blanking before this can be less than one bag, if
It is not desired to waste electuary just to need to collect the part electuary and return in material storing box, application is more inconvenient.
Summary of the invention
1. technical problems to be solved
The technical problem to be solved in the present invention is that a kind of Ni Lapani electuary and preparation method thereof efficiently utilized is provided,
Its granule provided can reduce the content for the Ni Lapani drug not played a role with excretion, and can make Ni Lapani
Drug action be maintained；The electuary packing machine used in the granule preparation process can avoid frequently opening and closing electrically-controlled valve
Door, service life are longer, it is ensured that each blanking is enough, and the electuary clout for making surplus be less than setting value stays in top discharge
In pipe, to continue blanking after feed supplement, application is more convenient.
2. technical solution
To solve the above problems, the present invention adopts the following technical scheme that:
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
5-10 parts of Ni Lapani；
3-5 parts of carboxylesterase inhibitor；
8-10 parts of glucose；
2-4 parts of vitamin C；
65-75 parts of filler；
3-5 parts of disintegrating agent.
Further, the filler is any one or more in pregelatinized starch, lactose and microcrystalline cellulose
Composition.
Further, the disintegrating agent is sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and cross-linked carboxymethyl fiber
The composition of any one or more in plain sodium.
The present invention also provides the preparation methods of the above-mentioned Ni Lapani electuary efficiently utilized, include the following steps:
S1. prepared by softwood: Ni Lapani electuary, carboxylesterase inhibitor, glucose and the vitamin C system that will efficiently utilize
After thick paste, softwood is mixed and made into filler and disintegrating agent；
S2. it makes wet grain: oscillating granulator being opened and is preheated, softwood obtained in step S1 is placed in oscillating granulator
The middle wet grain of system；
S3. it dries: wet grain obtained in step S2 is delivered in boiling drier, lead to hot wind, wet grain is through fluidized drying
After obtain particle crude product；
S4. whole grain, sieve grain: particle crude product obtained in step S3 is placed in pelletizing machine and carries out whole grain, is subsequently placed in double
In layer shaking screen, select to obtain particle fine work through two layer screen mesh screen；
S5. it packs: bag distribution packaging being carried out to particle fine work obtained in step S4 with electuary packing machine, Ni Lapani is made
Electuary finished product；
Further, the sieve mesh number of oscillating granulator described in step S2 is 50 mesh, the roller of oscillating granulator
Revolving speed is 70-80r/min.
Further, the temperature for the hot wind being passed through in boiling drier described in step S3 is 60 DEG C, air quantity 2000-
2500m/h。
Further, the sieve of the first layer of bilayer shaking screen described in step S4 is 20 mesh, and the sieve of the second layer is 60
Mesh.
The present invention also provides the electuary packing machine used in a kind of above-mentioned steps S5, specific structures are as follows:
The electuary packing machine includes from top to bottom sequentially connected material storing box, Quantitative dosing structure and automatic bag distribution packaging
Structure, material storing box upper end side are equipped with feed hopper, and the shape of the storing lower box part is tapered, and the bottom of material storing box is opened
Equipped with discharge port, transparent top discharge pipe is equipped in the discharge port vertically, top discharge pipe upper end passes through the top of material storing box
Portion is simultaneously connected with rotary electric machine one, and the position that the top of the material storing box and discharge outlet are passed through for top discharge pipe is respectively and fixedly provided with close
Bearing is sealed, equidistantly offers at least three along its border on the corresponding top discharge pipe in the tapered part of the storing lower box part
Enter the feed inlet in top discharge pipe for electuary；The fixed plate being fixed with inside the top discharge pipe above feed inlet, institute
It states and is equipped with electromagnet one in fixed plate, be connected with the lifters of face feed inlet below the fixed plate by spring one, it is described
Lifters top is built-in with the feeromagnetic metal block that can be adsorbed by electromagnet one, and the lifters lower part is equidistantly fixed along its border
Have and pass through corresponding feed inlet with the one-to-one scraper plate of feed inlet, the scraper plate other end, the width of the scraper plate be equal into
The width of material mouth；Material storing box bottom two opposite sides are respectively and fixedly provided with support column；
The Quantitative dosing structure include be respectively arranged on top discharge pipe two opposite sides infrared transmitter and infrared remote receiver,
The turntable being positioned horizontally in below top discharge pipe and the telescopic stop assembly set on turntable side, the infrared transmitter and red
Outer receiver is mounted on a clearance-type and is set on the disk on the outside of top discharge pipe, and the disk is connected with lifting assembly, institute
It states infrared transmitter leading flank and is fixed with indicator, label has ruler, altitude scale ruler on the support column leading flank
" 0 " graduation mark it is concordant with top discharge infratubal port, indicator extends at altitude scale ruler backwards to one end of infrared transmitter；
The turntable side offers the arc port with the perforation turntable upper and lower end face of turntable concentric, the width of the arc port
Not less than the bore of top discharge pipe, and arc leads to the corresponding radius in middle part between mouth inner and outer side and is equal at top discharge tube hub point
The arc groove with turntable concentric, institute are offered with the ring side middle part of the horizontal distance between the turntable center of circle, the turntable
It states turntable bottom center and is connected with rotary electric machine two；Where the telescopic stop assembly is mounted on it on support column of side,
The telescopic stop assembly includes fixed block and the telescopic scotch in fixed block, offers confession in the fixed block
The cavity of scotch telescopic moving, the scotch can be inserted into arc groove after stretching out cavity, the width etc. of the scotch
In the difference of the length of arc groove and arc port, the scotch is fixed with towards the side inside cavity and is connected in cavity
Spring two, the fixed block is built-in with electromagnet two backwards to the side of cavity port, the scotch be built-in with can and electromagnetism
Iron two generate magnetic repulsion permanent magnet, the scotch correspond to the side on rear side of turntable rotation direction it is embedded be equipped with approach open
It closes, is fixed with jingle bell component on the support column；The bottom discharge pipe of face top discharge pipe, the turntable are equipped with below the turntable
It is held between top discharge pipe and bottom discharge pipe, the automatic bag distribution packaging structure is connected to the lower end of bottom discharge pipe.
Further, the top discharge pipe, which is located on the outer surface of the part in material storing box, is fixed with paddle.It is rotating
When motor one drives the rotation of top discharge pipe, paddle, which rotates with it, to be stirred the electuary in material storing box, can avoid electuary
Accumulation squeezes, and then can ensure the smoothness of blanking.
Further, the lifters are " T " shape, and the feeromagnetic metal block is set in the crossbar sections of lifters, described
Scraper plate is fixed on the vertical bar part of lifters.Setting can provide enough parking spaces for feeromagnetic metal block and reduce liter in this way
The space that drop block occupies, so as to ensure that electuary falls in the top discharge pipe where elevator.
Further, the lifting assembly includes screw slider construction module and locking positioning module, the screw slider
The lead screw of construction module is set to top discharge pipe rear vertically, and the sliding block of screw slider construction module is fixedly connected with disk, described
The side of lead screw is equipped with guide rod in parallel, and the sleeve being set on guide rod, the upper and lower side point of the guide rod are fixed on the sliding block
It is not correspondingly provided with the upper plate and lower plate being connected on corresponding side support column, the lead screw upper end is equipped with and is fixed on upper plate
Bearing, lead screw lower end passes through and lower plate and is fixed with swing handle；Locking positioning module includes being horizontally fixed on disk
Gag lever post and the sliding slot being opened on the support column of gag lever post free end place side, the free end of the gag lever post is slidably connected to
In sliding slot, the free end of the gag lever post is vertically and fixedly provided with bolt, offers on the side wall of the sliding slot side and passes through for bolt
Strip-shaped hole, the part that the bolt is located on the outside of strip-shaped hole is arranged with nut compatible with bolt.After unscrewing nut, rotation
Swing handle directly can drive lead screw to rotate, because the mobile effect of the limit of guide rod and sleeve enables sliding block to move down along lead screw
Dynamic, so that disk be driven to move up and down, gag lever post moves up and down along the chute therewith, and bolt is moved up and down along strip-shaped hole, works as movement
When to object height, stops operating and swing handle and tighten nut, it can be achieved that locking to disk position, so as to stable infrared
The position of transmitter and infrared remote receiver.
Further, one end of the scotch connecting spring two is fixed with limited block, offers on the cavity side wall
For the mobile protrusion slot of limited block, the protrusion slot is located inside at cavity port backwards to one end of spring two.Setting can in this way
The fully extended cavity of scotch is prevented, is conducive to ensure that scotch can retract in cavity.
3. beneficial effect
(1) contain glucose and vitamin C in drug provided by the present invention.Vitamin C has strong reducing property, can be by people
The ferro element of body supplement is reduced into the iron of reduction-state, and human body intestinal canal is made to more easily absorb ferro element, i.e., vitamin C, which has, promotees
The function of absorbing into ferro element, ferro element are the primary raw materials for synthesizing hemoglobin；Glucose can provide thermal energy；Comprehensive aforementioned two
Person can promote hemoglobin regeneration to enrich blood, can weaken and cause after taking Ni Lapani while improving thermal energy, supplementing the nutrients
Make this adverse reaction of anaemia；In human body hemoglobin measure with promoted, then can increase Ni Lapani in conjunction with plasma protein
Amount can reduce the waste of Ni Lapani so as to reduce the content for the Ni Lapani drug not played a role with excretion, it is real
The efficient utilization of existing Ni Lapani.
(2) contain carboxylesterase inhibitor in drug provided by the present invention, glucose and vitamin C promote Ni Lapani
Amount in conjunction with plasma protein increases, this concentration that will lead to Ni Lapani Free drug reduces, to reduce drug action；
Carboxylesterase inhibitor can inhibit carboxy-lesterase to the metabolic activity of Ni Lapani drug ingedient, so that Ni Lapani trip can be improved
The concentration of release drug can be relieved the problem of Ni Lapani drug action caused by glucose and vitamin C reduces, so that Buddhist nun draws
The drug action of pa Buddhist nun is maintained.
(3) the electuary packing machine used in preparation method provided by the present invention includes material storing box and through the upper of material storing box
Discharge nozzle, top discharge pipe upper end are connected with rotary electric machine one, start rotary electric machine one, and top discharge pipe can be driven to rotate, so as to
It ensures that the upper surface of granule granule accumulation in top discharge pipe is more smooth, and then has ensured the accurate of subsequent infrared detection movement
Property；The part that top discharge pipe is located at bottom in material storing box offers the feed inlet entered in top discharge pipe for granule granule, above goes out
The width of feed inlet can be equal to along the scraper plate that feed inlet moves up and down, the width of scraper plate by being equipped in expects pipe, and scraper plate moves up and down
Feed inlet edge can be scraped, granule granule can be prevented to be adhered on feed inlet.
(4) electuary packing machine provided by the invention is equipped with the turntable for offering arc port, in the rotation process of turntable,
Only when arc port turns to below top discharge pipe, granule granule could pass through turntable and enter in bottom discharge pipe, and turntable turns
The time of the dynamic corresponding center of circle angular region of arc port is the time of a blanking, by the revolving speed controllable one for controlling turntable
The time of secondary blanking, and then control the amount of a blanking；When the other parts of turntable turn to below top discharge pipe, turntable envelope
The lower port for blocking discharge nozzle realizes intermittent Quantitative dosing (defined by amount adjustable), in order to bag distribution packaging, avoids electricity
The frequent opening and closing for controlling valve, is conducive to extend the service life of associated mechanisms.
(5) the top discharge pipe of electuary packing machine provided by the invention is transparent, and its two opposite sides be respectively equipped with it is infrared
Transmitter and infrared remote receiver issue infrared detection line by infrared transmitter, on height where infrared detection line is corresponding
The volume of discharge nozzle is containing quantity needed for a packaging bag, and the containing quantity is as setting value, if the electuary in top discharge pipe
Particle is greater than the set value, then infrared remote receiver cannot receive infrared signal；It is set once the granule granule in top discharge pipe is less than
Definite value, infrared remote receiver can receive infrared signal, and the operation for stopping blanking being controlled so as to triggering following；Turntable side is set
There is telescopic stop assembly, telescopic stop assembly is equipped with telescopic scotch, and scotch is equipped with close to switch, turntable
Ring offers arc groove on side, can start telescopic stop assembly when infrared remote receiver receives infrared signal, make it
Scotch is inserted into arc groove, if arc port is also located at immediately below top discharge pipe at this time, i.e., in a blanking process
(under material in shortage), there are also a distances for rear side end of the scotch apart from arc groove rotation direction at this time, then rotate electricity
Machine two continues to drive turntable rotation, continues blanking process and completes then when arc port has just left immediately below top discharge pipe
Primary enough blankings, the rear side end that scotch is located just at arc groove rotation direction at this time will connect with arc groove side wall
Touching could be triggered close to switch, and the rotation for the motor two that stops operating, turntable no longer rotates, and blocks top discharge infratubal port, together
Shi Qidong jingle bell component reminds related personnel to carry out feed supplement.It can guarantee that each blanking is enough, and surplus can be made to be less than setting
The electuary clout of value stays in top discharge pipe, and to continue blanking after feed supplement, application is more convenient.
(6) infrared transmitter of electuary packing machine provided by the invention and infrared remote receiver are installed in one and are sheathed on
On disk on the outside of discharge nozzle, disk is connected with lifting assembly, and the height of disk is adjusted by lifting assembly, that is, is adjustable red
The height of outer detection line can adjust Quantitative dosing structure and be limited so as to containing quantity needed for adjusting a packaging bag
The amount of a fixed blanking.
To sum up, granule provided by the present invention can reduce containing for the Ni Lapani drug not played a role with excretion
Amount, realizes the efficient utilization of Ni Lapani, and the drug action of Ni Lapani can be made to be maintained；It is prepared by the granule
The electuary packing machine used in journey can avoid frequently opening and closing electric control valve, and the service life of associated mechanisms is longer, it can be achieved that interval
Formula Quantitative dosing simultaneously guarantees that each blanking is enough, and defined by a blanking amount it is adjustable, moreover it is possible to make surplus be less than set
The electuary clout of definite value stays in top discharge pipe, and to continue blanking after feed supplement, application is more convenient.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of electuary packing machine provided by the invention；
Fig. 2 is the cross-sectional view that electuary packing machine is splitted along vertical median plane；
Fig. 3 is the structure enlargement diagram of region A in Fig. 1；
Fig. 4 is the structure enlargement diagram of region B in Fig. 2；
In the state that Fig. 5 is Quantitative dosing structure is in blanking process when scotch 23 is inserted into arc groove 20
The schematic top plan view of turntable 15 and telescopic stop assembly；
Fig. 6 is the schematic top plan view of the turntable 15 and telescopic stop assembly when being triggered close to switch 28.
Appended drawing reference: 1, feed hopper；2, top discharge pipe；3, rotary electric machine one；4, bearing is sealed；5, feed inlet；6, electromagnetism
Iron one；7, spring one；8, lifters；9, feeromagnetic metal block；10, material storing box；11, scraper plate；12, support column；13, infrared emission
Device；14, infrared remote receiver；15, turntable；16, disk；17, indicator；18, altitude scale ruler；19, arc port；20, arc
Groove；21, rotary electric machine two；22, fixed block；23, scotch；24, cavity；25, spring two；26, electromagnet two；27, permanent magnetism
Iron；28, close to switch；29, jingle bell component；30, automatic bag distribution packaging structure；31, bottom discharge pipe；32, paddle；33, lead screw；
34, sliding block；35, guide rod；36, sleeve；37, bearing；38, swing handle；39, gag lever post；40, sliding slot；41, bolt；42, bar shaped
Hole；43, nut；44, limited block；45, slot is protruded.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
Embodiment 1
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
5 parts of Ni Lapani；
5 parts of carboxylesterase inhibitor；
8 parts of glucose；
2 parts of vitamin C；
75 parts of filler；
3 parts of disintegrating agent.
In the present embodiment, the filler is pregelatinized starch.
In the present embodiment, the disintegrating agent is sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and cross-linked carboxymethyl
The composition of sodium cellulosate, their mass ratio are 2:1:1.
The preparation method of the above-mentioned Ni Lapani electuary efficiently utilized, includes the following steps:
S1. prepared by softwood: Ni Lapani electuary, carboxylesterase inhibitor, glucose and the vitamin C system that will efficiently utilize
After thick paste, softwood is mixed and made into filler and disintegrating agent；
S2. it makes wet grain: oscillating granulator being opened and is preheated, softwood obtained in step S1 is placed in oscillating granulator
The middle wet grain of system；
S3. it dries: wet grain obtained in step S2 is delivered in boiling drier, lead to hot wind, wet grain is through fluidized drying
After obtain particle crude product；
S4. whole grain, sieve grain: particle crude product obtained in step S3 is placed in pelletizing machine and carries out whole grain, is subsequently placed in double
In layer shaking screen, select to obtain particle fine work through two layer screen mesh screen；
S5. it packs: bag distribution packaging being carried out to particle fine work obtained in step S4 with electuary packing machine, Ni Lapani is made
Electuary finished product；
In the present embodiment, the sieve mesh number of oscillating granulator described in step S2 is 50 mesh, oscillating granulator
Drum rotation speed is 70r/min.
In the present embodiment, the temperature for the hot wind being passed through in boiling drier described in step S3 is 60 DEG C, and air quantity is
2000m/h。
In the present embodiment, the sieve of the first layer of bilayer shaking screen described in step S4 is 20 mesh, the sieve of the second layer
For 60 mesh.
The specific structure of the electuary packing machine used in above-mentioned steps S5 are as follows:
As shown in Figures 1 and 2, the electuary packing machine includes from top to bottom sequentially connected material storing box 10, Quantitative dosing
Structure and automatic bag distribution packaging structure 30, the 10 upper end side of material storing box are equipped with feed hopper 1, the shape of 10 lower part of material storing box
Shape is tapered, and the bottom of material storing box 10 offers discharge port, is equipped with transparent top discharge pipe 2, institute vertically in the discharge port
2 upper end of top discharge pipe is stated across the top of material storing box 10 and is connected with rotary electric machine 1, the top of the material storing box 10 and discharging
It is respectively and fixedly provided with sealing bearing 4 for the position that top discharge pipe 2 passes through at mouthful, the tapered part in 10 lower part of material storing box is corresponding
At least three feed inlets 5 entered for electuary in top discharge pipe 2 are equidistantly offered along its border on top discharge pipe 2；On described
The fixed plate being fixed with above feed inlet 5 inside discharge nozzle 2, the fixed plate is interior to be equipped with electromagnet 1, the fixed plate
Lower section is connected with the lifters 8 of face feed inlet 5 by spring 1, and 8 top of lifters is built-in with can be by electromagnet 1
The feeromagnetic metal block 9 of absorption, 8 lower part of lifters are equidistantly fixed with and the one-to-one scraper plate of feed inlet 5 along its border
11,11 other end of scraper plate passes through corresponding feed inlet 5, and the width of the scraper plate 11 is equal to the width of feed inlet 5；The storage
10 bottom two opposite sides of hopper are respectively and fixedly provided with support column 12；
The Quantitative dosing structure includes the infrared transmitter 13 and infrared receiver for being respectively arranged on 2 two opposite sides of top discharge pipe
Device 14, the turntable 15 for being positioned horizontally in 2 lower section of top discharge pipe and the telescopic stop assembly set on 15 side of turntable, it is described infrared
Transmitter 13 and infrared remote receiver 14 are mounted on a clearance-type and are set on the disk 16 in 2 outside of top discharge pipe, the disk
16 are connected with lifting assembly, and 13 leading flank of infrared transmitter is fixed with indicator 17, the 12 leading flank subscript of support column
Note has altitude scale ruler 18, and " 0 " graduation mark of altitude scale ruler 18 is concordant with 2 lower port of top discharge pipe (can be directly according to instruction
The signified data of needle 17 read the corresponding height that infrared transmitter 13 and infrared remote receiver 14 detect, so as to limit convenient for calculating
Electuary amount), indicator 17 extends at altitude scale ruler 18 backwards to one end of infrared transmitter 13；15 side of turntable
The arc port 19 with perforation 15 upper and lower end face of turntable of 15 concentric of turntable is offered, the width of the arc port 19 is not small
In the bore of top discharge pipe 2, and the corresponding radius in middle part in arc port 19 between outside is equal to 2 center of top discharge pipe
With the horizontal distance between 15 center of circle of turntable, the ring side middle part of the turntable 15 offers recessed with the arc of 15 concentric of turntable
Slot 20,15 bottom center of turntable are connected with rotary electric machine 2 21；The telescopic stop assembly is mounted on side where it
Support column 12 on, as shown in figure 4, the telescopic stop assembly include fixed block 22 and it is telescopic be set to fixed block 22 in
Scotch 23, the cavity 24 for 23 telescopic moving of scotch is offered in the fixed block 22, and the scotch 23 stretches out cavity
It can be inserted into arc groove 20 after 24, the width of the scotch 23 is equal to the difference of the length of arc groove 20 and arc port 19
(scotch 23 can be just played in the just separate top discharge pipe 2 of arc port 19 to the limit stopping function of turntable 15), it is described
Scotch 23 is fixed with the spring 2 25 being connected in cavity 24 towards the side inside cavity 24, and the fixed block 22 is backwards to appearance
The side of 24 port of chamber is built-in with electromagnet 2 26, and the scotch 23, which is built-in with, to generate magnetic repulsion forever with electromagnet 2 26
Magnet 27, it is embedded equipped with close switch 28, the support that the scotch 23 corresponds to the side on rear side of 15 rotation direction of turntable
Jingle bell component 29 is fixed on column 12；The bottom discharge pipe 31 of face top discharge pipe 2, the turntable 15 are equipped with below the turntable 15
It is held between top discharge pipe 2 and bottom discharge pipe 31, the automatic bag distribution packaging structure 30 is connected to the lower end of bottom discharge pipe 31.
In the present embodiment, as shown in Fig. 2, the top discharge pipe 2 is located on the outer surface of the part in material storing box 10 admittedly
Surely there is paddle 32.When rotary electric machine 1 drives top discharge pipe 2 to rotate, paddle 32 rotates with it can be in material storing box 10
Electuary be stirred, can avoid electuary accumulation and squeeze, and then can ensure the smoothness of blanking.
In the present embodiment, as shown in Fig. 2, the lifters 8 are " T " shape, the feeromagnetic metal block 9 is set to lifters 8
Crossbar sections in, the scraper plate 11 is fixed on the vertical bar part of lifters 8.Setting can provide in this way for feeromagnetic metal block 9
Enough parking spaces simultaneously reduce the space that elevator occupies, so as to ensure electuary in the top discharge pipe 2 where elevator
Interior whereabouts.
In the present embodiment, as shown in Figures 1 and 2, the lifting assembly includes that screw slider construction module and locking are fixed
The lead screw 33 of position module, the screw slider construction module is set to 2 rear of top discharge pipe, 33 sliding block of lead screw, 34 construction module vertically
Sliding block 34 be fixedly connected with disk 16, the side of the lead screw 33 is equipped with guide rod 35 in parallel, is fixed with set on the sliding block 34
The sleeve 36 being located on guide rod 35, the upper and lower side of the guide rod 35 respectively correspond upper on corresponding side support column 12 equipped with being connected to
Connecting plate and lower plate, 33 upper end of lead screw are equipped with the bearing 37 being fixed on upper plate, and 33 lower end of lead screw passes through lower plate simultaneously
It is fixed with swing handle 38；As shown in Figures 1 and 3, locking positioning module includes the gag lever post 39 being horizontally fixed on disk 16
And the sliding slot 40 where being opened in 39 free end of gag lever post on the support column 12 of side, the free end of the gag lever post 39 is slidably connected
In in sliding slot 40, the free end of the gag lever post 39 is vertically and fixedly provided with bolt 41, offers on the side wall of 40 side of sliding slot
For the strip-shaped hole 42 that bolt 41 passes through, the part that the bolt 41 is located at 42 outside of strip-shaped hole is arranged with compatible with bolt 41
Nut 43.After unscrewing nut 43, rotation swing handle 38 can directly drive lead screw 33 to rotate, because of the limit of guide rod 35 and sleeve 36
Being displaced dynamic effect enables sliding block 34 to move up and down along lead screw 33, so that disk 16 be driven to move up and down, the edge therewith of gag lever post 39
Sliding slot 40 moves up and down, and bolt 41 is moved up and down along strip-shaped hole 42, and when being moved to object height, stop operating swing handle 38
And tighten nut 43, it can be achieved that locking to 16 position of disk, so as to stable infrared transmitter 13 and infrared remote receiver 14
Position.
In the present embodiment, as shown in figure 4, one end of 23 connecting spring 2 25 of the scotch is fixed with limited block 44,
The protrusion slot 45 mobile for limited block 44 is offered on 24 side wall of cavity, the protrusion slot 45 is backwards to one end of spring 2 25
The inside at 24 port of cavity.Setting can prevent the fully extended cavity 24 of scotch 23 in this way, be conducive to ensure scotch 23
It can retract in cavity 24.
The action principle of the above-mentioned Ni Lapani electuary efficiently utilized includes: that glucose and vitamin C can be promoted in human body
The amount of hemoglobin can increase amount of the Ni Lapani in conjunction with plasma protein, not play a role so as to reduce with excretion
Ni Lapani drug content, the waste of Ni Lapani can be reduced, realize the efficient utilization of Ni Lapani；Carboxy-lesterase inhibits
Agent can inhibit carboxy-lesterase to the metabolic activity of Ni Lapani drug ingedient, so that the dense of Ni Lapani Free drug can be improved
Degree can be relieved the problem of Ni Lapani drug action caused by glucose and vitamin C reduces, so that the drug effect of Ni Lapani is made
With being maintained.
The specific mechanism of above-mentioned electuary packing machine are as follows:
Ni Lapani particle fine work obtained is poured into material storing box 10 from feed hopper 1, starting rotary electric machine 1 rotates,
Top discharge pipe 2 is driven to rotate, granule granule enters in top discharge pipe 2 from feed inlet 5, and the rotation of top discharge pipe 2 can ensure out
The upper surface that granule granule is accumulated in expects pipe 2 is more smooth, and then has ensured subsequent infrared detection accuracy of action；To electromagnetism
Iron 1 is powered, adsorbable feeromagnetic metal block 9, so that lifters 8 rise, drives scraper plate 11 to move up along feed inlet 5, one 7 quilt of spring
Compression；It is powered off to electromagnet 1, declines lifters 8,
Scraper plate 11 is driven to move down along feed inlet 5, moving up and down for scraper plate 11 can scrape 5 edge of feed inlet, can prevent electuary
Particle is adhered on feed inlet 5；
Granule granule falls along top discharge pipe 2, under original state, arc port 19 on turntable 15 not with top discharge pipe 2
Connection, granule granule are accumulated in top discharge pipe 2, and rotary electric machine 1 drives the rotation of top discharge pipe 2 so that in top discharge pipe 2
Granule granule realize smooth accumulation effect；Height and the locking of disk 16 are adjusted by lifting assembly, it can stable infrared
The position of transmitter 13 and infrared remote receiver 14 (determines the height of infrared detection line, the appearance of the corresponding top discharge pipe 2 of height
Product is containing quantity needed for a packaging bag, and the containing quantity is as setting value, and the setting value is adjustable), then start infrared
Transmitter 13, infrared remote receiver 14 and rotary electric machine 2 21, rotary electric machine 2 21 drives turntable 15 to rotate, when 19 turns of arc port
When moving supreme 2 underface of discharge nozzle, granule granule is fallen in bottom discharge pipe 31 by arc port 19, when arc port 19 from
When opening top discharge 2 underface of pipe, turntable 15 blocks 2 lower port of top discharge pipe, suspends blanking, and automatic bag distribution packaging structure 30 is accepted
Before descended material is packaged in a packaging bag；(because of top discharge pipe 2 before infrared remote receiver 14 receives infrared signal
The granule granule of interior accumulation blocks the propagation of infrared ray), Quantitative dosing structure carries out intermittent Quantitative dosing with abovementioned steps
The amount of a blanking (defined by adjustable), in order to bag distribution packaging, avoids the frequent opening and closing of electric control valve, is conducive to extend
The service life of associated mechanisms；
It (indicates that granule granule is less than setting value in top discharge pipe 2) when infrared remote receiver 14 receives infrared signal, gives
Electromagnet 2 26 is powered, the magnetic repulsion to permanent magnet 27 of generation, so that the protruding cavity 24 of scotch 23 and being inserted into arc
In groove 20, spring 2 25 is stretched, and is divided into two kinds of situations at this time, under just having left top discharge pipe 2 just one is arc port 19
Fang Shi has just completed primary enough blankings, scotch 23 is located just at the rear side end of 20 rotation direction of arc groove i.e. at this time
It will contact, be triggered close to switch 28, the rotation for the motor 2 21 that stops operating with 20 side wall of arc groove, turntable 15 no longer rotates,
And 2 lower port of top discharge pipe is blocked, while starting jingle bell component 29, remind related personnel to carry out feed supplement, rotary electric machine 2 21 stops
It after turning, is powered off to electromagnet 2 26, under the reset response of spring 2 25, scotch 23 is pulled to retract in cavity 24；It is another
When being that arc port 19 is also located at top discharge 2 underface of pipe, i.e., in a blanking process (under material in shortage), such as Fig. 5
Shown, rear side end of the scotch 23 apart from 20 rotation direction of arc groove be there are also a distance at this time, then rotary electric machine 2 21 after
It is continuous that turntable 15 is driven to rotate, continue blanking process and is completed then when arc port 19 has just left top discharge 2 underface of pipe
Primary enough blankings, the rear side end that scotch 23 is located just at 20 rotation direction of arc groove at this time will be with arc groove 20
Side wall contact, as shown in fig. 6, could trigger close to switch 28, stop blanking and remind carry out feed supplement；It can guarantee that each blanking is equal
It is enough, and the electuary clout that surplus can be made to be less than setting value stays in top discharge pipe 2, to it can continue after feed supplement under
Material, application are more convenient.
Embodiment 2
The present embodiment and 1 side of embodiment the difference is that:
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
6.5 parts of Ni Lapani；
4.5 parts of carboxylesterase inhibitor；
8.5 parts of glucose；
2.5 parts of vitamin C；
72 parts of filler；
3.5 parts of disintegrating agent.
In the present embodiment, the filler is the composition of lactose and microcrystalline cellulose, their mass ratio is 2:5.
In the present embodiment, the disintegrating agent is low-substituted hydroxypropyl cellulose.
In the present embodiment, the sieve mesh number of oscillating granulator described in the step S2 of preparation method is 50 mesh, is shaken
The drum rotation speed of pendulum-type granulator is 5r/min.
In the present embodiment, the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, feature exist
In the temperature for the hot wind being passed through in boiling drier described in the step S3 of preparation method is 60 DEG C, air quantity 2500m/
h。
Other are the same as embodiment 1.
Embodiment 3
The present embodiment and 1 side of embodiment the difference is that:
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
7.5 parts of Ni Lapani；
4 parts of carboxylesterase inhibitor；
9 parts of glucose；
3 parts of vitamin C；
70 parts of filler；
4 parts of disintegrating agent.
In the present embodiment, the filler is the composition of pregelatinized starch, lactose and microcrystalline cellulose, their matter
Amount is than being 3:1:2.
In the present embodiment, the disintegrating agent is the composition of sodium carboxymethyl starch and croscarmellose sodium, it
Mass ratio be 3:1.
In the present embodiment, the sieve mesh number of oscillating granulator described in the step S2 of preparation method is 50 mesh, is shaken
The drum rotation speed of pendulum-type granulator is 80r/min.
In the present embodiment, the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, feature exist
In the temperature for the hot wind being passed through in boiling drier described in the step S3 of preparation method is 60 DEG C, air quantity 2200m/
h。
Other are the same as embodiment 1.
Embodiment 4
The present embodiment and 1 side of embodiment the difference is that:
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
8.5 parts of Ni Lapani；
3.5 parts of carboxylesterase inhibitor；
9.5 parts of glucose；
3.5 parts of vitamin C；
68 parts of filler；
4.5 parts of disintegrating agent.
In the present embodiment, the filler is microcrystalline cellulose.
In the present embodiment, the disintegrating agent is the combination of low-substituted hydroxypropyl cellulose and croscarmellose sodium
Object, their mass ratio are 5:3.
In the present embodiment, the sieve mesh number of oscillating granulator described in the step S2 of preparation method is 50 mesh, is shaken
The drum rotation speed of pendulum-type granulator is 70r/min.
In the present embodiment, the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, feature exist
In the temperature for the hot wind being passed through in boiling drier described in the step S3 of preparation method is 60 DEG C, air quantity 2100m/
h。
Other are the same as embodiment 1.
Embodiment 5
The present embodiment and 1 side of embodiment the difference is that:
A kind of Ni Lapani electuary efficiently utilized, the component including following parts by weight:
10 parts of Ni Lapani；
3 parts of carboxylesterase inhibitor；
10 parts of glucose；
4 parts of vitamin C；
65 parts of filler；
5 parts of disintegrating agent.
In the present embodiment, the filler is the composition of pregelatinized starch and lactose, their mass ratio is 4:3.
In the present embodiment, the disintegrating agent is sodium carboxymethyl starch.
In the present embodiment, the sieve mesh number of oscillating granulator described in the step S2 of preparation method is 50 mesh, is shaken
The drum rotation speed of pendulum-type granulator is 80r/min.
In the present embodiment, the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, feature exist
In the temperature for the hot wind being passed through in boiling drier described in the step S3 of preparation method is 60 DEG C, air quantity 2400m/
h。
Other are the same as embodiment 1.
As shown in the above, granule provided by the present invention can reduce the Ni Lapa not played a role with excretion
The content of Buddhist nun's drug, realizes the efficient utilization of Ni Lapani, and the drug action of Ni Lapani can be made to be maintained；The electuary
The electuary packing machine used during medicine preparation can avoid frequently opening and closing electric control valve, and the service life of associated mechanisms is longer,
Intermittent Quantitative dosing can be achieved and guarantee that each blanking is enough, and defined by a blanking amount it is adjustable, moreover it is possible to make to remain
The electuary clout that surplus is less than setting value stays in top discharge pipe, and to continue blanking after feed supplement, application is more convenient.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen in scope of the presently claimed invention.
Claims (10)
1. the Ni Lapani electuary that one kind efficiently utilizes, which is characterized in that the component including following parts by weight:
5-10 parts of Ni Lapani；
3-5 parts of carboxylesterase inhibitor；
8-10 parts of glucose；
2-4 parts of vitamin C；
65-75 parts of filler；
3-5 parts of disintegrating agent；
The preparation method of the above-mentioned Ni Lapani electuary efficiently utilized, includes the following steps:
S1. prepared by softwood: the Ni Lapani electuary, carboxylesterase inhibitor, glucose and the vitamin C that efficiently utilize being made thick
After cream, softwood is mixed and made into filler and disintegrating agent；
S2. it makes wet grain: oscillating granulator being opened and is preheated, softwood obtained in step S1 is placed in oscillating granulator and is made
Wet grain；
S3. it dries: wet grain obtained in step S2 is delivered in boiling drier, lead to hot wind, wet grain obtains after fluidized drying
To particle crude product；
S4. whole grain, sieve grain: particle crude product obtained in step S3 is placed in pelletizing machine and carries out whole grain, is subsequently placed in double-layer vibration
It swings in sieve, selects to obtain particle fine work through two layer screen mesh screen；
S5. it packs: bag distribution packaging being carried out to particle fine work obtained in step S4 with electuary packing machine, Ni Lapani electuary is made
Finished product；
The specific structure of the electuary packing machine used in above-mentioned steps S5 are as follows:
The electuary packing machine includes from top to bottom sequentially connected material storing box (10), Quantitative dosing structure and automatic bag distribution packaging
Structure (30), material storing box (10) the upper end side are equipped with feed hopper (1), and the shape of material storing box (10) lower part is tapered,
And the bottom of material storing box (10) offers discharge port, is equipped with transparent top discharge pipe (2) in the discharge port vertically, it is described above to go out
Expects pipe (2) upper end pass through material storing box (10) top and be connected with rotary electric machine one (3), the top of the material storing box (10) and go out
The position passed through at material mouth for top discharge pipe (2) is respectively and fixedly provided with sealing bearing (4), the tapered portion in material storing box (10) lower part
On point corresponding top discharge pipe (2) along its border equidistantly offer at least three enter for electuary in top discharge pipe (2) into
Material mouth (5)；The fixed plate being fixed with above feed inlet (5) inside the top discharge pipe (2), the fixed plate is interior to be equipped with electricity
Magnet one (6), the fixed plate lower section are connected with the lifters (8) of face feed inlet (5), the lifting by spring one (7)
Part (8) top is built-in with the feeromagnetic metal block (9) that can be adsorbed by electromagnet one (6), and lifters (8) lower part is along its border etc.
Spacing, which is fixed with, passes through corresponding feed inlet with feed inlet (5) one-to-one scraper plate (11), scraper plate (11) other end
(5), the width of the scraper plate (11) is equal to the width of feed inlet (5)；Material storing box (10) the bottom two opposite sides are respectively and fixedly provided with
Support column (12)；
The Quantitative dosing structure includes the infrared transmitter (13) and infrared receiver for being respectively arranged on top discharge pipe (2) two opposite sides
Device (14), the turntable (15) being positioned horizontally in below top discharge pipe (2) and the telescopic stop assembly for being set to turntable (15) side,
The infrared transmitter (13) and infrared remote receiver (14) are mounted on the circle that a clearance-type is set on the outside of top discharge pipe (12)
On disk (16), the disk (16) is connected with lifting assembly, and infrared transmitter (13) leading flank is fixed with indicator (17),
Marking on support column (12) leading flank has ruler (18), " 0 " graduation mark of the altitude scale ruler (18) with it is upper
Discharge nozzle (2) lower port is concordant, and indicator (17) extends at altitude scale ruler (18) backwards to the one end of infrared transmitter (13)；
Turntable (15) side offers and the arc port (19) of perforation turntable (15) upper and lower end face of turntable (15) concentric, institute
The width for stating arc port (19) is not less than the bore of top discharge pipe (2), and the middle part in arc port (19) between outside is right
The radius answered is equal to the horizontal distance between top discharge pipe (2) center and turntable (15) center of circle, the ring of the turntable (15)
It is offered in the middle part of side and is connected with rotation with the arc groove (20) of turntable (15) concentric, turntable (15) bottom center
Motor two (21)；Where the telescopic stop assembly is mounted on it on support column (12) of side, the telescopic stop assembly
Including fixed block (22) and the telescopic scotch (23) in fixed block (22), offer in the fixed block (22) for stopping
The cavity (24) of motion block (23) telescopic moving, the scotch (23) can be inserted into arc groove (20) after stretching out cavity (24),
The width of the scotch (23) is equal to the difference of the length of arc groove (20) and arc port (19), scotch (23) court
The side internal to cavity (24) is fixed with the spring two (25) being connected in cavity (24), and the fixed block (22) is backwards to cavity
(24) side of port is built-in with electromagnet two (26), and the scotch (23) is built-in with can generate magnetic reprimand with electromagnet two (26)
The permanent magnet (27) of power, it is embedded equipped with close switch that the scotch (23) corresponds to the side on rear side of turntable (15) rotation direction
(28), jingle bell component (29) are fixed on the support column (12)；Face top discharge pipe (2) is equipped with below the turntable (15)
Bottom discharge pipe (31), the turntable (15) are held between top discharge pipe (2) and bottom discharge pipe (31), the automatic bag distribution packaging
Structure (30) is connected to the lower end of bottom discharge pipe (31).
2. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the filler is pre-
The composition of any one or more in gelling starch, lactose and microcrystalline cellulose.
3. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the disintegrating agent is carboxylic
The composition of any one or more in methyl starch sodium, low-substituted hydroxypropyl cellulose and croscarmellose sodium.
4. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the step of preparation method
The sieve mesh number of oscillating granulator described in rapid S2 is 50 mesh, and the drum rotation speed of oscillating granulator is 70-80r/min.
5. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the step of preparation method
The temperature for the hot wind being passed through in boiling drier described in rapid S3 is 60 DEG C, air quantity 2000-2500m/h.
6. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the step of preparation method
The sieve of the first layer of bilayer shaking screen described in rapid S4 is 20 mesh, and the sieve of the second layer is 60 mesh.
7. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the top discharge pipe
(2) it is located on the outer surface of the part in material storing box (10) and is fixed with paddle (32).
8. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the lifters (8)
" T " shape, the feeromagnetic metal block (9) is set in the crossbar sections of lifters (8), and the scraper plate (11) is fixed on lifters
(8) on vertical bar part.
9. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the lifting assembly packet
Screw slider construction module and locking positioning module are included, the lead screw (33) of the screw slider construction module is set to top discharge vertically
(2) rear is managed, the sliding block (34) of screw slider construction module is fixedly connected with disk (16), and the side of the lead screw (33) is parallel
Equipped with guide rod (35), be fixed with the sleeve (36) being set on guide rod (35) on the sliding block (34), the guide rod (35) it is upper
Lower end respectively corresponds the upper plate and lower plate for being equipped with and being connected on corresponding side support column (12), and lead screw (33) upper end is equipped with
The bearing (37) being fixed on upper plate, lead screw (33) lower end pass through lower plate and are fixed with swing handle (38)；Locking positioning
The support of side where module includes the gag lever post (39) being horizontally fixed on disk (16) and is opened in gag lever post (39) free end
Sliding slot (40) on column (12), the free end of the gag lever post (39) are slidably connected in sliding slot (40), the gag lever post (39)
Free end be vertically and fixedly provided with bolt (41), offer the bar shaped passed through for bolt (41) on the side wall of sliding slot (40) side
Hole (42), the bolt (41) are located at the part on the outside of strip-shaped hole (42) and are arranged with and bolt (41) compatible nut (43).
10. the Ni Lapani electuary that one kind according to claim 1 efficiently utilizes, which is characterized in that the scotch
(23) one end of connecting spring two (25) is fixed with limited block (44), is offered on cavity (24) side wall for limited block (44)
Mobile protrusion slot (45), protrusion slot (45) are located inside at cavity (24) port backwards to one end of spring two (25).
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| CN201910614587.8A CN110314094B (en) | 2019-07-09 | 2019-07-09 | High-efficiency utilized Nilaparib electuary and preparation method thereof |
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| CN110844191A (en) * | 2019-11-29 | 2020-02-28 | 福泉市康元农产品加工农民专业合作社 | Packing apparatus is used in red rice production and processing |
| CN111495271A (en) * | 2020-06-18 | 2020-08-07 | 广东睿智环保科技有限责任公司 | Powder coating extruder |
| CN112479146A (en) * | 2020-11-02 | 2021-03-12 | 安徽独秀山蓝莓科技开发有限公司 | Blueberry is raw materials extracting device for juice beverage processing |
| CN112590166A (en) * | 2020-12-18 | 2021-04-02 | 九江昌顺新材料有限公司 | Extruder raw materials ration unloading equipment |
| CN113148251A (en) * | 2021-02-26 | 2021-07-23 | 杨鸽 | Tea adding dish capable of quantitatively adjusting volume |
| CN113960609A (en) * | 2021-10-20 | 2022-01-21 | 杭州艾科赛德电子科技有限公司 | Non-contact mud layer interface instrument |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A highly effective Nilapani granules and its preparation method Effective date of registration: 20221019 Granted publication date: 20210723 Pledgee: Xingye Bank Limited by Share Ltd. Anqing branch Pledgor: ANHUI HAIKANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980018855 |
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Address after: 246000 No.21, Huancheng West Road, Daguan District, Anqing City, Anhui Province Patentee after: Anhui Haikang Pharmaceutical Co.,Ltd. Country or region after: China Address before: 246000 No.21, Huancheng West Road, Daguan District, Anqing City, Anhui Province Patentee before: ANHUI HAIKANG PHARMACEUTICAL Co.,Ltd. Country or region before: China |
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