CN110312717A - 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 - Google Patents

取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 Download PDF

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CN110312717A
CN110312717A CN201880012340.2A CN201880012340A CN110312717A CN 110312717 A CN110312717 A CN 110312717A CN 201880012340 A CN201880012340 A CN 201880012340A CN 110312717 A CN110312717 A CN 110312717A
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pyridine
imidazo
benzo
dimethyl
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CN110312717B (zh
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蔡遂雄
田野
王晓珠
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Impact Therapeutics Inc
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Abstract

本发明提供取代的稠合杂芳三环化合物作为激酶抑制剂及其应用。具体而言，本发明提供式(I)的化合物，或其可药用盐或前药，其中A1‑A3，B1‑B3，D1‑D4和R1‑R2为本文所定义。式I的化合物是ATM激酶抑制剂。因此，本发明的化合物可用于治疗因为DDR功能缺陷而引起的临床病症，例如癌症。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201880012340.2A 2017-02-27 2018-02-26 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 Active CN110312717B (zh)

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PCT/CN2018/077188 WO2018153365A1 (zh) 2017-02-27 2018-02-26 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用

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CN114026097B (zh) * 2019-07-10 2024-02-23 上海瑛派药业有限公司 取代的吡唑并喹唑啉酮化合物及其应用
EP4028400A4 (en) * 2019-09-12 2023-09-06 Impact Therapeutics (Shanghai), Inc SUBSTITUTED IMIDAZOQUINOXALINE COMPOUNDS AND THEIR USES
US11685734B2 (en) 2019-12-04 2023-06-27 Chdi Foundation, Inc. ATM kinase inhibitors and compositions and methods of use thereof

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WO2005016919A1 (en) * 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
WO2006085067A1 (en) * 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
WO2015170081A1 (en) * 2014-05-08 2015-11-12 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2016155884A1 (de) * 2015-04-02 2016-10-06 Merck Patent Gmbh Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

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WO2005016919A1 (en) * 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
WO2006085067A1 (en) * 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
WO2015170081A1 (en) * 2014-05-08 2015-11-12 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2016155884A1 (de) * 2015-04-02 2016-10-06 Merck Patent Gmbh Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

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MERIC, ASIYE等: "Synthesis of some 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines and evaluation of their cytotoxicities towards F2408 and 5RP7 cells", 《REVISTA DE CHIMIE (BUCHAREST, ROMANIA)》 *
SEREF DEMIRAYAK等: "Synthesis and anticancer and anti-HIV testing of some pyrazino[1,2-a]benzimidazole derivatives", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *

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